Pub Date : 2023-11-30DOI: 10.1101/2023.11.29.23299192
Madeline Hocking Osborne, Margaret Koeritzer, Hannah Herd, Melissa Jane Polonenko
Enlarged vestibular aqueduct (EVA) is a malformation associated with sensorineural hearing loss in children. Mutations in the SLC26A4 gene are also associated with EVA and may contribute to more severe hearing losses that progress, but the timescale of this progression remains unknown. Given that children undergo significant speech and language development, a better understanding of the timing and extent of hearing loss is needed for individuals who have EVA. Through a retrospective review of records in a local database, we aimed to 1) estimate the prevalence of a SLC26A4 mutation in this pediatric EVA cohort; and 2) compare hearing threshold severity and timing of progression across children who have EVA and different SLC26A4 statuses. Of 62 children with EVA, 39 had available genetic results and of these, 15 had at least one mutation of the SLC26A4 gene (38%). The children with a SLC26A4 mutation had a more severe onset of hearing loss and a more rapid progression of hearing loss over time, especially for higher frequencies, than children without a mutation in this gene. This longitudinal information may facilitate prognostic counseling to pediatric patients and better inform the audiology follow-up appointments for these families.
{"title":"Hearing Progression of Children with Enlarged Vestibular Aqueduct (EVA) According to SLC26A4 Genetic Mutation Status","authors":"Madeline Hocking Osborne, Margaret Koeritzer, Hannah Herd, Melissa Jane Polonenko","doi":"10.1101/2023.11.29.23299192","DOIUrl":"https://doi.org/10.1101/2023.11.29.23299192","url":null,"abstract":"Enlarged vestibular aqueduct (EVA) is a malformation associated with sensorineural hearing loss in children. Mutations in the <em>SLC26A4</em> gene are also associated with EVA and may contribute to more severe hearing losses that progress, but the timescale of this progression remains unknown. Given that children undergo significant speech and language development, a better understanding of the timing and extent of hearing loss is needed for individuals who have EVA. Through a retrospective review of records in a local database, we aimed to 1) estimate the prevalence of a <em>SLC26A4</em> mutation in this pediatric EVA cohort; and 2) compare hearing threshold severity and timing of progression across children who have EVA and different <em>SLC26A4</em> statuses. Of 62 children with EVA, 39 had available genetic results and of these, 15 had at least one mutation of the <em>SLC26A4</em> gene (38%). The children with a <em>SLC26A4</em> mutation had a more severe onset of hearing loss and a more rapid progression of hearing loss over time, especially for higher frequencies, than children without a mutation in this gene. This longitudinal information may facilitate prognostic counseling to pediatric patients and better inform the audiology follow-up appointments for these families.","PeriodicalId":501185,"journal":{"name":"medRxiv - Otolaryngology","volume":"243 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138510808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-22DOI: 10.1101/2023.11.22.23298893
W. Wiktor Jedrzejczak, Krzysztof Kochanek
Objective The purpose of this study was to evaluate three chatbots – OpenAI ChatGPT, Microsoft Bing Chat, and Google Bard – in terms of their responses to a defined set of audiological questions.
{"title":"Comparison of the audiological knowledge of three chatbots – ChatGPT, Bing Chat, and Bard","authors":"W. Wiktor Jedrzejczak, Krzysztof Kochanek","doi":"10.1101/2023.11.22.23298893","DOIUrl":"https://doi.org/10.1101/2023.11.22.23298893","url":null,"abstract":"<strong>Objective</strong> The purpose of this study was to evaluate three chatbots – OpenAI ChatGPT, Microsoft Bing Chat, and Google Bard – in terms of their responses to a defined set of audiological questions.","PeriodicalId":501185,"journal":{"name":"medRxiv - Otolaryngology","volume":"258 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138510806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-22DOI: 10.1101/2023.11.13.23298435
Aishwarya N Shetty, Hannah J Morgan, Linny K Phuong, John Mallard, Diana Vlasenko, Christopher Pearce, Nigel W Crawford, Jim P Buttery, Hazel J Clothier
Importance Evidence regarding audiovestibular adverse events post COVID-19 vaccination to date has been inconclusive regarding a potential etiological association. This study used a multi-data source approach to assess incidence of these events following COVID-19 vaccination.
{"title":"Audiovestibular adverse events following COVID-19 vaccinations","authors":"Aishwarya N Shetty, Hannah J Morgan, Linny K Phuong, John Mallard, Diana Vlasenko, Christopher Pearce, Nigel W Crawford, Jim P Buttery, Hazel J Clothier","doi":"10.1101/2023.11.13.23298435","DOIUrl":"https://doi.org/10.1101/2023.11.13.23298435","url":null,"abstract":"<strong>Importance</strong> Evidence regarding audiovestibular adverse events post COVID-19 vaccination to date has been inconclusive regarding a potential etiological association. This study used a multi-data source approach to assess incidence of these events following COVID-19 vaccination.","PeriodicalId":501185,"journal":{"name":"medRxiv - Otolaryngology","volume":"121 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138510819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The prevalence of chronic rhinosinusitis (CRS) has been reported to range from 5% to 12% in different parts of the world. However, the prevalence of CRS in Thailand has not been investigated. Our objective was to determine the prevalence of CRS among hospital workers and identify any potential problems encountered during the survey. Methods: Adult workers (>18 years) of Rajavithi Hospital, a tertiary hospital in Bangkok, Thailand, were recruited. This cross-sectional survey was conducted from September 2021 to September 2022. The participants were given a link to online questionnaires asking if they had nasal obstruction, discharge, decreased smell sensation, or facial pain and their respective duration. Phone numbers and email were asked for contact when needed. The participants who fulfilled the symptom and duration according to the European position paper on rhinosinusitis and nasal polyp 2020 were counted as symptom-based CRS patients. These patients were then contacted for nasal endoscopy. The endoscopic-based diagnosis of CRS was made after positive endoscopy findings. Result: A total of 1,025 participants (mean age of 33.7 years) were recruited. Of total, there were 34 (3.3%) and 6 (0.58%) participants fulfilled symptom- and endoscopy-based diagnoses, respectively. Fourteen participants did not respond to calls or emails. Five patients refused to visit the clinic due to inconveniences. One patient refused nasal endoscopy because of the expenses. Conclusion: The overall prevalence of chronic rhinosinusitis in workers of Rajavithi Hospital, was 3.3% and 0.58% by symptom- and endoscopy-based criteria, respectively. Difficulty reaching the participants for nasal endoscopy was the leading survey problem.
{"title":"Prevalence of Chronic Rhinosinusitis in Rajavithi hospital workers, Bangkok, Thailand","authors":"Wirach Chitsuthipakorn, Suphitsara Naphapunsakul, Patlada Korwattanamongkol, Kittichai Mongkolkul, Somjin Chindavijak","doi":"10.1101/2023.07.20.23292827","DOIUrl":"https://doi.org/10.1101/2023.07.20.23292827","url":null,"abstract":"Background: The prevalence of chronic rhinosinusitis (CRS) has been reported to range from 5% to 12% in different parts of the world. However, the prevalence of CRS in Thailand has not been investigated. Our objective was to determine the prevalence of CRS among hospital workers and identify any potential problems encountered during the survey.\u0000Methods: Adult workers (>18 years) of Rajavithi Hospital, a tertiary hospital in Bangkok, Thailand, were recruited. This cross-sectional survey was conducted from September 2021 to September 2022. The participants were given a link to online questionnaires asking if they had nasal obstruction, discharge, decreased smell sensation, or facial pain and their respective duration. Phone numbers and email were asked for contact when needed. The participants who fulfilled the symptom and duration according to the European position paper on rhinosinusitis and nasal polyp 2020 were counted as symptom-based CRS patients. These patients were then contacted for nasal endoscopy. The endoscopic-based diagnosis of CRS was made after positive endoscopy findings. Result: A total of 1,025 participants (mean age of 33.7 years) were recruited. Of total, there were 34 (3.3%) and 6 (0.58%) participants fulfilled symptom- and endoscopy-based diagnoses, respectively. Fourteen participants did not respond to calls or emails. Five patients refused to visit the clinic due to inconveniences. One patient refused nasal endoscopy because of the expenses. Conclusion: The overall prevalence of chronic rhinosinusitis in workers of Rajavithi Hospital, was 3.3% and 0.58% by symptom- and endoscopy-based criteria, respectively. Difficulty reaching the participants for nasal endoscopy was the leading survey problem.","PeriodicalId":501185,"journal":{"name":"medRxiv - Otolaryngology","volume":"245 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138510807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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