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Quasi-convex subsets in Alexandrov spaces with lower curvature bound 下曲率界Alexandrov空间中的拟凸子集
3区 数学 Q2 MATHEMATICS Pub Date : 2020-05-30 DOI: 10.1007/s11464-021-0955-0
Xiaole Su, Hongwei Sun, Yusheng Wang
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引用次数: 0
The Optimal Global Estimates and Boundary Behavior for Large Solutions to the k-Hessian Equation k-Hessian方程大解的最优全局估计和边界行为
3区 数学 Q2 MATHEMATICS Pub Date : 2020-04-27 DOI: 10.1007/s11464-020-0045-8
Haitao Wan, Yong-Guo Shi
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引用次数: 0
Quality improvements of safety-netting guidelines for cancer in UK primary care: insights from a qualitative interview study of GPs. 英国初级医疗癌症安全网指南的质量改进:全科医生定性访谈研究的启示。
IF 5.9 3区 数学 Q2 MATHEMATICS Pub Date : 2019-11-28 Print Date: 2019-12-01 DOI: 10.3399/bjgp19X706565
Alice Tompson, Brian D Nicholson, Sue Ziebland, Julie Evans, Clare Bankhead

Background: Safety netting is a diagnostic strategy that involves monitoring patients with symptoms possibly indicative of serious illness, such as cancer, until they are resolved. Optimising safety-netting practice in primary care has been proposed to improve quality of care and clinical outcomes. Introducing guidelines is a potential means to achieve this.

Aim: To seek the insight of frontline GPs regarding proposed safety-netting guidelines for suspected cancer in UK primary care.

Design and setting: A qualitative interview study with 25 GPs practising in Oxfordshire, UK.

Method: Transcripts from semi-structured interviews were analysed thematically by a multidisciplinary research team using a mind-mapping approach.

Results: GPs were supportive of initiatives to optimise safety netting. Guidelines on establishing who has responsibility for follow-up, keeping patient details up to date, and ensuring test result review is conducted by someone with knowledge of cancer guidelines were already being followed. Sharing diagnostic uncertainty and ensuring an up-to-date understanding of guidelines were only partially implemented. Neither informing patients of all (including negative) test results nor ensuring recurrent unexplained symptoms are always flagged and referred were considered feasible. The lack of detail, for example, the expected duration of symptoms, caused some concern. Overall, doubts were expressed about the feasibility of the guidelines given the time, recruitment, and resource challenges faced in UK primary care.

Conclusion: GPs expressed general support for safety netting, yet were unconvinced that key elements of the guidelines were feasible, especially in the context of pressures on general practice staffing and time.

背景:安全网疗法是一种诊断策略,即对有可能表明患有癌症等严重疾病症状的患者进行监测,直到症状得到缓解。有人提出,优化初级医疗中的安全网做法可提高医疗质量和临床效果。目的:了解一线全科医生对英国初级医疗中疑似癌症安全网指南建议的看法:对英国牛津郡的25名全科医生进行定性访谈研究:方法:由一个多学科研究小组采用思维导图法对半结构化访谈记录进行专题分析:结果:全科医生支持优化安全网的举措。全科医生已经开始遵守关于确定随访责任人、及时更新患者详细信息以及确保由了解癌症指南的人员进行检查结果复核的指导方针。分享诊断的不确定性和确保对指南的最新了解只得到了部分执行。无论是告知患者所有(包括阴性)检查结果,还是确保反复出现的不明原因症状始终被标记并转诊,都被认为是不可行的。缺乏细节,例如症状的预期持续时间,引起了一些担忧。总体而言,鉴于英国初级医疗面临时间、招聘和资源方面的挑战,人们对指南的可行性表示怀疑:全科医生对安全网疗法普遍表示支持,但不认为指南的关键要素是可行的,尤其是在全科医生人手和时间压力较大的情况下。
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引用次数: 0
Optimal global regularity for minimal graphs over convex domains in hyperbolic space 双曲空间凸域上极小图的最优全局正则性
3区 数学 Q2 MATHEMATICS Pub Date : 2019-08-18 DOI: 10.1007/s11464-021-0963-0
You Li, Yan-nan Liu
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引用次数: 0
Finite Generation and Holomorphic Anomaly Equation for Equivariant Gromov—Witten Invariants of $${K_{{mathbb{P}^1} times {mathbb{P}^1}}}$$ 的等变Gromov-Witten不变量的有限生成与全纯异常方程 $${K_{{mathbb{P}^1} times {mathbb{P}^1}}}$$
3区 数学 Q2 MATHEMATICS Pub Date : 2019-08-10 DOI: 10.1007/s11464-021-0225-1
Xin Wang
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引用次数: 2
Conformal biderivations of loop W(a, b) Lie conformal algebra 环W(a, b)的共形推导
3区 数学 Q2 MATHEMATICS Pub Date : 2019-03-27 DOI: 10.1007/s11464-021-0965-y
Jun Zhao, Liangyun Chen, Lamei Yuan
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引用次数: 2
Approximation of Beta-Jacobi Ensembles by Beta-Laguerre Ensembles β -雅可比系综与β -拉盖尔系综的近似
3区 数学 Q2 MATHEMATICS Pub Date : 2018-07-10 DOI: 10.1007/s11464-020-0018-y
Yutao Ma, Xinmei Shen
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引用次数: 2
A nonparametric regression method for multiple longitudinal phenotypes using multivariate adaptive splines. 利用多变量自适应样条对多重纵向表型进行非参数回归的方法。
3区 数学 Q2 MATHEMATICS Pub Date : 2013-06-01 DOI: 10.1007/s11464-012-0256-8
Wensheng Zhu, Heping Zhang

In genetic studies of complex diseases, particularly mental illnesses, and behavior disorders, two distinct characteristics have emerged in some data sets. First, genetic data sets are collected with a large number of phenotypes that are potentially related to the complex disease under study. Second, each phenotype is collected from the same subject repeatedly over time. In this study, we present a nonparametric regression approach to study multivariate and time-repeated phenotypes together by using the technique of the multivariate adaptive regression splines for analysis of longitudinal data (MASAL), which makes it possible to identify genes, gene-gene and gene-environment, including time, interactions associated with the phenotypes of interest. Furthermore, we propose a permutation test to assess the associations between the phenotypes and selected markers. Through simulation, we demonstrate that our proposed approach has advantages over the existing methods that examine each longitudinal phenotype separately or analyze the summarized values of phenotypes by compressing them into one-time-point phenotypes. Application of the proposed method to the Framingham Heart Study illustrates that the use of multivariate longitudinal phenotypes enhanced the significance of the association test.

在复杂疾病,尤其是精神疾病和行为障碍的基因研究中,一些数据集出现了两个明显的特征。首先,基因数据集收集了大量可能与所研究的复杂疾病有关的表型。其次,每种表型都是在一段时间内从同一受试者身上重复采集的。在本研究中,我们提出了一种非参数回归方法,通过使用用于纵向数据分析的多变量自适应回归样条(MASAL)技术,将多变量和时间重复表型结合在一起进行研究,从而有可能确定与相关表型相关的基因、基因-基因和基因-环境(包括时间)之间的相互作用。此外,我们还提出了一种 permutation 检验方法,用于评估表型与所选标记之间的关联。通过模拟,我们证明了我们提出的方法比现有的方法更有优势,现有的方法是将每个纵向表型分开研究,或将表型的汇总值压缩成一个时间点表型进行分析。将提出的方法应用于弗雷明汉心脏研究表明,使用多变量纵向表型提高了关联检验的显著性。
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引用次数: 0
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Frontiers of Mathematics in China
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