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Neurobiology of Avoidant/Restrictive Food Intake Disorder 回避型/限制型食物摄入障碍的神经生物学
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240117-02
Sophie Scharner
Avoidant/restrictive food intake disorder (ARFID) is a complex, phenotypically heterogenous, and often severe feeding and eating disorder. Genetic studies suggest that ARFID is highly heritable, and that genes involved in taste perception and neurodevelopmental disorders may confer increased risk for the disorder. Neuroimaging studies are limited but point toward greater activation in reward circuitry among individuals with ARFID who are also overweight or obese, compared to those of normal weight. Endocrine studies have identified maladaptively high satiety-promoting (Peptide YY, cholecystokinin, oxytocin) and low hunger-promoting (ghrelin) hormone levels among individuals with ARFID, which may contribute to disease etiology and/or maintenance. Although research is limited, emerging insights into the pathophysiology of this common and impairing disorder may pave the way for the development of novel biological and pharmacological treatments. [ Psychiatr Ann. 2024;54(2):e47–e50.]
回避型/限制型食物摄入障碍(ARFID)是一种复杂的、表型异质性的、通常严重的进食和饮食障碍。遗传学研究表明,ARFID 具有高度遗传性,涉及味觉感知和神经发育障碍的基因可能会增加患这种疾病的风险。神经影像学研究有限,但研究表明,与体重正常者相比,超重或肥胖的 ARFID 患者的奖赏回路激活程度更高。内分泌研究发现,ARFID 患者体内促进饱腹感的激素(肽 YY、胆囊收缩素、催产素)水平偏高,而促进饥饿感的激素(胃泌素)水平偏低,这可能是疾病的病因和/或维持因素。尽管研究有限,但对这种常见的损伤性疾病的病理生理学的新认识可能为开发新型生物和药物治疗方法铺平道路。 [ 《精神病学年鉴》,2024;54(2):e47-e50]。
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引用次数: 0
Epidemiological Association of Parental Substance Use History and Mental Health Disorders in Central Morocco 摩洛哥中部地区父母药物使用史与精神疾病的流行病学关联
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20231204-01
Abdelmounaim Baslam, Hajar Azraida, Aboufatima Rachida, Samia Boussaa, Abderrahman Chait
This cross-sectional study investigated the prevalence of substance use disorders and explored associations between parental substance use disorder history and mental health disorders among psychiatric hospital inpatients in central Morocco. A total of 723 participants were included in the study. Data were collected using a structured questionnaire and medical records, covering psychiatric diagnoses, sociodemographic characteristics, substance use disorders among patients and their parents, as well as the patient's psychiatric history and length of hospital stay. Participants were divided into two groups: those with parental history of substance use disorders (PSUD) and those without. Patients' mean ages were 34.40 years (± 11) and 35.5 years (± 12), respectively. The prevalence of substance use was notably high among participants, with cannabis use being the most prevalent (90.6%). Educational level was associated with PSUD, with participants having no formal education showing a higher likelihood of having parents with SUD (unadjusted odds ratio, UOR = 2.11, 95% CI = 1.1 to 4.03). Polysubstance use was also associated with the PSUD group (UOR = 2.42, 95% CI = 1.73 to 3.40). Regarding psychiatric disorders, one in five patients in the PSUD group had schizophrenia (21.35%), followed by acute psychotic episodes (20.5%), depression (20.29%), and anorexia (8.24%). The study revealed a high overall prevalence of substance use among participants with mental health disorder, highlighting the significance of parental SUD history as a predictor for patients' mental health disorders. This suggests the need for special attention and preventive measures. [ Psychiatr Ann . 2024;54(2):e56–e66.]
这项横断面研究调查了摩洛哥中部地区精神病院住院患者的药物使用障碍患病率,并探讨了父母药物使用障碍史与精神疾病之间的关联。共有 723 人参与了这项研究。研究使用结构化问卷和病历收集数据,内容包括精神病诊断、社会人口特征、患者及其父母的药物使用障碍,以及患者的精神病史和住院时间。参与者分为两组:父母有药物滥用史(PSUD)和无药物滥用史。患者的平均年龄分别为 34.40 岁(± 11)和 35.5 岁(± 12)。参与者使用药物的比例很高,其中使用大麻的比例最高(90.6%)。教育水平与 PSUD 相关,未受过正规教育的参与者的父母患有 SUD 的可能性更高(未调整的几率比,UOR = 2.11,95% CI = 1.1 至 4.03)。使用多种药物也与 PSUD 组相关(UOR = 2.42,95% CI = 1.73 至 3.40)。 在精神疾病方面,PSUD 组每五名患者中就有一名患有精神分裂症(21.35%),其次是急性精神病发作(20.5%)、抑郁症(20.29%)和厌食症(8.24%)。研究显示,在患有精神疾病的参与者中,药物使用的总体流行率很高,这凸显了父母的药物滥用史作为预测患者精神疾病的一个重要因素。这表明有必要给予特别关注并采取预防措施。 [ Psychiatr Ann .
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引用次数: 0
Thinking About the System (or Lack Thereof) of Psychiatric Care 思考精神病治疗体系(或缺乏体系)的问题
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240119-02
Andrew A. Nierenberg
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引用次数: 0
Epidemiological Association of Parental Substance Use History and Mental Health Disorders in Central Morocco 摩洛哥中部地区父母药物使用史与精神疾病的流行病学关联
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20231204-01
Abdelmounaim Baslam, Hajar Azraida, Aboufatima Rachida, Samia Boussaa, Abderrahman Chait
This cross-sectional study investigated the prevalence of substance use disorders and explored associations between parental substance use disorder history and mental health disorders among psychiatric hospital inpatients in central Morocco. A total of 723 participants were included in the study. Data were collected using a structured questionnaire and medical records, covering psychiatric diagnoses, sociodemographic characteristics, substance use disorders among patients and their parents, as well as the patient's psychiatric history and length of hospital stay. Participants were divided into two groups: those with parental history of substance use disorders (PSUD) and those without. Patients' mean ages were 34.40 years (± 11) and 35.5 years (± 12), respectively. The prevalence of substance use was notably high among participants, with cannabis use being the most prevalent (90.6%). Educational level was associated with PSUD, with participants having no formal education showing a higher likelihood of having parents with SUD (unadjusted odds ratio, UOR = 2.11, 95% CI = 1.1 to 4.03). Polysubstance use was also associated with the PSUD group (UOR = 2.42, 95% CI = 1.73 to 3.40). Regarding psychiatric disorders, one in five patients in the PSUD group had schizophrenia (21.35%), followed by acute psychotic episodes (20.5%), depression (20.29%), and anorexia (8.24%). The study revealed a high overall prevalence of substance use among participants with mental health disorder, highlighting the significance of parental SUD history as a predictor for patients' mental health disorders. This suggests the need for special attention and preventive measures. [ Psychiatr Ann . 2024;54(2):e56–e66.]
这项横断面研究调查了摩洛哥中部地区精神病院住院患者的药物使用障碍患病率,并探讨了父母药物使用障碍史与精神疾病之间的关联。共有 723 人参与了这项研究。研究使用结构化问卷和病历收集数据,内容包括精神病诊断、社会人口特征、患者及其父母的药物使用障碍,以及患者的精神病史和住院时间。参与者分为两组:父母有药物滥用史(PSUD)和无药物滥用史。患者的平均年龄分别为 34.40 岁(± 11)和 35.5 岁(± 12)。参与者使用药物的比例很高,其中使用大麻的比例最高(90.6%)。教育水平与 PSUD 相关,未受过正规教育的参与者的父母患有 SUD 的可能性更高(未调整的几率比,UOR = 2.11,95% CI = 1.1 至 4.03)。使用多种药物也与 PSUD 组相关(UOR = 2.42,95% CI = 1.73 至 3.40)。 在精神疾病方面,PSUD 组每五名患者中就有一名患有精神分裂症(21.35%),其次是急性精神病发作(20.5%)、抑郁症(20.29%)和厌食症(8.24%)。研究显示,在患有精神疾病的参与者中,药物使用的总体流行率很高,这凸显了父母的药物滥用史作为预测患者精神疾病的一个重要因素。这表明有必要给予特别关注并采取预防措施。 [ Psychiatr Ann .
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引用次数: 0
Differential Diagnosis Between Avoidant/Restrictive Food Intake Disorder and Anorexia Nervosa 回避型/限制型食物摄入障碍与神经性厌食症的鉴别诊断
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240110-01
P. E. Kambanis, Lilian P. Palmer, Lazaro Zayas
Differential diagnosis between avoidant/restrictive food intake disorder (ARFID) and anorexia nervosa may be challenging due to shared clinical features. Diagnostic criteria for ARFID prohibit disturbance of one's body shape/weight. In contrast to body image disturbance, body image dissatisfaction is normative and ubiquitous and may characterize those with ARFID. Distinguishing between body image disturbance and dissatisfaction is critical to derive accurate diagnoses. We compare these constructs, highlighting that body image dissatisfaction rises to the level of clinically significant body image disturbance when it results in: (1) behavioral symptoms, such as persistent behavior that interferes with weight gain; and/or (2) eating disorder cognitions, such as a distorted perception of one's shape/weight or overvaluation of shape/weight. We illustrate the application of this definition via a brief case example and conclude by providing recommendations to aid providers in differential diagnosis between ARFID and its most similar eating disorder, anorexia nervosa. [ Psychiatr Ann . 2024;54(2):e37–e41.]
由于具有共同的临床特征,对回避型/限制型食物摄入障碍(ARFID)和神经性厌食症进行鉴别诊断可能具有挑战性。ARFID的诊断标准禁止对自己的体形/体重进行干扰。与体像障碍相反,体像不满意是正常的、普遍存在的,可能是 ARFID 患者的特征。区分体像困扰和体像不满意对于得出准确的诊断结果至关重要。我们对这两个概念进行了比较,强调当身体形象不满意导致:(1)行为症状,如妨碍体重增加的持续行为;和/或(2)进食障碍认知,如对自身体形/体重的扭曲感知或对体形/体重的高估时,身体形象不满意就上升到了具有临床意义的身体形象障碍的水平。我们通过一个简短的病例说明了这一定义的应用,最后提出了一些建议,以帮助医疗服务提供者对 ARFID 及其最相似的饮食失调症(神经性厌食症)进行鉴别诊断。 [ Psychiatr Ann .
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引用次数: 3
Thinking About the System (or Lack Thereof) of Psychiatric Care 思考精神病治疗体系(或缺乏体系)的问题
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240119-02
Andrew A. Nierenberg
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引用次数: 0
Multidisciplinary Treatment of Avoidant/Restrictive Food Intake Disorder 避免性/限制性食物摄入障碍的多学科治疗
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240119-01
Copeland G. Winten, E. Strodl, Lynda J. Ross
Given that research into the treatment of avoidant/restrictive food intake disorder (ARFID) is in its early phases, there is a paucity of evidence-based guidelines directing best practices. However, there is still a need for clinicians to access summations of literature to guide clinical decision-making. Early data on the treatment of ARFID highlight the importance of a multidisciplinary team that can provide medical, pharmacologic, nutritional, and psychological care. While medical treatment is often informed by care guidelines for other eating disorders, pharmacological management often focuses on ARFID's psychiatric comorbidities. The psychological treatments with the strongest current evidence for ARFID include family-based therapy for young children, and cognitive-behavioral therapy for older children, adolescents, and adults. [ Psychiatr Ann. 2024;54(2):e51–e55.]
鉴于对回避型/限制型食物摄入障碍(ARFID)治疗的研究尚处于早期阶段,因此指导最佳治疗方法的循证指南非常缺乏。然而,临床医生仍然需要获取文献总结来指导临床决策。有关 ARFID 治疗的早期数据突显了多学科团队的重要性,该团队可提供医疗、药物、营养和心理治疗。医学治疗通常参考其他进食障碍的治疗指南,而药物治疗通常侧重于 ARFID 的精神并发症。目前对 ARFID 最有力的心理治疗包括针对幼儿的家庭治疗和针对年长儿童、青少年和成人的认知行为治疗。 [Psychiatr Ann. 2024; 54(2):e51-e55.]
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引用次数: 2
Neurobiology of Avoidant/Restrictive Food Intake Disorder 回避型/限制型食物摄入障碍的神经生物学
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240117-02
Sophie Scharner
Avoidant/restrictive food intake disorder (ARFID) is a complex, phenotypically heterogenous, and often severe feeding and eating disorder. Genetic studies suggest that ARFID is highly heritable, and that genes involved in taste perception and neurodevelopmental disorders may confer increased risk for the disorder. Neuroimaging studies are limited but point toward greater activation in reward circuitry among individuals with ARFID who are also overweight or obese, compared to those of normal weight. Endocrine studies have identified maladaptively high satiety-promoting (Peptide YY, cholecystokinin, oxytocin) and low hunger-promoting (ghrelin) hormone levels among individuals with ARFID, which may contribute to disease etiology and/or maintenance. Although research is limited, emerging insights into the pathophysiology of this common and impairing disorder may pave the way for the development of novel biological and pharmacological treatments. [ Psychiatr Ann. 2024;54(2):e47–e50.]
回避型/限制型食物摄入障碍(ARFID)是一种复杂的、表型异质性的、通常很严重的进食和饮食障碍。遗传学研究表明,ARFID 具有高度遗传性,涉及味觉感知和神经发育障碍的基因可能会增加患这种疾病的风险。神经影像学研究有限,但研究表明,与体重正常者相比,超重或肥胖的 ARFID 患者的奖赏回路激活程度更高。内分泌研究发现,ARFID 患者体内促进饱腹感的激素(肽 YY、胆囊收缩素、催产素)水平偏高,而促进饥饿感的激素(胃泌素)水平偏低,这可能是疾病的病因和/或维持因素。尽管研究有限,但对这种常见的损伤性疾病的病理生理学的新认识可能为开发新型生物和药物治疗方法铺平道路。 [ 《精神病学年鉴》,2024;54(2):e47-e50]。
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引用次数: 0
Epidemiology of Avoidant/Restrictive Food Intake Disorder 回避型/限制型食物摄入障碍的流行病学研究
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240117-01
Ashley Dunford, Jennifer J. Thomas
Avoidant/restrictive food intake disorder (ARFID) is a relatively new category within DSM-5 feeding and eating disorders, which expands beyond developmentally normative picky eating. Given its recent introduction to the diagnostic nomenclature, research on the epidemiology of ARFID is in its infancy. Prevalence estimates for ARFID vary considerably by methodology, setting, and population, but growing evidence suggests that ARFID is just as common as other more well-known eating disorders, affecting approximately 0.3% to 15.5% of children and 0.3% to 4.1% of adults. Despite common misconceptions, ARFID impacts a wide range of individuals across ages and genders, and both medical and psychiatric comorbidities are common. Limited research has investigated prognosis, but existing longitudinal studies highlight the persistence of the disorder and the possibility of diagnostic crossover to other eating disorders. [ Psychiatr Ann . 2024;54(2):e42–e46.]
回避型/限制型食物摄入障碍(ARFID)是《美国疾病分类与诊断标准》(DSM-5)中相对较新的喂养和进食障碍类别,它超出了发育正常的挑食范围。鉴于 ARFID 最近才被纳入诊断术语,有关其流行病学的研究尚处于起步阶段。对 ARFID 患病率的估计因方法、环境和人群的不同而有很大差异,但越来越多的证据表明,ARFID 与其他更广为人知的饮食失调症一样常见,约有 0.3% 至 15.5% 的儿童和 0.3% 至 4.1% 的成人受其影响。尽管存在一些常见的误解,但 ARFID 对不同年龄和性别的人群都有影响,而且医学和精神疾病并发症也很常见。对预后的调查研究有限,但现有的纵向研究强调了该疾病的持续性以及与其他进食障碍诊断交叉的可能性。 [ Psychiatr Ann .
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引用次数: 1
Differential Diagnosis Between Avoidant/Restrictive Food Intake Disorder and Anorexia Nervosa 回避型/限制型食物摄入障碍与神经性厌食症的鉴别诊断
Pub Date : 2024-02-01 DOI: 10.3928/00485713-20240110-01
P. E. Kambanis, Lilian P. Palmer, Lazaro Zayas
Differential diagnosis between avoidant/restrictive food intake disorder (ARFID) and anorexia nervosa may be challenging due to shared clinical features. Diagnostic criteria for ARFID prohibit disturbance of one's body shape/weight. In contrast to body image disturbance, body image dissatisfaction is normative and ubiquitous and may characterize those with ARFID. Distinguishing between body image disturbance and dissatisfaction is critical to derive accurate diagnoses. We compare these constructs, highlighting that body image dissatisfaction rises to the level of clinically significant body image disturbance when it results in: (1) behavioral symptoms, such as persistent behavior that interferes with weight gain; and/or (2) eating disorder cognitions, such as a distorted perception of one's shape/weight or overvaluation of shape/weight. We illustrate the application of this definition via a brief case example and conclude by providing recommendations to aid providers in differential diagnosis between ARFID and its most similar eating disorder, anorexia nervosa. [ Psychiatr Ann . 2024;54(2):e37–e41.]
由于具有共同的临床特征,对回避型/限制型食物摄入障碍(ARFID)和神经性厌食症进行鉴别诊断可能具有挑战性。ARFID的诊断标准禁止对自己的体形/体重进行干扰。与体像障碍相反,体像不满意是正常的、普遍存在的,可能是 ARFID 患者的特征。区分体像困扰和体像不满意对于得出准确的诊断结果至关重要。我们对这两个概念进行了比较,强调当身体形象不满意导致:(1)行为症状,如妨碍体重增加的持续行为;和/或(2)进食障碍认知,如对自身体形/体重的扭曲感知或对体形/体重的高估时,身体形象不满意就上升到了具有临床意义的身体形象障碍的水平。我们通过一个简短的病例说明了这一定义的应用,最后提出了一些建议,以帮助医疗服务提供者对 ARFID 及其最相似的饮食失调症(神经性厌食症)进行鉴别诊断。 [ Psychiatr Ann .
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引用次数: 3
期刊
Psychiatric Annals
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