首页 > 最新文献

AppliedMath最新文献

英文 中文
Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars 将 λ 折叠完整混合图分解为混合六星图
Pub Date : 2024-02-05 DOI: 10.3390/appliedmath4010011
Robert Gardner, Kazeem Kosebinu
Graph and digraph decompositions are a fundamental part of design theory. Probably the best known decompositions are related to decomposing the complete graph into 3-cycles (which correspond to Steiner triple systems), and decomposing the complete digraph into orientations of a 3-cycle (the two possible orientations of a 3-cycle correspond to directed triple systems and Mendelsohn triple systems). Decompositions of the λ-fold complete graph and the λ-fold complete digraph have been explored, giving generalizations of decompositions of complete simple graphs and digraphs. Decompositions of the complete mixed graph (which contains an edge and two distinct arcs between every two vertices) have also been explored in recent years. Since the complete mixed graph has twice as many arcs as edges, an isomorphic decomposition of a complete mixed graph into copies of a sub-mixed graph must involve a sub-mixed graph with twice as many arcs as edges. A partial orientation of a 6-star with two edges and four arcs is an example of such a mixed graph; there are five such mixed stars. In this paper, we give necessary and sufficient conditions for a decomposition of the λ-fold complete mixed graph into each of these five mixed stars for all λ>1.
图和数图分解是设计理论的基本组成部分。最著名的分解可能是将完整图分解为 3 个循环(对应于斯坦纳三重系统),以及将完整数图分解为 3 个循环的方向(3 个循环的两个可能方向对应于有向三重系统和门德尔松三重系统)。我们还探索了 λ 折叠完整图和 λ 折叠完整数图的分解,给出了完整简单图和数图分解的一般化。近年来,人们还探索了完整混合图(每两个顶点之间包含一条边和两条不同的弧)的分解。由于完整混合图的弧数是边数的两倍,因此将完整混合图分解为子混合图副本的同构分解必须涉及弧数是边数两倍的子混合图。具有两条边和四条弧的 6 星图的部分定向就是这种混合图的一个例子;共有五个这样的混合星图。在本文中,我们给出了在所有 λ>1 条件下,将 λ 折叠完整混合图分解为这五个混合星的必要条件和充分条件。
{"title":"Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars","authors":"Robert Gardner, Kazeem Kosebinu","doi":"10.3390/appliedmath4010011","DOIUrl":"https://doi.org/10.3390/appliedmath4010011","url":null,"abstract":"Graph and digraph decompositions are a fundamental part of design theory. Probably the best known decompositions are related to decomposing the complete graph into 3-cycles (which correspond to Steiner triple systems), and decomposing the complete digraph into orientations of a 3-cycle (the two possible orientations of a 3-cycle correspond to directed triple systems and Mendelsohn triple systems). Decompositions of the λ-fold complete graph and the λ-fold complete digraph have been explored, giving generalizations of decompositions of complete simple graphs and digraphs. Decompositions of the complete mixed graph (which contains an edge and two distinct arcs between every two vertices) have also been explored in recent years. Since the complete mixed graph has twice as many arcs as edges, an isomorphic decomposition of a complete mixed graph into copies of a sub-mixed graph must involve a sub-mixed graph with twice as many arcs as edges. A partial orientation of a 6-star with two edges and four arcs is an example of such a mixed graph; there are five such mixed stars. In this paper, we give necessary and sufficient conditions for a decomposition of the λ-fold complete mixed graph into each of these five mixed stars for all λ>1.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars 将 λ 折叠完整混合图分解为混合六星图
Pub Date : 2024-02-05 DOI: 10.3390/appliedmath4010011
Robert Gardner, Kazeem Kosebinu
Graph and digraph decompositions are a fundamental part of design theory. Probably the best known decompositions are related to decomposing the complete graph into 3-cycles (which correspond to Steiner triple systems), and decomposing the complete digraph into orientations of a 3-cycle (the two possible orientations of a 3-cycle correspond to directed triple systems and Mendelsohn triple systems). Decompositions of the λ-fold complete graph and the λ-fold complete digraph have been explored, giving generalizations of decompositions of complete simple graphs and digraphs. Decompositions of the complete mixed graph (which contains an edge and two distinct arcs between every two vertices) have also been explored in recent years. Since the complete mixed graph has twice as many arcs as edges, an isomorphic decomposition of a complete mixed graph into copies of a sub-mixed graph must involve a sub-mixed graph with twice as many arcs as edges. A partial orientation of a 6-star with two edges and four arcs is an example of such a mixed graph; there are five such mixed stars. In this paper, we give necessary and sufficient conditions for a decomposition of the λ-fold complete mixed graph into each of these five mixed stars for all λ>1.
图和数图分解是设计理论的基本组成部分。最著名的分解可能是将完整图分解为 3 个循环(对应于斯坦纳三重系统),以及将完整数图分解为 3 个循环的方向(3 个循环的两个可能方向对应于有向三重系统和门德尔松三重系统)。我们还探索了 λ 折叠完整图和 λ 折叠完整数图的分解,给出了完整简单图和数图分解的一般化。近年来,人们还探索了完整混合图(每两个顶点之间包含一条边和两条不同的弧)的分解。由于完整混合图的弧数是边数的两倍,因此将完整混合图分解为子混合图副本的同构分解必须涉及弧数是边数两倍的子混合图。具有两条边和四条弧的 6 星图的部分定向就是这种混合图的一个例子;共有五个这样的混合星图。在本文中,我们给出了在所有 λ>1 条件下,将 λ 折叠完整混合图分解为这五个混合星的必要条件和充分条件。
{"title":"Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars","authors":"Robert Gardner, Kazeem Kosebinu","doi":"10.3390/appliedmath4010011","DOIUrl":"https://doi.org/10.3390/appliedmath4010011","url":null,"abstract":"Graph and digraph decompositions are a fundamental part of design theory. Probably the best known decompositions are related to decomposing the complete graph into 3-cycles (which correspond to Steiner triple systems), and decomposing the complete digraph into orientations of a 3-cycle (the two possible orientations of a 3-cycle correspond to directed triple systems and Mendelsohn triple systems). Decompositions of the λ-fold complete graph and the λ-fold complete digraph have been explored, giving generalizations of decompositions of complete simple graphs and digraphs. Decompositions of the complete mixed graph (which contains an edge and two distinct arcs between every two vertices) have also been explored in recent years. Since the complete mixed graph has twice as many arcs as edges, an isomorphic decomposition of a complete mixed graph into copies of a sub-mixed graph must involve a sub-mixed graph with twice as many arcs as edges. A partial orientation of a 6-star with two edges and four arcs is an example of such a mixed graph; there are five such mixed stars. In this paper, we give necessary and sufficient conditions for a decomposition of the λ-fold complete mixed graph into each of these five mixed stars for all λ>1.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Convection of Physical Quantities of Random Density 随机密度物理量的对流
Pub Date : 2024-02-05 DOI: 10.3390/appliedmath4010012
E. Barletta, S. Dragomir, Francesco Esposito
We study the random flow, through a thin cylindrical tube, of a physical quantity of random density, in the presence of random sinks and sources. We model convection in terms of the expectations of the flux and density and solve the initial value problem for the resulting convection equation. We propose a difference scheme for the convection equation, that is both stable and satisfies the Courant–Friedrichs–Lewy test, and estimate the difference between the exact and approximate solutions.
我们研究了在存在随机汇和源的情况下,随机密度的物理量在细圆柱管中的随机流动。我们根据通量和密度的期望值建立对流模型,并求解对流方程的初值问题。我们为对流方程提出了一个既稳定又满足 Courant-Friedrichs-Lewy 检验的差分方案,并估算了精确解与近似解之间的差异。
{"title":"Convection of Physical Quantities of Random Density","authors":"E. Barletta, S. Dragomir, Francesco Esposito","doi":"10.3390/appliedmath4010012","DOIUrl":"https://doi.org/10.3390/appliedmath4010012","url":null,"abstract":"We study the random flow, through a thin cylindrical tube, of a physical quantity of random density, in the presence of random sinks and sources. We model convection in terms of the expectations of the flux and density and solve the initial value problem for the resulting convection equation. We propose a difference scheme for the convection equation, that is both stable and satisfies the Courant–Friedrichs–Lewy test, and estimate the difference between the exact and approximate solutions.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139862585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts 放疗前的细胞周期同步:在黑色素瘤异种移植物上使用吉西他滨的数学模型
Pub Date : 2024-02-04 DOI: 10.3390/appliedmath4010010
Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace
Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization.
如果细胞同步处于特定阶段,放疗会对细胞周期的不同阶段产生不同影响,从而可能增强对肿瘤生长的抑制作用。我们设计了一个模型来复制在不同剂量放疗前使用吉西他滨使细胞同步进入 S 期的实验,目的是量化这种影响。该模型用于模拟一项临床试验,其中一组 100 人只接受辐射,另一组 100 人在细胞同步化后接受辐射。本研究提供的模拟结果支持以下说法:在适当高的辐射水平下,治疗前用吉西他滨同步化黑色素瘤细胞可大大缩小最终的肿瘤大小。这种改善在统计学上是显著的,而且效果明显,在 8 格雷和 92% 同步时几乎抑制了肿瘤的生长。
{"title":"Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts","authors":"Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace","doi":"10.3390/appliedmath4010010","DOIUrl":"https://doi.org/10.3390/appliedmath4010010","url":null,"abstract":"Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139807015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts 放疗前的细胞周期同步:在黑色素瘤异种移植物上使用吉西他滨的数学模型
Pub Date : 2024-02-04 DOI: 10.3390/appliedmath4010010
Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace
Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization.
如果细胞同步处于特定阶段,放疗会对细胞周期的不同阶段产生不同影响,从而可能增强对肿瘤生长的抑制作用。我们设计了一个模型来复制在不同剂量放疗前使用吉西他滨使细胞同步进入 S 期的实验,目的是量化这种影响。该模型用于模拟一项临床试验,其中一组 100 人只接受辐射,另一组 100 人在细胞同步化后接受辐射。本研究提供的模拟结果支持以下说法:在适当高的辐射水平下,治疗前用吉西他滨同步化黑色素瘤细胞可大大缩小最终的肿瘤大小。这种改善在统计学上是显著的,而且效果明显,在 8 格雷和 92% 同步时几乎抑制了肿瘤的生长。
{"title":"Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts","authors":"Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace","doi":"10.3390/appliedmath4010010","DOIUrl":"https://doi.org/10.3390/appliedmath4010010","url":null,"abstract":"Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Model of Hepatitis B Viral Dynamics with Delays 带延迟的乙型肝炎病毒动态模型
Pub Date : 2024-02-01 DOI: 10.3390/appliedmath4010009
B. Chen-Charpentier
Hepatitis B is a liver disease caused by the human hepatitis B virus (HBV). Mathematical models help further the understanding of the processes involved and help make predictions. The basic reproduction number, R0, is an index that predicts whether the disease will be chronic or not. This is the single most-important information that a mathematical model can give. Within-host virus processes involve delays. We study two within-host hepatitis B virus infection models without and with delay. One is a standard one, and the other considering additional processes and with two delays is new. We analyze the basic reproduction number and alternative threshold indices. The values of R0 and the alternative indices change depending on the model. All these indices predict whether the infection will persist or not, but they do not give the same rate of growth of the infection when it is starting. Therefore, the choice of the model is very important in establishing whether the infection is chronic or not and how fast it initially grows. We analyze these indices to see how to decrease their value. We study the effect of adding delays and how the threshold indices depend on how the delays are included. We do this by studying the local asymptotic stability of the disease-free equilibrium or by using an equivalent method. We show that, for some models, the indices do not change by introducing delays, but they change when the delays are introduced differently. Numerical simulations are presented to confirm the results. Finally, some conclusions are presented.
乙型肝炎是由人类乙型肝炎病毒(HBV)引起的一种肝病。数学模型有助于进一步了解相关过程,并帮助做出预测。基本繁殖数 R0 是预测疾病是否会慢性化的指标。这是数学模型所能提供的最重要的信息。宿主内病毒过程涉及延迟。我们研究了两种无延迟和有延迟的宿主内乙型肝炎病毒感染模型。其中一个是标准模型,另一个是考虑了额外过程和两个延迟的新模型。我们分析了基本繁殖数量和替代阈值指数。R0 和替代指数的值随模型的不同而变化。所有这些指数都能预测感染是否会持续,但在感染开始时,它们给出的感染增长率并不相同。因此,模型的选择对于确定感染是否为慢性感染以及感染初期的增长速度非常重要。我们对这些指数进行分析,看看如何降低它们的值。我们研究了添加延迟的效果,以及阈值指数如何取决于延迟的加入方式。我们通过研究无病均衡的局部渐近稳定性或使用等效方法来实现这一点。我们的研究表明,对于某些模型,引入延迟并不会改变指数,但当引入延迟的方式不同时,指数就会发生变化。为了证实这些结果,我们还进行了数值模拟。最后,我们得出一些结论。
{"title":"A Model of Hepatitis B Viral Dynamics with Delays","authors":"B. Chen-Charpentier","doi":"10.3390/appliedmath4010009","DOIUrl":"https://doi.org/10.3390/appliedmath4010009","url":null,"abstract":"Hepatitis B is a liver disease caused by the human hepatitis B virus (HBV). Mathematical models help further the understanding of the processes involved and help make predictions. The basic reproduction number, R0, is an index that predicts whether the disease will be chronic or not. This is the single most-important information that a mathematical model can give. Within-host virus processes involve delays. We study two within-host hepatitis B virus infection models without and with delay. One is a standard one, and the other considering additional processes and with two delays is new. We analyze the basic reproduction number and alternative threshold indices. The values of R0 and the alternative indices change depending on the model. All these indices predict whether the infection will persist or not, but they do not give the same rate of growth of the infection when it is starting. Therefore, the choice of the model is very important in establishing whether the infection is chronic or not and how fast it initially grows. We analyze these indices to see how to decrease their value. We study the effect of adding delays and how the threshold indices depend on how the delays are included. We do this by studying the local asymptotic stability of the disease-free equilibrium or by using an equivalent method. We show that, for some models, the indices do not change by introducing delays, but they change when the delays are introduced differently. Numerical simulations are presented to confirm the results. Finally, some conclusions are presented.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139826722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Model of Hepatitis B Viral Dynamics with Delays 带延迟的乙型肝炎病毒动态模型
Pub Date : 2024-02-01 DOI: 10.3390/appliedmath4010009
B. Chen-Charpentier
Hepatitis B is a liver disease caused by the human hepatitis B virus (HBV). Mathematical models help further the understanding of the processes involved and help make predictions. The basic reproduction number, R0, is an index that predicts whether the disease will be chronic or not. This is the single most-important information that a mathematical model can give. Within-host virus processes involve delays. We study two within-host hepatitis B virus infection models without and with delay. One is a standard one, and the other considering additional processes and with two delays is new. We analyze the basic reproduction number and alternative threshold indices. The values of R0 and the alternative indices change depending on the model. All these indices predict whether the infection will persist or not, but they do not give the same rate of growth of the infection when it is starting. Therefore, the choice of the model is very important in establishing whether the infection is chronic or not and how fast it initially grows. We analyze these indices to see how to decrease their value. We study the effect of adding delays and how the threshold indices depend on how the delays are included. We do this by studying the local asymptotic stability of the disease-free equilibrium or by using an equivalent method. We show that, for some models, the indices do not change by introducing delays, but they change when the delays are introduced differently. Numerical simulations are presented to confirm the results. Finally, some conclusions are presented.
乙型肝炎是由人类乙型肝炎病毒(HBV)引起的一种肝病。数学模型有助于进一步了解相关过程,并帮助做出预测。基本繁殖数 R0 是预测疾病是否会慢性化的指标。这是数学模型所能提供的最重要的信息。宿主内病毒过程涉及延迟。我们研究了两种无延迟和有延迟的宿主内乙型肝炎病毒感染模型。其中一个是标准模型,另一个是考虑了额外过程和两个延迟的新模型。我们分析了基本繁殖数量和替代阈值指数。R0 和替代指数的值随模型的不同而变化。所有这些指数都能预测感染是否会持续,但在感染开始时,它们给出的感染增长率并不相同。因此,模型的选择对于确定感染是否为慢性感染以及感染初期的增长速度非常重要。我们对这些指数进行分析,看看如何降低它们的值。我们研究了添加延迟的效果,以及阈值指数如何取决于延迟的加入方式。我们通过研究无病均衡的局部渐近稳定性或使用等效方法来实现这一点。我们的研究表明,对于某些模型,引入延迟并不会改变指数,但当引入延迟的方式不同时,指数就会发生变化。为了证实这些结果,我们还进行了数值模拟。最后,我们得出一些结论。
{"title":"A Model of Hepatitis B Viral Dynamics with Delays","authors":"B. Chen-Charpentier","doi":"10.3390/appliedmath4010009","DOIUrl":"https://doi.org/10.3390/appliedmath4010009","url":null,"abstract":"Hepatitis B is a liver disease caused by the human hepatitis B virus (HBV). Mathematical models help further the understanding of the processes involved and help make predictions. The basic reproduction number, R0, is an index that predicts whether the disease will be chronic or not. This is the single most-important information that a mathematical model can give. Within-host virus processes involve delays. We study two within-host hepatitis B virus infection models without and with delay. One is a standard one, and the other considering additional processes and with two delays is new. We analyze the basic reproduction number and alternative threshold indices. The values of R0 and the alternative indices change depending on the model. All these indices predict whether the infection will persist or not, but they do not give the same rate of growth of the infection when it is starting. Therefore, the choice of the model is very important in establishing whether the infection is chronic or not and how fast it initially grows. We analyze these indices to see how to decrease their value. We study the effect of adding delays and how the threshold indices depend on how the delays are included. We do this by studying the local asymptotic stability of the disease-free equilibrium or by using an equivalent method. We show that, for some models, the indices do not change by introducing delays, but they change when the delays are introduced differently. Numerical simulations are presented to confirm the results. Finally, some conclusions are presented.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Co-Infection Model for Onchocerciasis and Lassa Fever with Optimal Control Analysis 带最优控制分析的盘尾丝虫病和拉沙热双重感染模型
Pub Date : 2024-01-10 DOI: 10.3390/appliedmath4010006
Kabiru Michael Adeyemo, K. Oshinubi, U. M. Adam, Adejimi Adeniji
A co-infection model for onchocerciasis and Lassa fever (OLF) with periodic variational vectors and optimal control is studied and analyzed to assess the impact of controls against incidence infections. The model is qualitatively examined in order to evaluate its asymptotic behavior in relation to the equilibria. Employing a Lyapunov function, we demonstrated that the disease-free equilibrium (DFE) is globally asymptotically stable; that is, the related basic reproduction number is less than unity. When it is bigger than one, we use a suitable nonlinear Lyapunov function to demonstrate the existence of a globally asymptotically stable endemic equilibrium (EE). Furthermore, the necessary conditions for the presence of optimum control and the optimality system for the co-infection model are established using Pontryagin’s maximum principle. The model is quantitatively analyzed by studying how sensitive the basic reproduction number is to the model parameters and the model simulation using Runge–Kutta technique of order 4 is also presented to study the effects of the treatments. We deduced from the quantitative analysis that, if there is an effective treatment and diagnosis of those exposed to and infected with the disease, the spread of the viral disease can be effectively managed. The results presented in this work will be useful for the proper mitigation of the disease.
本文研究和分析了一个具有周期性变异向量和最优控制的盘尾丝虫病和拉沙热(OLF)共同感染模型,以评估控制措施对发病感染的影响。对模型进行了定性研究,以评估其与均衡相关的渐近行为。利用 Lyapunov 函数,我们证明了无病平衡 (DFE) 是全局渐近稳定的;也就是说,相关的基本繁殖数小于 1。当基本繁殖数大于 1 时,我们使用一个合适的非线性 Lyapunov 函数来证明全局渐近稳定的地方病平衡(EE)的存在。此外,我们还利用庞特里亚金(Pontryagin)的最大值原理,建立了最佳控制存在的必要条件和共同感染模型的最优系统。通过研究基本繁殖数量对模型参数的敏感程度,对模型进行了定量分析,并使用 4 阶 Runge-Kutta 技术对模型进行了模拟,以研究处理方法的影响。我们从定量分析中推断出,如果对接触和感染该疾病的人进行有效的治疗和诊断,就能有效控制病毒性疾病的传播。这项工作所取得的成果将有助于适当缓解该疾病。
{"title":"A Co-Infection Model for Onchocerciasis and Lassa Fever with Optimal Control Analysis","authors":"Kabiru Michael Adeyemo, K. Oshinubi, U. M. Adam, Adejimi Adeniji","doi":"10.3390/appliedmath4010006","DOIUrl":"https://doi.org/10.3390/appliedmath4010006","url":null,"abstract":"A co-infection model for onchocerciasis and Lassa fever (OLF) with periodic variational vectors and optimal control is studied and analyzed to assess the impact of controls against incidence infections. The model is qualitatively examined in order to evaluate its asymptotic behavior in relation to the equilibria. Employing a Lyapunov function, we demonstrated that the disease-free equilibrium (DFE) is globally asymptotically stable; that is, the related basic reproduction number is less than unity. When it is bigger than one, we use a suitable nonlinear Lyapunov function to demonstrate the existence of a globally asymptotically stable endemic equilibrium (EE). Furthermore, the necessary conditions for the presence of optimum control and the optimality system for the co-infection model are established using Pontryagin’s maximum principle. The model is quantitatively analyzed by studying how sensitive the basic reproduction number is to the model parameters and the model simulation using Runge–Kutta technique of order 4 is also presented to study the effects of the treatments. We deduced from the quantitative analysis that, if there is an effective treatment and diagnosis of those exposed to and infected with the disease, the spread of the viral disease can be effectively managed. The results presented in this work will be useful for the proper mitigation of the disease.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Informational Updates and the Derivative Pricing Kernel 信息更新与衍生品定价内核
Pub Date : 2024-01-03 DOI: 10.3390/appliedmath4010005
Ayan Bhattacharya
It is common in financial markets for market makers to offer prices on derivative instruments even though they are uncertain about the underlying asset’s value. This paper studies the mathematical problem that arises as a result. Derivatives are priced in the risk-neutral framework, so as the market maker acquires more information about the underlying asset, the change of measure for transition to the risk-neutral framework (the pricing kernel) evolves. This evolution takes a precise form when the market maker is Bayesian. It is shown that Bayesian updates can be characterized as additional informational drift in the underlying asset’s stochastic process. With Bayesian updates, the change of measure needed for pricing derivatives is two-fold: the first change is from the prior probability measure to the posterior probability measure, and the second change is from the posterior probability measure to the risk-neutral measure. The relation between the regular pricing kernel and the pricing kernel under this two-fold change of measure is characterized.
在金融市场中,做市商在不确定相关资产价值的情况下为衍生工具报价的现象十分普遍。本文研究由此产生的数学问题。衍生工具是在风险中性框架下定价的,因此随着做市商获得更多相关资产的信息,过渡到风险中性框架的衡量标准(定价内核)也会发生变化。当做市商是贝叶斯时,这种演变会以精确的形式出现。研究表明,贝叶斯更新可以被描述为标的资产随机过程中的额外信息漂移。在贝叶斯更新的情况下,衍生品定价所需的度量变化有两个方面:第一个变化是从先验概率度量到后验概率度量,第二个变化是从后验概率度量到风险中性度量。在这种两重度量变化下,常规定价核与定价核之间的关系被描述出来。
{"title":"Informational Updates and the Derivative Pricing Kernel","authors":"Ayan Bhattacharya","doi":"10.3390/appliedmath4010005","DOIUrl":"https://doi.org/10.3390/appliedmath4010005","url":null,"abstract":"It is common in financial markets for market makers to offer prices on derivative instruments even though they are uncertain about the underlying asset’s value. This paper studies the mathematical problem that arises as a result. Derivatives are priced in the risk-neutral framework, so as the market maker acquires more information about the underlying asset, the change of measure for transition to the risk-neutral framework (the pricing kernel) evolves. This evolution takes a precise form when the market maker is Bayesian. It is shown that Bayesian updates can be characterized as additional informational drift in the underlying asset’s stochastic process. With Bayesian updates, the change of measure needed for pricing derivatives is two-fold: the first change is from the prior probability measure to the posterior probability measure, and the second change is from the posterior probability measure to the risk-neutral measure. The relation between the regular pricing kernel and the pricing kernel under this two-fold change of measure is characterized.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139388018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of the Isotropic Star Differential System from the Mathematical and Physical Point of Views 从数学和物理学角度看各向同性星体差分系统的动力学特性
Pub Date : 2024-01-02 DOI: 10.3390/appliedmath4010004
Joan C. Artés, J. Llibre, N. Vulpe
The following differential quadratic polynomial differential system  dxdt=y−x, dydt=2y−yγ−12−γy−5γ−4γ−1x, when the parameter γ∈(1,2] models the structure equations of an isotropic star having a linear barotropic equation of state, being x=m(r)/r where m(r)≥0 is the mass inside the sphere of radius r of the star, y=4πr2ρ where ρ is the density of the star, and t=ln(r/R) where R is the radius of the star. First, we classify all the topologically non-equivalent phase portraits in the Poincaré disc of these quadratic polynomial differential systems for all values of the parameter γ∈R∖{1}. Second, using the information of the different phase portraits obtained we classify the possible limit values of m(r)/r and 4πr2ρ of an isotropic star when r decreases.
当参数 γ∈(1,2]时,下列微分二次多项式微分方程系 dxdt=y-x, dydt=2y-yγ-12-γy-5γ-4γ-1x 模拟了具有线性气压状态方程的各向同性恒星的结构方程、其中,x=m(r)/r,m(r)≥0 是恒星半径 r 球内的质量;y=4πr2ρ,ρ 是恒星的密度;t=ln(r/R),R 是恒星的半径。首先,我们对参数γ∈R∖{1}的所有取值下,这些二次多项式微分系统的波恩卡莱圆盘中所有拓扑非等价相位肖像进行了分类。其次,利用所获得的不同相位肖像信息,我们对各向同性恒星在 r 减小时 m(r)/r 和 4πr2ρ 的可能极限值进行了分类。
{"title":"Dynamics of the Isotropic Star Differential System from the Mathematical and Physical Point of Views","authors":"Joan C. Artés, J. Llibre, N. Vulpe","doi":"10.3390/appliedmath4010004","DOIUrl":"https://doi.org/10.3390/appliedmath4010004","url":null,"abstract":"The following differential quadratic polynomial differential system  dxdt=y−x, dydt=2y−yγ−12−γy−5γ−4γ−1x, when the parameter γ∈(1,2] models the structure equations of an isotropic star having a linear barotropic equation of state, being x=m(r)/r where m(r)≥0 is the mass inside the sphere of radius r of the star, y=4πr2ρ where ρ is the density of the star, and t=ln(r/R) where R is the radius of the star. First, we classify all the topologically non-equivalent phase portraits in the Poincaré disc of these quadratic polynomial differential systems for all values of the parameter γ∈R∖{1}. Second, using the information of the different phase portraits obtained we classify the possible limit values of m(r)/r and 4πr2ρ of an isotropic star when r decreases.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
AppliedMath
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1