Pub Date : 2024-07-01DOI: 10.1016/j.ejso.2024.108536
{"title":"Reply to: Vascularized reconstruction following extremity sarcoma resection – more than just a means to close a wound’","authors":"","doi":"10.1016/j.ejso.2024.108536","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108536","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"40 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141709779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.ejso.2024.108546
R. Di Fiore, Rosa Drago‐Ferrante, S. Suleiman, Neville Calleja, J. Calleja-Agius
{"title":"The role of microRNA-9 in Ovarian and Cervical Cancers: an Updated Overview","authors":"R. Di Fiore, Rosa Drago‐Ferrante, S. Suleiman, Neville Calleja, J. Calleja-Agius","doi":"10.1016/j.ejso.2024.108546","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108546","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"58 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.ejso.2024.108549
D. Raos, Nikolina Vučemilo Paripović, P. Ozretić, M. Sabol
{"title":"Current status of in vitro models for rare gynaecological cancer research","authors":"D. Raos, Nikolina Vučemilo Paripović, P. Ozretić, M. Sabol","doi":"10.1016/j.ejso.2024.108549","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108549","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"53 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1016/j.ejso.2024.108352
T.M. Gilbert, L. Randle, M. Quinn, O. McGreevy, L. O’leary, R. Young, R. Diaz-Neito, R.P. Jones, B. Greenhalf, C. Goldring, S. Fenwick, H. Malik, D.H. Palmer
Cholangiocarcinoma (CCA) remains a devastating malignancy and a significant challenge to treat. The majority of CCA patients are diagnosed at an advanced stage, making the disease incurable in most cases. The advent of high-throughput genetic sequencing has significantly improved our understanding of the molecular biology underpinning cancer. The identification of ‘druggable’ genetic aberrations and the development of novel targeted therapies against them is opening up new treatment strategies. Currently, 3 targeted therapies are approved for use in CCA; Ivosidenib in patients with IDH1 mutations and Infigratinib/Pemigatinib in those with FGFR2 fusions. As our understanding of the biology underpinning CCA continues to improve it is highly likely that additional targeted therapies will become available in the near future. This is important, as it is thought up to 40 % of CCA patients harbour a potentially actionable mutation. In this review we provide an overview of the molecular pathogenesis of CCA and highlight currently available and potential future targeted treatments.
胆管癌（CCA）仍然是一种破坏性极大的恶性肿瘤，也是治疗上的一大挑战。大多数 CCA 患者在确诊时已是晚期，因此在大多数情况下无法治愈。高通量基因测序技术的出现大大提高了我们对癌症分子生物学基础的认识。发现 "可药物治疗 "的基因畸变并开发针对这些畸变的新型靶向疗法，为我们开辟了新的治疗策略。目前，有 3 种靶向疗法获准用于 CCA：Ivosidenib 用于 IDH1 基因突变的患者，Infigratinib/Pemigatinib 用于 FGFR2 基因融合的患者。随着我们对 CCA 生物学基础的了解不断加深，很有可能在不久的将来会有更多的靶向疗法问世。这一点非常重要，因为据认为多达 40% 的 CCA 患者存在潜在的可采取行动的突变。在这篇综述中，我们概述了 CCA 的分子发病机制，并重点介绍了目前可用的和未来潜在的靶向治疗方法。
{"title":"Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management","authors":"T.M. Gilbert, L. Randle, M. Quinn, O. McGreevy, L. O’leary, R. Young, R. Diaz-Neito, R.P. Jones, B. Greenhalf, C. Goldring, S. Fenwick, H. Malik, D.H. Palmer","doi":"10.1016/j.ejso.2024.108352","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108352","url":null,"abstract":"Cholangiocarcinoma (CCA) remains a devastating malignancy and a significant challenge to treat. The majority of CCA patients are diagnosed at an advanced stage, making the disease incurable in most cases. The advent of high-throughput genetic sequencing has significantly improved our understanding of the molecular biology underpinning cancer. The identification of ‘druggable’ genetic aberrations and the development of novel targeted therapies against them is opening up new treatment strategies. Currently, 3 targeted therapies are approved for use in CCA; Ivosidenib in patients with IDH1 mutations and Infigratinib/Pemigatinib in those with FGFR2 fusions. As our understanding of the biology underpinning CCA continues to improve it is highly likely that additional targeted therapies will become available in the near future. This is important, as it is thought up to 40 % of CCA patients harbour a potentially actionable mutation. In this review we provide an overview of the molecular pathogenesis of CCA and highlight currently available and potential future targeted treatments.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1016/j.ejso.2024.108316
Shady A. Saleem, Fatma El-Zahraa A. Mustafa, Hanan H. Abd-Elhafeez, Gilan A. Ahmed
Congenital tumors are rare, and malignant congenital tumors are uncommon. Benign tu,mors might be life-threatening, depending on the location and size of the tumor. Different factors affect congenital tumors, such as maternal and placental hormones and environmental factors such as drugs, radiation, and infection. Developing fetal imaging methods and continuous follow-up during pregnancy are important factors in congenital tumor prognosis. Ultrasound is the most common method used for fetal evaluation. The complementary evaluation method is MRI. Both methods are helpful and widely spread for the detection of congenital tumors. These imaging methods help the medical team make a suitable decision about therapy. Some of these tumors regressed spontaneously, and some need surgical treatments. Treatment of tumors has developed rapidly, and recently molecular-targeted drugs have been used.
{"title":"Congenital and gynecological tumors: A review","authors":"Shady A. Saleem, Fatma El-Zahraa A. Mustafa, Hanan H. Abd-Elhafeez, Gilan A. Ahmed","doi":"10.1016/j.ejso.2024.108316","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108316","url":null,"abstract":"Congenital tumors are rare, and malignant congenital tumors are uncommon. Benign tu,mors might be life-threatening, depending on the location and size of the tumor. Different factors affect congenital tumors, such as maternal and placental hormones and environmental factors such as drugs, radiation, and infection. Developing fetal imaging methods and continuous follow-up during pregnancy are important factors in congenital tumor prognosis. Ultrasound is the most common method used for fetal evaluation. The complementary evaluation method is MRI. Both methods are helpful and widely spread for the detection of congenital tumors. These imaging methods help the medical team make a suitable decision about therapy. Some of these tumors regressed spontaneously, and some need surgical treatments. Treatment of tumors has developed rapidly, and recently molecular-targeted drugs have been used.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140806464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1016/j.ejso.2024.108293
Giulio Anichini, Maria Leiloglou, Zepeng Hu, Kevin O'Neill, Daniel Elson
The neuro-surgical community is witnessing a rising interest for surgical application of multispectral/hyperspectral imaging. Several potential technical applications of this optical imaging are reported, but the set-up is variable and so are the processing methods. We present a systematic review of the relevant literature on the topic. A literature search based on the PRISMA principles was performed on PubMed, SCOPUS, and Web of Science, using MESH terms and Boolean operators. Papers regarding intra-operative in-vivo application of multispectral and/or hyperspectral imaging in humans during neurosurgical procedures were included. Papers reporting technologies related to radiological applications were excluded. A meta-analysis on the performance metrics was also conducted. Our search string retrieved 20 papers. The main applications of optical imaging during neurosurgery concern tumour detection and improvement of the extent of resection (15 papers) or visualization of perfusion changes during neuro-oncology or neuro-vascular surgery (5 papers). All the retrieved articles were pilot studies, proof of concepts, or case reports, with limited number of patients recruited. Sensitivity, specificity, and accuracy were promising in most of the reports, but the metanalysis showed heterogeneous approaches and results among studies. The present review shows that several approaches are currently being tested to integrate hyperspectral imaging in neurosurgery, but most of the studies reported a limited pool of patients, with different approaches to data collection and analysis. Further studies on larger cohorts of patients are therefore desirable to fully explore the potential of this imaging technique.
神经外科界对多光谱/高光谱成像在外科手术中的应用越来越感兴趣。有报道称，这种光学成像技术有多种潜在应用，但其设置和处理方法各不相同。我们对该主题的相关文献进行了系统回顾。根据 PRISMA 原则，我们使用 MESH 术语和布尔运算符在 PubMed、SCOPUS 和 Web of Science 上进行了文献检索。纳入了有关在神经外科手术过程中在人体术中应用多光谱和/或超光谱成像的论文。报告与放射学应用相关技术的论文除外。此外还对性能指标进行了荟萃分析。我们的搜索字符串检索到 20 篇论文。神经外科手术中光学成像的主要应用涉及肿瘤检测和改善切除范围（15 篇论文）或神经肿瘤学或神经血管手术中灌注变化的可视化（5 篇论文）。所有检索到的文章均为试点研究、概念验证或病例报告，招募的患者人数有限。大多数报告的灵敏度、特异性和准确性都很不错，但荟萃分析表明不同研究的方法和结果各不相同。本综述显示，目前正在测试几种将高光谱成像整合到神经外科中的方法，但大多数研究报告的患者人数有限，数据收集和分析方法也不尽相同。因此，需要对更多的患者进行进一步研究，以充分发掘这种成像技术的潜力。
{"title":"Hyperspectral and multispectral imaging in neurosurgery: a systematic literature review and meta-analysis","authors":"Giulio Anichini, Maria Leiloglou, Zepeng Hu, Kevin O'Neill, Daniel Elson","doi":"10.1016/j.ejso.2024.108293","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108293","url":null,"abstract":"The neuro-surgical community is witnessing a rising interest for surgical application of multispectral/hyperspectral imaging. Several potential technical applications of this optical imaging are reported, but the set-up is variable and so are the processing methods. We present a systematic review of the relevant literature on the topic. A literature search based on the PRISMA principles was performed on PubMed, SCOPUS, and Web of Science, using MESH terms and Boolean operators. Papers regarding intra-operative in-vivo application of multispectral and/or hyperspectral imaging in humans during neurosurgical procedures were included. Papers reporting technologies related to radiological applications were excluded. A meta-analysis on the performance metrics was also conducted. Our search string retrieved 20 papers. The main applications of optical imaging during neurosurgery concern tumour detection and improvement of the extent of resection (15 papers) or visualization of perfusion changes during neuro-oncology or neuro-vascular surgery (5 papers). All the retrieved articles were pilot studies, proof of concepts, or case reports, with limited number of patients recruited. Sensitivity, specificity, and accuracy were promising in most of the reports, but the metanalysis showed heterogeneous approaches and results among studies. The present review shows that several approaches are currently being tested to integrate hyperspectral imaging in neurosurgery, but most of the studies reported a limited pool of patients, with different approaches to data collection and analysis. Further studies on larger cohorts of patients are therefore desirable to fully explore the potential of this imaging technique.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140799339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ejso.2023.107327
Jeongshin An, Hyungju Kwon, Young Ju Kim
{"title":"Analysis of microbiome involved in the development of second primary cancer in patients with breast cancer","authors":"Jeongshin An, Hyungju Kwon, Young Ju Kim","doi":"10.1016/j.ejso.2023.107327","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107327","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ejso.2023.107469
Giovanni Cisternino, Rosa Di Micco, Margherita Monticelli, Veronica Zuber, Sara Baleri, Elena Venturini, Carla Canevari, Patrizia Magnani, Nicole Rotmensz, Angelica Critelli, Annarita Savi, Michela Olivieri, Paola Silvia Corona, Francesca Calabretto, Mario Rampa, Pietro Panizza, Arturo Chiti, Isabella Sassi, Oreste Davide Gentilini
{"title":"High-resolution PET-CT imaging for intraoperative margin assessment in early-stage breast cancer: initial results from a prospective international clinical study.","authors":"Giovanni Cisternino, Rosa Di Micco, Margherita Monticelli, Veronica Zuber, Sara Baleri, Elena Venturini, Carla Canevari, Patrizia Magnani, Nicole Rotmensz, Angelica Critelli, Annarita Savi, Michela Olivieri, Paola Silvia Corona, Francesca Calabretto, Mario Rampa, Pietro Panizza, Arturo Chiti, Isabella Sassi, Oreste Davide Gentilini","doi":"10.1016/j.ejso.2023.107469","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107469","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"1993 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ejso.2023.107459
Sofia Boligo, Vasco Silva Cardoso, Miguel Trigo Silvestre, Joana Pedro Marques, Margarida Santos Bessa, Ana Rita Martins, Patrícia Amaral, Zacharoula Sidiropoulou
{"title":"Prevalence of Imaging Detected Silent Female Breast Cancer in Autopsy Specimens: Study of the Disease Held by Image-Guided Biopsies","authors":"Sofia Boligo, Vasco Silva Cardoso, Miguel Trigo Silvestre, Joana Pedro Marques, Margarida Santos Bessa, Ana Rita Martins, Patrícia Amaral, Zacharoula Sidiropoulou","doi":"10.1016/j.ejso.2023.107459","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107459","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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