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The Role of the Massage Method with Deep Breathing Relaxation in Reducing the Intensity of Labor Pain: A Randomized Clinical Trial at Mukomuko Regional General Hospital, Indonesia 深呼吸放松按摩法在减轻分娩疼痛强度中的作用:印度尼西亚 Mukomuko 地区综合医院的随机临床试验
Pub Date : 2024-07-16 DOI: 10.37275/amcr.v5i3.603
Sulastri, Kartika Murya Nigrum
Labor pain is a significant concern for expectant mothers, often leading to anxiety and potential complications. Non-pharmacological interventions like massage and deep breathing relaxation (DBR) have gained attention as safe and effective pain management options. This randomized clinical trial aimed to investigate the efficacy of combining massage and DBR in reducing labor pain intensity at Mukomuko Regional General Hospital, Indonesia. A randomized controlled trial was conducted with 100 pregnant women experiencing labor pain. Participants were randomly assigned to either the intervention group (massage + DBR) or the control group (standard care). Pain intensity was assessed using the Visual Analog Scale (VAS) before and after the intervention. Data were analyzed using appropriate statistical tests. The intervention group demonstrated a significantly greater reduction in VAS scores compared to the control group (p < 0.05). Participants in the intervention group reported higher satisfaction with pain management and a more positive childbirth experience. In conclusion, the combination of massage and DBR is a safe and effective non-pharmacological intervention for reducing labor pain intensity. This approach can be easily integrated into standard care practices, offering a valuable tool for improving maternal comfort and well-being during childbirth.
分娩疼痛是准妈妈们最关心的问题,往往会导致焦虑和潜在的并发症。按摩和深呼吸放松(DBR)等非药物干预措施作为安全有效的疼痛治疗方法已受到关注。这项随机临床试验旨在研究在印度尼西亚 Mukomuko 地区综合医院将按摩和深呼吸放松相结合对降低分娩疼痛强度的效果。这项随机对照试验由 100 名经历过分娩疼痛的孕妇参加。参与者被随机分配到干预组(按摩+DBR)或对照组(标准护理)。在干预前后使用视觉模拟量表(VAS)对疼痛强度进行评估。采用适当的统计检验对数据进行分析。与对照组相比,干预组的 VAS 评分明显降低(P < 0.05)。干预组的参与者对疼痛控制的满意度更高,分娩体验更积极。总之,将按摩和 DBR 结合使用是一种安全有效的非药物干预方法,可降低分娩疼痛强度。这种方法可以很容易地融入到标准护理实践中,为提高产妇在分娩过程中的舒适度和幸福感提供了一种有价值的工具。
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引用次数: 0
The Effectiveness of Relaxation Meditation on Anxiety in Third Trimester Pregnant Women at Embung Fatimah Regional Hospital Batam, Indonesia: A Randomized Controlled Trial 放松冥想对印度尼西亚巴淡岛 Embung Fatimah 地区医院怀孕三个月孕妇焦虑症的疗效:随机对照试验
Pub Date : 2024-07-11 DOI: 10.37275/amcr.v5i3.602
Gusmadewi, Sunesni, Elwitri Silvia, Marlena
Anxiety during the third trimester of pregnancy can negatively impact both maternal and fetal well-being. Relaxation meditation has shown promise as a non-pharmacological intervention for anxiety reduction. This study aimed to evaluate the effectiveness of a structured relaxation meditation program on anxiety levels in third-trimester pregnant women at Embung Fatimah Regional Hospital Batam, Indonesia. A randomized controlled trial was conducted with 60 third-trimester pregnant women. Participants were randomly assigned to either an intervention group (n=30), receiving a six-week relaxation meditation program, or a control group (n=30) receiving standard prenatal care. Anxiety levels were assessed using the State-Trait Anxiety Inventory (STAI) at baseline, after the intervention (week 6), and at a four-week follow-up. Significant reductions in both state and trait anxiety scores were observed in the intervention group compared to the control group at week 6 (p<0.001) and at the four-week follow-up (p<0.01). No adverse events were reported in either group. Relaxation meditation is an effective and safe intervention for reducing anxiety in third-trimester pregnant women. This study supports the integration of relaxation meditation into routine prenatal care at Embung Fatimah Regional Hospital Batam and potentially other healthcare settings.
怀孕三个月期间的焦虑会对孕妇和胎儿的健康产生负面影响。放松冥想作为一种非药物干预措施,有望减轻焦虑。本研究旨在评估印度尼西亚巴淡岛恩榜-法蒂玛地区医院(Embung Fatimah Regional Hospital Batam)开展的结构化放松冥想项目对怀孕三个月孕妇焦虑水平的影响。研究人员对 60 名怀孕三个月的孕妇进行了随机对照试验。参与者被随机分配到干预组(30 人),接受为期六周的放松冥想课程,或对照组(30 人),接受标准产前护理。分别在基线、干预后(第 6 周)和为期四周的随访中使用状态-特质焦虑量表(STAI)对焦虑水平进行评估。与对照组相比,干预组在第 6 周(P<0.001)和四周随访(P<0.01)时的状态和特质焦虑得分均有显著下降。两组均未出现不良反应。放松冥想是一种有效且安全的干预方法,可减轻怀孕三周孕妇的焦虑。这项研究支持将放松冥想纳入巴淡岛安邦法蒂玛地区医院的常规产前护理中,也可能纳入其他医疗机构的产前护理中。
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引用次数: 0
Risk Factor Analysis of Maternal Compliance in Polio Immunization for Toddlers: An Observational Study in Padang Pariaman, Indonesia 幼儿脊髓灰质炎免疫接种中母亲依从性的风险因素分析:印度尼西亚巴东帕里亚曼的观察研究
Pub Date : 2024-07-10 DOI: 10.37275/amcr.v5i3.601
Dina Ayuning Tyas, Ira Maulina Sa’danoer, Meli Sundari
Polio remains a significant global health concern, with maternal compliance in immunization programs playing a crucial role in eradication efforts. This study aimed to identify risk factors associated with maternal compliance with polio immunization for toddlers in Padang Pariaman, Indonesia. A cross-sectional observational study was conducted among 350 mothers of toddlers (12-23 months) in Padang Pariaman. Data were collected using a structured questionnaire, including socio-demographic characteristics, knowledge and attitudes towards immunization, access to healthcare services, and perceived barriers. Compliance was assessed based on immunization card records and maternal recall. Multivariable logistic regression analysis was employed to identify independent risk factors. The overall compliance rate for polio immunization was 78.3%. Factors significantly associated with non-compliance included lower maternal education level (OR=3.12; 95% CI: 1.85-5.27), lack of knowledge about polio and its immunization (OR=2.65; 95% CI: 1.56-4.49), residing in rural areas (OR=2.08; 95% CI: 1.23-3.51), and perceived barriers to immunization (OR=4.78; 95% CI: 2.85-7.99). Several modifiable risk factors for non-compliance with polio immunization were identified. Targeted interventions addressing maternal education, knowledge enhancement, access to healthcare, and addressing perceived barriers could significantly improve polio immunization coverage in Padang Pariaman and similar settings.
小儿麻痹症仍然是全球关注的一个重大健康问题,在根除小儿麻痹症的工作中,孕产妇对免疫接种计划的依从性起着至关重要的作用。本研究旨在确定与印度尼西亚巴东帕里亚曼(Padang Pariaman)幼儿脊髓灰质炎免疫接种的产妇依从性相关的风险因素。研究对巴东帕里亚曼地区 350 名幼儿(12-23 个月)的母亲进行了横断面观察研究。研究采用结构式问卷收集数据,包括社会人口特征、对免疫接种的认识和态度、获得医疗保健服务的途径以及感知到的障碍。根据免疫接种卡记录和产妇回忆,对依从性进行了评估。采用多变量逻辑回归分析来确定独立的风险因素。脊髓灰质炎免疫接种的总体依从率为 78.3%。与未依从性明显相关的因素包括:孕产妇教育水平较低(OR=3.12;95% CI:1.85-5.27)、缺乏脊髓灰质炎及其免疫接种知识(OR=2.65;95% CI:1.56-4.49)、居住在农村地区(OR=2.08;95% CI:1.23-3.51)以及认为存在免疫接种障碍(OR=4.78;95% CI:2.85-7.99)。研究发现了几个可改变不遵守脊髓灰质炎免疫接种的风险因素。针对孕产妇教育、增强知识、获得医疗保健服务以及消除认知障碍等问题采取有针对性的干预措施,可显著提高巴东帕里亚曼及类似地区的脊髓灰质炎免疫接种覆盖率。
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引用次数: 0
Prothrombin Complex Concentrate as a Key Adjunct in Massive Hemorrhage Management in Placenta Accreta Spectrum Disorder: A Case Report 凝血酶原复合物浓缩物是胎盘早剥综合征大出血处理的重要辅助手段:病例报告
Pub Date : 2024-07-09 DOI: 10.37275/amcr.v5i3.599
Putu Bagus, G. Pramana, Tjokorda Gde, Agung Senapathi, Pontisomaya Parami, Tjahya Aryasa, Putu Bagus Gin, G. Pramana
Placenta accreta spectrum disorder (PASD) is a severe obstetric complication associated with significant hemorrhage risk. This report highlights the successful use of prothrombin complex concentrate (PCC) as part of a multidisciplinary approach to managing a case of massive hemorrhage in PASD. A 36-year-old woman, G3P2002, at 33 weeks gestation, diagnosed with placenta previa totalis and suspected PASD, underwent a planned cesarean hysterectomy. The surgery was complicated by 5200 mL hemorrhage due to placental invasion and bladder injury. Hemodynamic instability was managed with massive transfusion protocol activation, including PCC, tranexamic acid, and packed red blood cells. Intra-abdominal packing was performed for hemostasis, and the bladder injury was repaired. Continued PCC administration in the ICU, along with other supportive measures, resulted in hemorrhage control and stabilization. The patient was successfully extubated and discharged after a second surgery to remove packing. This case emphasizes the vital role of PCC in the multidisciplinary management of massive hemorrhage in PASD. Early recognition of PASD risk factors and prompt intervention, including PCC administration, are crucial for optimal maternal outcomes.
胎盘早剥谱系障碍(PASD)是一种严重的产科并发症,具有极大的出血风险。本报告重点介绍了凝血酶原复合物浓缩物(PCC)作为多学科方法的一部分,在处理 PASD 大量出血病例中的成功应用。一名 36 岁的产妇 G3P2002 在妊娠 33 周时被诊断为全前置胎盘并疑似 PASD,她接受了计划中的剖宫产子宫切除术。手术因胎盘侵入和膀胱损伤导致 5200 毫升大出血而变得复杂。在处理血流动力学不稳定时,启动了大量输血方案,包括 PCC、氨甲环酸和包装红细胞。为止血进行了腹腔内填塞,并修复了膀胱损伤。在重症监护室继续使用 PCC 以及其他支持措施后,出血得到控制,病情也趋于稳定。患者在第二次手术移除填料后成功拔管并出院。本病例强调了 PCC 在 PASD 大量出血的多学科治疗中的重要作用。早期识别 PASD 风险因素并及时采取干预措施(包括使用 PCC)对于获得最佳产妇预后至关重要。
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引用次数: 0
Analysis of Risk Factors of Husband's Readiness and Involvement in Accompanying Wives in Childbirth: An Observational Study in Bengkulu City, Indonesia 丈夫陪伴妻子分娩的准备程度和参与程度的风险因素分析:印度尼西亚明古鲁市的观察研究
Pub Date : 2024-07-08 DOI: 10.37275/amcr.v5i3.597
Murwati, Tita Septi Handayani, Ida Samidah
The husband's role in assisting wives in childbirth has a significant impact on the birth experience and the health of the mother and baby. This study aims to analyze the risk factors that influence the role of husbands in accompanying their wives in childbirth in Bengkulu City, Indonesia. Analytical observational research was conducted on 200 married couples who gave birth in health facilities in Bengkulu City. Data was collected through questionnaires, interviews, and participant observation. Data analysis was carried out using logistic regression to identify risk factors related to the husband's role in accompanying wives in childbirth. The results showed that significant risk factors related to the husband's role in assisting wives in childbirth were the husband's education level (OR = 2.34; 95% CI: 1.21-4.53), the husband's knowledge about childbirth (OR = 3.12; 95% CI: 1.68-5.79), husband's attitude towards the role of mentoring (OR = 2.87; 95% CI: 1.45-5.68), social support from the family (OR = 1.98; 95% CI: 1.05-3.73), and previous birth experience (OR = 2.15; 95% CI: 1.12-4.14). This research identifies several risk factors that influence the husband's role in assisting wives in childbirth. Interventions aimed at increasing husbands' education, knowledge, and positive attitudes towards the role of companionship, as well as strengthening social support from the family, can increase husbands' involvement in the childbirth process.
丈夫在协助妻子分娩过程中所扮演的角色对分娩体验和母婴健康有着重要影响。本研究旨在分析影响印度尼西亚明古鲁市丈夫陪伴妻子分娩的风险因素。本研究对 200 对在明古鲁市医疗机构分娩的已婚夫妇进行了分析观察研究。研究通过问卷、访谈和参与观察收集数据。数据分析采用逻辑回归法进行,以确定与丈夫陪伴妻子分娩的角色相关的风险因素。结果显示,与丈夫在陪伴妻子分娩中的作用相关的重要风险因素是丈夫的受教育程度(OR = 2.34;95% CI:1.21-4.53)、丈夫的分娩知识(OR = 3.12;95% CI:1.68-5.79)、丈夫对指导角色的态度(OR = 2.87;95% CI:1.45-5.68)、来自家庭的社会支持(OR = 1.98;95% CI:1.05-3.73)和以前的分娩经历(OR = 2.15;95% CI:1.12-4.14)。这项研究确定了影响丈夫协助妻子分娩的几个风险因素。旨在提高丈夫对陪伴角色的教育、知识和积极态度,以及加强来自家庭的社会支持的干预措施,可以提高丈夫在分娩过程中的参与度。
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引用次数: 0
The Role of Branched-Chain Amino Acids and Eicosapentaenoic Acid in Improving Body Composition and Functional Capacity in Nasopharyngeal Carcinoma Patients with Cancer Cachexia: A Case Report 支链氨基酸和二十碳五烯酸在改善鼻咽癌患者的身体成分和功能能力方面的作用:病例报告
Pub Date : 2024-07-04 DOI: 10.37275/amcr.v5i3.596
K. BetaNovianti, Krisadelfa Sutanto, N. Ratna, Mutu Manikam
Introduction: Cancer cachexia is a debilitating syndrome characterized by involuntary weight loss, muscle wasting, and functional decline, negatively impacting quality of life and survival. Nutritional interventions, including branched-chain amino acids (BCAAs) and eicosapentaenoic acid (EPA), have shown promise in ameliorating cachexia. This case report illustrates the potential benefits of these nutrients in a patient with nasopharyngeal carcinoma. Case presentation: A 65-year-old female presented with severe fatigue, dysphagia, and significant weight loss (11 kg in 6 months) secondary to nasopharyngeal carcinoma (T1N3Mx, stage IV). She was diagnosed with cancer cachexia and severe malnutrition. Nutritional therapy included enteral nutrition with 1.5-2 g/kgBW/day protein, 11-12 g/day BCAAs, and 1-2 g/day EPA. Conclusion: This case report suggests that a nutritional approach combining high protein, BCAAs, and EPA may improve body composition and functional capacity in patients with cancer cachexia. Further research is warranted to confirm these findings in larger studies.
简介癌症恶病质是一种使人衰弱的综合征,其特征是不自主的体重减轻、肌肉萎缩和功能衰退,对生活质量和存活率产生负面影响。营养干预措施,包括支链氨基酸(BCAAs)和二十碳五烯酸(EPA),已显示出改善恶病质的前景。本病例报告说明了这些营养素对鼻咽癌患者的潜在益处。病例介绍:一名 65 岁的女性因鼻咽癌(T1N3Mx,IV 期)而出现严重疲劳、吞咽困难和体重明显下降(6 个月内体重下降 11 公斤)。她被诊断为癌症恶病质和严重营养不良。营养治疗包括肠内营养,每天每公斤体重 1.5-2 克蛋白质、每天 11-12 克 BCAAs 和每天 1-2 克 EPA。结论本病例报告表明,结合高蛋白、BCAAs 和 EPA 的营养方法可改善癌症恶病质患者的身体组成和功能能力。有必要进行进一步研究,以便在更大规模的研究中证实这些发现。
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引用次数: 0
Prepregnancy Body Mass Index and Risk of Preeclampsia: A Meta-Analysis 孕前体重指数与先兆子痫风险:一项 Meta 分析
Pub Date : 2024-07-01 DOI: 10.37275/amcr.v5i3.595
Nurul Azizah Suwarsa, Fadli Ananda, H. Muh Nur Abadi
Preeclampsia is a serious complication of pregnancy and is associated with an increased risk of maternal and fetal morbidity and mortality. Body mass index (BMI) before pregnancy has been identified as a potential risk factor for preeclampsia. This study aims to conduct a meta-analysis to evaluate the relationship between BMI before pregnancy and the incidence of preeclampsia, as well as identify effective prevention strategies. A literature search was conducted on the PubMed, Scopus, and Web of Science databases to identify observational studies published between 2018 and 2024. Studies that met the inclusion criteria had their data extracted and analyzed using a random effects model. Heterogeneity between studies was evaluated using the I2 statistic. Subgroup analyzes were performed based on geographic region and study design. A total of 25 studies with 534,000 respondents were included in this meta-analysis. The results of the analysis showed that increasing BMI before pregnancy was significantly associated with an increased risk of preeclampsia 2.22 (95% CI: 1.72-3.35). Subgroup analyzes revealed that these associations were consistent across geographic regions and study designs. This meta-analysis provides strong evidence that BMI before pregnancy is an independent risk factor for preeclampsia. Interventions to optimize BMI before pregnancy, such as nutritional counseling and promotion of physical activity, may be an effective preventive strategy to reduce the risk of preeclampsia.
先兆子痫是一种严重的妊娠并发症,会增加母体和胎儿的发病率和死亡率。孕前体重指数(BMI)已被确定为子痫前期的潜在风险因素。本研究旨在进行荟萃分析,评估孕前体重指数与子痫前期发病率之间的关系,并找出有效的预防策略。我们在 PubMed、Scopus 和 Web of Science 数据库中进行了文献检索,以确定 2018 年至 2024 年间发表的观察性研究。对符合纳入标准的研究进行了数据提取,并采用随机效应模型进行了分析。研究之间的异质性采用 I2 统计量进行评估。根据地理区域和研究设计进行了分组分析。本次荟萃分析共纳入了 25 项研究,受访者达 534,000 人。分析结果表明,孕前体重指数增加与子痫前期风险增加有显著相关性,相关性为 2.22(95% CI:1.72-3.35)。亚组分析表明,这些关联在不同的地理区域和研究设计中都是一致的。这项荟萃分析提供了强有力的证据,证明孕前体重指数是子痫前期的一个独立风险因素。优化孕前体重指数的干预措施,如营养咨询和促进体育锻炼,可能是降低子痫前期风险的有效预防策略。
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引用次数: 0
The Effect of Probiotics on Radiation Enteritis in Endometrial Cancer Patients Undergoing Radiotherapy 益生菌对接受放疗的子宫内膜癌患者放射性肠炎的影响
Pub Date : 2024-04-24 DOI: 10.37275/amcr.v5i3.551
Bernardine Godong, Nurul Ratna Mutumanikam, Diana Sunardi
Introduction: Radiation enteritis is damage to the small and large intestines caused by radiation therapy for regional cancer treatment. The incidence is around 90% in patients undergoing radiation in the pelvic and abdominal regions. This study aimed to report the effect of probiotics on radiation enteritis in endometrial cancer patients. Case presentation: A 57-year-old morbidly obese woman diagnosed with endometrial cancer underwent chemoradiation therapy. On the 21st out of 25 radiation sessions and the 2nd chemotherapy session, the patient visited the nutrition clinic at the Radiation Oncology Therapy Center with a complaint of diarrhea for the past 5 days. The diarrhea occurred approximately 10 times a day, with each bowel movement being approximately 50 ml and yellow in color. The patient was then treated with anti-diarrheal therapy, probiotics (Lactobacillus acidophilus, Bifidobacterium longum, and Streptococcus thermophilus) 2 times a day, zinc 20 mg once a day, and prescribed a low-fat and lactose-free diet. After monitoring on the 21st day, the frequency of liquid bowel movements decreased to 2 times a day, and the appetite improved. Conclusion: Patients with radiation enteritis who are given probiotics may experience a reduction in symptoms of acute diarrhea. Direct administration of probiotics increases beneficial bacteria in the digestive tract.
导言放射性肠炎是指区域性癌症放射治疗对小肠和大肠造成的损伤。在盆腔和腹部接受放射治疗的患者中,发病率约为 90%。本研究旨在报告益生菌对子宫内膜癌患者放射性肠炎的影响。病例介绍:一名 57 岁的病态肥胖妇女被诊断为子宫内膜癌,接受了化学放疗。在 25 次放疗中的第 21 次放疗和第 2 次化疗时,患者到放射肿瘤治疗中心的营养门诊就诊,主诉过去 5 天一直腹泻。腹泻每天约 10 次,每次约 50 毫升,呈黄色。患者随后接受了止泻治疗、益生菌(嗜酸乳杆菌、长双歧杆菌和嗜热链球菌)每天 2 次、锌 20 毫克每天 1 次,以及低脂和无乳糖饮食。经过第 21 天的监测,排便次数减少到每天 2 次,食欲也有所改善。结论放射性肠炎患者服用益生菌后,急性腹泻症状可能会减轻。直接服用益生菌可增加消化道中的有益菌。
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引用次数: 0
Factors Related to the Unsafe Act in Office Construction Project Workers at PT. X North Jakarta, Indonesia 印尼雅加达北部 X 公司办公楼建设项目工人不安全行为的相关因素印度尼西亚雅加达北部 X
Pub Date : 2024-04-16 DOI: 10.37275/amcr.v5i3.552
Yacoba Jennyver Simopiaref
Unsafe act is a worker's failure to follow correct work procedures, giving rise to the potential for work accidents. Human factors with unsafe act are the cause of 85% of work accidents. This research aims to determine factors related to unsafe act, namely K3 knowledge, K3 supervision, K3 training, and fatigue in office construction project workers by PT. X in North Jakarta. This type of research is quantitative with a cross sectional study design. The research sample used a total sampling of 72 workers. Research variables were analyzed using the Chi-square test. The highest proportion of respondents were workers who behaved safely (53%), had good K3 knowledge (66%), good K3 supervision (65%), had attended K3 training (54%), and experienced severe fatigue (54%). Bivariate results show a relationship between K3 knowledge (p-value = 0.020), K3 training (p-value = 0.001), and fatigue (p-value = 0.004) with unsafe act. There is no relationship between K3 supervision (p-value = 0.731) and unsafe act. In conclusion, K3 knowledge, K3 training, and fatigue are related to unsafe act in workers.
不安全行为是指工人没有遵守正确的工作程序,从而导致工伤事故的可能性。与不安全行为有关的人为因素是造成 85% 工伤事故的原因。本研究旨在确定与不安全行为有关的因素,即 K3 知识、K3 监督、K3 培训和 PT.X公司在雅加达北部的办公室建筑项目工人的疲劳程度。此类研究采用横断面研究设计,为定量研究。研究样本共抽取了 72 名工人。研究变量采用卡方检验进行分析。受访者中行为安全(53%)、K3 知识丰富(66%)、K3 监督良好(65%)、参加过 K3 培训(54%)和经历过严重疲劳(54%)的工人比例最高。双变量结果显示,K3 知识(p 值 = 0.020)、K3 培训(p 值 = 0.001)和疲劳(p 值 = 0.004)与不安全行为之间存在关系。K3 监督(p 值 = 0.731)与不安全行为之间没有关系。总之,K3 知识、K3 培训和疲劳与工人的不安全行为有关。
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引用次数: 0
The Effect of Vitamin D Supplementation on Autoimmune Bullous Skin Disorder Intensity Score on Bullous Pemphigoid and Acute Kidney Injury: A Case Report 补充维生素 D 对大疱性类天疱疮和急性肾损伤的自身免疫性大疱性皮肤病强度评分的影响:病例报告
Pub Date : 2024-03-18 DOI: 10.37275/amcr.v5i3.529
Kartika Soka Rahmita, D. E. Andayani, Diana Sunardi, Kartika Soka
Introduction: Bullous pemphigoid is the most common bullous-type autoimmune disease. Hypovitaminosis D is often associated with autoimmune disease and found in 86,7% bullous pemphigoid patients. Vitamin D supplementation in bullous pemphigoid patients ought to ameliorate its clinical symptoms. Case presentation: A-58 years old male patient with bullous pemphigoid and acute kidney injury admitted with a chief complaint of infected blisters all over the body. The patient had been treated for 1 week with worsening swallowing pain and low intake. On the 12th day of hospitalization, the patient was given calcitriol supplementation of 0,25 mcg per day. There was an improvement in clinical symptoms shown on autoimmune bullous skin disorder intensity score (ABSIS) from 57 on inpatient day 7 to 17.5 on inpatient day 20. Patient discharged on the 20th day of hospitalization with no emerging blisters and the ability to swallow minced food by mouth. Conclusion: Calcitriol supplementation of 0,25 mcg per day for 10 days helps to improve the ABSIS score in bullous pemphigoid patient with acute kidney injury. Administration of calcitriol is considered safe and well tolerated.
简介大疱性类天疱疮是最常见的大疱型自身免疫性疾病。维生素 D 过低通常与自身免疫性疾病相关,86.7% 的大疱性类天疱疮患者会出现维生素 D 过低。对大疱性类天疱疮患者补充维生素 D 可改善其临床症状。病例介绍:一名 58 岁的男性患者,患有大疱性类天疱疮和急性肾损伤,入院时主诉全身感染性水疱。患者因吞咽疼痛加重和进食量少已接受治疗 1 周。住院第 12 天,患者开始补充钙三醇,每天 0.25 微克。自身免疫性大疱性皮肤病强度评分(ABSIS)显示,临床症状有所改善,从住院第 7 天的 57 分降至住院第 20 天的 17.5 分。患者在住院第 20 天出院时,身上没有出现新的水泡,并能用嘴吞咽碎食物。结论连续10天每天补充0.25微克的降钙素三醇有助于改善伴有急性肾损伤的大疱性类天疱疮患者的ABSIS评分。服用降钙素三醇安全且耐受性良好。
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引用次数: 0
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