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Chlamydia Trachomatis Infection among Pelvic Inflammatory Disease Patients Attending the Gynaecology Clinic of a Private Tertiary Hospital in Ogun State, Nigeria 尼日利亚奥贡州一家私立三级医院妇科门诊就诊的盆腔炎患者中的沙眼衣原体感染情况
Pub Date : 2024-07-24 DOI: 10.9734/ijtdh/2024/v45i71572
T. Ajani, C. Elikwu, Olufunmilola Makanjuola, Chika Okangba, T. Oluwasola, C. Anaedobe
Background: Pelvic inflammatory disease (PID) is one of the very serious complications arising from sexually transmitted infections (STIs) and Chlamydia trachomatis has been implicated as one of the commonest causes of STI. Considering the adverse sequelae of PID, there is a need for locally relevant data which will guide preventive and therapeutic efforts. Detection of a combination of immunoglobulin G (IgG) and immunoglobulin A (IgA) has been described as an indicator of an actively chronic infection Aims: The aim of this study was to determine the prevalence of Chlamydia trachomatis infection by the use of IgA and IgG and evaluate the associated risk factors among females that presented with Pelvic inflammatory disease at the gynaecology clinic of Babcock University Teaching Hospital. Ilishan-Remo, Ogun State, Nigeria. (BUTH) Materials and Methods: This was a hospital–based, case-controlled study involving 44 patients diagnosed with PID and 44 age-matched controls at the gynaecology clinic of BUTHI. Interviewer-administered questionnaires were used to obtain information on socio-demographic characteristics, and risk factors for PID, from consenting participants. Blood samples were collected from each participant and analysed, using the enzyme-linked immunosorbent assay, for Chlamydia trachomatis type‑specific for IgA and IgG. Analysis was done by SPSS, IBM version 23.0 Results: Both IgG and IgA were present in 15 cases (34.1%) as compared to none of the controls. The difference between Chlamydia IgG, IgA and (IgG+IgA) among the cases and the controls were statistically significant. Majority of the participants positive for the immunoglobulins were aged 25 years or younger (11, 73.3%), number of lifetime sex partners and age of first sexual intercourse being 18 years or younger were statistically associated with Chlamydia trachomatis causing PID. Conclusion: Chlamydia trachomatis remains an important causative pathogen of PID and more prevalent among the young people. Screening is advocated among the young in resource limited countries.
背景:盆腔炎(PID)是性传播感染(STI)引起的非常严重的并发症之一,而沙眼衣原体已被认为是性传播感染最常见的病因之一。考虑到 PID 的不良后遗症,有必要提供与本地相关的数据,以指导预防和治疗工作。免疫球蛋白 G(IgG)和免疫球蛋白 A(IgA)组合的检测被认为是慢性感染活跃的指标。 这项研究的目的是通过使用 IgA 和 IgG 来确定沙眼衣原体感染的流行率,并评估巴布科克大学教学医院妇科诊所中患盆腔炎的女性的相关风险因素。尼日利亚奥贡州伊利山-雷莫。(材料与方法:这是一项基于医院的病例对照研究,涉及巴布科克大学教学医院妇科诊所的 44 名确诊为 PID 的患者和 44 名年龄匹配的对照者。研究人员采用访谈式问卷调查的方式,从征得同意的参与者那里获得有关社会人口学特征和 PID 风险因素的信息。研究人员采集了每位受试者的血液样本,并使用酶联免疫吸附试验分析了沙眼衣原体特异性 IgA 和 IgG。分析由 IBM 23.0 版 SPSS 完成:15 例病例(34.1%)中同时存在 IgG 和 IgA,而对照组中没有。病例和对照组的衣原体 IgG、IgA 和(IgG+IgA)之间的差异具有统计学意义。大多数免疫球蛋白呈阳性的参与者年龄在 25 岁或以下(11 人,占 73.3%),一生中性伴侣的数量和 18 岁或以下的初次性交年龄与沙眼衣原体导致的 PID 有统计学关联。结论沙眼衣原体仍然是 PID 的重要致病病原体,而且在年轻人中更为流行。在资源有限的国家,提倡对年轻人进行筛查。
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引用次数: 0
Comparative Evaluation of Diabetes Complication Using Liver Function Parameters as Indices between Male and Female Alloxan Induced Diabetic Rats 以肝功能参数为指标比较评估雌雄阿脲诱导糖尿病大鼠的糖尿病并发症
Pub Date : 2024-07-23 DOI: 10.9734/ijtdh/2024/v45i71571
Iwuji Joy Chidinma, Nwanjo Harrison Ugochukwu, Nwosu Dennis C, Onuoha Chisom Precious, Emerole Chinwe Nelly, Ohaeri Evangelina Ozoemena
It is known that diabetes causes liver damage. On the other hand, because most cases of liver damage have been investigated in males, examining the relationship of this disease in both sexes is of great importance. This study was aimed at, comparatively evaluating diabetic complications using histopathological examination and liver function parameters as indices in alloxan-induced diabetic rats. A total of 24 male and female rats divided into four groups of six animals each were used for the experiment. Group A were female control, Group B were male control while group C and D were alloxan induced diabetic female and male rats respectively. Groups A and B were non diabetic rats fed with rat diet all through the experiment. Group C and D were diabetes induced with a single intraperitoneal injection of alloxan (120mg/kg). At the end of the inducement period, the rats were fasted overnight and sacrificed. Blood was collected by ocular puncture for the determination of fasting plasma glucose (FPG) and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), direct bilirubin (DB), total protein (TP) and albumin (ALB) using spectrophotometric method. Histology of the liver was determined by H and E technique. The results showed the experimental group C (365.83±43.6mg/dl) and D (368.94±43.93mg/dl) had significantly elevated levels of FPG when compared with the controls group A (116.00±9.11mg/dl) and B (108.33±5.5mg/dl) confirming the induction of diabetes (P=0.000). The liver of both male and female diabetic rats showed ballooning degeneration. In the males, these were arranged in normal sheets and cord around central vein in some areas of the center, on the other hand, the central vein of the female diabetic rats appears slightly enlarged containing blood clots and the arrangement of the hepatocytes in sheets or cords around the central vein was completely distorted. There was no significant difference (p>0.05) in the mean serum levels of ALP, AST, ALT, DB, TP and ALB in female diabetics when compared to male diabetic rats. The mean serum level of TB was significantly reduced (p=0.004) in female diabetics (0.53±0.05) than in the male diabetic albino rats (0.69±0.09). This study showed the liver histology and function are variably altered in diabetes mellitus. Further research on the causes of liver damage will help us to unravel the pathogenesis of diabetes and its complications.  
众所周知,糖尿病会导致肝损伤。另一方面,由于大多数肝损伤病例的调查对象是男性,因此研究这种疾病与男性和女性的关系非常重要。本研究旨在使用组织病理学检查和肝功能参数作为指标,对阿脲诱导的糖尿病大鼠的糖尿病并发症进行比较评估。实验共使用了 24 只雌雄大鼠,分为四组,每组六只。A 组为雌性对照组,B 组为雄性对照组,C 组和 D 组分别为阿脲诱导的糖尿病雌性和雄性大鼠。A 组和 B 组为非糖尿病大鼠,在整个实验期间均以大鼠饮食喂养。C 组和 D 组大鼠腹腔注射阿脲(120 毫克/千克)诱发糖尿病。诱导期结束后,大鼠禁食一夜并处死。通过眼部穿刺采集血液,采用分光光度法测定空腹血浆葡萄糖(FPG)和血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、总胆红素(TB)、直接胆红素(DB)、总蛋白(TP)和白蛋白(ALB)的水平。肝脏组织学采用 H 和 E 技术进行测定。结果显示,与对照组 A(116.00±9.11mg/dl)和 B(108.33±5.5mg/dl)相比,实验组 C(365.83±43.6mg/dl)和 D(368.94±43.93mg/dl)的 FPG 水平明显升高,证实了糖尿病的诱导(P=0.000)。雄性和雌性糖尿病大鼠的肝脏均出现气球变性。雄性糖尿病大鼠的肝细胞呈正常的片状和条索状排列在中央静脉周围的某些区域,而雌性糖尿病大鼠的中央静脉出现轻微肿大,内含血块,肝细胞呈片状或条索状排列在中央静脉周围的区域完全变形。与雄性糖尿病大鼠相比,雌性糖尿病大鼠血清中 ALP、AST、ALT、DB、TP 和 ALB 的平均水平无明显差异(P>0.05)。雌性糖尿病大鼠血清中 TB 的平均水平(0.53±0.05)比雄性糖尿病白化大鼠(0.69±0.09)明显降低(p=0.004)。这项研究表明,糖尿病患者的肝脏组织学和功能会发生不同程度的改变。对肝损伤原因的进一步研究将有助于我们揭示糖尿病及其并发症的发病机制。
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引用次数: 0
Sero-Prevalence of HBV and HIV Co-Infection in the Senatorial Districts of Ekiti State, Southwest, Nigeria 尼日利亚西南部埃基蒂州参议院辖区的 HBV 和 HIV 合并感染血清流行率
Pub Date : 2024-07-19 DOI: 10.9734/ijtdh/2024/v45i71570
Famoni O. P, Oyinloye J. M. A, Okiki P. A, Daramola G. O, Ojerinde A. O, Ajayi O. D, Esan C. O
Hepatitis is an inflammatory disease of the liver which can be acute or chronic. It can be caused by viruses (viral hepatitis), certain chemicals, drugs, prolonged or excessive consumption of alcohol (alcoholic hepatitis), some genetic abnormalities or a dysfunctional immune system (autoimmune hepatitis). And of the five types of viral hepatitis, HBV infection is the most virulent and infectious. According to a CDC (Centres for Disease Control and Prevention) estimate, nearly 300 million people are infected with hepatitis B virus (HBV), globally. It is a major public health challenge in most countries of the world, particularly in endemic areas. If HBV infection is bad for the general (healthy) populace, it is worse for the people living with HIV (PLWH). While HIV in PLWH helps to weaken or wreck the immune system, HBV attacks the liver- the most important organs in the body as far metabolism of drugs and related substances are concerned. This thus makes an already bad situation for the PLWH complicated and difficult to manage. It is critical and vital to screen all PLWH for HBV infection or assess their risks of contracting HBV infection. In the light of this, this study was designed to determine the sero-prevalence of HIV- HBV co-infection among PLWH/suspected PLWH in the three senatorial districts in Ekiti State (southwest, Nigeria).To do this, 209 PLWH/suspected PLWH were consecutively enrolled in the study population. The PLWH/suspected PLWH attending anti-retroviral (ARV) various clinics in the districts were re-screened with enzyme linked immunosorbent assay (ELISA) to establish that they were truly HIV positive. They were also screened for HBV using a rapid test kit and ELISA. Self-administered questionnaires were served on the subjects in order to collect their demographic data and investigate likely predisposing factors. Both descriptive and inferential statistical analyses were carried out using different statistical techniques with the aid of SPSS. The results of the study indicated that 29 of the subjects had HIV- HBV co-infection, thus representing an overall co-infection prevalence of 13.9%. One hundred and sixty-two of the subjects were HIV positive, representing 78% of the study population.  Twelve (5.4%) were negative to both HIV and HBV, while 6 (2.9%) were positive to HBV but negative to HIV. The study investigated the association between certain demographic variables and HBV, viz; age, gender, marital status, religion, tribe and occupation and some risk factors like smoking, use of sharp objects in initiation procedures. Subjects within the 26-35years age bracket had the highest HBV rate (6.3%), while 56-65 had the least (0.5%), female subjects had higher rate (11.7%) than the male subjects No significant association was established between HBV and any of the demographic variable or suspected risk factors. The findings of this study have shown that the prevalence of HIV-HBV co-infection among people living with HIV/AIDS in Ek
肝炎是一种急性或慢性肝脏炎症性疾病。它可由病毒(病毒性肝炎)、某些化学物质、药物、长期或过量饮酒(酒精性肝炎)、某些基因异常或免疫系统功能紊乱(自身免疫性肝炎)引起。而在五种病毒性肝炎中,HBV 感染的毒性和传染性最强。据美国疾病控制和预防中心(CDC)估计,全球有近 3 亿人感染了乙型肝炎病毒(HBV)。在世界大多数国家,尤其是在流行地区,这是一项重大的公共卫生挑战。如果说乙型肝炎病毒感染对普通(健康)人群不利,那么对艾滋病病毒感染者(PLWH)来说则更糟。艾滋病病毒感染者会削弱或破坏免疫系统,而 HBV 则会攻击肝脏--肝脏是人体代谢药物和相关物质的最重要器官。因此,这使得 PLWH 本已糟糕的状况变得更加复杂和难以控制。对所有 PLWH 进行 HBV 感染筛查或评估他们感染 HBV 的风险至关重要。有鉴于此,本研究旨在确定埃基蒂州(尼日利亚西南部)三个参议院辖区的 PLWH/疑似 PLWH 中 HIV- HBV 合并感染的血清流行率。对在各区抗逆转录病毒(ARV)诊所就诊的 PLWH/疑似 PLWH 使用酶联免疫吸附试验(ELISA)进行了重新筛查,以确定他们确实是 HIV 阳性者。此外,还使用快速检测试剂盒和酶联免疫吸附试验对他们进行了乙肝病毒筛查。对受试者进行了自填式问卷调查,以收集他们的人口统计学数据并调查可能的易感因素。在 SPSS 的帮助下,使用不同的统计技术进行了描述性和推论性统计分析。研究结果表明,29 名受试者同时感染了艾滋病毒和乙肝病毒,总感染率为 13.9%。162 名受试者艾滋病毒呈阳性,占研究人数的 78%。 12人(5.4%)对艾滋病毒和乙肝病毒均呈阴性,6人(2.9%)对乙肝病毒呈阳性,但对艾滋病毒呈阴性。该研究调查了某些人口统计学变量与 HBV 之间的关系,即年龄、性别、婚姻状况、宗教、部落和职业以及一些风险因素,如吸烟、在开始程序中使用尖锐物品。26-35 岁年龄段的受试者感染 HBV 的比例最高(6.3%),56-65 岁年龄段的受试者感染 HBV 的比例最低(0.5%),女性受试者感染 HBV 的比例(11.7%)高于男性受试者。本研究结果表明,埃基蒂州艾滋病毒/艾滋病感染者中艾滋病毒-HBV 合并感染的流行率相对较高。因此,建议埃基蒂州免费为该州所有儿童接种肝炎疫苗,尤其是 HBV 疫苗。 此外,政府最好对该州成年人的肝炎疫苗接种提供大量补贴。
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引用次数: 0
Antimicrobial Resistance Patterns of Bacteria Isolated from Pharmacy Technicians' Hands in Ghana 加纳药剂师手部分离细菌的抗菌药耐药性模式
Pub Date : 2024-07-18 DOI: 10.9734/ijtdh/2024/v45i71569
E. U. Osisiogu, Hamidu Tampuori Abdul-Razak, Clement Wepia Abosum, Genevive Afia Amoakoa Agyapong, F. K. Bawa, Emmanuel Mawuli Nattah, R. E. Amemo, Ngmennasong Antoanette
Background: Pharmacy technicians play a critical role in healthcare delivery, particularly in developing countries like Ghana. However, there is limited knowledge about the microbial contamination of their hands and the antimicrobial susceptibility patterns of these microbes. This study aimed at investigating the presence of bacteria on the hands of pharmacy technicians in the Upper West region of Ghana and to determine the antimicrobial susceptibility patterns of the isolated organisms. Methods: A cross-sectional study was conducted from January to April 2019. Hand swabs were collected from pharmacy technicians working in hospital pharmacies, community pharmacies, and over-the-counter medicine shops. Samples were cultured, and isolated bacteria were identified using standard microbiological techniques. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disc diffusion method. Results: Thirty samples were collected across the three pharmacy categories. The study identified Bacillus species, Staphylococcus species, and Enterobacter species on the hands of pharmacy technicians. Bacillus species were the most prevalent and were generally sensitive to most antibiotics tested. Staphylococcus species, however, showed resistance to multiple antibiotics. Enterobacter species demonstrated mixed susceptibility patterns. Conclusion: The study revealed significant microbial contamination on the hands of pharmacy technicians, with some isolates showing alarming antimicrobial resistance patterns. These findings emphasize the need for improved hand hygiene practices and regular antimicrobial susceptibility surveillance among pharmacy technicians to prevent the spread of potentially harmful bacteria in healthcare settings.
背景:药房技术人员在医疗保健服务中发挥着至关重要的作用,尤其是在加纳这样的发展中国家。然而,人们对他们双手的微生物污染以及这些微生物的抗菌药敏感性模式了解有限。本研究旨在调查加纳上西部地区药房技术人员手上存在的细菌,并确定分离出的微生物的抗菌药敏感性模式。研究方法于 2019 年 1 月至 4 月进行了一项横断面研究。研究人员收集了在医院药房、社区药房和非处方药店工作的药学技术人员的手拭子。对样本进行培养,并使用标准微生物学技术鉴定分离出的细菌。采用柯比-鲍尔盘扩散法进行抗菌药敏感性测试。结果在三类药房中收集了 30 个样本。研究在药房技术人员的手上发现了芽孢杆菌、葡萄球菌和肠杆菌。芽孢杆菌是最常见的菌种,通常对测试的大多数抗生素都很敏感。不过,葡萄球菌对多种抗生素表现出耐药性。肠杆菌则表现出不同的药敏模式。结论研究显示,药房技术人员的双手受到严重的微生物污染,其中一些分离物显示出令人担忧的抗菌药耐药性模式。这些发现强调了改善手部卫生习惯和定期对药房技术人员进行抗菌药敏感性监测的必要性,以防止潜在的有害细菌在医疗机构中传播。
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引用次数: 0
A Retrospective Medical Record Review on the Outcome of Enhanced Adherence Counseling among Unsuppressed HIV Clients in Benue State, Nigeria 对尼日利亚贝努埃州未接受艾滋病毒治疗的患者加强依从性咨询的结果进行回顾性病历审查
Pub Date : 2024-05-13 DOI: 10.9734/ijtdh/2024/v45i61549
Orsar Orhemba-ga Dennis, Daniel Eje Ukpabi, Victor Orih, Doofan Ortese Ayatse, Stella Ngusuur Haanongon, E. Ejimkaraonye, Gabriel Alobo, G. Anefu, Jude Zugu, Tule, Terver Zua
Background: According to the WHO estimation, up to 70 % of patients with an initial high viral load will achieve viral load suppression following an adherence intervention. In Benue State, very limited studies have been done that show viral load suppression following enhanced adherence counselling (EAC). This study assesses viral suppression after enhanced adherence counselling and its predictors among unsuppressed HIV seropositive people in the State, the time to commence EAC after the unsuppressed VL result, and to estimate the time to repeat the viral load test after EAC.Methods: This was a retrospective review of electronic medical records of all HIV-infected people with a viral load greater than 1000 copies/ml after six months on HAART as of December 2022, in Benue State. Patients with VL ≥ 1000 copies/ml were expected to receive EAC and have a repeat VL after three months of good adherence. Six months following the documented unsuppressed result, we determined: the viral load suppression rate after EAC, the time to commencement of EAC, the time to repeat the viral load test after EAC, and the predictors of viral load suppression among clients with unsuppressed viral load.Result: Of the 234,185 People Living with HIV (PLHIV) on ART between December 2022 and July 2023, up to 210, 514 (89.9%) did viral load testing and 9194 (3.9%) had VL >1000 copies/ml. Of these 9,194 unsuppressed PLHIV, EAC uptake was 90.3% (n=8,307), EAC completion rate was 62.5% (n=5,220), and viral suppression rate following EAC was 93.8% (4897/5220). PLHIV who have been on treatment for less than five years were more likely to achieve viral load suppression.Conclusion: The study demonstrated a post-EAC viral load re-suppression rate of 93.8%, indicating significant effectiveness. Nonetheless, notable deficiencies were observed in both EAC enrollment and completion. It is imperative to identify and address the underlying reasons for these gaps to fully optimize the benefits of Enhanced Adherence Counseling (EAC).
背景:根据世卫组织的估计,最初病毒载量较高的患者在接受依从性干预后,多达 70% 的病毒载量将得到抑制。在贝努埃州,显示加强依从性咨询(EAC)后病毒载量抑制的研究非常有限。本研究评估了贝努埃州未获抑制的艾滋病毒血清阳性者在接受强化依从性咨询后的病毒抑制情况及其预测因素、在未获抑制的病毒载量结果出来后开始接受强化依从性咨询的时间,以及估计在接受强化依从性咨询后重复病毒载量检测的时间:这是对贝努埃州截至 2022 年 12 月接受 HAART 治疗 6 个月后病毒载量大于 1000 copies/ml 的所有 HIV 感染者的电子病历进行的回顾性审查。病毒载量≥1000拷贝/毫升的患者预计将接受EAC治疗,并在坚持治疗三个月后再次检测病毒载量。在记录未抑制结果六个月后,我们确定了:EAC 后的病毒载量抑制率、开始 EAC 的时间、EAC 后重复病毒载量检测的时间,以及未抑制病毒载量患者的病毒载量抑制预测因素:在2022年12月至2023年7月期间接受抗逆转录病毒疗法的234 185名艾滋病病毒感染者中,有210 514人(89.9%)进行了病毒载量检测,9194人(3.9%)的病毒载量大于1000拷贝/毫升。在这9194名未被抑制的艾滋病毒感染者中,接受EAC的比例为90.3%(人数=8307),EAC完成率为62.5%(人数=5220),EAC后的病毒抑制率为93.8%(4897/5220)。接受治疗不足五年的艾滋病毒感染者更有可能实现病毒载量抑制:该研究显示,EAC 后病毒载量再抑制率为 93.8%,表明疗效显著。然而,EAC 的注册和完成情况都存在明显不足。当务之急是找出并解决造成这些不足的根本原因,以充分发挥强化依从性咨询(EAC)的效益。
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引用次数: 0
Adolescent Morbidity Pattern in Nigeria: Is the Pattern Changing? 尼日利亚青少年的发病模式:模式是否正在改变?
Pub Date : 2024-05-11 DOI: 10.9734/ijtdh/2024/v45i61548
W. Wonodi, T. Okari
Background: Adolescents make up a large and growing percentage of populations in the world, especially in the developing nations. They have peculiar health needs which are often neglected due to paucity of data from our health institutions and non-implementation of existing adolescent health policies.Objective: The aim of the study was to determine the morbidity pattern among adolescents attending the Paediatric outpatient clinic of a tertiary health facility.Methodology: This was a cross-sectional study of adolescents aged 10-17 years seen at the Paediatric Outpatient Clinic (POPC) from first of July to 31st of December 2022. Consent was obtained from parents/caregivers and assent from the adolescents. The socio-demographic data obtained from them as well as the clinical details and diagnoses made by attending physicians were recorded in the study proforma. Data was analyzed with IBM Statistical Package for the Social Sciences version 23 and data presented in tables and charts.Results: A total of 136 adolescents were enrolled in the study with a male: female ratio of 1:1.6. Most 90 (66.2%) were early adolescents, attended private secondary schools and belonged to the middle socioeconomic class. The commonest presenting complaints were body pains 24 (17.6%), convulsion 22 (16.2%) and cough 17 (12.5%). The three commonest diagnoses made were epilepsy 25(18.4%), respiratory tract infections 15 (11%), and sickle cell disease (9.6%).  Non-communicable diseases (61%) were more prevalent, but there was no statistical difference in its prevalence among their socio-demographic characteristics. Eleven (8.1%) had surgical diagnoses such as appendicitis, inguino-scrotal hernia and ganglion.Conclusion: The morbidity pattern of adolescents in the study consisted of medical and surgical diagnoses. There appears to be a shift in morbidity pattern from communicable to non-communicable diseases among adolescents in the locality and this may be put into consideration in policy formulation for adolescents.
背景:在世界人口中,青少年所占的比例很大,而且还在不断增长,尤其是在发展中国家。他们有特殊的健康需求,但由于我们的医疗机构数据匮乏以及现有的青少年健康政策未得到执行,这些需求往往被忽视:本研究旨在确定在一家三级医疗机构儿科门诊就诊的青少年的发病模式:这是一项横断面研究,研究对象为2022年7月1日至12月31日期间在儿科门诊就诊的10-17岁青少年。研究征得了家长/监护人的同意和青少年的同意。从他们那里获得的社会人口学数据以及临床详情和主治医生的诊断均记录在研究表格中。数据采用 IBM 社会科学统计软件包第 23 版进行分析,并以表格和图表的形式呈现:共有 136 名青少年参加了研究,男女比例为 1:1.6。大多数 90 名(66.2%)青少年就读于私立中学,属于中等社会经济阶层。最常见的主诉是身体疼痛 24 人(17.6%)、抽搐 22 人(16.2%)和咳嗽 17 人(12.5%)。最常见的三种诊断是癫痫 25(18.4%)、呼吸道感染 15(11%)和镰状细胞病(9.6%)。 非传染性疾病(61%)的发病率较高,但其发病率在社会人口特征方面没有统计学差异。有 11 人(8.1%)被诊断为阑尾炎、阴囊腹股沟疝和神经节等外科疾病:本研究中青少年的发病模式包括内科和外科诊断。该地区青少年的发病模式似乎正从传染病向非传染病转变,在制定青少年政策时可以考虑这一点。
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引用次数: 0
Comparative Study on Anti-Diabetic Activity of Momordica charantia and Psidium guajava 关于 Momordica charantia 和 Psidium guajava 抗糖尿病活性的比较研究
Pub Date : 2024-05-08 DOI: 10.9734/ijtdh/2024/v45i61546
Pillalamarri Madhavi, D. Niharika, B. Niharika, Marfat Ali, Saidul Islam, C. Ramya
Diabetes is a metabolic disease characterised by decreased insulin signalling and persistent hyperglycaemia. The most frequent progression of diabetes is known as diabetes mellitus which is defined as persistent hyperglycaemia brought on by either peripheral insulin resistance or impaired pancreatic β cell production of insulin. This condition is caused by the disruptions in the digestion of carbohydrates, fats and proteins which are caused by defects in the production, release and regulation of insulin. The breakdown of carbohydrates is significantly aided by the intestinal digestive enzymes α-glucosidase and α-amylase. One type of antidiabetic treatment is to lower the blood glucose levels after a meal by blocking the enzymes α-glucosidase and α-amylase. This could be a key tactic in blood glucose control. When compared to other commercial pharmaceuticals used to treat diabetes, herbal treatments are thought to be more in harmony with the human body and to have less harmful side effects. This herbal remedy is reasonably priced as well. The aim of the  current study is to compare the anti- diabetic activity of the methanolic extracts of Momordica charantia and Psidium guajava. The methods used in the determination of invitro antidiabetic activity are alpha amylase and alpha glucosidase inhibitory assays. In the current study, when compared the individual inhibition activity of Momordica charantia and Psidium guajava on the intestinal enzymes (alpha amylase and alpha glucosidase), Momordica charantia has the highest inhibition that is 79.83% at 0.8 mL concentration while the Psidium guajava has shown only 70.58% inhibition at 0.8 mL concentration. Which suggests that the presence of bio active compounds may be responsible for the plants many medicinal uses, including the treatment of diabetes.
糖尿病是一种以胰岛素信号减弱和持续高血糖为特征的代谢性疾病。糖尿病最常见的发展过程被称为糖尿病,其定义是由于外周胰岛素抵抗或胰腺β细胞胰岛素分泌受损而导致的持续性高血糖。这种病症是由于胰岛素的产生、释放和调节出现缺陷,导致碳水化合物、脂肪和蛋白质的消化紊乱而引起的。α-葡萄糖苷酶和α-淀粉酶在很大程度上有助于碳水化合物的分解。一种抗糖尿病治疗方法是通过阻断α-葡萄糖苷酶和α-淀粉酶来降低餐后血糖水平。这可能是控制血糖的关键手段。与其他用于治疗糖尿病的商业药物相比,草药疗法被认为与人体更加协调,而且副作用较小。而且这种草药价格合理。本研究的目的是比较 Momordica charantia 和 Psidium guajava 的甲醇提取物的抗糖尿病活性。测定体外抗糖尿病活性的方法是α-淀粉酶和α-葡萄糖苷酶抑制试验。在目前的研究中,当比较 Momordica charantia 和 Psidium guajava 对肠道酶(α-淀粉酶和α-葡萄糖苷酶)的单独抑制活性时,Momordica charantia 在 0.8 mL 浓度下的抑制率最高,为 79.83%,而 Psidium guajava 在 0.8 mL 浓度下的抑制率仅为 70.58%。这表明生物活性化合物的存在可能是该植物具有多种药用价值的原因,包括治疗糖尿病。
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引用次数: 0
Assessment of Production and Risks of Consumption of Artisanal Refreshing Drinks (Bissap, Gnamankoudji) in Haut Sassandra (Daloa-Côte d'Ivoire) 上萨桑德拉(达洛亚-科特迪瓦)手工提神饮料(Bissap、Gnamankoudji)的生产和消费风险评估
Pub Date : 2024-05-08 DOI: 10.9734/ijtdh/2024/v45i61547
K. Christelle, K. Clément, Kouassi Kra Athanase, Konaté Ibrahim
Introduction: The production and consumption of artisanal refreshing drinks (Bissap, Gnamankoudji) in the Haut Sassandra region are anchored in local culture. These artisanal drinks are experiencing considerable growth despite their artisanal and unstable production.Objective: The objective of this study is to diagnose the production of these artisanal drinks and to assess the potential risks associated with their consumption in the Haut Sassandra region.Methodology: A cross-sectional and retrospective survey was carried out with producers to make the diagnosis and with consumers to identify some main conditions linked to the consumption of these drinks. 52 producers were investigated, and 780 consumers were submitted to a questionnaire, for a total of 832 people audited.Results: Bissap and Gnamankoudji have many similar unit operations. In addition, Bissap undergoes heat treatment. The drinks are mostly packaged in used pots. The main conditions encountered were diarrhea (8.3% and 8.7%), belly bloating (2.4% and 2.8%), fever (1.80% and 2.30%), nausea (1.80% and 1.90%), vomiting (0.90% and 1%) respectively after consumption of Gnamankoudji and Bissap.Conclusion: The study collected data on the production of artisanal drinks and the risks incurred by consumers. The consumption of these drinks represents a major risk for public health.
简介上萨桑德拉地区的手工清凉饮料(Bissap、Gnamankoudji)的生产和消费是当地文化的根基。尽管这些手工饮料的生产具有手工性和不稳定性,但它们正在经历着可观的增长:本研究的目的是诊断这些手工饮料的生产情况,并评估上萨桑德拉地区饮用这些饮料的潜在风险:方法:对生产者进行了横向和回顾性调查,以进行诊断;对消费者进行了横向和回顾性调查,以确定与饮用这些饮料有关的一些主要情况。对 52 家生产商进行了调查,对 780 名消费者进行了问卷调查,共调查了 832 人:结果:Bissap 和 Gnamankoudji 有许多相似的生产单位。此外,Bissap 还经过热处理。饮料大多用旧锅包装。食用 Gnamankoudji 和 Bissap 后出现的主要情况分别是腹泻(8.3% 和 8.7%)、腹胀(2.4% 和 2.8%)、发烧(1.80% 和 2.30%)、恶心(1.80% 和 1.90%)、呕吐(0.90% 和 1%):研究收集了有关手工饮料生产和消费者风险的数据。饮用这些饮料对公众健康构成重大风险。
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引用次数: 0
Umbilical Cord Care Knowledge and Practice among Caregivers in Yenagoa, Bayelsa State, Nigeria 尼日利亚巴耶尔萨州耶纳戈阿市护理人员的脐带护理知识与实践
Pub Date : 2024-03-07 DOI: 10.9734/ijtdh/2024/v45i41524
Chinelo Juliana Ozigbo, Okemena Esther Onotume
Aim: To assess the knowledge and practice of current cord care recommendations among care givers in Yenagoa, and to identify gaps to be addressed to prevent neonatal sepsis. Study Design: This was a descriptive cross-sectional study. Place and Duration of Study:  The study was carried out at the well-child clinics (WCC) of 3 major healthcare facilities in Yenagoa namely, Agudama Primary Health Centre, Yenizue-gene Comprehensive Health Centre, and Diete Koki Memorial Hospital, from August to September 2023. Methodology: The study was conducted among 285 caregivers in the study sites. Data on cord care knowledge and practices was collected using self-administered structured questionnaires administered proportionately across the study sites. Data was analysed using the Statistical Package for Social Sciences (SPSS) version 23, from which descriptive statistics were generated. All necessary ethical considerations were upheld. Results: In this study, 268 (97.1%) of the respondents had antenatal care, over 77% delivered in healthcare facilities, 252 (88.4%) indicated that they knew how to properly care for their children’s cord and 244 (85.6%) had been taught cord care. While 269 (94.4%) respondents were aware of the use of methylated spirit for cord care, only 96 (33.8%) were aware of the use of chlorhexidine gel. Good umbilical cord care knowledge score of 51.6% was obtained while good umbilical cord care practice score was 32.7%. Conclusion and Recommendation: Modest umbilical cord care knowledge gap and huge practice gap were found in this study. The knowledge gaps were mainly with the use of chlorhexidine gel, dry cord care, and application of substances to the cord, and these reflected remarkably in their practice. There is urgent need for improvement in umbilical cord care knowledge and practice among caregivers, a review of cord care knowledge of frontline health educators and the contents of their cord care education.
目的:评估耶纳戈阿市护理人员对当前脐带护理建议的了解和实践情况,并找出预防新生儿败血症需要解决的问题。研究设计:这是一项描述性横断面研究。研究地点和时间: 研究于 2023 年 8 月至 9 月在叶纳戈阿市的 3 家主要医疗机构,即 Agudama 初级保健中心、Yenizue-ene 综合保健中心和 Diete Koki 纪念医院的健康儿童诊所 (WCC) 进行。研究方法:研究对象为研究地点的 285 名护理人员。通过在研究地点按比例发放自填式结构问卷,收集有关脐带护理知识和实践的数据。数据使用社会科学统计软件包(SPSS)第 23 版进行分析,并从中生成描述性统计数据。所有必要的伦理考虑均得到了遵守。结果在这项研究中,268 名受访者(97.1%)接受过产前护理,77% 以上在医疗机构分娩,252 名受访者(88.4%)表示知道如何正确护理孩子的脐带,244 名受访者(85.6%)接受过脐带护理教育。有 269 名(94.4%)受访者知道使用甲酸灵护理脐带,但只有 96 名(33.8%)受访者知道使用洗必泰凝胶。脐带护理知识良好率为 51.6%,脐带护理实践良好率为 32.7%。结论和建议:本研究发现脐带护理知识差距不大,实践差距很大。知识差距主要体现在氯己定凝胶的使用、干脐带护理和在脐带上涂抹物质等方面,而这些都明显反映在他们的实践中。因此,迫切需要提高护理人员的脐带护理知识和实践水平,并对一线健康教育工作者的脐带护理知识和脐带护理教育内容进行审查。
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引用次数: 0
Prevalence of Malaria and Helminth Infections and Their Link to Knowledge on Preventive Strategies among Asymptomatic Pupils in Rural-urban Cameroon 喀麦隆城乡无症状学生中疟疾和螺旋体感染流行率及其与预防策略知识的联系
Pub Date : 2024-02-20 DOI: 10.9734/ijtdh/2024/v45i31519
J. Ebogo-Belobo, Rodrigue Roman Dongang-Nana, Lucie Josiane Ojong, E. Ndzi, Nathalie Amvongo-Adjia, L. Ngum, G. Kame-Ngasse, Ngwene Hycentha Diengou, E. Atembeh-Noura, Ousmanou Djabidatou, Salioh Mbuh, Valerie Makoge
Aim: The aim of our study was to investigate the prevalence of malaria and helminth infection among asymptomatic primary school children in rural and urban Yaoundé-Cameroon, to assess pupils’ knowledge about malaria and STH infection, and to evaluate the association between this knowledge and actual disease prevalence. Study Design: This study was a cross-sectional and was carried out between October 2019 and December 2019 in six primary schools in the Centre region of Cameroon. Methodology:Pupils in classes 3 to six were recruited for the study. Blood and stool samples were collected and analysed to determine pupils’ disease prevalence. Questionnaires following the KAP and health belief model frameworks were administered to evaluate pupils’ health literacy in malaria and helminths. Results: 457 pupils from rural and urban zones participated in this study. 245 (53.6 %) were female and 212 (46.4 %) were male. The prevalence of anaemia was higher in urban than rural zones. Total malaria prevalence was 17.7%. Malaria parasitaemia prevalence classified according to settings revealed rural zones at 28.6% and urban zones at 13.9%. STH infection showed a total prevalence of 4.8% and 7.9% and 3.7% in rural and urban zones respectively. The prevalence of co-infection was 1.2%. Health-literacy gaps in malaria and helminths were identified. Schooling in rural settings and being older were predictors for having a good knowledge of the diseases. However, having good knowledge was not significantly associated to actual malaria parasitaemia or STH prevalence. Conclusion: Insights from this study are essential for the implementation of successful, sustainable and targeted health-promotion strategies to improve the health and well-being of pupils.
研究目的:我们的研究旨在调查喀麦隆雅温得城乡地区无症状小学生中疟疾和蠕虫感染的发病率,评估小学生对疟疾和 STH 感染的了解程度,并评估这些知识与实际发病率之间的联系。研究设计:本研究为横断面研究,于2019年10月至2019年12月期间在喀麦隆中部地区的六所小学进行。研究方法:研究招募了三至六年级的学生。收集并分析血液和粪便样本,以确定小学生的患病率。按照 KAP 和健康信念模式框架进行问卷调查,以评估学生对疟疾和螺旋体的健康知识了解程度。结果:来自农村和城市地区的 457 名学生参加了此次研究。其中 245 名(53.6%)为女性,212 名(46.4%)为男性。城市地区的贫血患病率高于农村地区。疟疾总发病率为 17.7%。根据环境分类的疟疾寄生虫感染率显示,农村地区为 28.6%,城市地区为 13.9%。性传播疾病的总感染率为 4.8%,农村地区为 7.9%,城市地区为 3.7%。合并感染率为 1.2%。疟疾和螺旋体疾病方面的卫生知识差距已经确定。在农村地区上学和年龄较大是对疾病有较好了解的预测因素。然而,良好的知识水平与实际疟疾寄生虫血症或 STH 感染率并无明显关联。结论:这项研究的启示对于实施成功、可持续和有针对性的健康促进战略以改善学生的健康和福祉至关重要。
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引用次数: 0
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International Journal of TROPICAL DISEASE & Health
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