Research communications in molecular pathology and pharmacology最新文献

英文中文

Tetrahydrobiopterin inhibits copper-induced oxidation of low density lipoprotein. 四氢生物蝶呤可抑制铜诱导的低密度脂蛋白氧化。

Research communications in molecular pathology and pharmacology

Pub Date : 2000-05-01

S Sakuma, Y Fujimoto, Y Gohda, T Fujita

The effect of tetrahydrobiopterin (BPH4) on Cu2+-induced oxidation of low density lipoprotein (LDL) prepared from rabbit plasma was examined. BPH4 (0.5-10 microM) inhibited the formation of thiobarbituric acid-reactive substances (TBARS) in LDL induced by 5 microM Cu2+ in a dose-dependent manner. BPH4 also suppressed the increase in relative electrophoretic mobility (REM) of LDL in the presence of 5 microM Cu2+. The potency of inhibitions of BPH4 on TBARS formation and REM was the same as or stronger than that of ascorbic acid and alpha-tocopherol, which are known as endogenous inhibitors of LDL oxidation. These results suggest that BPH4 could act as an efficacious endogenous inhibitor of atherogenic LDL modification.

研究了四氢生物蝶呤（BPH4）对 Cu2+ 诱导的兔血浆低密度脂蛋白（LDL）氧化的影响。BPH4（0.5-10 微摩尔）以剂量依赖的方式抑制了 5 微摩尔 Cu2+ 诱导的低密度脂蛋白中硫代巴比妥酸反应物质（TBARS）的形成。BPH4 还能抑制 5 微摩尔 Cu2+ 诱导的低密度脂蛋白相对电泳迁移率（REM）的增加。BPH4 对 TBARS 形成和 REM 的抑制作用与抗坏血酸和α-生育酚相同或更强，而抗坏血酸和α-生育酚是已知的低密度脂蛋白氧化内源性抑制剂。这些结果表明，BPH4 可作为致动脉粥样硬化低密度脂蛋白修饰的有效内源性抑制剂。

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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