Pub Date : 2024-04-16DOI: 10.1101/2024.04.15.24305842
Adenike Oluwakemi Ogah, James-Aaron Ogah, Elizabeth Edigwu Ogah
Background Sustaining a high rate of adherence to exclusive breastfeeding may be challenging in resource constrained setting. This study established the levels of exclusive breastfeeding, alternate feeding patterns, health and growth impacts, among 10 weeks old infants in a remote, understudied village in East Africa.
{"title":"LEVELS OF EXCLUSIVE BREASTFEEDING AND CORRELATES AT 10WEEKS POST-DELIVERY IN A RURAL SETTING","authors":"Adenike Oluwakemi Ogah, James-Aaron Ogah, Elizabeth Edigwu Ogah","doi":"10.1101/2024.04.15.24305842","DOIUrl":"https://doi.org/10.1101/2024.04.15.24305842","url":null,"abstract":"<strong>Background</strong> Sustaining a high rate of adherence to exclusive breastfeeding may be challenging in resource constrained setting. This study established the levels of exclusive breastfeeding, alternate feeding patterns, health and growth impacts, among 10 weeks old infants in a remote, understudied village in East Africa.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives Three-dimensional gait analysis is the ‘gold standard’ for measurement and description of gait. Gait variability can arise from intrinsic and extrinsic factors and may vary between walking conditions. This study aimed to define the inter-trial and inter-session repeatability in gait analysis data of children with cerebral palsy (CP) who were walking in four conditions, namely barefoot or with ankle-foot orthosis (AFO), and overground or treadmill.
{"title":"Repeatability of gait of children with spastic cerebral palsy in different walking conditions","authors":"Laure Everaert, Tijl Dewit, Catherine Huenaerts, Anja Van Campenhout, Luc Labey, Kaat Desloovere","doi":"10.1101/2024.04.10.24304953","DOIUrl":"https://doi.org/10.1101/2024.04.10.24304953","url":null,"abstract":"<strong>Objectives</strong> Three-dimensional gait analysis is the ‘gold standard’ for measurement and description of gait. Gait variability can arise from intrinsic and extrinsic factors and may vary between walking conditions. This study aimed to define the inter-trial and inter-session repeatability in gait analysis data of children with cerebral palsy (CP) who were walking in four conditions, namely barefoot or with ankle-foot orthosis (AFO), and overground or treadmill.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1101/2024.04.09.24305590
Elizabeth A. Onugha, Ankona Banerjee, Kenneth J. Nobleza, Duc T. Nguyen, Omar Rosales, Abiodun Oluyomi, Jayna M. Dave, Joshua Samuels
Background Hypertension, a major modifiable risk factor for cardiovascular disease, is increasing among adolescents. While socioeconomic factors have been shown to contribute to hypertension risk in adults, similar data in children is lacking. We examined the association between socioeconomic characteristics of school neighborhoods and the prevalence of hypertension in adolescents.
{"title":"School Neighborhood Deprivation is Associated with a Higher Prevalence of Hypertension","authors":"Elizabeth A. Onugha, Ankona Banerjee, Kenneth J. Nobleza, Duc T. Nguyen, Omar Rosales, Abiodun Oluyomi, Jayna M. Dave, Joshua Samuels","doi":"10.1101/2024.04.09.24305590","DOIUrl":"https://doi.org/10.1101/2024.04.09.24305590","url":null,"abstract":"<strong>Background</strong> Hypertension, a major modifiable risk factor for cardiovascular disease, is increasing among adolescents. While socioeconomic factors have been shown to contribute to hypertension risk in adults, similar data in children is lacking. We examined the association between socioeconomic characteristics of school neighborhoods and the prevalence of hypertension in adolescents.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1101/2024.04.05.24305394
Rainer Tan, Godfrey Kavishe, Alexandra V Kulinkina, Sabine Renggli, Lameck B Luwanda, Chacha Mangu, Geofrey Ashery, Margaret Jorram, Ibrahim Evans Mtebene, Peter Agrea, Humphrey Mhagama, Kristina Keitel, Marie-Annick Le Pogam, Nyanda Ntinginya, Honorati Masanja, Valérie D’Acremont
Digital clinical decision support tools have contributed to improved quality of care at primary care level health facilities. However, data from real-world randomized trials are lacking.
数字临床决策支持工具有助于提高基层医疗机构的医疗质量。然而，目前还缺乏来自真实世界的随机试验数据。
{"title":"Quality of care when using a digital clinical decision support algorithm to manage sick children at primary care health facilities in Tanzania: a cross-sectional cluster randomized controlled trial (DYNAMIC study)","authors":"Rainer Tan, Godfrey Kavishe, Alexandra V Kulinkina, Sabine Renggli, Lameck B Luwanda, Chacha Mangu, Geofrey Ashery, Margaret Jorram, Ibrahim Evans Mtebene, Peter Agrea, Humphrey Mhagama, Kristina Keitel, Marie-Annick Le Pogam, Nyanda Ntinginya, Honorati Masanja, Valérie D’Acremont","doi":"10.1101/2024.04.05.24305394","DOIUrl":"https://doi.org/10.1101/2024.04.05.24305394","url":null,"abstract":"Digital clinical decision support tools have contributed to improved quality of care at primary care level health facilities. However, data from real-world randomized trials are lacking.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"229 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-06DOI: 10.1101/2024.04.05.24305283
Sabryna Nantel, Corey Arnold, Maala Bhatt, Yannick Galipeau, Benoîte Bourdin, Jennifer Bowes, Roger L. Zemek, Marc-André Langlois, Caroline Quach, Hélène Decaluwe, Anne Pham-Huy
Background SARS-CoV-2 infection elicits distinct clinical features in children and adults. Profiling the adaptive immune response following infection in children is essential to better understand and characterize these differences.
{"title":"Differential Adaptive Immune Responses Following SARS-CoV-2 Infection in Children Compared to Adults","authors":"Sabryna Nantel, Corey Arnold, Maala Bhatt, Yannick Galipeau, Benoîte Bourdin, Jennifer Bowes, Roger L. Zemek, Marc-André Langlois, Caroline Quach, Hélène Decaluwe, Anne Pham-Huy","doi":"10.1101/2024.04.05.24305283","DOIUrl":"https://doi.org/10.1101/2024.04.05.24305283","url":null,"abstract":"<strong>Background</strong> SARS-CoV-2 infection elicits distinct clinical features in children and adults. Profiling the adaptive immune response following infection in children is essential to better understand and characterize these differences.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-06DOI: 10.1101/2024.04.05.24305325
C. Lambrechts, J. Deschrevel, K. Maes, A. Andries, N. De Beukelaer, B. Hanssen, I. Vandekerckhove, A. Van Campenhout, G. Gayan-Ramirez, K. Desloovere
Children with spastic cerebral palsy (CP) are characterized by altered muscle growth, secondary to the pathological neural input to the muscular system, caused by the primary brain lesion. As a result, their medial gastrocnemius is commonly affected and is characterized by altered macro and microscopic muscular alterations. At the macroscopic level, the muscle volume (MV), anatomical cross-sectional area of the muscle belly (Belly-CSA), muscle belly length (ML), and the intrinsic muscle quality are reduced. At the microscopic level, the cross-sectional area of the fiber (Fiber-CSA) is characterized by an increased within-patient variability (coefficient of variation (CV)), the fiber type proportion is altered and capillarization is reduced. However, the relations between the muscular alterations at the macro- and microscopic level are not yet known. Therefore, this cross-sectional study integrated macro- and microscopic parameters of the medial gastrocnemius in one cohort of young ambulant children with CP and age-matched TD children, and explored how deficits in macroscopic muscle size are associated with alterations at the microscopic level. A group of 46 children with CP (median age 5.4 (3.3) years) and a control group of 34 TD children (median age 6.3 (3.4) years), who had data on microscopic muscular properties (defined through the histological analyses of muscle biopsies), as well as macroscopic muscle properties (defined by 3D freehand ultrasound) were included. We defined Pearson or Spearman correlations, depending on the data distribution. The macroscopic muscle size parameters (MV, Belly-CSA, ML) showed significant moderate correlations (0.504-0.592) with the microscopic average Fiber-CSA in TD and CP. To eliminate the common effect of anthropometric growth at the macro- as well as microscopic level, the data were expressed as deficits (i.e. z-scores from normative centile curves or means) or were normalized to body size parameters. A significant but low correlation was found between the z-scores of MV with the z-scores of the Fiber-CSA (r=0.420, p=0.006). The normalized muscle parameters also showed only low correlations between the macro- and microscopic muscle size parameters, namely between Belly-CSA and Fiber-CSA, both in the TD (r=0.408, p=0.023) and the CP (ρ=0.329, p=0.041) group. Explorations between macroscopic muscle parameters and other microscopic muscle parameters (capillary density, capillary to fiber ratio, and fiber type proportion) revealed no or only low correlations. These results highlighted the complexity of the interacting network of intrinsic muscle structures, with mainly low associations between the macro- and microstructural level, and it remains unclear how alterations in microscopic muscle structures contribute to the macroscopic muscle size deficits in children with CP.
{"title":"The relation between macro- and microscopic intrinsic muscular alterations of the medial gastrocnemius in children with spastic cerebral palsy","authors":"C. Lambrechts, J. Deschrevel, K. Maes, A. Andries, N. De Beukelaer, B. Hanssen, I. Vandekerckhove, A. Van Campenhout, G. Gayan-Ramirez, K. Desloovere","doi":"10.1101/2024.04.05.24305325","DOIUrl":"https://doi.org/10.1101/2024.04.05.24305325","url":null,"abstract":"Children with spastic cerebral palsy (CP) are characterized by altered muscle growth, secondary to the pathological neural input to the muscular system, caused by the primary brain lesion. As a result, their medial gastrocnemius is commonly affected and is characterized by altered macro and microscopic muscular alterations. At the macroscopic level, the muscle volume (MV), anatomical cross-sectional area of the muscle belly (Belly-CSA), muscle belly length (ML), and the intrinsic muscle quality are reduced. At the microscopic level, the cross-sectional area of the fiber (Fiber-CSA) is characterized by an increased within-patient variability (coefficient of variation (CV)), the fiber type proportion is altered and capillarization is reduced. However, the relations between the muscular alterations at the macro- and microscopic level are not yet known. Therefore, this cross-sectional study integrated macro- and microscopic parameters of the medial gastrocnemius in one cohort of young ambulant children with CP and age-matched TD children, and explored how deficits in macroscopic muscle size are associated with alterations at the microscopic level. A group of 46 children with CP (median age 5.4 (3.3) years) and a control group of 34 TD children (median age 6.3 (3.4) years), who had data on microscopic muscular properties (defined through the histological analyses of muscle biopsies), as well as macroscopic muscle properties (defined by 3D freehand ultrasound) were included. We defined Pearson or Spearman correlations, depending on the data distribution. The macroscopic muscle size parameters (MV, Belly-CSA, ML) showed significant moderate correlations (0.504-0.592) with the microscopic average Fiber-CSA in TD and CP. To eliminate the common effect of anthropometric growth at the macro- as well as microscopic level, the data were expressed as deficits (i.e. z-scores from normative centile curves or means) or were normalized to body size parameters. A significant but low correlation was found between the z-scores of MV with the z-scores of the Fiber-CSA (r=0.420, p=0.006). The normalized muscle parameters also showed only low correlations between the macro- and microscopic muscle size parameters, namely between Belly-CSA and Fiber-CSA, both in the TD (r=0.408, p=0.023) and the CP (ρ=0.329, p=0.041) group. Explorations between macroscopic muscle parameters and other microscopic muscle parameters (capillary density, capillary to fiber ratio, and fiber type proportion) revealed no or only low correlations. These results highlighted the complexity of the interacting network of intrinsic muscle structures, with mainly low associations between the macro- and microstructural level, and it remains unclear how alterations in microscopic muscle structures contribute to the macroscopic muscle size deficits in children with CP.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-05DOI: 10.1101/2024.04.04.24305194
Charly Billaud, Amanda G. Wood, Daniel Griffiths-King, Klaus Kessler, Evangeline Wassmer, Elaine Foley, Sukhvir K. Wright
Paediatric autoimmune encephalitis (e.g., acute disseminated encephalomyelitis, N-methyl-D-aspartate receptor antibody encephalitis) is an inflammatory brain disease that causes cognitive deficits, psychiatric symptoms, seizures, MRI, and EEG abnormalities. Patients can continue to experience residual cognitive difficulties months to years after the acute illness. Magnetoencephalography (MEG) can examine neural changes in the absence of frank structural abnormalities and may help identify factors predicting children at risk of long-term cognitive deficits. We predicted that theta and delta brain functional connectivity networks would be associated with processing speed and working memory in children with autoimmune encephalitis.
{"title":"Linking brain networks to cognition with magnetoencephalography in paediatric autoimmune encephalitis","authors":"Charly Billaud, Amanda G. Wood, Daniel Griffiths-King, Klaus Kessler, Evangeline Wassmer, Elaine Foley, Sukhvir K. Wright","doi":"10.1101/2024.04.04.24305194","DOIUrl":"https://doi.org/10.1101/2024.04.04.24305194","url":null,"abstract":"Paediatric autoimmune encephalitis (e.g., acute disseminated encephalomyelitis, N-methyl-D-aspartate receptor antibody encephalitis) is an inflammatory brain disease that causes cognitive deficits, psychiatric symptoms, seizures, MRI, and EEG abnormalities. Patients can continue to experience residual cognitive difficulties months to years after the acute illness. Magnetoencephalography (MEG) can examine neural changes in the absence of frank structural abnormalities and may help identify factors predicting children at risk of long-term cognitive deficits. We predicted that theta and delta brain functional connectivity networks would be associated with processing speed and working memory in children with autoimmune encephalitis.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.1101/2024.04.03.24305279
Paola Fonseca-Romero, Sharia M. Ahmed, Ben J. Brintz, D. Matthew Vierkant, Jennifer Dien Bard, Daniel M. Cohen, Ara Festekjian, Amy L. Leber, Jami T. Jackson, Neena Kanwar, Chari Larsen, Rangaraj Selvarangan, Kimberle C. Chapin, Andrew T. Pavia, Daniel T. Leung, IMPACT study investigators
Among 111 children presenting with bloody diarrhea in a multicenter study of molecular testing in US emergency departments, we found viral pathogens in 18%, bacteria in 48%, protozoa in 2%, and no pathogens detected in 38%.
{"title":"Etiologies of bloody diarrhea in children presenting with acute gastroenteritis to US emergency departments","authors":"Paola Fonseca-Romero, Sharia M. Ahmed, Ben J. Brintz, D. Matthew Vierkant, Jennifer Dien Bard, Daniel M. Cohen, Ara Festekjian, Amy L. Leber, Jami T. Jackson, Neena Kanwar, Chari Larsen, Rangaraj Selvarangan, Kimberle C. Chapin, Andrew T. Pavia, Daniel T. Leung, IMPACT study investigators","doi":"10.1101/2024.04.03.24305279","DOIUrl":"https://doi.org/10.1101/2024.04.03.24305279","url":null,"abstract":"Among 111 children presenting with bloody diarrhea in a multicenter study of molecular testing in US emergency departments, we found viral pathogens in 18%, bacteria in 48%, protozoa in 2%, and no pathogens detected in 38%.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"292 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-03DOI: 10.1101/2024.04.02.24305202
Efthymios Papatzikis, Maria Agapaki, Rosari Naveena Selvan, Deanna Hanson-Abromeit, Christian Gold, Shulammit Epstein, U Wun Vivian Lok, Evrykleia Barda, Varun Pandey
In recent years, the use of music as a therapeutic and developmental tool for infants, especially within neonatal intensive care units (NICUs), has seen a surge in interest. Despite a growing body of research underscoring the potential benefits of music therapy and music medicine in enhancing infant development and aiding medical practices, the specific characteristics of music that maximize these benefits remain poorly understood. This systematic review aims to fill this gap by investigating the effects of passive music listening on the development and medical outcomes of infants, both full-term and premature. Following the PRISMA guidelines, a comprehensive literature search was conducted, covering studies published up until December 2022. The focus was on passive music listening, with a deliberate exclusion of active music interventions. Out of the initial pool of studies, 56 met the inclusion criteria, determined by the PICO framework, focusing on passive music exposure among full-term and preterm infants. Starting with a descriptive analysis approach, the study employed Non-negative Matrix Factorization (NMF) and Latent Dirichlet Allocation (LDA) to identify key themes, including the physiological impacts of music, its role in pain management, effects on sleep and stress, and influences on feeding and weight gain. The review revealed a predominance of quantitative research methods, a significant concentration of studies from the United States, suggesting potential geographical bias, and a notable clinical setting bias. These findings indicate a critical need for methodological diversity and a more culturally inclusive and interdisciplinary approach to research. Although this systematic review highlights the beneficial role of passive music listening in pediatric care, it also points to the necessity for standardized music intervention protocols to optimize therapeutic and developmental outcomes for this vulnerable population. Future research should aim to bridge the methodological gaps identified, integrating both qualitative and quantitative approaches to provide a comprehensive understanding of music’s impact on infant development and medical practices in a global, culturally nuanced context.
{"title":"Music Medicine and Music Therapy in Pediatric Care: A systematic review of passive music listening research applications and findings on infant development and medical practice","authors":"Efthymios Papatzikis, Maria Agapaki, Rosari Naveena Selvan, Deanna Hanson-Abromeit, Christian Gold, Shulammit Epstein, U Wun Vivian Lok, Evrykleia Barda, Varun Pandey","doi":"10.1101/2024.04.02.24305202","DOIUrl":"https://doi.org/10.1101/2024.04.02.24305202","url":null,"abstract":"In recent years, the use of music as a therapeutic and developmental tool for infants, especially within neonatal intensive care units (NICUs), has seen a surge in interest. Despite a growing body of research underscoring the potential benefits of music therapy and music medicine in enhancing infant development and aiding medical practices, the specific characteristics of music that maximize these benefits remain poorly understood. This systematic review aims to fill this gap by investigating the effects of passive music listening on the development and medical outcomes of infants, both full-term and premature. Following the PRISMA guidelines, a comprehensive literature search was conducted, covering studies published up until December 2022. The focus was on passive music listening, with a deliberate exclusion of active music interventions. Out of the initial pool of studies, 56 met the inclusion criteria, determined by the PICO framework, focusing on passive music exposure among full-term and preterm infants. Starting with a descriptive analysis approach, the study employed Non-negative Matrix Factorization (NMF) and Latent Dirichlet Allocation (LDA) to identify key themes, including the physiological impacts of music, its role in pain management, effects on sleep and stress, and influences on feeding and weight gain. The review revealed a predominance of quantitative research methods, a significant concentration of studies from the United States, suggesting potential geographical bias, and a notable clinical setting bias. These findings indicate a critical need for methodological diversity and a more culturally inclusive and interdisciplinary approach to research. Although this systematic review highlights the beneficial role of passive music listening in pediatric care, it also points to the necessity for standardized music intervention protocols to optimize therapeutic and developmental outcomes for this vulnerable population. Future research should aim to bridge the methodological gaps identified, integrating both qualitative and quantitative approaches to provide a comprehensive understanding of music’s impact on infant development and medical practices in a global, culturally nuanced context.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.1101/2024.03.27.24304866
Ines Vandekerckhove, Britta Hanssen, Nicky Peeters, Tijl Dewit, Nathalie De Beukelaer, Marleen Van den Hauwe, Liesbeth De Waele, Anja Van Campenhout, Friedl De Groote, Kaat Desloovere
Abstract Aims: To establish anthropometric-related percentile curves for muscle size and strength in a cohort of typically developing (TD) children and to demonstrate their use through applications in children with cerebral palsy (CP) and Duchenne muscular dystrophy (DMD). Methods: Lower limb muscle size and strength were assessed in a large cross-sectional cohort of TD children with 3D freehand ultrasound (four muscles, n=154, ♂/♀=82/72, age range: 0y7mo-17y10mo) and fixed dynamometry (seven muscle groups, n=153, ♂/♀=108/45, age range: 4y6mo-16y1mo), respectively. Generalized additive models for location, scale and shape were used to estimate anthropometric-related, i.e. body mass and height, TD percentile curves and to convert outcomes of individual patients with CP and DMD into z-scores. Results: Muscle size and strength, as well as their inter-subject variation, increased with increasing anthropometric values. Individual patients exhibited negative z-scores, indicating muscle size and strength deficits in reference to TD peers. Interpretation: The established anthropometric-related percentile curves for muscle size and strength in a cohort of TD children can successfully be used to express patient outcomes in reference to TD. This facilitates the interpretation of muscle size and weakness in children with a motor disability and allows for the evaluation of the disease progression and treatment impact during growth.
摘要：目的：在一组典型发育（TD）儿童中建立与人体测量相关的肌肉尺寸和力量百分位曲线，并通过在脑瘫（CP）和杜氏肌营养不良症（DMD）儿童中的应用来证明其用途。方法：通过三维徒手超声波（四块肌肉，n=154，♂/♀=82/72，年龄范围：0y7mo-17y10mo）和固定测力法（七组肌肉，n=153，♂/♀=108/45，年龄范围：4y6mo-16y1mo）分别对TD儿童的下肢肌肉大小和力量进行评估。使用位置、尺度和形状的广义加法模型估算人体测量相关指标，即体重和身高、TD 百分位曲线，并将个别 CP 和 DMD 患者的结果转换为 z 分数。研究结果随着人体测量值的增加，肌肉大小和力量及其受试者之间的差异也随之增加。个别患者的 z 值为负值，表明与 TD 同龄人相比，他们的肌肉尺寸和力量存在缺陷。解释：在一组 TD 儿童中建立的与人体测量相关的肌肉尺寸和力量百分位曲线可成功用于表达患者与 TD 相关的结果。这有助于解释运动障碍儿童的肌肉大小和薄弱情况，并可评估成长过程中的疾病进展和治疗效果。
{"title":"Anthropometric-related percentile curves for muscle size and strength of lower limb muscles of typically developing children","authors":"Ines Vandekerckhove, Britta Hanssen, Nicky Peeters, Tijl Dewit, Nathalie De Beukelaer, Marleen Van den Hauwe, Liesbeth De Waele, Anja Van Campenhout, Friedl De Groote, Kaat Desloovere","doi":"10.1101/2024.03.27.24304866","DOIUrl":"https://doi.org/10.1101/2024.03.27.24304866","url":null,"abstract":"Abstract\u0000Aims: To establish anthropometric-related percentile curves for muscle size and strength in a cohort of typically developing (TD) children and to demonstrate their use through applications in children with cerebral palsy (CP) and Duchenne muscular dystrophy (DMD). Methods: Lower limb muscle size and strength were assessed in a large cross-sectional cohort of TD children with 3D freehand ultrasound (four muscles, n=154, ♂/♀=82/72, age range: 0y7mo-17y10mo) and fixed dynamometry (seven muscle groups, n=153, ♂/♀=108/45, age range: 4y6mo-16y1mo), respectively. Generalized additive models for location, scale and shape were used to estimate anthropometric-related, i.e. body mass and height, TD percentile curves and to convert outcomes of individual patients with CP and DMD into z-scores. Results: Muscle size and strength, as well as their inter-subject variation, increased with increasing anthropometric values. Individual patients exhibited negative z-scores, indicating muscle size and strength deficits in reference to TD peers. Interpretation: The established anthropometric-related percentile curves for muscle size and strength in a cohort of TD children can successfully be used to express patient outcomes in reference to TD. This facilitates the interpretation of muscle size and weakness in children with a motor disability and allows for the evaluation of the disease progression and treatment impact during growth.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140323567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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