Pub Date : 2024-03-01DOI: 10.15625/2525-2518/17100
D. Nguyen, N. H. Nguyen, C. Nguyen
Hollow mesoporous silica nanoparticles (HMSN), a member of mesoporous silica family synthesized mainly with har-templating method, has gained great interest in pharmaceutical applications due to their impress characteristics such as good biocompatibility, large specific surface area and pore volume, controllable particle size, large cavity for cargo loading, and flexible surface functionalization possibilities. However, controlling the optimal particle size and shortening the synthesis time have been the issues of HMSN synthesis that needed to be improved. In this study, HMSN was synthesized using hard-templating with some modifications to shorten the synthesis time and adjust the particle size to nearly 100 nm. The obtained HMSN particles showed high uniform morphology as spheres with hollow core-mesoporous shell structure, having the particle diameter of about 90 nm, the hollow diameter of about 68 nm, and the mesoporous shell thickness of about 11 nm. The total time for the main reactions was shortened by more than half from 21 hours to 9 hours. Additionally, MTT assays revealed that the synthesized HMSN was biocompatible material. This modified hard-template method with shorter synthesis time and nearly 100 nm obtained particle diameter would be meaningful for scientific research and industrial scale production.
{"title":"A modified hard-templating for hollow mesoporous silica nanoparticles with suitable particle size and shortened synthetic time","authors":"D. Nguyen, N. H. Nguyen, C. Nguyen","doi":"10.15625/2525-2518/17100","DOIUrl":"https://doi.org/10.15625/2525-2518/17100","url":null,"abstract":"Hollow mesoporous silica nanoparticles (HMSN), a member of mesoporous silica family synthesized mainly with har-templating method, has gained great interest in pharmaceutical applications due to their impress characteristics such as good biocompatibility, large specific surface area and pore volume, controllable particle size, large cavity for cargo loading, and flexible surface functionalization possibilities. However, controlling the optimal particle size and shortening the synthesis time have been the issues of HMSN synthesis that needed to be improved. In this study, HMSN was synthesized using hard-templating with some modifications to shorten the synthesis time and adjust the particle size to nearly 100 nm. The obtained HMSN particles showed high uniform morphology as spheres with hollow core-mesoporous shell structure, having the particle diameter of about 90 nm, the hollow diameter of about 68 nm, and the mesoporous shell thickness of about 11 nm. The total time for the main reactions was shortened by more than half from 21 hours to 9 hours. Additionally, MTT assays revealed that the synthesized HMSN was biocompatible material. This modified hard-template method with shorter synthesis time and nearly 100 nm obtained particle diameter would be meaningful for scientific research and industrial scale production.","PeriodicalId":506542,"journal":{"name":"Vietnam Journal of Science and Technology","volume":"11 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.15625/2525-2518/18128
Binh Le Huy, Hai Bui Thi Phuong, Yen Do Hai, Kim Anh Trinh Thi, Binh Nguyen Thi Thanh, Minh Nguyen Hong, Luong Xuan Huy Huy.luongxuan@phenikaa-uni.edu.vn, Hoang Vu Dinh
Bee venom is abundant in potential antimicrobial peptides, AMPs, . Among them, Mastoparan C and Polybia-MP1 are two well-known AMPs that were found in the European Hornet Vespa crabro and social wasp Polybia paulista, respectively. Due to the potent antimicrobial activity toward a wide range of microbial pathogens, including Gram-negative, Gram-positive and fungal species, they are promising to tackle the global antimicrobial resistance crisis. Thus, understanding the structure and activity relationships (SARs) is essential for the development of potential therapeutic applications. In this study, we synthesized and compared the differences in biological properties of these two antimicrobial peptides. The preliminary data suggests various important information regarding the structural requirements for optimizing the pharmacological properties of antimicrobial peptides.
{"title":"SYNTHESIS AND BIOLOGICAL COMPARISON OF TWO ANTIMICROBIAL PEPTIDES ORIGINATED FROM THE VENOM OF VESPA CRABRO AND POLYBIA PAULISTA","authors":"Binh Le Huy, Hai Bui Thi Phuong, Yen Do Hai, Kim Anh Trinh Thi, Binh Nguyen Thi Thanh, Minh Nguyen Hong, Luong Xuan Huy Huy.luongxuan@phenikaa-uni.edu.vn, Hoang Vu Dinh","doi":"10.15625/2525-2518/18128","DOIUrl":"https://doi.org/10.15625/2525-2518/18128","url":null,"abstract":"Bee venom is abundant in potential antimicrobial peptides, AMPs, . Among them, Mastoparan C and Polybia-MP1 are two well-known AMPs that were found in the European Hornet Vespa crabro and social wasp Polybia paulista, respectively. Due to the potent antimicrobial activity toward a wide range of microbial pathogens, including Gram-negative, Gram-positive and fungal species, they are promising to tackle the global antimicrobial resistance crisis. Thus, understanding the structure and activity relationships (SARs) is essential for the development of potential therapeutic applications. In this study, we synthesized and compared the differences in biological properties of these two antimicrobial peptides. The preliminary data suggests various important information regarding the structural requirements for optimizing the pharmacological properties of antimicrobial peptides.","PeriodicalId":506542,"journal":{"name":"Vietnam Journal of Science and Technology","volume":"8 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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