Pub Date : 2024-06-01DOI: 10.1097/dad.0000000000002727
R. Abadi, M. Kurban, O. Abbas
{"title":"Painless Symmetric Thickening of Proximal Interphalangeal Joints in an Adolescent Girl: Challenge","authors":"R. Abadi, M. Kurban, O. Abbas","doi":"10.1097/dad.0000000000002727","DOIUrl":"https://doi.org/10.1097/dad.0000000000002727","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1097/dad.0000000000002679
Michael Tang, Brett C. Neill, Stanislav N. Tolkachjov, Cary Chisholm
{"title":"A Firm, Subcutaneous Nodule on the Temple of an Adolescent African American Male: Answer","authors":"Michael Tang, Brett C. Neill, Stanislav N. Tolkachjov, Cary Chisholm","doi":"10.1097/dad.0000000000002679","DOIUrl":"https://doi.org/10.1097/dad.0000000000002679","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1097/dad.0000000000002645
Nada Shaker, Omar P. Sangueza
{"title":"Discrete Acral Papular Mucinosis","authors":"Nada Shaker, Omar P. Sangueza","doi":"10.1097/dad.0000000000002645","DOIUrl":"https://doi.org/10.1097/dad.0000000000002645","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.1097/dad.0000000000002734
Shaymaa Hegazy, Rana Naous
Superficial anaplastic lymphoma kinase (ALK)–rearranged myxoid spindle cell neoplasm (SAMS) is a recently described entity which coexpresses ALK, CD34, and commonly S100. These neoplasms are characterized morphologically by concentric spindle cell whorls and cords and are commonly set in an abundant myxoid to myxocollagenous stroma, thus mimicking perineurioma or hybrid nerve sheath tumor. EMA immunostain has been reported to be negative in SAMS which helps in excluding the latter entities. Herein, we report the first EMA-positive SAMS of the right leg in a 37-year-old female patient masquerading as perineurioma/hybrid nerve sheath tumor. The tumor morphologically was comprised of spindle cells arranged in loose whorls and short fascicles set in myxoid to collagenous stroma and coexpressed CD34 and EMA, reminiscent of perineurioma. S100 showed focal staining. ALK immunostain was subsequently performed and was positive. ALK gene rearrangement was identified by fluorescence in situ hybridization break-apart assay and was further confirmed by next-generation sequencing–based RNA sequencing demonstrating FLNA::ALK fusion, thus supporting the diagnosis of SAMS. In conclusion, EMA can be expressed in SAMS, thus posing as a diagnostic pitfall. ALK immunostain and molecular studies are essential for confirming the diagnosis of SAMS and excluding potential mimickers, particularly perineurioma or hybrid nerve sheath tumor.
{"title":"EMA-Positive Superficial ALK–Rearranged Myxoid Spindle Cell Neoplasm Masquerading as Perineurioma/Hybrid Nerve Sheath Tumor","authors":"Shaymaa Hegazy, Rana Naous","doi":"10.1097/dad.0000000000002734","DOIUrl":"https://doi.org/10.1097/dad.0000000000002734","url":null,"abstract":"\u0000 Superficial anaplastic lymphoma kinase (ALK)–rearranged myxoid spindle cell neoplasm (SAMS) is a recently described entity which coexpresses ALK, CD34, and commonly S100. These neoplasms are characterized morphologically by concentric spindle cell whorls and cords and are commonly set in an abundant myxoid to myxocollagenous stroma, thus mimicking perineurioma or hybrid nerve sheath tumor. EMA immunostain has been reported to be negative in SAMS which helps in excluding the latter entities. Herein, we report the first EMA-positive SAMS of the right leg in a 37-year-old female patient masquerading as perineurioma/hybrid nerve sheath tumor. The tumor morphologically was comprised of spindle cells arranged in loose whorls and short fascicles set in myxoid to collagenous stroma and coexpressed CD34 and EMA, reminiscent of perineurioma. S100 showed focal staining. ALK immunostain was subsequently performed and was positive. ALK gene rearrangement was identified by fluorescence in situ hybridization break-apart assay and was further confirmed by next-generation sequencing–based RNA sequencing demonstrating FLNA::ALK fusion, thus supporting the diagnosis of SAMS. In conclusion, EMA can be expressed in SAMS, thus posing as a diagnostic pitfall. ALK immunostain and molecular studies are essential for confirming the diagnosis of SAMS and excluding potential mimickers, particularly perineurioma or hybrid nerve sheath tumor.","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141003287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/dad.0000000000002664
Alexandra R. Fiedler, Kevin Brittan, C. Georgesen, Wuttiporn Manatsathit
{"title":"An Unusual Rash in a Recent Liver Transplant Recipient: Answer","authors":"Alexandra R. Fiedler, Kevin Brittan, C. Georgesen, Wuttiporn Manatsathit","doi":"10.1097/dad.0000000000002664","DOIUrl":"https://doi.org/10.1097/dad.0000000000002664","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/dad.0000000000002682
Katherine L Wang, Matthew R. Hall, S. Chumsri, O. Sokumbi
{"title":"Soft Pink Plaques at Site of Breast Cancer Vaccination: Challenge","authors":"Katherine L Wang, Matthew R. Hall, S. Chumsri, O. Sokumbi","doi":"10.1097/dad.0000000000002682","DOIUrl":"https://doi.org/10.1097/dad.0000000000002682","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/dad.0000000000002693
Uiju Cho, Jihae Lee, C. Yoo
{"title":"Bullous Dermatosis on the Whole Body: Answer","authors":"Uiju Cho, Jihae Lee, C. Yoo","doi":"10.1097/dad.0000000000002693","DOIUrl":"https://doi.org/10.1097/dad.0000000000002693","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141027530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/dad.0000000000002703
Uiju Cho, Gyong Moon Kim, C. Yoo
{"title":"Multiple, Grouped Translucent Papulovesicles on the Lower Lip: Answer","authors":"Uiju Cho, Gyong Moon Kim, C. Yoo","doi":"10.1097/dad.0000000000002703","DOIUrl":"https://doi.org/10.1097/dad.0000000000002703","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141030074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/dad.0000000000002663
Alexandra R. Fiedler, Kevin Brittan, C. Georgesen, Wuttiporn Manatsathit
{"title":"An Unusual Rash in a Recent Liver Transplant Recipient: Challenge","authors":"Alexandra R. Fiedler, Kevin Brittan, C. Georgesen, Wuttiporn Manatsathit","doi":"10.1097/dad.0000000000002663","DOIUrl":"https://doi.org/10.1097/dad.0000000000002663","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/dad.0000000000002668
Jill Stachowski, James Strassner, Christopher G. Bazewicz, Thomas N. Helm
{"title":"Small Vesicles and Tense Bullae on Face, Neck, and Upper Trunk: Challenge","authors":"Jill Stachowski, James Strassner, Christopher G. Bazewicz, Thomas N. Helm","doi":"10.1097/dad.0000000000002668","DOIUrl":"https://doi.org/10.1097/dad.0000000000002668","url":null,"abstract":"","PeriodicalId":501833,"journal":{"name":"The American Journal of Dermatopathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141052101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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