{"title":"VIRUS DEFECTIVENESS AND CELL TRANSFORMATION IN THE ROUS SARCOMA.","authors":"H Rubin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23771522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MUTAGENESIS AND CHROMOSOME STRUCTURE.","authors":"F J Deserres","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23771527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE AMBER MUTATION.","authors":"S Brenner, A O Stretton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23771528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ELECTRONIC ASPECTS OF THE INTERACTIONS BETWEEN THE CARCINOGENS AND POSSIBLE CELLULAR SITES OF THEIR ACTIVITY.","authors":"B Pullman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23771531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE ROLE OF PURINE AND PYRIMIDINE BASES AND THEIR ANALOGUES IN RADIATION SENSITIVITY.","authors":"H S Kaplan, J D Earle, F L Howsden","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23771530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SUMMARY OF 1964 BIOLOGY RESEARCH CONFERENCE.","authors":"R Dulbecco","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1964-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23771523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: 13C-hiolein is a purified algal triglyceride which is synthesized with 98% of all carbon atoms of the molecule uniformly 13C-labeled. Orlistat is the new name for tetrahydrolipstatin (THL), which is a specific and potent inhibitor of gastrointestinal lipases which induces artificial fat malabsorption in humans. The aim of the present study was to use the 13C-hiolein breath test (HBT) to assess THL-induced fat malabsorption in healthy volunteers. Methods: Eight healthy volunteers of normal body weight underwent 2 study periods of 4 days of diet with or without THL 120 mg t.i.d. On day 5, a HBT was performed. 13CO2 recovery in breath samples was measured over 24 h by isotope ratio mass spectrometry. Results: The peak 13CO2 excretion occurred only after 5 h in both treatment groups with little difference during the first 4 h between the groups. THL potently reduced fat digestion and absorption with the most pronounced effect observed after 8 h: 1.1± 0.2 vs. 2.3 ± 0.3% dose in control experiments (p < 0.05). The 24-hour cumulative 13CO2 excretion was also significantly reduced by THL: 14.9 ± 2.2 vs. 28.4 ± 4.1% dose in control experiments (p < 0.05). In 6 of the 8 subjects, the cumulative 13CO2 excretion was lower with THL 120 mg t.i.d. than with placebo. Conclusion: The HBT well reflects THL-induced artificial fat maldigestion in healthy volunteers.
{"title":"ELECTROPHYSIOLOGY OF THE SOMATIC MUSCLE CELLS OF ASCARIS LUMBRICOIDES.","authors":"J T DEBELL, J DELCASTILLO, V SANCHEZ","doi":"10.1159/000007808","DOIUrl":"https://doi.org/10.1159/000007808","url":null,"abstract":"Background: 13C-hiolein is a purified algal triglyceride which is synthesized with 98% of all carbon atoms of the molecule uniformly 13C-labeled. Orlistat is the new name for tetrahydrolipstatin (THL), which is a specific and potent inhibitor of gastrointestinal lipases which induces artificial fat malabsorption in humans. The aim of the present study was to use the 13C-hiolein breath test (HBT) to assess THL-induced fat malabsorption in healthy volunteers. Methods: Eight healthy volunteers of normal body weight underwent 2 study periods of 4 days of diet with or without THL 120 mg t.i.d. On day 5, a HBT was performed. 13CO2 recovery in breath samples was measured over 24 h by isotope ratio mass spectrometry. Results: The peak 13CO2 excretion occurred only after 5 h in both treatment groups with little difference during the first 4 h between the groups. THL potently reduced fat digestion and absorption with the most pronounced effect observed after 8 h: 1.1± 0.2 vs. 2.3 ± 0.3% dose in control experiments (p < 0.05). The 24-hour cumulative 13CO2 excretion was also significantly reduced by THL: 14.9 ± 2.2 vs. 28.4 ± 4.1% dose in control experiments (p < 0.05). In 6 of the 8 subjects, the cumulative 13CO2 excretion was lower with THL 120 mg t.i.d. than with placebo. Conclusion: The HBT well reflects THL-induced artificial fat maldigestion in healthy volunteers.","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000007808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23648876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NUCLEIC ACIDS AND INFORMATION TRANSFER.","authors":"L F CAVALIERI","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23651990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ROLE OF PROTEIN SYNTHESIS IN DNA REPLICATION CYCLE IN BACTERIA.","authors":"O. Maaløe","doi":"10.1002/JCP.1030620405","DOIUrl":"https://doi.org/10.1002/JCP.1030620405","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/JCP.1030620405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50891602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TETRAHYMENA CELLS IN THE G2 PHASE-SENSITIVITY TO TEMPERATURE AND TO INHIBITORS OF PROTEIN SYNTHESIS.","authors":"E ZEUTHEN","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1963-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"23651676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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