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Matrix Metalloproteinase 基质金属蛋白酶
Pub Date : 2020-02-02 DOI: 10.1007/978-3-540-47648-1_3556
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引用次数: 108
41 : inside the presidency of George H.W. Bush 乔治·h·w·布什总统任期内
Pub Date : 2017-01-31 DOI: 10.7591/9780801470820
Michael C. Nelson, Barbara A. Perry
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引用次数: 2
Risk factors for lymph node metastasis in mucosal gastric cancer and re-evaluation of endoscopic submucosal dissection 粘膜胃癌淋巴结转移的危险因素及内镜下粘膜剥离的再评价
Pub Date : 2016-08-29 DOI: 10.4174/astr.2016.91.3.118
S. Lee, C. Choi, S. Kim, C. Choi, D. Kim, T. Jeon, Dong-Heon Kim, H. J. Lee, Ki-Hyun Kim, Sun-Hwi Hwang
Purpose The selection of the appropriate treatment strategy for patients with mucosal gastric cancer (MGC) remains controversial. In the present study, we aimed to determine the risk factors for lymph node (LN) metastasis in MGC and reassess the role of endoscopic submucosal dissection (ESD). Methods We examined 1,191 MGC patients who underwent curative gastrectomy between January 2005 and December 2014. We determined the clinicopathologic risk factors for LN metastasis among the MGC patients. Results Among 1,191 patients with MGC, 42 patients (3.5%) had LN metastasis. Univariate analysis indicated that age ≤ 50 years (P = 0.045), tumor invasion to the muscularis mucosa (P < 0.001), tumor size > 2 cm (P = 0.014), presence of ulceration (P = 0.01), diffuse type as per Lauren classification (P = 0.005), and undifferentiated-type histology (P = 0.001) were associated with LN metastasis. Moreover, multivariate analysis indicated that tumor invasion to the muscularis mucosa (P = 0.001; odds ratio [OR], 4.909), presence of ulceration (P = 0.036; OR, 1.982), and undifferentiated-type histology (P = 0.025; OR, 4.233) were independent risk factors for LN metastasis. In particular, LN metastasis was observed in some MGC cases with indications for ESD, including absolute indications (1 of 179, 0.6%) and expanded indications (9 of 493, 1.8%). Conclusion Although MGC patients can be treated via ESD, we recommend that they undergo a more aggressive treatment strategy if they have tumor invasion to the muscularis mucosa, ulceration, or undifferentiated-type histology in the final pathology report.
目的黏膜胃癌(MGC)患者选择合适的治疗策略一直存在争议。在本研究中,我们旨在确定MGC中淋巴结(LN)转移的危险因素,并重新评估内镜下粘膜下剥离(ESD)的作用。方法对2005年1月至2014年12月间行根治性胃切除术的1191例MGC患者进行回顾性分析。我们确定了MGC患者发生淋巴结转移的临床病理危险因素。结果1191例MGC患者中有42例(3.5%)发生淋巴结转移。单因素分析显示,年龄≤50岁(P = 0.045)、肿瘤侵袭肌层粘膜(P < 0.001)、肿瘤大小为bbb2cm (P = 0.014)、有无溃疡(P = 0.01)、Lauren分类中的弥漫性(P = 0.005)和未分化型组织学(P = 0.001)与淋巴结转移相关。此外,多因素分析显示肿瘤侵袭肌层粘膜(P = 0.001;优势比[OR], 4.909),溃疡的存在(P = 0.036;OR, 1.982),未分化型组织学(P = 0.025;OR(4.233)是淋巴结转移的独立危险因素。特别是在一些有ESD适应症的MGC病例中观察到淋巴结转移,包括绝对适应症(179例中有1例,0.6%)和扩展适应症(493例中有9例,1.8%)。结论:虽然MGC患者可以通过ESD进行治疗,但我们建议在最终病理报告中,如果肿瘤浸润到肌层粘膜、溃疡或未分化型组织学,则应采用更积极的治疗策略。
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引用次数: 7
Feasibility and safety of laparoscopic resection following stent insertion for obstructing left-sided colon cancer. 左侧结肠癌支架置入术后腹腔镜切除的可行性及安全性。
Pub Date : 2013-12-01 Epub Date: 2013-11-26 DOI: 10.4174/jkss.2013.85.6.290
Seoung Yoon Rho, Sung Uk Bae, Se Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim

Purpose: The aim of this study was to assess the feasibility and safety of laparoscopic resection following the insertion of self-expanding metallic stents (SEMS) for the treatment of obstructing left-sided colon cancer.

Methods: Between October 2006 and December 2012, laparoscopic resection following SEMS insertion was performed in 54 patients with obstructing left-sided colon cancer.

Results: All 54 procedures were technically successful without the need for conversion to open surgery. The median interval from SEMS insertion to laparoscopic surgery was 9 days (range, 3-41 days). The median surgery time was 200 minutes (range, 57-444 minutes), and estimated blood loss was 50 mL (range, 10-3,500 mL). The median time to soft diet was 4 days (range, 2-8 days) and possible length of stay (hypothetical length of stay according to the discharge criteria) was 7 days (range, 4-22 days). The median total number of lymph nodes harvested was 23 (range, 8-71) and loop ileostomy was performed in 2 patients (4%). Six patients (11%) developed postoperative complications: 2 patients with anastomotic leakages, 1 with bladder leakage, and 3 with ileus. There was no mortality within 30 days.

Conclusion: The present study shows that the presence of a SEMS does not compromise the laparoscopic approach. Laparoscopic resection following stent insertion for obstructing left-sided colon cancer could be performed with a favorable safety profile and short-term outcome. Large-scale comparative studies with long-term follow-up are needed to demonstrate a significant benefit of this approach.

目的:本研究的目的是评估自膨胀金属支架(SEMS)插入后腹腔镜切除治疗梗阻性左侧结肠癌的可行性和安全性。方法:2006年10月至2012年12月,对54例梗阻性左侧结肠癌患者行SEMS插入后腹腔镜切除术。结果:54例手术在技术上均获得成功,无需转开腹手术。从SEMS插入到腹腔镜手术的中位间隔为9天(范围3-41天)。中位手术时间为200分钟(范围,57-444分钟),估计失血量为50 mL(范围,10- 3500 mL)。软性饮食的中位时间为4天(范围2-8天),可能的住院时间(根据出院标准假设的住院时间)为7天(范围4-22天)。淋巴结总数中位数为23(范围8-71),2例(4%)患者行回肠袢造口术。术后并发症6例(11%),吻合口漏2例,膀胱漏1例,肠梗阻3例。30天内无死亡病例。结论:目前的研究表明,SEMS的存在并不影响腹腔镜入路。腹腔镜下支架置入术治疗梗阻性左侧结肠癌具有良好的安全性和短期疗效。需要长期随访的大规模比较研究来证明这种方法的显著益处。
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引用次数: 22
Torsion of the gallbladder in pregnancy. 妊娠期胆囊的扭转
Pub Date : 2013-12-01 Epub Date: 2013-11-26 DOI: 10.4174/jkss.2013.85.6.302
Seung Eun Lee, Yoo Shin Choi, Beom Jin Kim

Torsion of the gallbladder is a rare condition that is difficult to diagnose preoperatively, but prompt surgical intervention is necessary to avoid possible sepsis and death. A 36-year-old pregnant woman presented to Emergency Department with a constant epigastric pain at 17 weeks of gestation. Abdominal ultrasonography and magnetic resonance imaging demonstrated a distended gallbladder that contained no stones but had mild wall thickening. Laparoscopic cholecystectomy using three ports was performed under the impression of an acalculous cholecystitis. The gallbladder was found to be rotated 180 degrees clockwise on gallbladder mesentery and to be gangrenous. The postoperative course was uneventful and the patient was discharged on the 4th day after surgery. It is important to keep in mind gallbladder torsion in the differential diagnosis from acute cholecystitis when the patient has an acute onset of abdominal pain and a severely distended gallbldder. Prompt cholecystectomy via a laparoscopic approach should be performed.

胆囊扭转是一种罕见的疾病,术前诊断困难,但及时的手术干预是必要的,以避免可能的败血症和死亡。一位36岁的孕妇在妊娠17周时以持续的上腹痛就诊于急诊科。腹部超声和磁共振成像显示胆囊膨胀,不含结石,但有轻度壁增厚。在无结石性胆囊炎的情况下,使用三个端口进行腹腔镜胆囊切除术。胆囊在胆囊肠系膜上顺时针旋转180度,呈坏疽。术后过程顺利,患者于术后第4天出院。当病人有急性腹痛和胆囊严重膨胀时,在鉴别诊断急性胆囊炎时,记住胆囊扭转是很重要的。应及时行腹腔镜胆囊切除术。
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引用次数: 15
Variation or newly identified glissonian pedicles between the lateral and medial sections of the liver, using cadaver dissection. 变异或新发现的滑脱蒂之间的外侧和内侧部分的肝脏,使用尸体解剖。
Pub Date : 2013-12-01 Epub Date: 2013-11-26 DOI: 10.4174/jkss.2013.85.6.261
In-Gyu Kim, Weiguang Xu, Hee-Jung Wang, Yong-Keun Park, Bong-Wan Kim

Purpose: Studies of liver anatomy have developed alongside clinical achievements, as these types of research complement each other. The aim of this study is to determine whether or not the portal vein branches (P4d) in 'Nagino's trisectionectomy' exist, and to examine their characteristics using cadaver dissection.

Methods: From April 2012 to July 2012, 31 adult cadavers were delicately dissected. We defined a 'NewGP' as an extra glissonian pedicle (GP) other than the traditional GPs that supply segments II, III, IVa, and IVb in the ordinary direction, and anatomically located superior to the umbilical fissure (UF).

Results: We identified 'NewGPs' based on the UF and UF vein. The incidence of 'NewGPs' was 30/31 (96.8%). The diameter of the 'NewGPs' ranged from 3.5 to 5.6 mm, which was not significantly different from that of traditional GPs (II-, III-, or IV-GP), which have diameters ranging from 3.7 to 9.7 mm.

Conclusion: We think that the P4d in 'Nagino's trisectionectomy' correspond to the 'IVa NewGP' and the additional pedicle. We believe the clinical significance of the 'NewGP' is to complement the traditional II, III, IVa, and IVb pedicles in supplying the liver.

目的:肝脏解剖学的研究是随着临床成果而发展的,因为这些类型的研究是相辅相成的。本研究的目的是确定“Nagino三节切除术”中是否存在门静脉分支(P4d),并通过尸体解剖检查其特征。方法:2012年4月至7月对31具成人尸体进行解剖。我们将“NewGP”定义为在常规方向上供应II节、III节、IVa节和IVb节的传统GP之外的额外滑脱蒂(GP),解剖位置位于脐裂(UF)之上。结果:我们根据UF和UF静脉鉴定了“newgp”。“newgp”的发生率为30/31(96.8%)。“NewGP”的直径范围为3.5至5.6 mm,与传统gp (II-, III-或IV-GP)的直径范围为3.7至9.7 mm没有显著差异。结论:我们认为“Nagino三节切除术”中的P4d对应于“IVa NewGP”和额外的蒂。我们相信“NewGP”的临床意义在于补充传统的II、III、IVa和IVb蒂供应肝脏。
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引用次数: 1
The optimal follow-up period in patients with above 5-year disease-free survival after curative liver resection for hepatocellular carcinoma. 肝细胞癌根治性肝切除术后5年以上无病生存期的最佳随访期。
Pub Date : 2013-12-01 Epub Date: 2013-11-26 DOI: 10.4174/jkss.2013.85.6.269
Sang Hyun Ahn, Sung Hoon Kim, Gi Hong Choi, Jin Sub Choi, Kyung Sik Kim

Purpose: Although many patients with hepatocellular carcinoma experience recurrence within 2 years after hepatectomy, some patients with T1 and T2 hepatocellular carcinoma show recurrence-free survival for more than 5 years after surgery. This study was designed to analyze the optimal follow-up period on patients with T1 and T2 hepatocellular carcinoma (HCC) showing recurrence-free survival 5 years after surgery.

Methods: One hundred seventy patients underwent hepatectomy from January 1995 to December 1999. Numbers of patients with T1 and T2 HCC were 76 and 73, respectively. The recurrence patterns of patients experiencing recurrence more than 5 years after liver resection were analyzed in aspect of clinicopathological features and follow-up period.

Results: Thirteen patients experienced recurrence more than 5 years after surgery. Only age was found as a significant factor for recurrence. Eight patients were checked regularly with 6-month intervals and the others were checked with 12-month or more intervals. The size of the recurrent tumors in the 6-month interval group had a median of 1.1 cm (range, 1 to 4.2 cm) and the size of the recurrent tumors in the 12-month or more interval group had a median of 3 cm (range, 1.6 to 4 cm). The tumor size was significantly smaller in the 6-month interval group.

Conclusion: Though the patients with early stage HCC showed high overall survival, some patients experienced a late recurrence of more than 5 years after surgery. Patients less than 60 years old with early stage HCC should be checked regularly with 6-month intervals even over 5 years after liver resection.

目的:虽然许多肝细胞癌患者在肝切除术后2年内复发,但一些T1和T2肝细胞癌患者术后无复发生存期超过5年。本研究旨在分析术后5年无复发生存的T1和T2肝细胞癌患者的最佳随访时间。方法:1995年1月至1999年12月行肝切除术的170例患者。T1和T2 HCC患者分别为76例和73例。从临床病理特征及随访时间等方面分析肝切除术后复发5年以上患者的复发类型。结果:术后5年以上复发13例。只有年龄是复发的重要因素。8例患者每隔6个月定期检查一次,其余患者每隔12个月或更长时间检查一次。间隔6个月组复发肿瘤大小中位数为1.1 cm(范围1 ~ 4.2 cm),间隔12个月或更长时间组复发肿瘤大小中位数为3cm(范围1.6 ~ 4cm)。间隔6个月组肿瘤大小明显变小。结论:早期HCC患者总体生存率较高,但部分患者术后5年以上复发。年龄小于60岁的早期HCC患者应定期检查,间隔6个月,甚至在肝切除术后5年以上。
{"title":"The optimal follow-up period in patients with above 5-year disease-free survival after curative liver resection for hepatocellular carcinoma.","authors":"Sang Hyun Ahn,&nbsp;Sung Hoon Kim,&nbsp;Gi Hong Choi,&nbsp;Jin Sub Choi,&nbsp;Kyung Sik Kim","doi":"10.4174/jkss.2013.85.6.269","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.6.269","url":null,"abstract":"<p><strong>Purpose: </strong>Although many patients with hepatocellular carcinoma experience recurrence within 2 years after hepatectomy, some patients with T1 and T2 hepatocellular carcinoma show recurrence-free survival for more than 5 years after surgery. This study was designed to analyze the optimal follow-up period on patients with T1 and T2 hepatocellular carcinoma (HCC) showing recurrence-free survival 5 years after surgery.</p><p><strong>Methods: </strong>One hundred seventy patients underwent hepatectomy from January 1995 to December 1999. Numbers of patients with T1 and T2 HCC were 76 and 73, respectively. The recurrence patterns of patients experiencing recurrence more than 5 years after liver resection were analyzed in aspect of clinicopathological features and follow-up period.</p><p><strong>Results: </strong>Thirteen patients experienced recurrence more than 5 years after surgery. Only age was found as a significant factor for recurrence. Eight patients were checked regularly with 6-month intervals and the others were checked with 12-month or more intervals. The size of the recurrent tumors in the 6-month interval group had a median of 1.1 cm (range, 1 to 4.2 cm) and the size of the recurrent tumors in the 12-month or more interval group had a median of 3 cm (range, 1.6 to 4 cm). The tumor size was significantly smaller in the 6-month interval group.</p><p><strong>Conclusion: </strong>Though the patients with early stage HCC showed high overall survival, some patients experienced a late recurrence of more than 5 years after surgery. Patients less than 60 years old with early stage HCC should be checked regularly with 6-month intervals even over 5 years after liver resection.</p>","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.6.269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31980574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Peterson's hernia and subsequent small bowel volvulus: surgical reconstruction utilizing transverse colon as a new Roux-en-Y limb - 1 case. 彼得森疝并发小肠扭转:利用横结肠作为Roux-en-Y肢体的手术重建1例。
Pub Date : 2013-12-01 Epub Date: 2013-11-26 DOI: 10.4174/jkss.2013.85.6.309
Jae Seong Jang, Dong Gue Shin

Peterson's hernia is an internal hernia that can occur after Roux-en-Y anastomosis. It often accompanies small bowel volvulus and is prone to strangulation. Reconstruction of intestinal continuity after massive small bowel resection in a patient who undergoes near total gastrectomy and Roux-en-Y anastomosis can be difficult. A 74-year-old man who had undergone a near total gastrectomy and Roux-en-Y gastrojejunostomy for stomach cancer presented with abdominal pain. The preoperative computed tomography showed strangulated small bowel volvulus. During the emergent laparotomy, we found a strangulated Peterson's hernia with small bowel volvulus. After resection of the necrotized intestine, we made a new Roux-en-Y anastomosis connecting the remnant stomach and the jejunum with a transverse colon segment. We were safely able to connect the remnant stomach and the jejunum by making a new Roux-en-Y anastomosis utilizing a transverse colon segment as a new Roux-limb by two stage operation.

彼得森疝是一种可在Roux-en-Y吻合术后发生的内疝。常伴小肠扭转,易致绞窄。在接受近全胃切除术和Roux-en-Y吻合术的患者中,大量小肠切除后肠连续性的重建可能是困难的。74岁男性,因胃癌行近全胃切除术及Roux-en-Y胃空肠造口术,腹痛。术前电脑断层显示小肠绞窄扭转。在紧急剖腹手术中,我们发现了一个绞窄性彼得森疝气伴小肠扭转。切除坏死肠后,我们用横结肠段将残胃和空肠连接成新的Roux-en-Y吻合术。我们利用横结肠段作为新的roux -肢体,通过两阶段手术进行新的Roux-en-Y吻合术,安全地连接了残胃和空肠。
{"title":"A Peterson's hernia and subsequent small bowel volvulus: surgical reconstruction utilizing transverse colon as a new Roux-en-Y limb - 1 case.","authors":"Jae Seong Jang,&nbsp;Dong Gue Shin","doi":"10.4174/jkss.2013.85.6.309","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.6.309","url":null,"abstract":"<p><p>Peterson's hernia is an internal hernia that can occur after Roux-en-Y anastomosis. It often accompanies small bowel volvulus and is prone to strangulation. Reconstruction of intestinal continuity after massive small bowel resection in a patient who undergoes near total gastrectomy and Roux-en-Y anastomosis can be difficult. A 74-year-old man who had undergone a near total gastrectomy and Roux-en-Y gastrojejunostomy for stomach cancer presented with abdominal pain. The preoperative computed tomography showed strangulated small bowel volvulus. During the emergent laparotomy, we found a strangulated Peterson's hernia with small bowel volvulus. After resection of the necrotized intestine, we made a new Roux-en-Y anastomosis connecting the remnant stomach and the jejunum with a transverse colon segment. We were safely able to connect the remnant stomach and the jejunum by making a new Roux-en-Y anastomosis utilizing a transverse colon segment as a new Roux-limb by two stage operation. </p>","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.6.309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31980581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The comparison of single incision laparoscopic cholecystectomy and three port laparoscopic cholecystectomy: prospective randomized study. 单切口腹腔镜胆囊切除术与三孔腹腔镜胆囊切除术的比较:前瞻性随机研究。
Pub Date : 2013-12-01 Epub Date: 2013-11-26 DOI: 10.4174/jkss.2013.85.6.275
Ugur Deveci, Umut Barbaros, Mahmut Sertan Kapakli, Manuk Norayk Manukyan, Selçuk Simşek, Abut Kebudi, Selçuk Mercan

Purpose: Laparoscopic techniques have allowed surgeons to perform complicated intra-abdominal surgery with minimal trauma. Single incision laparoscopic surgery (SILS) was developed with the aim of reducing the invasiveness of conventional laparoscopy. In this study we aimed to compare results of SILS cholecystectomy and three port conventional laparoscopic (TPCL) cholecystectomy prospectively.

Methods: In this prospective study, 100 patients who underwent laparoscopic cholecystectomy for gallbladder disease were randomly allocated to SILS cholecystectomy (group 1) or TPCL cholecystectomy (group 2). Demographics, pathologic diagnosis, operating time, blood loss, length of hospital stay, complications, pain score, conversion rate, and satisfaction of cosmetic outcome were recorded.

Results: Forty-four SILS cholesystectomies (88%) and 42 TPCL cholecystectomies (84%) were completed successfully. Conversion to open surgery was required for 4 cases in group 1 and 6 cases in group 2. Operating time was significantly longer in group 1 compared with group 2 (73 minutes vs. 48 minutes; P < 0.05). Higher pain scores were observed in group 1 versus group 2 in postoperative day 1 (P < 0.05). There was higher cosmetic satisfaction in group 1 (P < 0.05).

Conclusion: SILS cholecystectomy performed by experienced surgeons is at least as successful, feasible, effective and safe as a TPCL cholecystectomy. Surgeons performing SILS should have a firm foundation of advanced minimal access surgical skills and a cautious, gradated approach to attempt the various procedures. Prospective randomized studies comparing single access versus conventional multiport laparoscopic cholecystectomy, with large volumes and long-term follow-up, are needed to confirm our initial experience. (ClinicalTrials.gov Identifier: NCT01772745.).

目的:腹腔镜技术使外科医生能够以最小的创伤进行复杂的腹腔手术。单切口腹腔镜手术(SILS)是为了减少传统腹腔镜的侵入性而发展起来的。在这项研究中,我们旨在前瞻性地比较SILS胆囊切除术和三孔传统腹腔镜胆囊切除术的结果。方法:本前瞻性研究选取100例因胆囊疾病行腹腔镜胆囊切除术的患者,随机分为SILS胆囊切除术(1组)和TPCL胆囊切除术(2组)两组。记录人口统计学、病理诊断、手术时间、出血量、住院时间、并发症、疼痛评分、转换率和美容效果满意度。结果:成功完成44例SILS胆囊切除术(88%)和42例TPCL胆囊切除术(84%)。1组4例,2组6例需转开腹手术。1组手术时间明显长于2组(73 min vs. 48 min;P < 0.05)。术后第1天,1组疼痛评分高于2组(P < 0.05)。第一组患者美容满意度较高(P < 0.05)。结论:经验丰富的外科医生行SILS胆囊切除术与TPCL胆囊切除术一样成功、可行、有效和安全。进行SILS手术的外科医生应具备先进的微创手术技术的坚实基础,并采取谨慎、渐进的方法来尝试各种手术。比较单通道与传统多口腹腔镜胆囊切除术的前瞻性随机研究,需要大容量和长期随访,以证实我们的初步经验。(ClinicalTrials.gov识别码:NCT01772745)。
{"title":"The comparison of single incision laparoscopic cholecystectomy and three port laparoscopic cholecystectomy: prospective randomized study.","authors":"Ugur Deveci,&nbsp;Umut Barbaros,&nbsp;Mahmut Sertan Kapakli,&nbsp;Manuk Norayk Manukyan,&nbsp;Selçuk Simşek,&nbsp;Abut Kebudi,&nbsp;Selçuk Mercan","doi":"10.4174/jkss.2013.85.6.275","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.6.275","url":null,"abstract":"<p><strong>Purpose: </strong>Laparoscopic techniques have allowed surgeons to perform complicated intra-abdominal surgery with minimal trauma. Single incision laparoscopic surgery (SILS) was developed with the aim of reducing the invasiveness of conventional laparoscopy. In this study we aimed to compare results of SILS cholecystectomy and three port conventional laparoscopic (TPCL) cholecystectomy prospectively.</p><p><strong>Methods: </strong>In this prospective study, 100 patients who underwent laparoscopic cholecystectomy for gallbladder disease were randomly allocated to SILS cholecystectomy (group 1) or TPCL cholecystectomy (group 2). Demographics, pathologic diagnosis, operating time, blood loss, length of hospital stay, complications, pain score, conversion rate, and satisfaction of cosmetic outcome were recorded.</p><p><strong>Results: </strong>Forty-four SILS cholesystectomies (88%) and 42 TPCL cholecystectomies (84%) were completed successfully. Conversion to open surgery was required for 4 cases in group 1 and 6 cases in group 2. Operating time was significantly longer in group 1 compared with group 2 (73 minutes vs. 48 minutes; P < 0.05). Higher pain scores were observed in group 1 versus group 2 in postoperative day 1 (P < 0.05). There was higher cosmetic satisfaction in group 1 (P < 0.05).</p><p><strong>Conclusion: </strong>SILS cholecystectomy performed by experienced surgeons is at least as successful, feasible, effective and safe as a TPCL cholecystectomy. Surgeons performing SILS should have a firm foundation of advanced minimal access surgical skills and a cautious, gradated approach to attempt the various procedures. Prospective randomized studies comparing single access versus conventional multiport laparoscopic cholecystectomy, with large volumes and long-term follow-up, are needed to confirm our initial experience. (ClinicalTrials.gov Identifier: NCT01772745.).</p>","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.6.275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31980575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Perineal accessory scrotum with a lipomatous hamartoma in an adult male. 成年男性会阴副阴囊伴脂肪瘤错构瘤。
Pub Date : 2013-12-01 Epub Date: 2013-11-26 DOI: 10.4174/jkss.2013.85.6.305
Jong Im Lee, Ho Geun Jung

Accessory scrotum is a rare congenital anomaly that is often associated with perineal tumor or other developmental abnormalities. Because most cases are diagnosed and treated in early childhood, little is known about the natural biologic course of this entity and associated lesions through time. We present a case of accessory scrotum associated with lipomatous hamartoma in a 46-year-old man who was born with a perineal mass. We evaluate the clinicopathologic features and discuss the pathogenesis with a review of the literature.

副阴囊是一种罕见的先天性异常,通常与会阴肿瘤或其他发育异常有关。由于大多数病例是在儿童早期诊断和治疗的,因此人们对这种疾病的自然生物学过程和相关病变知之甚少。我们提出一个病例的副阴囊与脂肪瘤错构瘤在一个46岁的男子谁出生与会阴肿块。我们评估临床病理特征,并讨论发病机制与文献回顾。
{"title":"Perineal accessory scrotum with a lipomatous hamartoma in an adult male.","authors":"Jong Im Lee,&nbsp;Ho Geun Jung","doi":"10.4174/jkss.2013.85.6.305","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.6.305","url":null,"abstract":"<p><p>Accessory scrotum is a rare congenital anomaly that is often associated with perineal tumor or other developmental abnormalities. Because most cases are diagnosed and treated in early childhood, little is known about the natural biologic course of this entity and associated lesions through time. We present a case of accessory scrotum associated with lipomatous hamartoma in a 46-year-old man who was born with a perineal mass. We evaluate the clinicopathologic features and discuss the pathogenesis with a review of the literature. </p>","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.6.305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31980580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
期刊
Journal of the Korean Surgical Society
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