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Get Your Game Face On: Utilizing Alternative Forms of Patient Education for Cardiac Care - A Pilot Study. 让你的游戏脸:利用替代形式的病人教育心脏护理-试点研究。
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-25 DOI: 10.1177/10547738261428069
Kayla Lucena-Glass

To respond to the local cardiovascular health literacy need through means of alternative forms of education utilizing serious games. A quality improvement project design utilizing pretest-posttest with in-depth literature review. A Cardiovascular (CV) BINGO game was developed, implemented, and analyzed for efficacy. Focus group participants (n = 10) were asked to recommend or advise against implementation of the serious game, then pilot study participants (n = 7) were asked to complete a five question Likert-scale survey along with one fill-in-the-blank action plan goal pre- and postgame implementation. Comparison between pretest and posttest surveys revealed an improved participant-perceived understanding and completion of personal action plans postimplementation. Overall, participants and instructors voiced satisfaction and lobbied for future use of this education tool. Literature supports the efficacy of serious games in knowledge and outcome improvement. The CV Bingo game applies alternative forms of education to establish deeper understanding of the material, spark health consumer interest, and open dialogue barriers. Application of serious games can be applied to any chronic disease process. The goal for the dissemination of this pilot study is to introduce new educational concepts and encourage fellow clinicians to utilize alternative forms of patient education.

通过利用严肃游戏的替代教育形式,响应当地心血管健康素养的需求。采用前测后测法进行质量改进项目设计,并进行深入的文献回顾。一个心血管(CV) BINGO游戏开发,实施,并分析其疗效。焦点小组参与者(n = 10)被要求对严肃游戏的实施提出建议或反对意见,然后试点研究参与者(n = 7)被要求完成一份包含5个问题的李克特量表调查,并填写一份游戏前后实施的行动计划目标。测试前和测试后调查的比较显示,参与者对个人行动计划实施后的理解和完成情况有所改善。总体而言,参与者和教师表示满意,并游说未来使用这种教育工具。文献支持严肃游戏在知识和结果改善方面的功效。CV Bingo游戏应用了其他形式的教育来建立对材料的更深层次的理解,激发健康消费者的兴趣,并打开对话障碍。严肃游戏的应用可以应用于任何慢性疾病过程。这项试点研究的传播目标是引入新的教育概念,并鼓励临床医生利用其他形式的患者教育。
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引用次数: 0
Workplace Environment and Psychological Distress of Nurses and Nursing Assistants During COVID-19. COVID-19期间护士和护理员的工作环境与心理困扰
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-23 DOI: 10.1177/10547738261429339
Harry Adynski, Cassandra Dictus, Mary K Killela, Gillian I Adynski, Elizabeth Allen Myer, Leah Morgan, Hayden Hmiel, Jessica R Williams

Registered nurses (RNs) and nursing assistants (NAs) play critical roles during crises. Understanding how the perceived work environment affects psychological distress among these healthcare workers is essential for developing interventions that support mental health and organizational outcomes. This study examined the association between perceived workplace environment and psychological distress, including stress, depressive, anxiety, and somatic symptoms, among inpatient RNs and NAs during the COVID-19 pandemic. A cross-sectional survey was conducted with 84 RNs and NAs employed at a large academic medical center between April and September 2021. The Practice Environment Scale of the Nursing Work Index (PES-NWI) was used to measure the perceived workplace environment, while psychological distress symptoms were assessed using the Perceived Stress Scale, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7, and PHQ-15. Descriptive statistics and independent t-tests analyzed cohort characteristics. A stepwise approach with univariate and adjusted linear regression models assessed the relationship between workplace environment scores and psychological distress, incorporating demographic variables. Approximately one-third of participants reported moderate to severe psychological distress. No significant differences in distress symptoms were found between RNs and NAs; however, NAs rated Collegial Nurse-Physician Relations significantly lower than RNs (t = -3.84, 95% confidence interval [CI] [-1.15, -0.33], p = .001). Across all unadjusted models, higher PES-NWI total scores were associated with lower psychological distress. In adjusted models, unit-level Nurse Manager Leadership and Support subscale was significantly related to lower depressive (estimate: -2.03, 95% CI [-4.01, -0.04], p = .045) and somatic symptoms (estimate: -2.11, 95% CI [-4.16, -0.06], p = .044). These findings underscore the critical role of nurse managers in fostering supportive workplace environments and highlight the unique challenges faced by NAs. Targeted interventions at the unit and hospital levels can enhance RN and NA well-being, improve organizational outcomes, and build a resilient nursing workforce equipped to navigate future crises.

注册护士(RNs)和护理助理(NAs)在危机中发挥着关键作用。了解感知到的工作环境如何影响这些卫生保健工作者的心理困扰,对于制定支持心理健康和组织成果的干预措施至关重要。本研究调查了2019冠状病毒病大流行期间住院注册护士和注册护士感知的工作环境与心理困扰(包括压力、抑郁、焦虑和躯体症状)之间的关系。从2021年4月到9月,对在某大型学术医疗中心工作的84名注册护士和NAs进行了横断面调查。采用护理工作指数实践环境量表(PES-NWI)测量工作环境感知,采用感知压力量表、患者健康问卷-9 (PHQ-9)、广泛性焦虑障碍量表-7和PHQ-15评估心理困扰症状。描述性统计和独立t检验分析了队列特征。采用单变量和调整后的线性回归模型逐步评估了工作环境得分与心理困扰之间的关系,并纳入了人口统计学变量。大约三分之一的参与者报告有中度到重度的心理困扰。RNs与NAs在焦虑症状上无显著差异;然而,NAs对学院护士-医师关系的评价显著低于RNs (t = -3.84, 95%可信区间[CI] [-1.15, -0.33], p = .001)。在所有未调整的模型中,较高的PES-NWI总分与较低的心理困扰相关。在调整后的模型中,单位级护士经理领导和支持分量表与较低的抑郁水平显著相关(估计:-2.03,95% CI [-4.01, -0.04], p =。045)和躯体症状(估计:-2.11,95% CI [-4.16, -0.06], p = 0.044)。这些发现强调了护士管理者在培养支持性工作环境方面的关键作用,并强调了护士面临的独特挑战。在单位和医院层面进行有针对性的干预可以提高注册护士和注册护士的福祉,改善组织成果,并建立一支有弹性的护理队伍,以应对未来的危机。
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引用次数: 0
Effect of Music Intervention on Pain, Anxiety, and Vital Signs in Radiotherapy Patients: A Randomized Controlled Trial Based on the Roy Adaptation Model. 音乐干预对放疗患者疼痛、焦虑和生命体征的影响:一项基于Roy适应模型的随机对照试验
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-23 DOI: 10.1177/10547738261428534
Duygu Akbas Uysal, Fısun Senuzun Aykar, Oguzhan Ayrancıoglu, Zumre Arıcan Alıcıkus

Cancer is the second leading cause of death globally, following cardiovascular diseases. Radiotherapy (RT), a common cancer treatment modality, often induces both physical discomfort and psychological distress, including pain and anxiety. Although music interventions have shown promise in reducing such symptoms, most studies lack a theoretical foundation, limiting their generalizability and application in nursing practice. This study aimed to evaluate the effects of a music intervention on pain, anxiety, and vital signs in patients undergoing RT, using the Roy Adaptation Model (RAM) as the theoretical framework. A randomized controlled trial was conducted between May 2024 and April 2025 in the Radiation Oncology Department. A total of 120 patients were randomly assigned to either the intervention group (n = 60) or control group (n = 60). The intervention group listened to specially composed therapeutic music via speakers for 20 to 40 min during weekly RT sessions. Pain (Visual Analog Scale), anxiety (Facial Anxiety Scale), and vital signs (blood pressure, heart rate, and respiratory rate) were measured before and after RT sessions. Data were analyzed using paired-sample t-tests and Cohen's d for effect sizes. The music intervention significantly reduced pain and anxiety scores in the intervention group compared to the control group (p < .001). Additionally, positive changes in vital signs were observed, including decreased systolic blood pressure and heart rate. The findings support the regulatory and cognator adaptive responses described in RAM, indicating that music functions as an effective coping mechanism for physiological and psychological stressors during RT. Music intervention is a safe, non-pharmacological, and cost-effective strategy for enhancing patient adaptation during RT. This study contributes to the evidence base by integrating a theoretical model into clinical nursing practice and underscores the importance of model-based interventions in improving holistic patient care.

癌症是全球第二大死因,仅次于心血管疾病。放射治疗(RT)是一种常见的癌症治疗方式,通常会引起身体不适和心理困扰,包括疼痛和焦虑。虽然音乐干预在减轻这些症状方面显示出希望,但大多数研究缺乏理论基础,限制了它们在护理实践中的推广和应用。本研究旨在评估音乐干预对RT患者疼痛、焦虑和生命体征的影响,采用罗伊适应模型(RAM)作为理论框架。一项随机对照试验于2024年5月至2025年4月在放射肿瘤科进行。120例患者被随机分为干预组(n = 60)和对照组(n = 60)。干预组在每周的RT疗程中通过扬声器听20到40分钟的特别作曲的治疗音乐。疼痛(视觉模拟量表)、焦虑(面部焦虑量表)和生命体征(血压、心率和呼吸频率)在RT治疗前后进行测量。数据分析采用配对样本t检验,效应量采用Cohen’s d。与对照组相比,音乐干预显著降低了干预组的疼痛和焦虑得分(p
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引用次数: 0
The Effects of Midwife-Led Care on the Perception of Labor Pain, Labor Duration, Labor Comfort, and Respectful Maternity Care: A Single-Blind Randomized Controlled Trial. 助产士主导护理对分娩疼痛感知、分娩持续时间、分娩舒适度和尊重产妇护理的影响:一项单盲随机对照试验。
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-23 DOI: 10.1177/10547738261428073
Betül Uncu, Hicret Gök, Bihter Akın

Continuous care provided by the same midwife throughout the maternity journey may have significant benefits for labor outcomes and women's childbirth experiences. This single-blind randomized controlled trial, conducted in a public hospital in Türkiye between October 2024 and February 2025, investigated the effects of continuous midwifery care on labor pain, duration, comfort, and the perception of respectful maternity care. A total of 85 women were randomly assigned to either an intervention group (n = 43), receiving care from the same midwife during the prenatal, intrapartum, and postnatal periods, or a control group (n = 42), where care was provided by different midwives. Findings revealed that women in the intervention group experienced significantly lower pain during labor, shorter labor durations, and greater comfort. Additionally, their perceptions of respectful maternity care were markedly more positive than those in the control group (p < .001). These results suggest that continuity of midwifery care enhances both clinical and experiential outcomes for women. Implementing midwife-led continuity of care models in Türkiye could contribute to more personalized, comfortable, and respectful childbirth experiences, ultimately improving maternal satisfaction and well-being.

在整个分娩过程中,由同一名助产士持续提供护理可能对分娩结果和妇女的分娩经历有重大好处。这项单盲随机对照试验于2024年10月至2025年2月在日本一家公立医院进行,研究了持续助产护理对分娩疼痛、持续时间、舒适度和尊重产妇护理的影响。共有85名妇女被随机分配到干预组(n = 43)和对照组(n = 42),干预组在产前、产中和产后接受同一名助产士的护理,对照组由不同的助产士提供护理。研究结果显示,干预组的妇女在分娩过程中疼痛明显减轻,分娩持续时间缩短,舒适度更高。此外,他们对尊重产妇护理的看法明显比对照组更积极
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引用次数: 0
Avoiding Fragmentation and Salami Slicing in Mixed Methods Research. 避免碎裂和香肠切片混合方法的研究。
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-19 DOI: 10.1177/10547738261431626
Nick Nijkamp, Pauline Calleja, Leanne Jack, Ashlyn Sahay

Mixed methods research (MMR) offers rich opportunities for doctoral inquiry, but its complexity demands careful navigation of design, data integration, and dissemination. For doctoral candidates, one under-recognised risk is the ethical and methodological challenge of fragmentation and salami-slicing practices that undermine the coherence and transparency central to MMR. Fragmentation involves separating components of a study across publications, while salami slicing divides a dataset into minimally contributive outputs, often misaligning with the original study design. This discussion paper addresses the implications of these practices in the context of doctoral research and supervision. It highlights the need for supervisory guidance in ethically planning publications, particularly in aligning dissemination with MMR design logic. Drawing on doctoral inquiry and supervisory discourse, the paper proposes design-informed strategies to help candidates and supervisors protect the integrity of MMR. In doing so, it contributes to the methodological literature by offering actionable guidance for ethically navigating dissemination within the context of complex, mixed methods doctoral projects.

混合方法研究(MMR)为博士探究提供了丰富的机会,但其复杂性要求对设计、数据整合和传播进行仔细的导航。对于博士候选人来说,一个未被认识到的风险是碎片化和香肠切片做法在伦理和方法上的挑战,这些做法破坏了MMR的核心一致性和透明度。碎片化涉及在出版物中分离研究的组成部分,而香肠切片将数据集划分为贡献最小的输出,通常与原始研究设计不一致。本文讨论了这些实践对博士研究和监督的影响。它强调了对出版物进行道德规划的监督指导的必要性,特别是在使传播与MMR设计逻辑保持一致方面。借鉴博士探究和导师话语,本文提出了设计知情策略,以帮助候选人和导师保护MMR的完整性。在这样做的过程中,它通过为复杂、混合方法博士项目背景下的伦理导航传播提供可操作的指导,为方法学文献做出了贡献。
{"title":"Avoiding Fragmentation and Salami Slicing in Mixed Methods Research.","authors":"Nick Nijkamp, Pauline Calleja, Leanne Jack, Ashlyn Sahay","doi":"10.1177/10547738261431626","DOIUrl":"https://doi.org/10.1177/10547738261431626","url":null,"abstract":"<p><p>Mixed methods research (MMR) offers rich opportunities for doctoral inquiry, but its complexity demands careful navigation of design, data integration, and dissemination. For doctoral candidates, one under-recognised risk is the ethical and methodological challenge of fragmentation and salami-slicing practices that undermine the coherence and transparency central to MMR. Fragmentation involves separating components of a study across publications, while salami slicing divides a dataset into minimally contributive outputs, often misaligning with the original study design. This discussion paper addresses the implications of these practices in the context of doctoral research and supervision. It highlights the need for supervisory guidance in ethically planning publications, particularly in aligning dissemination with MMR design logic. Drawing on doctoral inquiry and supervisory discourse, the paper proposes design-informed strategies to help candidates and supervisors protect the integrity of MMR. In doing so, it contributes to the methodological literature by offering actionable guidance for ethically navigating dissemination within the context of complex, mixed methods doctoral projects.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"10547738261431626"},"PeriodicalIF":1.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Maternal Self-Efficacy and Social Support in the Development of Postpartum Depression among Primiparous Mothers in Jordan: A Cross-Sectional Study. 母亲自我效能感和社会支持对约旦初产妇产后抑郁发展的影响:一项横断面研究。
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-18 DOI: 10.1177/10547738261428815
Khitam I Mohammad, Roaa N Al-Noaimy, Nour A Alrida, Mohammad K Allafi, Mohammed ALBashtawy, Abdullah Alkhawaldeh, Asem Abdalrahim, Debra Creedy, Jenny Gamble

To explore the effect of maternal self-efficacy and social support in the development of postpartum depression (PPD) among Jordanian primiparous mothers. In a cross-sectional study using convenience sampling, 250 mothers aged 18 years or above, 6 to 8 weeks postpartum, and who could speak and read Arabic were interviewed in a participating health clinic. The interview occurred before or after a woman's scheduled clinic appointment. It included sociodemographic data, Edinburgh Postnatal Depression Scale (EPDS), the Perceived Maternal Parental Self-Efficacy Scale, and the Perinatal Infant Care Social Support Scale. Data were analyzed using IBM SPSS Statistics (version 24; IBM Corp., Armonk, NY, USA). Reporting followed the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Results revealed that 47.2% of participants had probable PPD (EPDS ≥ 13); 35.2% had low maternal self-efficacy, and 36.8% had low functional social support. Older and employed mothers were at increased risk of PPD symptoms. In contrast, higher monthly income, greater maternal self-efficacy, and higher functional social support were significantly associated with decreased risk of PPD symptoms. The prevalence of PPD reported in the current study warrants immediate action on early assessment, detection, and intervention. The findings also call for culturally tailored interventions and greater involvement of healthcare professionals and families to support maternal mental health. The study highlights the need for early screening and culturally tailored interventions to strengthen maternal self-efficacy and social support in preventing PPD. Nurses and midwives should collaborate with families to provide holistic, patient-centered care that addresses both emotional and practical needs of primiparous mothers.

目的探讨自我效能感和社会支持在约旦初产母亲产后抑郁(PPD)发生中的作用。在一项采用方便抽样的横断面研究中,250名年龄在18岁或以上、产后6至8周、会说和读阿拉伯语的母亲在一家参与的保健诊所接受了采访。访谈发生在女性预定的门诊预约之前或之后。包括社会人口学资料、爱丁堡产后抑郁量表(EPDS)、父母自我效能感量表和围产期婴儿护理社会支持量表。数据分析使用IBM SPSS Statistics (version 24; IBM Corp., Armonk, NY, USA)。报告遵循《加强流行病学观察性研究报告指南》。结果显示,47.2%的参与者可能患有PPD (EPDS≥13);35.2%的产妇自我效能低,36.8%的产妇功能性社会支持低。年龄较大和有工作的母亲患产后抑郁症的风险增加。相反,较高的月收入、较高的母亲自我效能感和较高的功能性社会支持与PPD症状风险降低显著相关。当前研究报告的PPD患病率需要立即采取行动进行早期评估、检测和干预。研究结果还呼吁采取适合不同文化的干预措施,并呼吁卫生保健专业人员和家庭更多地参与,以支持产妇的心理健康。该研究强调了早期筛查和文化定制干预的必要性,以加强母亲的自我效能感和社会支持,以预防产后抑郁症。护士和助产士应与家庭合作,提供全面的、以病人为中心的护理,解决初产妇的情感和实际需求。
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引用次数: 0
Sleep Characteristics and Cognitive Symptoms Among Adults with Inflammatory Bowel Disease. 成人炎症性肠病患者的睡眠特征和认知症状
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-13 DOI: 10.1177/10547738261427988
Stacy Al-Saleh, Melanie Schneekloth, Sunanda Kane, Kendra Kamp, Nancy S Redeker, Samantha Conley

Individuals with inflammatory bowel disease (IBD) experience overlooked deficits in objectively measured cognitive functioning; however, there is limited knowledge about self-reported cognitive symptoms in this group. Sleep characteristics, such as insomnia, poor sleep quality, or fragmented sleep, may be key modifiable factors that are associated with cognitive symptoms among individuals with IBD. This study aimed to describe cognitive symptoms and examine the relationship between these symptoms and sleep characteristics among adults with IBD. We conducted a descriptive, cross-sectional study using the Pittsburgh Sleep Quality Index, wrist actigraphy, the Insomnia Severity Index, and the FACT-Cog Perceived Cognitive Impairments subscale. Bivariate statistics were used to evaluate relationships between variables. The sample included 83 participants (mean age 40.44 years [standard deviation 10.7], 71% female). Over 77% (n = 60) had poor self-reported sleep quality, and 69.5% (n = 57) had clinically meaningful insomnia. The most frequently reported cognitive symptoms (experienced two or more times a week) were trouble concentrating (51.3%), forgetting names (43.8%), forgetting intended tasks (38.9%), and slow thinking (37.6%). Insomnia severity was moderately correlated with three out of the four most common cognitive symptoms (trouble concentrating: rs = .51, p < .01; forgetting intended tasks: rs = .38, p < .01; slow thinking: rs = .46, p < .01). Future research is needed to examine relationships between objective cognitive measures and sleep characteristics and to test the effects of insomnia treatment on daytime cognitive symptoms in this complex patient population.

患有炎症性肠病(IBD)的个体在客观测量的认知功能方面存在被忽视的缺陷;然而,对这一群体自我报告的认知症状的了解有限。睡眠特征,如失眠、睡眠质量差或睡眠碎片化,可能是与IBD患者认知症状相关的关键可改变因素。本研究旨在描述IBD成人患者的认知症状,并检查这些症状与睡眠特征之间的关系。我们使用匹兹堡睡眠质量指数、手腕活动记录仪、失眠严重程度指数和FACT-Cog感知认知障碍亚量表进行了一项描述性横断面研究。采用双变量统计来评价变量之间的关系。样本包括83名参与者(平均年龄40.44岁[标准差10.7],71%为女性)。超过77% (n = 60)的患者自我报告睡眠质量较差,69.5% (n = 57)的患者有临床意义的失眠。最常见的认知症状(一周经历两次或两次以上)是难以集中注意力(51.3%),忘记名字(43.8%),忘记预定任务(38.9%)和思维缓慢(37.6%)。失眠严重程度与四种最常见的认知症状中的三种中度相关(注意力不集中:rs =。51, p rs =。38、p rs =。46岁的p
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引用次数: 0
Correlation Between Symptom Clusters and Self-Management in Renal Transplant Recipients: Multicenter Cross-Sectional Study. 肾移植受者症状群与自我管理的相关性:多中心横断面研究
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1177/10547738251412723
Ying Zhang, Hongqin Li, Junling Wei, Sainan Liu, Qi Miao, Xu Zhang, Xiaofei Li

Previous studies have shown that single symptoms are associated with self-management, and symptom clusters are still a sparsely investigated field. This study aimed to explore the possible symptom clusters after renal transplantation and investigate the correlation between symptom clusters and self-management. A cross-sectional survey was conducted on 381 renal transplant recipients (RTRs) from 2 tertiary hospitals in different regions. Sociodemographic and clinical characteristics, Symptom Experience Scale, and RTRs Self-Management Scale were used. Symptom clusters were created with exploratory factor analysis. Multiple regression analysis was used to explore the relationship between self-management and symptom clusters. Four symptom clusters were extracted, which were related to activity endurance, emotion, neuro-gastrointestinal, and hormone. Symptom clusters were negatively correlated with self-management (p < .001), and the activity endurance symptom cluster was the influencing factor of self-management (β = -.209, p < .001). The impact of symptom clusters on self-management among RTRs exhibits heterogeneity. Clinical therapies should prioritize the activity endurance symptom cluster since it is a substantial risk factor for impaired self-management ability.

先前的研究表明,单一症状与自我管理有关,而症状群仍然是一个研究较少的领域。本研究旨在探讨肾移植术后可能出现的症状群,并探讨症状群与自我管理的关系。对不同地区2所三级医院的381例肾移植受者进行了横断面调查。采用社会人口学和临床特征、症状体验量表和RTRs自我管理量表。采用探索性因素分析建立症状聚类。采用多元回归分析探讨自我管理与症状聚类的关系。提取与活动耐力、情绪、神经胃肠和激素相关的4个症状群。症状分型与自我管理呈负相关(p < 0.05)
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引用次数: 0
Sex Differences in Predictors of Frailty among Community-Dwelling Older Adults: Machine Learning Approach. 社区居住老年人衰弱预测因子的性别差异:机器学习方法。
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-01 Epub Date: 2026-02-20 DOI: 10.1177/10547738261417607
Alejandra-Ximena Araya, Evelyn Iriarte, María Beatriz Fernández-Lorca, Carolina Cornejo

The identification of frail older adults is a critical public health challenge and a growing priority in geriatric research. Nevertheless, the identification of sex-specific predictors of frailty remains an unsolved challenge. The objective of this study is to examine sex differences in the predictors of physical frailty among community-dwelling older adults in Chile. A nationally representative sample of 9,123 individuals aged 60 and older (n = 5,363 women; n = 3,760 men) from the National Disability and Dependency Survey was analyzed. Supervised machine learning regression models were applied to identify the most relevant predictors of physical frailty. In both male and female subjects, the predominant predictor was the number of health conditions present. For men, physical activity emerged as the second most salient factor, while for women, engagement in leisure and recreational activities demonstrated a more pronounced correlation with frailty. The findings of the study demonstrated that age was a significant predictor in both male and female subjects. These findings offer valuable insights for developing gender-responsive strategies to prevent or delay the progression of physical frailty among older adults in Chile.

识别体弱多病的老年人是一项重大的公共卫生挑战,也是老年病学研究中日益优先考虑的问题。然而,性别特异性脆弱预测因子的识别仍然是一个未解决的挑战。本研究的目的是检查智利社区居住老年人身体虚弱预测因素的性别差异。研究人员分析了来自全国残疾和抚养调查的9123名60岁及以上的人(n = 5363名女性;n = 3760名男性)的全国代表性样本。应用监督机器学习回归模型来确定最相关的身体虚弱预测因素。在男性和女性受试者中,主要的预测因子是存在健康状况的数量。对男性来说,体育锻炼是第二个最重要的因素,而对女性来说,参与休闲和娱乐活动与身体虚弱的关系更为明显。研究结果表明,年龄在男性和女性受试者中都是一个重要的预测因素。这些发现为制定促进性别平等的战略提供了宝贵的见解,以防止或延缓智利老年人身体虚弱的进展。
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引用次数: 0
Oxidative Stress, Telomere Length, and Post-Intensive Care Syndrome in Mechanically Ventilated ICU Survivors. 机械通气ICU幸存者的氧化应激、端粒长度和重症监护后综合征。
IF 1.8 4区 医学 Q2 NURSING Pub Date : 2026-03-01 Epub Date: 2026-02-15 DOI: 10.1177/10547738261417632
Elaine E Saugar, Zhan Liang, Arsham Alamian, Tanira Ferreira, Charles A Downs

ICU survivors are at increased risk for persistent physical, cognitive, and psychological impairments, collectively known as Post-Intensive Care Syndrome (PICS). Critically ill patients, especially those on mechanical ventilation, experience increased oxidative stress burden, potentially contributing to telomere shortening. However, the relationship between oxidative stress, telomere attrition, and PICS-related outcomes remains unclear. Our objective was to examine associations among oxidative stress markers, telomere length, clinical characteristics, and PICS-related outcomes in mechanically ventilated ICU survivors. A cross-sectional study design was used. Blood samples were collected at two timepoints: study enrollment and within 48 hr of ICU discharge. PICS-related outcome measures were assessed within 48 hr of ICU discharge. Oxidative stress markers-including plasma protein carbonyls, vitamin C, reduced-to-oxidized glutathione ratio (GSH:GSSG), and total antioxidant capacity (TAC)-were quantified via ELISA. Three oxidative stress indices were calculated: vitamin C/GSH:GSSG, TAC/GSH:GSSG, and protein carbonyls/GSH:GSSG. Telomere length was determined using RT-qPCR. Clinical data included APACHE III and SOFA scores, ICU and hospital length of stay (LOS), and duration of mechanical ventilation. PICS-related outcomes included grip and foot strength, National Institutes of Health (NIH) Toolbox Cognition and Emotion assessments, and the Connor-Davidson Resilience Scale. Pearson's correlations were performed. Twenty-one participants were included in the final analysis. Plasma antioxidant status positively correlated with muscle strength and psychological resilience. Elevated plasma oxidant levels were associated with poorer cognitive outcomes. ICU LOS and duration of mechanical ventilation negatively correlated with muscle strength and cognitive performance. No significant correlations were observed between telomere length changes and PICS-related outcomes. Oxidative stress during acute critical illness may impede recovery and contribute to PICS. The lack of short-term associations with telomere length suggests that telomere-related effects on PICS may, possibly, become apparent over a longer post-ICU period.

ICU幸存者出现持续性身体、认知和心理障碍的风险增加,这些障碍统称为重症监护后综合征(PICS)。危重患者,特别是那些机械通气的患者,经历了增加的氧化应激负担,可能导致端粒缩短。然而,氧化应激、端粒磨损和pics相关结果之间的关系尚不清楚。我们的目的是研究机械通气ICU幸存者的氧化应激标志物、端粒长度、临床特征和pics相关结果之间的关系。采用横断面研究设计。在两个时间点采集血样:研究入组和ICU出院48小时内。在ICU出院后48小时内评估pics相关结果。氧化应激标志物,包括血浆蛋白羰基、维生素C、还原性与氧化性谷胱甘肽比(GSH:GSSG)和总抗氧化能力(TAC),通过ELISA进行定量。计算三个氧化应激指标:维生素C/GSH:GSSG、TAC/GSH:GSSG和蛋白羰基/GSH:GSSG。采用RT-qPCR测定端粒长度。临床数据包括APACHE III和SOFA评分、ICU和住院时间(LOS)以及机械通气持续时间。pics相关结果包括握力和足部力量、美国国立卫生研究院(NIH)工具箱认知和情绪评估以及康纳-戴维森弹性量表。进行Pearson相关性分析。21名参与者被纳入最终分析。血浆抗氧化水平与肌肉力量和心理弹性呈正相关。血浆氧化剂水平升高与较差的认知结果有关。ICU LOS和机械通气时间与肌力和认知能力呈负相关。端粒长度变化与pics相关结果之间未观察到显著相关性。急性危重疾病期间的氧化应激可能阻碍康复并导致PICS。端粒长度与PICS缺乏短期相关性表明,端粒相关的影响可能在icu后较长时间内变得明显。
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