Pub Date : 2024-05-03DOI: 10.1101/2024.05.01.24306705
Melissa R. Kaufman, Amy E. Hwang, Anthony M. Pickrel, Cassandra M. Gray, Kriti M. Goel, David N. Dhanraj, Jerome L. Yaklic, Rose A. Maxwell, Thomas L. Brown
The aim of this study was to evaluate maternal and infant Val158Met polymorphisms of Catechol-O-Methyltransferase (COMT), a reported indicator of preeclamptic risk, in a United States population. Healthy control, early-onset preeclamptic, and late-onset preeclamptic patients were enrolled in this study. Genomic DNA was isolated from mothers and infants via buccal swabs and DNA was genotyped via tetra-primer amplification PCR. Our findings indicate that the COMT genotype was not significantly associated with late-onset PE. While there were no significant differences between African American and Caucasian races, the maternal COMTMet158Met genotype was significantly associated with early-onset preeclampsia in both African Americans and Caucasians when compared to COMTVal158Val or COMTVal158Met. These results suggest that the maternal COMTMet158Met genotype may be a risk factor for early-onset PE.
本研究旨在评估美国人群中母婴儿茶酚-O-甲基转移酶（COMT）的 Val158Met 多态性。本研究招募了健康对照组、早发先兆子痫患者和晚发先兆子痫患者。通过口腔拭子从母亲和婴儿体内分离出基因组 DNA，并通过四引物扩增 PCR 对 DNA 进行基因分型。我们的研究结果表明，COMT 基因型与晚发型 PE 并无明显关联。虽然非裔美国人和白种人之间没有明显差异，但与 COMTVal158Val 或 COMTVal158Met 相比，非裔美国人和白种人的母体 COMTMet158Met 基因型与早发子痫前期有明显相关性。这些结果表明，母体 COMTMet158Met 基因型可能是早发性子痫前期的一个风险因素。
{"title":"The COMT Val158Met Polymorphism is Significantly Associated with Early Onset Preeclampsia in Both African American and Caucasian Mothers","authors":"Melissa R. Kaufman, Amy E. Hwang, Anthony M. Pickrel, Cassandra M. Gray, Kriti M. Goel, David N. Dhanraj, Jerome L. Yaklic, Rose A. Maxwell, Thomas L. Brown","doi":"10.1101/2024.05.01.24306705","DOIUrl":"https://doi.org/10.1101/2024.05.01.24306705","url":null,"abstract":"The aim of this study was to evaluate maternal and infant Val<sup>158</sup>Met polymorphisms of Catechol-O-Methyltransferase (COMT), a reported indicator of preeclamptic risk, in a United States population. Healthy control, early-onset preeclamptic, and late-onset preeclamptic patients were enrolled in this study. Genomic DNA was isolated from mothers and infants via buccal swabs and DNA was genotyped via tetra-primer amplification PCR. Our findings indicate that the COMT genotype was not significantly associated with late-onset PE. While there were no significant differences between African American and Caucasian races, the maternal COMT<sup>Met158Met</sup> genotype was significantly associated with early-onset preeclampsia in both African Americans and Caucasians when compared to COMT<sup>Val158Val</sup> or COMT<sup>Val158Met</sup>. These results suggest that the maternal COMT<sup>Met158Met</sup> genotype may be a risk factor for early-onset PE.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140887715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-03DOI: 10.1101/2024.05.02.24306775
Martyna Andrzejczak, Gareth Elfed Jones, Gareth Anthony Nye
Pregnancy requires appropriate guidance and support from healthcare professionals. Understanding women’s experiences of effective patient-provider communication through antenatal care is critical, as evidence suggests, inadequate communication could pose various risks to maternal and neonatal well-being. Despite efforts to modernise maternity services, recent assessments reveal persistent challenges, with nearly half of maternity services inspections categorised as ‘inadequate’ or ‘requires improvement’. This qualitative systematic review investigated effective patient-provider communication in antenatal care settings across England, contributing essential insights into women’s experiences and feelings from various backgrounds.
{"title":"Examining Effective Patient-Provider Communication in Antenatal Settings across England: An In-Depth Analysis of Woman’s Experiences","authors":"Martyna Andrzejczak, Gareth Elfed Jones, Gareth Anthony Nye","doi":"10.1101/2024.05.02.24306775","DOIUrl":"https://doi.org/10.1101/2024.05.02.24306775","url":null,"abstract":"Pregnancy requires appropriate guidance and support from healthcare professionals. Understanding women’s experiences of effective patient-provider communication through antenatal care is critical, as evidence suggests, inadequate communication could pose various risks to maternal and neonatal well-being. Despite efforts to modernise maternity services, recent assessments reveal persistent challenges, with nearly half of maternity services inspections categorised as ‘inadequate’ or ‘requires improvement’. This qualitative systematic review investigated effective patient-provider communication in antenatal care settings across England, contributing essential insights into women’s experiences and feelings from various backgrounds.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140928827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1101/2024.04.29.24306527
Rita Grabowska
PCOS is the most common hormonal disorder and cause of infertility in females of reproductive age. The symptoms and their severity vary strongly between particular cases. PCOS is correlated with hormonal, environmental and genetic factors. Complex interactions between genetics and hormonal levels is important to understand the hormonal 31 abnormality and to assess the chance of pregnancy in women with PCOS.
{"title":"Usage of AMH as a determining test of fertility in women with polycystic ovary 2 syndrome (PCOS)","authors":"Rita Grabowska","doi":"10.1101/2024.04.29.24306527","DOIUrl":"https://doi.org/10.1101/2024.04.29.24306527","url":null,"abstract":"PCOS is the most common hormonal disorder and cause of infertility in females of reproductive age. The symptoms and their severity vary strongly between particular cases. PCOS is correlated with hormonal, environmental and genetic factors. Complex interactions between genetics and hormonal levels is important to understand the hormonal 31 abnormality and to assess the chance of pregnancy in women with PCOS.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.1101/2024.04.29.24306539
Gareth A Nye, George Abou Deb, Seóna Dunne
INTRODUCTION Pregnancy is a crucial period which ultimately directly impacts two individuals health and wellbeing. Within the UK, a standardised pattern of care is established with collaborations across disciplines to the benefit of women and babies. During the COVID19 pandemic, this pattern of care was disrupted to align with protective protocols which until now, has not been formally reported.
{"title":"EVALUATING THE IMPACT OF COVID-19 ON THE PREGNANCY AND POSTNATAL PERIOD FOR UK WOMEN","authors":"Gareth A Nye, George Abou Deb, Seóna Dunne","doi":"10.1101/2024.04.29.24306539","DOIUrl":"https://doi.org/10.1101/2024.04.29.24306539","url":null,"abstract":"<strong>INTRODUCTION</strong> Pregnancy is a crucial period which ultimately directly impacts two individuals health and wellbeing. Within the UK, a standardised pattern of care is established with collaborations across disciplines to the benefit of women and babies. During the COVID19 pandemic, this pattern of care was disrupted to align with protective protocols which until now, has not been formally reported.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-29DOI: 10.1101/2024.04.27.24306482
Jalal Uddin, Shahida Sultana Shumi
Objectives This study aimed to investigate musculoskeletal pain among pregnant women in Dhaka Division, Bangladesh, considering demographic factors, pain and pregnancy-related experiences.
本研究旨在调查孟加拉国达卡省孕妇的肌肉骨骼疼痛情况，其中考虑到了人口因素、疼痛和与怀孕有关的经历。
{"title":"Investigating Musculoskeletal Pain Among Pregnant Women in Dhaka Division: A Cross-Sectional Study","authors":"Jalal Uddin, Shahida Sultana Shumi","doi":"10.1101/2024.04.27.24306482","DOIUrl":"https://doi.org/10.1101/2024.04.27.24306482","url":null,"abstract":"<strong>Objectives</strong> This study aimed to investigate musculoskeletal pain among pregnant women in Dhaka Division, Bangladesh, considering demographic factors, pain and pregnancy-related experiences.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-28DOI: 10.1101/2024.04.25.24306406
Matthew Anyanwu, Admire Coker, Donkor Simon
Background Following a caesarean section performed under spinal anaesthesia, a common complication is post-dural puncture headache (PDPH). Spinal anaesthesia has become the most common anaesthetic procedure during caesarean section in our practice. Therefore, knowing the prevalence and risk factors of PDPH will inform practice and add value in our obstetrics practice.
{"title":"Prevalence of Dural Puncture headache after caesarean section at a Tertiary Hospital in the Gambia","authors":"Matthew Anyanwu, Admire Coker, Donkor Simon","doi":"10.1101/2024.04.25.24306406","DOIUrl":"https://doi.org/10.1101/2024.04.25.24306406","url":null,"abstract":"<strong>Background</strong> Following a caesarean section performed under spinal anaesthesia, a common complication is post-dural puncture headache (PDPH). Spinal anaesthesia has become the most common anaesthetic procedure during caesarean section in our practice. Therefore, knowing the prevalence and risk factors of PDPH will inform practice and add value in our obstetrics practice.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-27DOI: 10.1101/2024.04.26.24306455
Sarah Goodday, Robin Yang, Emma Karlin, Jonell Tempero, Christiana Harry, Alexa Brooks, Tina Behrouzi, Jennifer Yu, Anna Goldenberg, Marra Francis, Daniel Karlin, Corey Centen, Sarah Smith, Stephen Friend
Wearables, apps and other remote smart devices can capture rich, objective physiologic, metabolic, and behavioral information that is particularly relevant to pregnancy. The objectives of this paper were to 1) characterize individual level pregnancy self-reported symptoms and objective features from wearables compared to the aggregate; 2) determine whether pregnancy self-reported symptoms and objective features can differentiate pregnancy-related conditions; and 3) describe associations between self-reported symptoms and objective features. Data are from the Better Understanding the Metamorphosis of Pregnancy study, which followed individuals from preconception to three-months postpartum. Participants (18-40 years) were provided with an Oura smart ring, a Garmin smartwatch, and a Bodyport Cardiac Scale. They also used a study smartphone app with surveys and tasks to measure symptoms. Analyses included descriptive spaghetti plots for both individual-level data and cohort averages for select weekly reported symptoms and objective measures from wearables. This data was further stratified by pregnancy-related clinical conditions such as preeclampsia and preterm birth. Mean Spearman correlations between pairs of self-reported symptoms and objective features were estimated. Self-reported symptoms and objective features during pregnancy were highly heterogeneous between individuals. While some aggregate trends were notable, including an inflection in heart rate variability approximately eight weeks prior to delivery, these average trends were highly variable at the n-of-1 level, even among healthy individuals. Pregnancy conditions were not well differentiated by objective features. With the exception of self-reported swelling and body fluid volume, self-reported symptoms and objective features were weakly correlated (mean Spearman correlations <0.1).
{"title":"Does anyone fit the average? Describing the heterogeneity of pregnancy symptoms using wearables and mobile apps","authors":"Sarah Goodday, Robin Yang, Emma Karlin, Jonell Tempero, Christiana Harry, Alexa Brooks, Tina Behrouzi, Jennifer Yu, Anna Goldenberg, Marra Francis, Daniel Karlin, Corey Centen, Sarah Smith, Stephen Friend","doi":"10.1101/2024.04.26.24306455","DOIUrl":"https://doi.org/10.1101/2024.04.26.24306455","url":null,"abstract":"Wearables, apps and other remote smart devices can capture rich, objective physiologic, metabolic, and behavioral information that is particularly relevant to pregnancy. The objectives of this paper were to 1) characterize individual level pregnancy self-reported symptoms and objective features from wearables compared to the aggregate; 2) determine whether pregnancy self-reported symptoms and objective features can differentiate pregnancy-related conditions; and 3) describe associations between self-reported symptoms and objective features. Data are from the Better Understanding the Metamorphosis of Pregnancy study, which followed individuals from preconception to three-months postpartum. Participants (18-40 years) were provided with an Oura smart ring, a Garmin smartwatch, and a Bodyport Cardiac Scale. They also used a study smartphone app with surveys and tasks to measure symptoms. Analyses included descriptive spaghetti plots for both individual-level data and cohort averages for select weekly reported symptoms and objective measures from wearables. This data was further stratified by pregnancy-related clinical conditions such as preeclampsia and preterm birth. Mean Spearman correlations between pairs of self-reported symptoms and objective features were estimated. Self-reported symptoms and objective features during pregnancy were highly heterogeneous between individuals. While some aggregate trends were notable, including an inflection in heart rate variability approximately eight weeks prior to delivery, these average trends were highly variable at the n-of-1 level, even among healthy individuals. Pregnancy conditions were not well differentiated by objective features. With the exception of self-reported swelling and body fluid volume, self-reported symptoms and objective features were weakly correlated (mean Spearman correlations <0.1).","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140842167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.1101/2024.04.14.24305051
Hassine S Abouda, Haithem Aloui, Sofiene B Marzouk, Hatem Frikha, Rami Hammami, Rachid Hentati, Badis Chennoufi, Hayen Maghrebi
Introduction The surgical procedure known as one-step conservative surgery for placenta accreta spectrum involves the excision of the placenta and its attachment site on the myometrium. We aimed to conduct a non-randomized comparative study between conservative surgical treatment of placenta accreta spectrum and classical caesarean hysterectomy, under the name of the “CMNT PAS” study. To determine the sample size and the expected difference between the two groups, we conduct this pilot study.
引言 被称为 "一步到位 "的胎盘早剥保守治疗手术包括切除胎盘及其在子宫肌层上的附着点。我们以 "CMNT PAS "研究为名，旨在对胎盘早剥保守手术治疗和传统剖腹产子宫切除术进行非随机比较研究。为了确定样本量和两组之间的预期差异，我们进行了这项试验性研究。
{"title":"Modified one-step conservative surgery for placenta accreta spectrum versus caesarean hysterectomy: The CMNT PAS prospective comparative Non-Randomized pilot study","authors":"Hassine S Abouda, Haithem Aloui, Sofiene B Marzouk, Hatem Frikha, Rami Hammami, Rachid Hentati, Badis Chennoufi, Hayen Maghrebi","doi":"10.1101/2024.04.14.24305051","DOIUrl":"https://doi.org/10.1101/2024.04.14.24305051","url":null,"abstract":"<strong>Introduction</strong> The surgical procedure known as one-step conservative surgery for placenta accreta spectrum involves the excision of the placenta and its attachment site on the myometrium. We aimed to conduct a non-randomized comparative study between conservative surgical treatment of placenta accreta spectrum and classical caesarean hysterectomy, under the name of the “CMNT PAS” study. To determine the sample size and the expected difference between the two groups, we conduct this pilot study.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140609073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the digital age, the prevalence of infertility and the trend of delaying childbearing have significantly influenced fertility choices. Social media, particularly Instagram, has emerged as a vital part of daily life for many, with a notable percentage of American adults engaging daily. Recognizing the impact of online platforms, this cross-sectional observational study, conducted in May 2023, delved into the nature and quality of 673 Instagram posts related to infertility. It aimed to analyze the information and support available to individuals’ navigating infertility, particularly focusing on the posts DISCERN and Global Quality Scores (GQS) to assess their reliability and quality.
{"title":"Exploring the Digital Landscape: A Comprehensive Analysis of Infertility Narratives on Instagram","authors":"Abhijay Gillellamudi, Venkata Sujatha Vellanki, Binay Kumar Panjiyar","doi":"10.1101/2024.04.07.24305110","DOIUrl":"https://doi.org/10.1101/2024.04.07.24305110","url":null,"abstract":"In the digital age, the prevalence of infertility and the trend of delaying childbearing have significantly influenced fertility choices. Social media, particularly Instagram, has emerged as a vital part of daily life for many, with a notable percentage of American adults engaging daily. Recognizing the impact of online platforms, this cross-sectional observational study, conducted in May 2023, delved into the nature and quality of 673 Instagram posts related to infertility. It aimed to analyze the information and support available to individuals’ navigating infertility, particularly focusing on the posts DISCERN and Global Quality Scores (GQS) to assess their reliability and quality.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-03DOI: 10.1101/2024.04.03.24304152
Taewoon Kim, Jee Yoon Park, Hyo Jin Lee, Bo young Choi, Hyeon Ji Kim, Luke P. Lee, Jong Wook Hong
Preterm labor is a serious issue that can lead to preterm birth, posing significant risks to both the mother and the neonate. Despite the high incidence of approximately 15 million preterm births worldwide per year, there is a lack of sufficient strategies for predicting and preventing preterm labor. Here, we found that exosomal miRNAs in maternal vaginal discharge can serve as biomarkers for early diagnosis of life-threatening conditions in both the mother and neonate. Our non-invasive biopsy of vaginal discharge using a swab allows us to isolate enriched exosomes via an advanced microfluidic platform called BEST (Biologically intact Exosome Separation Technology). We have identified specific miRNAs differentially expressed in mothers with preterm labor compared to those with full-term mothers. These miRNAs included hsa-miR-206, which was up-regulated in preterm labor, and hsa-miR-3674, hsa-miR-365a-5p, and hsa-miR-193b-3p, which were down-regulated. We believe our discovery of unique miRNAs as biomarkers can aid in early detection and effective treatment of preterm labor, potentially revolutionizing global healthcare.
{"title":"Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy","authors":"Taewoon Kim, Jee Yoon Park, Hyo Jin Lee, Bo young Choi, Hyeon Ji Kim, Luke P. Lee, Jong Wook Hong","doi":"10.1101/2024.04.03.24304152","DOIUrl":"https://doi.org/10.1101/2024.04.03.24304152","url":null,"abstract":"Preterm labor is a serious issue that can lead to preterm birth, posing significant risks to both the mother and the neonate. Despite the high incidence of approximately 15 million preterm births worldwide per year, there is a lack of sufficient strategies for predicting and preventing preterm labor. Here, we found that exosomal miRNAs in maternal vaginal discharge can serve as biomarkers for early diagnosis of life-threatening conditions in both the mother and neonate. Our non-invasive biopsy of vaginal discharge using a swab allows us to isolate enriched exosomes via an advanced microfluidic platform called BEST (Biologically intact Exosome Separation Technology). We have identified specific miRNAs differentially expressed in mothers with preterm labor compared to those with full-term mothers. These miRNAs included hsa-miR-206, which was up-regulated in preterm labor, and hsa-miR-3674, hsa-miR-365a-5p, and hsa-miR-193b-3p, which were down-regulated. We believe our discovery of unique miRNAs as biomarkers can aid in early detection and effective treatment of preterm labor, potentially revolutionizing global healthcare.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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