Pub Date : 2023-12-07DOI: 10.1007/s40271-023-00654-7
Theresa Coles, Molly McFatrich, Helen Ding, Nicole Lucas, Erin Daniell, Aparna Swaminathan, Jonathan Schelfhout, Reed Johnson
Objectives
This study aimed to describe quality of life for patients with chronic cough (CC) and identify meaningful attributes that affect patient treatment preferences to inform the design of a quantitative preference study.
Methods
Eligible patients (≥ 18 years) with a CC (> 8 weeks) participated in qualitative interviews with two defined steps. Step one: concept elicitation and bidding games were used to collect descriptions of patient experiences with CC and identify important CC-related attributes. Step two: attributes were confirmed using concept elicitation and bidding games and prioritized using structured card sort activities. Purposive sampling ensured diversity of patient experiences. Qualitative content analysis was used to analyze participant narratives, and descriptive statistics were used to summarize card sort results. This study follows a fully mixed concurrent dominant status design, with qualitative (dominant) and quantitative components.
Results
A total of 20 participants were interviewed with a mean age of 61.4 years (range 24–79 years). Coughing episodes, described as intense consecutive coughs that made catching breath difficult, were important to most participants (n = 17). Participants emphasized the emotional impact of episodes including feelings of uncertainty, loss of control, self-consciousness, and fear. Severity of CC was most often judged by frequency (n = 11) and intensity (n = 12) of cough. Daily, physical, or social activities were impacted for most participants. Impact on sleep (n = 14) included waking during the night, difficulty falling asleep, and daytime fatigue. Medication-related taste disturbances were an important consideration for what participants were willing to accept in exchange for cough relief.
Conclusions
This study emphasizes the importance of coughing episodes for adults with CC and provides initial evidence that taste alterations are an important component of patient treatment decisions for CC.
目的本研究旨在描述慢性咳嗽（CC）患者的生活质量，并确定影响患者治疗偏好的有意义的属性，为定量偏好研究的设计提供参考。方法符合条件的 CC（8 周）患者（≥ 18 岁）参加定性访谈，访谈分为两个步骤。第一步：通过概念诱导和竞标游戏收集患者对CC的体验描述，并确定与CC相关的重要属性。第二步：使用概念激发和竞标游戏确认属性，并使用结构化卡片排序活动确定优先顺序。有目的的抽样确保了患者经历的多样性。定性内容分析用于分析参与者的叙述，描述性统计用于总结卡片分类结果。本研究采用完全混合的并发主导状态设计，包括定性（主导）和定量两个部分。对大多数参与者（17 人）来说，咳嗽发作（被描述为使呼吸困难的剧烈连续咳嗽）是非常重要的。参与者强调咳嗽发作对情绪的影响，包括不确定感、失控感、自我意识和恐惧感。CC的严重程度最常通过咳嗽频率（11人）和咳嗽强度（12人）来判断。大多数参与者的日常活动、体力活动或社交活动都受到了影响。对睡眠的影响（14 人）包括夜醒、入睡困难和白天疲劳。这项研究强调了咳嗽发作对成人 CC 患者的重要性，并提供了初步证据表明味觉改变是 CC 患者治疗决策的重要组成部分。
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