Ziyang Pan, Jawaher Alharthi, A. Bayoumi, Jacob George, M. Eslam
{"title":"A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on Immune Cells","authors":"Ziyang Pan, Jawaher Alharthi, A. Bayoumi, Jacob George, M. Eslam","doi":"10.31083/j.fbl2904148","DOIUrl":"https://doi.org/10.31083/j.fbl2904148","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140715476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao
Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes. As the principal substrate and cofactor engaged in diverse metabolic reactions, CoA and its derivatives exert central influence over various physiological processes, primarily modulating lipid and ketone metabolism, as well as protein modification. This paper presents a comprehensive review of the molecular mechanisms by which CoA influences the onset and progression of cancer, cardiovascular disease (CVD), neurodegenerative disorders, and other illnesses. The main focal points include the following. (1) In cancer, enzymes such as acetyl-CoA synthetase 2, ATP citrate lyase, and acetyl-CoA carboxylase regulate lipid synthesis and energy metabolism by modulating acetyl-CoA levels. (2) In CVD, the effects of enzymes such as stearoyl-CoA desaturase-1, 3-hydroxy-3-methylglutaryl-CoA (HMGC) synthase 2, and HMGC reductase on the formation and advancement of these diseases are elucidated by their regulation of CoA metabolism across multiple organs. (3) In neurodegenerative disorders, the significance of CoA in maintaining cholesterol homeostasis in the brain and its implications on the development of such disorders are thoroughly discussed. The metabolic processes involving CoA and its derivatives span all physiological aspects within cells, playing a critical role in the onset and progression of various diseases. Elucidating the role of CoA in these conditions yields important insights that can serve as valuable references and guidance for disease diagnosis, treatment, and drug development.
辅酶 A（CoA）是细胞内酰基的重要载体，在调节酰基转移反应和参与细胞代谢过程中发挥着重要作用。作为参与各种代谢反应的主要底物和辅助因子，CoA 及其衍生物对各种生理过程具有核心影响，主要调节脂质和酮体代谢以及蛋白质修饰。本文全面综述了 CoA 影响癌症、心血管疾病（CVD）、神经退行性疾病和其他疾病的发生和发展的分子机制。主要焦点包括以下几点。(1）在癌症中，乙酰-CoA 合成酶 2、ATP 柠檬酸裂解酶和乙酰-CoA 羧化酶等酶通过调节乙酰-CoA 水平来调节脂质合成和能量代谢。(2）在心血管疾病中，硬脂酰-CoA 去饱和酶-1、3-羟基-3-甲基戊二酰-CoA（HMGC）合成酶 2 和 HMGC 还原酶等酶通过调节多个器官的 CoA 代谢，对这些疾病的形成和发展产生影响。(3）在神经退行性疾病中，CoA 在维持大脑胆固醇平衡中的重要作用及其对此类疾病发展的影响得到了深入探讨。涉及 CoA 及其衍生物的代谢过程横跨细胞内的所有生理环节，在各种疾病的发生和发展过程中起着至关重要的作用。阐明 CoA 在这些病症中的作用可以获得重要的见解，为疾病诊断、治疗和药物开发提供有价值的参考和指导。
{"title":"The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases","authors":"Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao","doi":"10.31083/j.fbl2904143","DOIUrl":"https://doi.org/10.31083/j.fbl2904143","url":null,"abstract":"Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes. As the principal substrate and cofactor engaged in diverse metabolic reactions, CoA and its derivatives exert central influence over various physiological processes, primarily modulating lipid and ketone metabolism, as well as protein modification. This paper presents a comprehensive review of the molecular mechanisms by which CoA influences the onset and progression of cancer, cardiovascular disease (CVD), neurodegenerative disorders, and other illnesses. The main focal points include the following. (1) In cancer, enzymes such as acetyl-CoA synthetase 2, ATP citrate lyase, and acetyl-CoA carboxylase regulate lipid synthesis and energy metabolism by modulating acetyl-CoA levels. (2) In CVD, the effects of enzymes such as stearoyl-CoA desaturase-1, 3-hydroxy-3-methylglutaryl-CoA (HMGC) synthase 2, and HMGC reductase on the formation and advancement of these diseases are elucidated by their regulation of CoA metabolism across multiple organs. (3) In neurodegenerative disorders, the significance of CoA in maintaining cholesterol homeostasis in the brain and its implications on the development of such disorders are thoroughly discussed. The metabolic processes involving CoA and its derivatives span all physiological aspects within cells, playing a critical role in the onset and progression of various diseases. Elucidating the role of CoA in these conditions yields important insights that can serve as valuable references and guidance for disease diagnosis, treatment, and drug development.","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140724697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Theodora M Stougiannou, Konstantinos C. Christodoulou, T. Koufakis, F. Mitropoulos, Dimitrios Mikroulis, Cyril David Mazer, Dimos Karangelis
{"title":"Progenitor Cell Function and Cardiovascular Remodelling Induced by SGLT2 Inhibitors","authors":"Theodora M Stougiannou, Konstantinos C. Christodoulou, T. Koufakis, F. Mitropoulos, Dimitrios Mikroulis, Cyril David Mazer, Dimos Karangelis","doi":"10.31083/j.fbl2904145","DOIUrl":"https://doi.org/10.31083/j.fbl2904145","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140722007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. R. Ahmad, Md. Zeyaullah, Abdullah M. AlShahrani, Adam Dawria, Haroon Ali, Ali Mohieldin, Abdelrhman AG Altijani, Ufaq Razi, Munzila Mehdi, Sabika Akram, Ejaz Rizvi Hussain
{"title":"Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders","authors":"S. R. Ahmad, Md. Zeyaullah, Abdullah M. AlShahrani, Adam Dawria, Haroon Ali, Ali Mohieldin, Abdelrhman AG Altijani, Ufaq Razi, Munzila Mehdi, Sabika Akram, Ejaz Rizvi Hussain","doi":"10.31083/j.fbl2904142","DOIUrl":"https://doi.org/10.31083/j.fbl2904142","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nan Wei, Xuan Wu, Yi Yu, Huanhuan Zhou, Kai Cui, Xingru Zhao, Xiaoju Zhang
{"title":"CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via PI3K/Akt Signaling Pathway","authors":"Nan Wei, Xuan Wu, Yi Yu, Huanhuan Zhou, Kai Cui, Xingru Zhao, Xiaoju Zhang","doi":"10.31083/j.fbl2904140","DOIUrl":"https://doi.org/10.31083/j.fbl2904140","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140731772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maolin Tang, Shisheng Zhao, Ling Ren, Qianqian Li, Li Li, Chaoli Wang, Chunmei Meng, Yuling Chen, Weimin Hu
Background : Mounting evidence indicates that complement components play a crucial role in cancer progression. Recent findings indicate that certain complement components display a significant rise in expression within esophageal squamous cell carcinoma (ESCC). However, the specific tumorigenic functions of these components remain unclear. This study focuses on investigating the expression pattern of C1r, elucidating a role for C1r in ESCC, as well as exploring underlying mechanisms controlled by C1r. Methods : The expression of C1r in ESCC tissues, malignant epithelial cells, and its relationship with survival were analyzed using the Gene Expression Omnibus (GEO) database and tissue microarrays. Single-cell RNA sequencing (scRNA-seq) was used to study the expression of C1r in malignant epithelial cells. C1r knockdown or C1r overexpression in cultured ESCC cells were used to assess the effects of C1r on proliferation, migration, invasion, cell-matrix adhesion, apoptosis, and growth of xenografted tumors in immunocompromised (nude) mice. Western blotting was used to detect the expression of MMP-1 and MMP-10 in C1r knockdown or C1r overexpressing ESCC cells. Results : C1r was highly expressed in ESCC tissues, malignant epithelial cells, and cultured ESCC cell lines. High C1r expression indicated a poor prognosis. Knockdown of C1r significantly suppressed the proliferation, migration, invasion, cell-matrix adhesion, and promoted apoptosis in cultured ESCC cells. Additionally, knockdown of C1r markedly inhibited tumor growth in nude mice. Overexpression of C1r had the opposite effects. C1r induced the expression of MMP-1 and MMP-10. Conclusions : C1r is highly expressed in ESCC and promotes the progression of this tumor type. Our findings suggest that C1r may serve as a novel prognostic biomarker and therapeutic target in ESCC.
{"title":"Tumor Cell-Derived Complement Component C1r Acts as a Prognostic Biomarker and Promotes Esophageal Squamous Cell Carcinoma Progression","authors":"Maolin Tang, Shisheng Zhao, Ling Ren, Qianqian Li, Li Li, Chaoli Wang, Chunmei Meng, Yuling Chen, Weimin Hu","doi":"10.31083/j.fbl2904138","DOIUrl":"https://doi.org/10.31083/j.fbl2904138","url":null,"abstract":"Background : Mounting evidence indicates that complement components play a crucial role in cancer progression. Recent findings indicate that certain complement components display a significant rise in expression within esophageal squamous cell carcinoma (ESCC). However, the specific tumorigenic functions of these components remain unclear. This study focuses on investigating the expression pattern of C1r, elucidating a role for C1r in ESCC, as well as exploring underlying mechanisms controlled by C1r. Methods : The expression of C1r in ESCC tissues, malignant epithelial cells, and its relationship with survival were analyzed using the Gene Expression Omnibus (GEO) database and tissue microarrays. Single-cell RNA sequencing (scRNA-seq) was used to study the expression of C1r in malignant epithelial cells. C1r knockdown or C1r overexpression in cultured ESCC cells were used to assess the effects of C1r on proliferation, migration, invasion, cell-matrix adhesion, apoptosis, and growth of xenografted tumors in immunocompromised (nude) mice. Western blotting was used to detect the expression of MMP-1 and MMP-10 in C1r knockdown or C1r overexpressing ESCC cells. Results : C1r was highly expressed in ESCC tissues, malignant epithelial cells, and cultured ESCC cell lines. High C1r expression indicated a poor prognosis. Knockdown of C1r significantly suppressed the proliferation, migration, invasion, cell-matrix adhesion, and promoted apoptosis in cultured ESCC cells. Additionally, knockdown of C1r markedly inhibited tumor growth in nude mice. Overexpression of C1r had the opposite effects. C1r induced the expression of MMP-1 and MMP-10. Conclusions : C1r is highly expressed in ESCC and promotes the progression of this tumor type. Our findings suggest that C1r may serve as a novel prognostic biomarker and therapeutic target in ESCC.","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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