Pub Date : 2024-07-01DOI: 10.1016/j.ejso.2024.108536
{"title":"Reply to: Vascularized reconstruction following extremity sarcoma resection – more than just a means to close a wound’","authors":"","doi":"10.1016/j.ejso.2024.108536","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108536","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"40 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141709779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.ejso.2024.108546
R. Di Fiore, Rosa Drago‐Ferrante, S. Suleiman, Neville Calleja, J. Calleja-Agius
{"title":"The role of microRNA-9 in Ovarian and Cervical Cancers: an Updated Overview","authors":"R. Di Fiore, Rosa Drago‐Ferrante, S. Suleiman, Neville Calleja, J. Calleja-Agius","doi":"10.1016/j.ejso.2024.108546","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108546","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"58 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.ejso.2024.108549
D. Raos, Nikolina Vučemilo Paripović, P. Ozretić, M. Sabol
{"title":"Current status of in vitro models for rare gynaecological cancer research","authors":"D. Raos, Nikolina Vučemilo Paripović, P. Ozretić, M. Sabol","doi":"10.1016/j.ejso.2024.108549","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108549","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"53 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1016/j.ejso.2024.108352
T.M. Gilbert, L. Randle, M. Quinn, O. McGreevy, L. O’leary, R. Young, R. Diaz-Neito, R.P. Jones, B. Greenhalf, C. Goldring, S. Fenwick, H. Malik, D.H. Palmer
Cholangiocarcinoma (CCA) remains a devastating malignancy and a significant challenge to treat. The majority of CCA patients are diagnosed at an advanced stage, making the disease incurable in most cases. The advent of high-throughput genetic sequencing has significantly improved our understanding of the molecular biology underpinning cancer. The identification of ‘druggable’ genetic aberrations and the development of novel targeted therapies against them is opening up new treatment strategies. Currently, 3 targeted therapies are approved for use in CCA; Ivosidenib in patients with IDH1 mutations and Infigratinib/Pemigatinib in those with FGFR2 fusions. As our understanding of the biology underpinning CCA continues to improve it is highly likely that additional targeted therapies will become available in the near future. This is important, as it is thought up to 40 % of CCA patients harbour a potentially actionable mutation. In this review we provide an overview of the molecular pathogenesis of CCA and highlight currently available and potential future targeted treatments.
胆管癌（CCA）仍然是一种破坏性极大的恶性肿瘤，也是治疗上的一大挑战。大多数 CCA 患者在确诊时已是晚期，因此在大多数情况下无法治愈。高通量基因测序技术的出现大大提高了我们对癌症分子生物学基础的认识。发现 "可药物治疗 "的基因畸变并开发针对这些畸变的新型靶向疗法，为我们开辟了新的治疗策略。目前，有 3 种靶向疗法获准用于 CCA：Ivosidenib 用于 IDH1 基因突变的患者，Infigratinib/Pemigatinib 用于 FGFR2 基因融合的患者。随着我们对 CCA 生物学基础的了解不断加深，很有可能在不久的将来会有更多的靶向疗法问世。这一点非常重要，因为据认为多达 40% 的 CCA 患者存在潜在的可采取行动的突变。在这篇综述中，我们概述了 CCA 的分子发病机制，并重点介绍了目前可用的和未来潜在的靶向治疗方法。
{"title":"Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management","authors":"T.M. Gilbert, L. Randle, M. Quinn, O. McGreevy, L. O’leary, R. Young, R. Diaz-Neito, R.P. Jones, B. Greenhalf, C. Goldring, S. Fenwick, H. Malik, D.H. Palmer","doi":"10.1016/j.ejso.2024.108352","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108352","url":null,"abstract":"Cholangiocarcinoma (CCA) remains a devastating malignancy and a significant challenge to treat. The majority of CCA patients are diagnosed at an advanced stage, making the disease incurable in most cases. The advent of high-throughput genetic sequencing has significantly improved our understanding of the molecular biology underpinning cancer. The identification of ‘druggable’ genetic aberrations and the development of novel targeted therapies against them is opening up new treatment strategies. Currently, 3 targeted therapies are approved for use in CCA; Ivosidenib in patients with IDH1 mutations and Infigratinib/Pemigatinib in those with FGFR2 fusions. As our understanding of the biology underpinning CCA continues to improve it is highly likely that additional targeted therapies will become available in the near future. This is important, as it is thought up to 40 % of CCA patients harbour a potentially actionable mutation. In this review we provide an overview of the molecular pathogenesis of CCA and highlight currently available and potential future targeted treatments.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1016/j.ejso.2024.108316
Shady A. Saleem, Fatma El-Zahraa A. Mustafa, Hanan H. Abd-Elhafeez, Gilan A. Ahmed
Congenital tumors are rare, and malignant congenital tumors are uncommon. Benign tu,mors might be life-threatening, depending on the location and size of the tumor. Different factors affect congenital tumors, such as maternal and placental hormones and environmental factors such as drugs, radiation, and infection. Developing fetal imaging methods and continuous follow-up during pregnancy are important factors in congenital tumor prognosis. Ultrasound is the most common method used for fetal evaluation. The complementary evaluation method is MRI. Both methods are helpful and widely spread for the detection of congenital tumors. These imaging methods help the medical team make a suitable decision about therapy. Some of these tumors regressed spontaneously, and some need surgical treatments. Treatment of tumors has developed rapidly, and recently molecular-targeted drugs have been used.
{"title":"Congenital and gynecological tumors: A review","authors":"Shady A. Saleem, Fatma El-Zahraa A. Mustafa, Hanan H. Abd-Elhafeez, Gilan A. Ahmed","doi":"10.1016/j.ejso.2024.108316","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108316","url":null,"abstract":"Congenital tumors are rare, and malignant congenital tumors are uncommon. Benign tu,mors might be life-threatening, depending on the location and size of the tumor. Different factors affect congenital tumors, such as maternal and placental hormones and environmental factors such as drugs, radiation, and infection. Developing fetal imaging methods and continuous follow-up during pregnancy are important factors in congenital tumor prognosis. Ultrasound is the most common method used for fetal evaluation. The complementary evaluation method is MRI. Both methods are helpful and widely spread for the detection of congenital tumors. These imaging methods help the medical team make a suitable decision about therapy. Some of these tumors regressed spontaneously, and some need surgical treatments. Treatment of tumors has developed rapidly, and recently molecular-targeted drugs have been used.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140806464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ejso.2023.107327
Jeongshin An, Hyungju Kwon, Young Ju Kim
{"title":"Analysis of microbiome involved in the development of second primary cancer in patients with breast cancer","authors":"Jeongshin An, Hyungju Kwon, Young Ju Kim","doi":"10.1016/j.ejso.2023.107327","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107327","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ejso.2023.107469
Giovanni Cisternino, Rosa Di Micco, Margherita Monticelli, Veronica Zuber, Sara Baleri, Elena Venturini, Carla Canevari, Patrizia Magnani, Nicole Rotmensz, Angelica Critelli, Annarita Savi, Michela Olivieri, Paola Silvia Corona, Francesca Calabretto, Mario Rampa, Pietro Panizza, Arturo Chiti, Isabella Sassi, Oreste Davide Gentilini
{"title":"High-resolution PET-CT imaging for intraoperative margin assessment in early-stage breast cancer: initial results from a prospective international clinical study.","authors":"Giovanni Cisternino, Rosa Di Micco, Margherita Monticelli, Veronica Zuber, Sara Baleri, Elena Venturini, Carla Canevari, Patrizia Magnani, Nicole Rotmensz, Angelica Critelli, Annarita Savi, Michela Olivieri, Paola Silvia Corona, Francesca Calabretto, Mario Rampa, Pietro Panizza, Arturo Chiti, Isabella Sassi, Oreste Davide Gentilini","doi":"10.1016/j.ejso.2023.107469","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107469","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"1993 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ejso.2023.107459
Sofia Boligo, Vasco Silva Cardoso, Miguel Trigo Silvestre, Joana Pedro Marques, Margarida Santos Bessa, Ana Rita Martins, Patrícia Amaral, Zacharoula Sidiropoulou
{"title":"Prevalence of Imaging Detected Silent Female Breast Cancer in Autopsy Specimens: Study of the Disease Held by Image-Guided Biopsies","authors":"Sofia Boligo, Vasco Silva Cardoso, Miguel Trigo Silvestre, Joana Pedro Marques, Margarida Santos Bessa, Ana Rita Martins, Patrícia Amaral, Zacharoula Sidiropoulou","doi":"10.1016/j.ejso.2023.107459","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107459","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1016/j.ejso.2023.107466
Vivien Ceccato, Lauren Wallaert, Thomas Gaillard, Noémie Girard, Lauren Darrigues, Léa Pauly, Elodie Gauroy, Sophie Michel, Fabien Reyal, Beatriz Grandal, Judicaël Hotton
{"title":"Initial experience of guided magnetic marker in non-palpable breast excision: first 80 cases in a French centre","authors":"Vivien Ceccato, Lauren Wallaert, Thomas Gaillard, Noémie Girard, Lauren Darrigues, Léa Pauly, Elodie Gauroy, Sophie Michel, Fabien Reyal, Beatriz Grandal, Judicaël Hotton","doi":"10.1016/j.ejso.2023.107466","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107466","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139957063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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