Impairment of mental status is frequently seen in cancer patients. Common causes are infection, metabolic disturbance, organ failure, medication, delirium or metastatic disease. Wernicke encephalopathy (WE) is likely to be underestimated in clinical practice in nonalcoholic population including this special patient group. The purpose of this paper is to take attention to WE and cancer concomitance, and emphasize the role of magnetic resonance imaging (MRI) in the early diagnosis of this complicated disease. We report two cancer patients who were consulted to our neurology department because of altered mental status and other neurological disabilities. When the patients underwent brain MRI for differential diagnosis, symmetrical perimidline lesions of the brain made the suspicion of WE diagnosis. In addition, one of the patient's MRI showed symmetric cortical and cerebellar involvement that is more typical in nonalcoholic form of WE. Both patients mostly recovered clinically, also showed concordant resolution of MRI abnormalities within 4-8 weeks after thiamine supplementation. WE diagnose should be kept in mind in cancer patients with altered mental status and thiamine treatment should be started during undergoing evaluation and differential diagnose to prevent irreversible clinical sequelae. Improved recognition of radiologists and well-known imaging findings of WE can facilitate early detection and effective treatment in nonalcoholic WE patients.
{"title":"An Underestimated Diagnosis in Practice: Wernicke Encephalopathy in Two Patients With Cancer","authors":"M. Ünsal, D. Kaya","doi":"10.24165/JNS.9541.16","DOIUrl":"https://doi.org/10.24165/JNS.9541.16","url":null,"abstract":"Impairment of mental status is frequently seen in cancer patients. Common causes are infection, metabolic disturbance, organ failure, medication, delirium or metastatic disease. Wernicke encephalopathy (WE) is likely to be underestimated in clinical practice in nonalcoholic population including this special patient group. The purpose of this paper is to take attention to WE and cancer concomitance, and emphasize the role of magnetic resonance imaging (MRI) in the early diagnosis of this complicated disease. We report two cancer patients who were consulted to our neurology department because of altered mental status and other neurological disabilities. When the patients underwent brain MRI for differential diagnosis, symmetrical perimidline lesions of the brain made the suspicion of WE diagnosis. In addition, one of the patient's MRI showed symmetric cortical and cerebellar involvement that is more typical in nonalcoholic form of WE. Both patients mostly recovered clinically, also showed concordant resolution of MRI abnormalities within 4-8 weeks after thiamine supplementation. WE diagnose should be kept in mind in cancer patients with altered mental status and thiamine treatment should be started during undergoing evaluation and differential diagnose to prevent irreversible clinical sequelae. Improved recognition of radiologists and well-known imaging findings of WE can facilitate early detection and effective treatment in nonalcoholic WE patients.","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88770400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Sirin, E. Orhan, H. Durmuş, P. Oflazer, Y. Parman, A. Oge, F. Deymeer, M. Baslo
{"title":"Jitter measurement using a concentric needle in 133 patients with myasthenia gravis: A retrospective analysis","authors":"N. Sirin, E. Orhan, H. Durmuş, P. Oflazer, Y. Parman, A. Oge, F. Deymeer, M. Baslo","doi":"10.24165/JNS.10168.17","DOIUrl":"https://doi.org/10.24165/JNS.10168.17","url":null,"abstract":"","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81900736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Amnestic mild cognitive impairment (aMCI) refers to cognitive changes that occur during the period of normal cognitive decline and very early dementia. We aimed to assess the efficacy of memantine used for the treatment of patients with aMCI. Methods: All patients were diagnosed as having aMCI according to the Petersen criteria and were assigned to one of three groups. Group 1 comprised patients who received memantine following examination (n=23), group 2 included patients who did not receive memantine treatment following examination (n=22), and group 3 was constituted by healthy age-matched volunteers (n=20). Following the examinations, neuropsychiatric tests from the Turquoise Alzheimer"s Study Group database used in dementia polyclinics were performed. Results: The mean age of patients was 66±7.04 years in group 1, 65.3±6.20 years in group 2, and 57.6±5.40 years in group 3. The most noticeable improvements in group 1 were seen in the Mini-Mental State Exam, Wechsler memory scale subtests, Blessed Dementia Rating Scale, and the Boston Naming Test (p<0.05). Treatment with memantine was associated with an improvement in Geriatric Dementia Scale scores over the 24week study period. Conclusion: These results suggest that memantine treatment in patients with aMCI acts to enhance cognitive functioning compared with no treatment. These findings suggest the need for a larger randomized placebo-controlled trial.
{"title":"The effect of memantine on cognitive performance with amnestic mild cognitive impairment","authors":"D. Ilhan, S. Daglı, S. Ozkan, D. Ozbabalık","doi":"10.24165/JNS.9922.16","DOIUrl":"https://doi.org/10.24165/JNS.9922.16","url":null,"abstract":"Objective: Amnestic mild cognitive impairment (aMCI) refers to cognitive changes that occur during the period of normal cognitive decline and very early dementia. We aimed to assess the efficacy of memantine used for the treatment of patients with aMCI. Methods: All patients were diagnosed as having aMCI according to the Petersen criteria and were assigned to one of three groups. Group 1 comprised patients who received memantine following examination (n=23), group 2 included patients who did not receive memantine treatment following examination (n=22), and group 3 was constituted by healthy age-matched volunteers (n=20). Following the examinations, neuropsychiatric tests from the Turquoise Alzheimer\"s Study Group database used in dementia polyclinics were performed. Results: The mean age of patients was 66±7.04 years in group 1, 65.3±6.20 years in group 2, and 57.6±5.40 years in group 3. The most noticeable improvements in group 1 were seen in the Mini-Mental State Exam, Wechsler memory scale subtests, Blessed Dementia Rating Scale, and the Boston Naming Test (p<0.05). Treatment with memantine was associated with an improvement in Geriatric Dementia Scale scores over the 24week study period. Conclusion: These results suggest that memantine treatment in patients with aMCI acts to enhance cognitive functioning compared with no treatment. These findings suggest the need for a larger randomized placebo-controlled trial.","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89074104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of different duration time of exposure to 2100 mhz electromagnetic radiation on behaviour and hippocampal level of protein kinases on rats","authors":"Ç. Saraç, H. Er","doi":"10.24165/JNS.10160.17","DOIUrl":"https://doi.org/10.24165/JNS.10160.17","url":null,"abstract":"","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78716334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gündüz, E. Meral, Kumru Hatice, O. Semra, Kızıltan Gunes, Ertan Sibel, Apaydın Hulya
{"title":"Cortical relay time shortens in parkinsons disease with apraxia","authors":"A. Gündüz, E. Meral, Kumru Hatice, O. Semra, Kızıltan Gunes, Ertan Sibel, Apaydın Hulya","doi":"10.24165/jns.9736.16","DOIUrl":"https://doi.org/10.24165/jns.9736.16","url":null,"abstract":"","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73931814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Çiçekçi, Dincer Yuksekkavas, A. Aydın, A. Karaibrahimoğlu, A. U. Uca
The Comparison of Socio-Demographic and Clinical Variables of Inmates Using Gabapentin For Medicinal Purposes and Those Abusing The Drug Faruk CİCEKCİ, Dincer YUKSEKKAVAS, Adem AYDIN, Adnan KARAİBRAHİMOGLU, Ali Ulvi UCA Selçuk University, Medical Faculty, Anesthesiology and Reanimasion, Konya, Turkey Konya E Type Prison, Department of Medicine, Konya, Turkey Necmettin Erbakan University, Medical Faculty, Department of Psychiatry, Konya, Turkey Necmettin Erbakan University, Medical Faculty, Department of Medical Education and Informatics, Konya, Turkey Necmettin Erbakan University, Medical Faculty, Department of Nerology, Konya, Turkey
使用加巴喷丁和滥用加巴喷丁的囚犯的社会人口学和临床变量的比较Faruk CİCEKCİ， Dincer YUKSEKKAVAS, Adem AYDIN, Adnan KARAİBRAHİMOGLU, Ali Ulvi UCA sel鲁克大学医学院，麻醉学和康复学，土耳其科尼亚科尼亚E型监狱，医学系，科尼亚，土耳其Necmettin Erbakan大学医学院，精神病学系，科尼亚，土耳其Necmettin Erbakan大学医学院，土耳其科尼亚，医学教育和信息系，Necmettin Erbakan大学，医学院，神经学系，科尼亚
{"title":"The comparison of socio-demographic and clinical variables between inmates using gabapentin for medicinal purposes and those abusing the drug","authors":"F. Çiçekçi, Dincer Yuksekkavas, A. Aydın, A. Karaibrahimoğlu, A. U. Uca","doi":"10.24165/jns.10014.17","DOIUrl":"https://doi.org/10.24165/jns.10014.17","url":null,"abstract":"The Comparison of Socio-Demographic and Clinical Variables of Inmates Using Gabapentin For Medicinal Purposes and Those Abusing The Drug Faruk CİCEKCİ, Dincer YUKSEKKAVAS, Adem AYDIN, Adnan KARAİBRAHİMOGLU, Ali Ulvi UCA Selçuk University, Medical Faculty, Anesthesiology and Reanimasion, Konya, Turkey Konya E Type Prison, Department of Medicine, Konya, Turkey Necmettin Erbakan University, Medical Faculty, Department of Psychiatry, Konya, Turkey Necmettin Erbakan University, Medical Faculty, Department of Medical Education and Informatics, Konya, Turkey Necmettin Erbakan University, Medical Faculty, Department of Nerology, Konya, Turkey","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82692151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Gürgör, Y. Beckmann, N. Hassanzadeh, Ş. Arıcı, T. Incesu, Y. Seçil, C. Erteki̇n
There are very close relationships among deglutition, taste sensations, and facial expressions in humans. However, the associations among mimicking, swallowing, and the suprahyoid/submental muscle group (SM) during deglutition events have yet to be investigated using electrophysiological techniques to elucidate taste sensation and facial expression further. Thus, this study used surface EMG to evaluate synchronous electromyography activity in the facial and swallowing muscles during the swallowing of water and sour boluses in 20 normal healthy adults. All participants were instructed to swallow four bolus volumes (5, 10, 15, and 20 ml) each of a water bolus and a sour bolus (lemon juice) in a neutral head position. EMG recordings were obtained from the orbicularis oculi (OC; a mimic muscle), orbicularis oris (OR; a mimic and swallowing muscle), and SM (deglutition muscles) to determine whether these muscles were synchronously activated during voluntary oropharyngeal swallowing. The mimic (OC and OR) and swallowing muscles (SM) were synchronously activated in more than 90% of participants during water swallowing. Swallowing lemon juice increased the number of spontaneous swallows after the first deglutition and significantly shortened the duration of a single swallowing apnea. The present findings indicate that both taste and the intraoral trigeminal afferents of water and sour boluses excite facial neurons via the nucleus tractus solitarius and/or a central pattern generator. Additionally, sour boluses produced stronger and safer oropharyngeal swallowing in conjunction with increases in facial expressions due to the activation of facial mimic muscles.
{"title":"Activity of facial and swallowing muscles during water and sour bolus deglutition in healthy adult humans","authors":"N. Gürgör, Y. Beckmann, N. Hassanzadeh, Ş. Arıcı, T. Incesu, Y. Seçil, C. Erteki̇n","doi":"10.24165/jns.9875.16","DOIUrl":"https://doi.org/10.24165/jns.9875.16","url":null,"abstract":"There are very close relationships among deglutition, taste sensations, and facial expressions in humans. However, the associations among mimicking, swallowing, and the suprahyoid/submental muscle group (SM) during deglutition events have yet to be investigated using electrophysiological techniques to elucidate taste sensation and facial expression further. Thus, this study used surface EMG to evaluate synchronous electromyography activity in the facial and swallowing muscles during the swallowing of water and sour boluses in 20 normal healthy adults. All participants were instructed to swallow four bolus volumes (5, 10, 15, and 20 ml) each of a water bolus and a sour bolus (lemon juice) in a neutral head position. EMG recordings were obtained from the orbicularis oculi (OC; a mimic muscle), orbicularis oris (OR; a mimic and swallowing muscle), and SM (deglutition muscles) to determine whether these muscles were synchronously activated during voluntary oropharyngeal swallowing. The mimic (OC and OR) and swallowing muscles (SM) were synchronously activated in more than 90% of participants during water swallowing. Swallowing lemon juice increased the number of spontaneous swallows after the first deglutition and significantly shortened the duration of a single swallowing apnea. The present findings indicate that both taste and the intraoral trigeminal afferents of water and sour boluses excite facial neurons via the nucleus tractus solitarius and/or a central pattern generator. Additionally, sour boluses produced stronger and safer oropharyngeal swallowing in conjunction with increases in facial expressions due to the activation of facial mimic muscles.","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76769217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Bayazit, S. Kocaaslan, Mürşide Tunçel, A. Karagulle, D. Gökengin
{"title":"Effects of hiv on neuroelectric responses: aerp and eda","authors":"O. Bayazit, S. Kocaaslan, Mürşide Tunçel, A. Karagulle, D. Gökengin","doi":"10.24165/jns.9860.16","DOIUrl":"https://doi.org/10.24165/jns.9860.16","url":null,"abstract":"","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"237 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73523345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Head bath: as a specific trigger for migraine and tension-type headaches","authors":"M. Gonen, Emrah Aytaç, B. Müngen","doi":"10.24165/JNS.10091.17","DOIUrl":"https://doi.org/10.24165/JNS.10091.17","url":null,"abstract":"","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80758081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sarsilmaz, Z. Firat, A. Uluğ, G. Karlıkaya, C. Bingol, A. Hamamci, I. Kovanlikaya
{"title":"Diffusion tensor imaging in early amyotrophic lateral sclerosis at 3t MRI","authors":"A. Sarsilmaz, Z. Firat, A. Uluğ, G. Karlıkaya, C. Bingol, A. Hamamci, I. Kovanlikaya","doi":"10.24165/JNS.9795.16","DOIUrl":"https://doi.org/10.24165/JNS.9795.16","url":null,"abstract":"","PeriodicalId":50116,"journal":{"name":"Journal of Neurological Sciences-Turkish","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78444397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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