{"title":"Associations Between Vitamin K and Suicide Attempts in Patients with Depression: A Case-Control Study [Letter]","authors":"Song Wang, Xi Wang, Xiaolian Jiang","doi":"10.2147/jir.s486032","DOIUrl":"https://doi.org/10.2147/jir.s486032","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao Hong, Junyao Zheng, Haimin Shi, Suya Zhou, Yue Chen, Ming Li
{"title":"Prediction Model for Early-Stage CKD Using the Naples Prognostic Score and Plasma Indoleamine 2,3-dioxygenase Activity","authors":"Hao Hong, Junyao Zheng, Haimin Shi, Suya Zhou, Yue Chen, Ming Li","doi":"10.2147/jir.s460643","DOIUrl":"https://doi.org/10.2147/jir.s460643","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"6 S2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Liu, Shanshan Liu, Fuyan Bai, Yangxin Deng, Xinhuan Zhang, Li Wang
{"title":"Investigating the Role of Inflammatory Response in Polycystic Ovary Syndrome Using Integrated RNA-Seq Analysis","authors":"Lei Liu, Shanshan Liu, Fuyan Bai, Yangxin Deng, Xinhuan Zhang, Li Wang","doi":"10.2147/jir.s460437","DOIUrl":"https://doi.org/10.2147/jir.s460437","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"191 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barakat M AlRashdi, Diaa Massoud, Hager K. Rashwan, Shahenda Mahgoub, Nermeen Z Abuelezz, Ali Nasr, Rami Kassab, Hatem K. Amin
{"title":"The Protecting Role of Black Seed Oil and Its Nano-Formulation in LPS-Induced Acute Kidney Injury in Mice: Evaluation of Oxidative Stress, Biochemical & Molecular Parameters","authors":"Barakat M AlRashdi, Diaa Massoud, Hager K. Rashwan, Shahenda Mahgoub, Nermeen Z Abuelezz, Ali Nasr, Rami Kassab, Hatem K. Amin","doi":"10.2147/jir.s463369","DOIUrl":"https://doi.org/10.2147/jir.s463369","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrative Pan-Cancer Analysis Reveals the Oncogenic Role of MND1 and Validation of MND1’s Role in Breast Cancer","authors":"Wenwu Zhang, Yuhan Xiao, Xin Zhu, Yanxia Zhang, Qin Xiang, Shunhong Wu, Xiaoyu Song, Junxiu Zhao, Ruanfei Yuan, Qiguang Li, Bin Xiao, Linhai Li","doi":"10.2147/jir.s458832","DOIUrl":"https://doi.org/10.2147/jir.s458832","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"61 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Acute lung injury (ALI) manifests through harm to the capillary endothelium and alveolar epithelial cells, arising from a multitude of factors, leading to scattered interstitial alterations, pulmonary edema, and subsequent acute hypoxic respiratory insufficiency. Acute lung injury (ALI), along with its more serious counterpart, acute respiratory distress syndrome (ARDS), carry a fatality rate that hovers around 30–40%. Its principal pathological characteristic lies in the unchecked inflammatory reaction. Currently, the main strategies for treating ALI are alleviation of inflammation and prevention of respiratory failure. Concerning the etiology of ALI, NLRP3 Inflammasome is essential to the body’s innate immune response. The composition of this inflammasome complex includes NLRP3, the pyroptosis mediator ASC, and pro-caspase-1. Recent research has reported that the inflammatory response centered on NLRP3 inflammasomes plays a key part in inflammation in ALI, and may hence be a prospective candidate for therapeutic intervention. In the review, we present an overview of the ailment characteristics of acute lung injury along with the constitution and operation of the NLRP3 inflammasome within this framework. We also explore therapeutic strategies targeting the NLRP3 inflammasome to combat acute lung injury.
摘要 急性肺损伤（ALI）表现为毛细血管内皮细胞和肺泡上皮细胞受到多种因素的损害，导致肺间质分散性改变、肺水肿以及随后的急性缺氧性呼吸功能不全。急性肺损伤（ALI）以及更严重的急性呼吸窘迫综合征（ARDS）的致死率徘徊在 30%-40% 左右。其主要病理特征在于不受控制的炎症反应。目前，治疗 ALI 的主要策略是缓解炎症反应和预防呼吸衰竭。关于 ALI 的病因，NLRP3 炎症小体是人体先天性免疫反应的关键。该炎症小体复合物的组成包括 NLRP3、炎症介质 ASC 和原aspase-1。最近有研究报告称，以 NLRP3 炎症小体为中心的炎症反应在 ALI 炎症中起着关键作用，因此可能是治疗干预的潜在候选对象。在这篇综述中，我们概述了急性肺损伤的疾病特征以及 NLRP3 炎性体在这一框架中的构成和运作。我们还探讨了针对 NLRP3 炎性体的治疗策略，以对抗急性肺损伤。
{"title":"Acute Lung Injury and the NLRP3 Inflammasome","authors":"Wanjun Gu, Qi Zeng, Xin Wang, H. Jasem, Ling Ma","doi":"10.2147/JIR.S464838","DOIUrl":"https://doi.org/10.2147/JIR.S464838","url":null,"abstract":"Abstract Acute lung injury (ALI) manifests through harm to the capillary endothelium and alveolar epithelial cells, arising from a multitude of factors, leading to scattered interstitial alterations, pulmonary edema, and subsequent acute hypoxic respiratory insufficiency. Acute lung injury (ALI), along with its more serious counterpart, acute respiratory distress syndrome (ARDS), carry a fatality rate that hovers around 30–40%. Its principal pathological characteristic lies in the unchecked inflammatory reaction. Currently, the main strategies for treating ALI are alleviation of inflammation and prevention of respiratory failure. Concerning the etiology of ALI, NLRP3 Inflammasome is essential to the body’s innate immune response. The composition of this inflammasome complex includes NLRP3, the pyroptosis mediator ASC, and pro-caspase-1. Recent research has reported that the inflammatory response centered on NLRP3 inflammasomes plays a key part in inflammation in ALI, and may hence be a prospective candidate for therapeutic intervention. In the review, we present an overview of the ailment characteristics of acute lung injury along with the constitution and operation of the NLRP3 inflammasome within this framework. We also explore therapeutic strategies targeting the NLRP3 inflammasome to combat acute lung injury.","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"17 5‐6","pages":"3801 - 3813"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141397765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhou Zhao, Menghua Yan, Huayang Pang, Lihui Chen, Xi Tang, Zhixiong Chen, Xiufeng Chen, Hao Sun
{"title":"Significance of Nutritional-Inflammatory Index as Predictors for Total Neoadjuvant Therapy-Induced Tumor Regression in Locally Advanced Rectal Cancer Patients","authors":"Zhou Zhao, Menghua Yan, Huayang Pang, Lihui Chen, Xi Tang, Zhixiong Chen, Xiufeng Chen, Hao Sun","doi":"10.2147/jir.s462985","DOIUrl":"https://doi.org/10.2147/jir.s462985","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141405062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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