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Underreporting and Underrepresentation of Race and Ethnicity in Head and Neck Cancer Trials, 2010-2020: A Systematic Review. 2010-2020 年头颈部癌症试验中种族和民族的报告不足和代表性不足:系统回顾。
IF 6 Pub Date : 2022-07-01 DOI: 10.1001/jamaoto.2022.1028
Adam B Sauer, Ghazal S Daher, Christine M Lohse, Amy E Glasgow, Elizabeth B Habermann, Dontre' M Douse, Eric J Moore, Eseosa T Ighodaro, Kathryn M Van Abel, Linda X Yin

Importance: There is substantial evidence demonstrating racial disparities in the survival outcomes of patients with head and neck cancer. The reporting and representation of race and ethnicity in cancer trials is crucial for generalizability of trial results to patient care and reduction of racial health disparities in head and neck cancers. Racial disparities in oncologic outcomes across various therapeutic interventions may only manifest when diverse races are appropriately represented in trials.

Objective: To characterize the reporting and representation of race and ethnicity in head and neck cancer clinical trials.

Evidence review: A systematic search of published trials and those available on ClinicalTrials.gov was conducted to identify 3973 studies from 2010 to 2020. Title, abstract, and full-text review yielded 155 trials for data extraction of patient demographics. Year of publication, type of intervention, publication source, and funding source were also collected. Race and ethnicity data were compared with Surveillance, Epidemiology, and End Results (SEER) Program cancer registry data.

Findings: Of the 155 included studies, only 89 (57%) reported race or ethnicity. Only 81 (52%) of the studies reported detailed classification of race or ethnicity per the US Census Bureau classification scheme. Race and ethnicity reporting varied considerably with year of publication, type of intervention, data source, and funding source. Studies in the latter half of the decade were more likely to report race or ethnicity (odds ratio, 2.78; 95% CI, 1.33-5.80), with the highest number in 2019 (24 of 30 [80%] trials), followed by 2020 (20 of 29 [69%] trials). Among the possible interventions, trials on therapeutic chemoradiation most frequently reported race or ethnicity (11 of 12 [92%]), followed by supportive drug trials (22 of 31 [71%]), and then therapeutic chemotherapy trials (28 of 48 [58%]). When compared with SEER data, race and ethnicity distribution in clinical trials showed fewer Black patients (10% vs 8%) and Asian or Pacific Islander patients (6% vs 2%).

Conclusions and relevance: In this systematic review, nearly half of head and neck cancer trials in the past decade did not report the race or ethnicity of participants. Participation of Black and Asian or Pacific Islander patients does not adequately reflect the US population's head and neck cancer demographics, limiting the generalizability of trial results and adding to racial health disparities in patients with head and neck cancers.

重要性:有大量证据表明,头颈部癌症患者的生存结果存在种族差异。癌症试验中种族和民族的报告和代表性对于将试验结果推广到患者护理以及减少头颈部癌症的种族健康差异至关重要。只有当不同种族在试验中具有适当代表性时,各种治疗干预措施在肿瘤治疗结果上的种族差异才会显现出来:目的:描述头颈部癌症临床试验中种族和民族的报告和代表性:对已发表的试验和ClinicalTrials.gov网站上提供的试验进行了系统检索,确定了2010年至2020年的3973项研究。通过对标题、摘要和全文的审查,得出了 155 项用于提取患者人口统计学数据的试验。此外,还收集了发表年份、干预类型、发表来源和资金来源。种族和民族数据与监测、流行病学和最终结果(SEER)计划癌症登记数据进行了比较:在纳入的 155 项研究中,只有 89 项(57%)报告了种族或民族情况。根据美国人口普查局的分类方案,只有 81 项(52%)研究报告了详细的种族或民族分类。种族和民族报告因发表年份、干预类型、数据来源和资金来源的不同而有很大差异。这十年后半期的研究更有可能报告种族或民族(几率比,2.78;95% CI,1.33-5.80),其中 2019 年的数量最多(30 项试验中有 24 项[80%]),其次是 2020 年(29 项试验中有 20 项[69%])。在可能的干预措施中,治疗性化学放疗试验最常报告种族或民族(12 项试验中的 11 项 [92%]),其次是支持性药物试验(31 项试验中的 22 项 [71%]),然后是治疗性化疗试验(48 项试验中的 28 项 [58%])。与 SEER 数据相比,临床试验中的种族和民族分布显示黑人患者(10% 对 8% )和亚裔或太平洋岛民患者(6% 对 2%)较少:在本次系统回顾中,过去十年中近一半的头颈癌试验没有报告参与者的种族或族裔。黑人和亚裔或太平洋岛民患者的参与并不能充分反映美国头颈部癌症患者的人口统计学特征,从而限制了试验结果的推广性,加剧了头颈部癌症患者的种族健康差异。
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引用次数: 0
Influencers for Adoption of Robots in Indian Construction Industry 影响印度建筑业采用机器人的因素
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8060-7.ch058
Sachin Jain, M. Phadtare
Robots are developed for various construction processes and used in countries such as the USA, Japan and China. However, their adoption in India is very limited due to weaknesses in the construction sector. The Indian construction industry is poised to grow at a faster rate due to planned investment. Robots will benefit construction industry by way of better productivity, quality, timely completion, etc. resulting in the growth of construction industry. This paper identifies the structure of influencers of adoption of robots in the Indian infrastructure construction sector using exploratory factor analsis. This structure was validated using confirmatory factor analysis. A total of 20 influencers are identified and grouped in eight factors. Based on these influencers, strategies are recommended to enhance adoption of robots in Indian infrastructure construction industry. Finally the authors identify the influencers that are common to India and other countries in Asia, America, Europe and Australia.
机器人是为各种建筑工艺开发的,并在美国、日本和中国等国家使用。然而,由于建筑行业的弱点,它们在印度的采用非常有限。由于计划投资,印度建筑业有望以更快的速度增长。机器人将通过提高生产率、质量、及时完工等方式使建筑业受益,从而促进建筑业的发展。本文利用探索性因素分析确定了印度基础设施建设部门采用机器人的影响因素的结构。该结构采用验证性因子分析进行验证。总共有20个影响者被确定并分为8个因素。基于这些影响因素,提出了在印度基础设施建设行业中加强机器人采用的策略。最后,作者确定了印度和亚洲、美洲、欧洲和澳大利亚其他国家共同的影响因素。
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引用次数: 0
Swarm Intelligent Optimization Algorithms and Its Application in Mobile Robot Path Planning 群智能优化算法及其在移动机器人路径规划中的应用
Pub Date : 2019-01-01 DOI: 10.4018/978-1-4666-9572-6.CH011
Xiu-juan Lei, Fei Wang, Ying Tan
Mobile robot path planning is generally a kind of optimal problems, which is to find a best path of a track between a starting point to a goal point in the constraint conditions. Mobile robot path planning can be divided into two categories according to different environment planning awareness information: one is the global path planning and the other is the local path planning. We employed ACO, PSO, FA, FOA, FWA and ABC swarm intelligent optimization algorithms to optimize the global and local path planning of mobile robot, and gave the detailed implement steps and the comparing results to show the feasibility of using swarm intelligence optimization algorithms to solve the robot path planning problems.
移动机器人路径规划一般是一类最优问题,即在约束条件下,从起点到目标点寻找一条轨迹的最优路径。根据环境规划感知信息的不同,移动机器人路径规划可分为两类:一类是全局路径规划,另一类是局部路径规划。采用ACO、PSO、FA、FOA、FWA和ABC等群智能优化算法对移动机器人的全局和局部路径规划进行了优化,给出了详细的实现步骤和比较结果,证明了利用群智能优化算法解决机器人路径规划问题的可行性。
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引用次数: 6
Intention and Body-Mood Engineering via Proactive Robot Moves in HRI 基于机器人主动动作的HRI意向与身心工程
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8060-7.CH012
O. Görür, A. Erkmen
This chapter focuses on emotion and intention engineering by socially interacting robots that induce desired emotions/intentions in humans. The authors provide all phases that pave this road, supported by overviews of leading works in the literature. The chapter is partitioned into intention estimation, human body-mood detection through external-focused attention, path planning through mood induction and reshaping intention. Moreover, the authors present their novel concept, with implementation, of reshaping current human intention into a desired one, using contextual motions of mobile robots. Current human intention has to be deviated towards the new desired one by destabilizing the obstinance of human intention, inducing positive mood and making the “robot gain curiosity of human”. Deviations are generated as sequences of transient intentions tracing intention trajectories. The authors use elastic networks to generate, in two modes of body mood: “confident” and “suspicious”, transient intentions directed towards the desired one, choosing among intentional robot moves previously learned by HMM.
本章重点关注通过社会互动机器人诱导人类期望的情感/意图的情感和意图工程。作者提供了铺这条路的所有阶段,由文献中主要作品的概述支持。本章分为意图估计、通过外部集中注意进行人体情绪检测、通过情绪诱导进行路径规划和意图重塑。此外,作者提出了他们的新概念,并实现了利用移动机器人的上下文运动将当前的人类意图重塑为期望的意图。当前的人类意图必须通过破坏人类意图的执拗性,诱导积极情绪,使“机器人获得人类的好奇心”,从而向新的期望意图偏离。偏差是作为瞬态意图跟踪意图轨迹的序列产生的。作者使用弹性网络,在“自信”和“怀疑”两种身体情绪模式下,产生指向预期目标的短暂意图,在HMM之前学习的有意机器人动作中进行选择。
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引用次数: 3
Robots in Medicine 医学中的机器人
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8060-7.ch073
Hruday Kasina, M. R. Bahubalendruni, Rahul Botcha
Robots are wide across used in several industrial applications. Robot applications are more found in medical industry in recent days. In initial days, robots were mostly used for simple surgeries and medical applications such as laparoscopic surgery and minimally invasive surgery in 1980's. At that time robotic surgeries were performed with the presence of surgeons in operation theatre. The present day technology has been so much advanced with more enhanced capabilities to perform several complicated tasks such as remote surgery and micro robotic surgery. The current paper discuss about the history and evolution of robots in medical industry and their latest technological advances, applications in various fields in medicine and limitations of robots in medical industry along with its future scope.
机器人广泛应用于几个工业领域。近年来,机器人在医疗行业的应用越来越多。在最初的日子里,机器人主要用于简单的手术和医疗应用,如80年代的腹腔镜手术和微创手术。当时,机器人手术是在外科医生在场的情况下在手术室进行的。当今的技术已经非常先进,有更多的增强能力来执行一些复杂的任务,如远程手术和微型机器人手术。本文讨论了机器人在医疗行业的历史和发展及其最新技术进展,在医学各个领域的应用,机器人在医疗行业的局限性以及未来的范围。
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引用次数: 0
RobotBASIC RobotBASIC
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8060-7.ch001
J. Blankenship, S. Mishal
Unlike most chapters in this book, this chapter does not introduce new methods or algorithms related to robotic navigation systems. Instead, it provides an overview of a simulation tool that, in some situations, can be useful for quickly evaluating the overall appropriateness of a wide variety of alternatives before focusing more advanced development activities on a chosen design. In addition, since the tool described herein is totally free, it can be used to help students and others new to robotics understand the value of utilizing a design-simulate-deploy approach to developing robotic behaviors. Robot Simulators can emulate nearly all aspects of a robot's functionality. Unfortunately, many programming environments that support simulation have steep learning curves and are difficult to use because of their ability to handle complex attributes such as 3D renderings and bearing friction. Fortunately, there are many situations where advanced attributes are unnecessary. When the primary goal is to quickly test the feasibility of a variety of algorithms for robotic behaviors, RobotBASIC provides an easy-to-use, economical alternative to more complex systems without sacrificing the features necessary to implement a complete design-simulate-deploy cycle. RobotBASIC's ability to simulate a variety of sensors makes it easy to quickly test the performance of various configurations in an assortment of environments. Once algorithm development is complete, the same programs used during the simulation phase of development can immediately control a real robot.
与本书的大多数章节不同,本章不介绍与机器人导航系统相关的新方法或算法。相反,它提供了一个模拟工具的概述,在某些情况下,在将更高级的开发活动集中在选定的设计上之前,该工具可以用于快速评估各种备选方案的总体适当性。此外,由于这里描述的工具是完全免费的,它可以用来帮助学生和其他新接触机器人的人理解利用设计-模拟-部署方法开发机器人行为的价值。机器人模拟器可以模拟机器人功能的几乎所有方面。不幸的是,许多支持模拟的编程环境都有陡峭的学习曲线,并且很难使用,因为它们能够处理复杂的属性,如3D渲染和轴承摩擦。幸运的是,在许多情况下,高级属性是不必要的。当主要目标是快速测试机器人行为的各种算法的可行性时,RobotBASIC为更复杂的系统提供了一种易于使用,经济的替代方案,而不会牺牲实现完整设计-模拟-部署周期所需的功能。RobotBASIC模拟各种传感器的能力使得在各种环境中快速测试各种配置的性能变得很容易。一旦算法开发完成,在模拟开发阶段使用的相同程序可以立即控制真实的机器人。
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引用次数: 0
Standardized Dynamic Reconfiguration of Control Applications in Industrial Systems 工业系统控制应用的标准化动态重构
Pub Date : 2019-01-01 DOI: 10.4018/IJAIE.2014010104
T. Strasser, M. Rooker, G. Ebenhofer, Alois Zoitl
Industrial areas like manufacturing, logistics and power systems require highly flexible and adaptable control solutions in order to fulfill future requirements. An industrial automation system has to provide technologies, concepts and mechanisms allowing the adaption of control logic during operation. Proper engineering approaches as well as execution environments with dynamic reconfiguration capabilities are needed to turn this vision into reality. This article provides an overview of applying the IEC 61499 reference model for distributed automation as basis for a standard-compliant reconfigurable method in industrial environments. It covers the modeling and engineering of reconfiguration applications and their execution on distributed embedded controllers using IEC 61499. This approach significantly increases engineering efficiency and reuse in component-based design of industrial automation and control applications. A special focus of this contribution is the discussion of implemented industrial use cases from the manufacturing, robotics and power systems domain.
制造业、物流和电力系统等工业领域需要高度灵活和适应性强的控制解决方案,以满足未来的需求。工业自动化系统必须提供技术、概念和机制,以便在操作过程中适应控制逻辑。要将这一愿景变为现实,需要适当的工程方法以及具有动态重新配置功能的执行环境。本文概述了如何将IEC 61499参考模型应用于分布式自动化,作为工业环境中符合标准的可重构方法的基础。它涵盖了重构应用程序的建模和工程,以及它们在使用IEC 61499的分布式嵌入式控制器上的执行。这种方法显著提高了基于组件的工业自动化和控制应用设计的工程效率和重用性。本贡献的一个特别重点是对来自制造、机器人和电力系统领域的实现工业用例的讨论。
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引用次数: 9
Real-Time Scheduling and Control of Single-Arm Cluster Tools With Residency Time Constraint and Activity Time Variation by Using Resource-Oriented Petri Nets 基于资源导向Petri网的驻留时间约束和活动时间变化单臂集群工具实时调度与控制
Pub Date : 2019-01-01 DOI: 10.4018/978-1-4666-4034-4.CH008
Yan Qiao, N. Wu, Mengchu Zhou
In semiconductor manufacturing, when a wafer is processed, it requires unloading from its process module in a given time interval, otherwise it is scraped. This requirement is called wafer residency time constraints. Thus, it is crucial to schedule a cluster tool such that the wafer sojourn time in a process module is within a given time window to satisfy the wafer residency time constraints. Besides wafer residency time constraints, in a cluster tool, the activity time is subject to variation. The activity time variation can make a feasible schedule obtained under the assumption of deterministic activity times become infeasible. To solve this problem, it is important to reveal the wafer sojourn time fluctuations with bounded activity time variation. Such an issue is addressed in this chapter for single-arm cluster tools. A single-arm cluster tool is modeled by a resource-oriented Petri net to describe the wafer fabrication processes. Based on it, a real-time control policy is proposed such that it offsets the effect of the activity time variation as much as possible. Then, the wafer sojourn time delay in a process module is analyzed and analytical expressions are derived to calculate the upper bound. With the help of the real-time control policy and wafer sojourn time delay analysis results, schedulability conditions and scheduling algorithms for an off-line schedule are presented in this chapter. The schedulability conditions can be analytically checked. If schedulable, an off-line schedule can be analytically found. The off-line schedule together with the real-time control policy forms the real-time schedule for the system. It is optimal in terms of cycle time minimization. Examples are given to show the application of the proposed approach.
在半导体制造中,当一个晶圆被加工时,它需要在给定的时间间隔内从它的处理模块中卸载,否则它就会被刮掉。这种要求称为晶圆驻留时间限制。因此,至关重要的是安排一个集群工具,使工艺模块中的晶圆停留时间在给定的时间窗口内,以满足晶圆停留时间的限制。除了晶圆驻留时间的限制外,在聚类工具中,活动时间也会发生变化。活动时间的变化会使在活动时间确定的假设下得到的可行计划变得不可行。为了解决这一问题,揭示有界活动时间变化下的晶圆停留时间波动是很重要的。本章将针对单臂集群工具解决这样的问题。利用面向资源的Petri网对单臂簇工具进行建模,以描述晶圆制造过程。在此基础上,提出了一种尽可能抵消活动时间变化影响的实时控制策略。然后,分析了工艺模块的晶圆逗留时间延迟,并推导出其上界的解析表达式。本章结合实时控制策略和时延分析结果,给出了离线调度的可调度性条件和调度算法。可调度性条件可以解析检验。如果可调度,则可以分析地找到离线调度。离线调度与实时控制策略共同构成系统的实时调度。它在周期时间最小化方面是最优的。通过实例说明了该方法的应用。
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引用次数: 0
A Virtual Simulator for the Embedded Control System Design for Navigation of Mobile Robots Applied in Wheelchairs 轮椅移动机器人导航嵌入式控制系统设计的虚拟模拟器
Pub Date : 2019-01-01 DOI: 10.4018/978-1-4666-2658-4.CH011
L. F. Melo, S. G. S. Cervantes, J. M. Rosário
This chapter presents a virtual environment implementation for embedded design, simulation, and conception of supervision and control systems for mobile robots, which are capable of operating and adapting to different environments and conditions. The purpose of this virtual system is to facilitate the development of embedded architecture systems, emphasizing the implementation of tools that allow the simulation of the kinematic, dynamic, and control conditions, in real time monitoring of all important system points. To achieve this, an open control architecture is proposed, integrating the two main techniques of robotic control implementation at the hardware level: systems microprocessors and reconfigurable hardware devices. The utilization of a hierarchic and open architecture, distributing the diverse actions of control in increasing levels of complexity and the use of resources of reconfigurable computation are made in a virtual simulator for mobile robots. The validation of this environment is made in a nonholonomic mobile robot and in a wheelchair; both of them used an embedded control rapid prototyping technique for the best navigation strategy implementation. After being tested and validated in the simulator, the control system is programmed in the control board memory of the mobile robot or wheelchair. Thus, the use of time and material is optimized, first validating the entire model virtually and then operating the physical implementation of the navigation system.
本章提出了一种用于嵌入式设计、仿真和移动机器人监控系统概念的虚拟环境实现,该系统能够运行并适应不同的环境和条件。该虚拟系统的目的是促进嵌入式体系结构系统的开发,强调实现允许模拟运动,动态和控制条件的工具,实时监控所有重要的系统点。为了实现这一目标,提出了一种开放的控制体系结构,在硬件层面集成了机器人控制实现的两种主要技术:系统微处理器和可重构硬件设备。在移动机器人的虚拟仿真器中,利用分层开放的体系结构,将不同的控制动作分布到不同的复杂程度,并利用可重构计算资源。在非完整移动机器人和轮椅上对该环境进行验证;它们都使用嵌入式控制快速原型技术来实现最佳导航策略。在模拟器上进行测试验证后,将控制系统编程到移动机器人或轮椅的控制板存储器中。因此,时间和材料的使用得到了优化,首先虚拟验证整个模型,然后操作导航系统的物理实现。
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引用次数: 0
Walking Control of Humanoid Robots on Uneven Ground Using Fuzzy Algorithm 基于模糊算法的仿人机器人不平整地面行走控制
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-1639-2.CH014
Saeed Abdolshah, M. Abdolshah, Majid Abdolshah, S. V. Hashemi
Walking control of humanoid robots is a challenging issue. In this chapter, a method for modeling humanoid robots is presented considering the human being indices such as DOFs, mass and the moment of inertia of the segments. In the next step, a walking pattern on the flat ground is generated and the robot motion is simulated in the MSC. Visual Nastran 4D™ software. ZMP trajectory of the simulated humanoid robot in walking cycle has been obtained. An uneven ground is generated in the software, where the robot falls down during the motion. A fuzzy algorithm is employed to balance the robot; input is defined as the differences between the projections of ZMP in flat and uneven ground and output is a compensative signal to make the robot follow the flat ground ZMP pattern to refuse the robot falling. Output signal is distributed in different joints to make faster and more effective compensation. Although the type of uneven ground can be important, but the robot could successfully pass the designed uneven ground in MSC.Visual Nastran 4D.
人形机器人的行走控制是一个具有挑战性的问题。在本章中,提出了一种考虑人的指标,如自由度、质量和关节的转动惯量的仿人机器人建模方法。下一步,在平地上生成行走模式,并在MSC中模拟机器人的运动。Visual Nastran 4D™软件。仿真得到了仿人机器人行走周期的ZMP轨迹。在软件中产生一个不平坦的地面,机器人在运动过程中会在那里摔倒。采用模糊算法对机器人进行平衡;输入定义为平坦地面和不平坦地面上ZMP投影的差值,输出是补偿信号,使机器人遵循平坦地面ZMP模式,拒绝机器人坠落。输出信号分布在不同的接头,使补偿更快、更有效。虽然不平整地面的类型可能很重要,但机器人可以成功地通过MSC设计的不平整地面。视觉Nastran 4D。
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引用次数: 1
期刊
Journal of Rapid Methods and Automation in Microbiology
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