Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.14765
Rezq Ahmed Shakir, H. Al-Tameemi, Hayder K Hasson, Zahraa Ayad Zahraa Ayad, Raaed Hamza Jawad, Haider Abd AlRouda Jassim
Background: The presence of cerebral cortical lesions in multiple sclerosis has an important clinical impact on the prognosis of the disease and associated disability. However, the accurate detection of cortical lesions using conventional magnetic resonance imaging sequences remains challenging. The study aims to assess the value of phase-sensitive inversion recovery sequence in the detection of cortical lesions in multiple sclerosis patients and to evaluate their relation with clinical subtypes, duration, and clinical disability of the disease. Patients and Methods: Seventy cases, 51 females and 19 males, of multiple sclerosis, confirmed by McDonald criteria, were enrolled in this cross-sectional study and phase-sensitive inversion recovery images, axial and coronal sections, were obtained for each patient in every MRI session. Cortical lesions were subclassified into intracortical, leukocortical, and juxtacortical. Clinical disability was assessed using the extended disability status scale. The number of detected cortical lesions on phase-sensitive inversion recovery images was calculated and compared with that detected on conventional T2-weighted and fluid-attenuated inversion recovery images. Results: The number of cortical lesions detected on phase-sensitive inversion recovery was lesser compared to the T2-weighted sequence, a total of 1151 versus 1258 lesions respectively. The T2-weighted sequence was significantly better in the detection of leukocortical and juxtacortical. On the other hand, phase-sensitive inversion recovery was better than fluid-attenuated inversion recovery in detecting intracortical, while fluid-attenuated inversion recovery was better in detecting juxtacortical, and both sequences detected the same number of leukocortical lesions. The overall number of detected cortical lesions showed a statistically significant correlation only with the extended disability status scale and not with the clinical subtype or duration of multiple sclerosis. Conclusion: phase-sensitive inversion recovery detected more intracortical lesions and fewer juxtacortical lesions than fluid-attenuated inversion recovery, cortical lesions were significantly correlated with the degree of clinical disability of multiple sclerosis.
{"title":"Usefulness of Phase Sensitive Inversion Recovery MRI Sequence in the Detection of Cortical Lesions in Multiple Sclerosis","authors":"Rezq Ahmed Shakir, H. Al-Tameemi, Hayder K Hasson, Zahraa Ayad Zahraa Ayad, Raaed Hamza Jawad, Haider Abd AlRouda Jassim","doi":"10.36330/kmj.v20i1.14765","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.14765","url":null,"abstract":"Background: The presence of cerebral cortical lesions in multiple sclerosis has an important clinical impact on the prognosis of the disease and associated disability. However, the accurate detection of cortical lesions using conventional magnetic resonance imaging sequences remains challenging. The study aims to assess the value of phase-sensitive inversion recovery sequence in the detection of cortical lesions in multiple sclerosis patients and to evaluate their relation with clinical subtypes, duration, and clinical disability of the disease. Patients and Methods: Seventy cases, 51 females and 19 males, of multiple sclerosis, confirmed by McDonald criteria, were enrolled in this cross-sectional study and phase-sensitive inversion recovery images, axial and coronal sections, were obtained for each patient in every MRI session. Cortical lesions were subclassified into intracortical, leukocortical, and juxtacortical. Clinical disability was assessed using the extended disability status scale. The number of detected cortical lesions on phase-sensitive inversion recovery images was calculated and compared with that detected on conventional T2-weighted and fluid-attenuated inversion recovery images. Results: The number of cortical lesions detected on phase-sensitive inversion recovery was lesser compared to the T2-weighted sequence, a total of 1151 versus 1258 lesions respectively. The T2-weighted sequence was significantly better in the detection of leukocortical and juxtacortical. On the other hand, phase-sensitive inversion recovery was better than fluid-attenuated inversion recovery in detecting intracortical, while fluid-attenuated inversion recovery was better in detecting juxtacortical, and both sequences detected the same number of leukocortical lesions. The overall number of detected cortical lesions showed a statistically significant correlation only with the extended disability status scale and not with the clinical subtype or duration of multiple sclerosis. Conclusion: phase-sensitive inversion recovery detected more intracortical lesions and fewer juxtacortical lesions than fluid-attenuated inversion recovery, cortical lesions were significantly correlated with the degree of clinical disability of multiple sclerosis.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.15375
Abbas Hussein Al-salami, Majida Malik Al-shammari, Majid Hadi Al-Kalabi
Background: Methicillin-resistant Staphylococcus aureus is a significant pathogen associated with multidrug infections among diabetic foot infections. The Panton-Valentine Leukocidin (pvl) gene is an MRSA marker frequently present in community-acquired infections; it causes deep skin and soft tissue infections and osteomyelitis. Objectives: This study aimed to detect the prevalence of the PVL gene in MRSA isolates. Materials and methods: A cross-sectional study conducted from August 2023 to January 2024 investigated MRSA in 150 patients with DFIs at As-in Al-Manathira Hospital in Al-Najaf, Iraq. The S. aureus isolates were diagnosed using the Vitek® 2 technique. Methicillin-resistant S. aureus isolates were detected by a phenotypic method depending on cefoxitin disk diffusion and confirmed by a genotypic method by PCR targeting the mecA, and then the pvl gene was investigated. The genotypic methods employed particularly primers targeting the macA gene and pvl gene using the monoplex PCR technique. Results: The findings demonstrated that 95 (93.1%) of the 102 S. aureus isolates were resistant to cefoxitin, and according to the findings of the molecular study, only 96 (94.11%) isolates showed the mecA gene. Regarding the pvl gene, 97 (95.09%) of isolates produced positive findings. Conclusions: Diabetic foot infections exhibited a significantly high presence of the pvl gene within MRSA strains. These were confirmed using PCR, the gold standard method for detecting the mecA gene associated with methicillin resistance.
{"title":"Investigating the Panton-Valentine Leukocidin Gene in Methicillin-Resistant Staphylococcus aureus from Diabetic Foot Infections","authors":"Abbas Hussein Al-salami, Majida Malik Al-shammari, Majid Hadi Al-Kalabi","doi":"10.36330/kmj.v20i1.15375","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.15375","url":null,"abstract":"Background: Methicillin-resistant Staphylococcus aureus is a significant pathogen associated with multidrug infections among diabetic foot infections. The Panton-Valentine Leukocidin (pvl) gene is an MRSA marker frequently present in community-acquired infections; it causes deep skin and soft tissue infections and osteomyelitis. Objectives: This study aimed to detect the prevalence of the PVL gene in MRSA isolates. Materials and methods: A cross-sectional study conducted from August 2023 to January 2024 investigated MRSA in 150 patients with DFIs at As-in Al-Manathira Hospital in Al-Najaf, Iraq. The S. aureus isolates were diagnosed using the Vitek® 2 technique. Methicillin-resistant S. aureus isolates were detected by a phenotypic method depending on cefoxitin disk diffusion and confirmed by a genotypic method by PCR targeting the mecA, and then the pvl gene was investigated. The genotypic methods employed particularly primers targeting the macA gene and pvl gene using the monoplex PCR technique. Results: The findings demonstrated that 95 (93.1%) of the 102 S. aureus isolates were resistant to cefoxitin, and according to the findings of the molecular study, only 96 (94.11%) isolates showed the mecA gene. Regarding the pvl gene, 97 (95.09%) of isolates produced positive findings. Conclusions: Diabetic foot infections exhibited a significantly high presence of the pvl gene within MRSA strains. These were confirmed using PCR, the gold standard method for detecting the mecA gene associated with methicillin resistance.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.15362
Ahmed Faaz Nasser, H. Al-Tameemi
Background: Chronic Liver disease (CLD) is a global public health problem and one of the leading causes of mortality worldwide with many complications like portal hypertension (PH) and esophageal varices (EV). Researchers have investigated the role of shear-wave elastography (SWE) as a non-invasive method to assess patients with cirrhosis and PH. However, studies evaluating the role of splenic stiffness (SS) have shown variable results. Aim of the study: This study aims to assess the SS in a patient with CLD compared to controlled cases and to evaluate its role in the prediction of EV grade. Material and Methods. The study included 60 participants; 30 patients diagnosed with CLD by the clinical, laboratory, and radiological investigation, who underwent upper gastrointestinal endoscopy; and 30 control health individuals. The mean splenic size, SS, and platelet counts were measured for all participants. Mean SS was compared between two groups, and then its validity in differentiated between low and high-risk groups of EV was assessed. Results. Patients with CLD and controls were significantly different in SS values with cut-off value of 12.49 Kpa. Among CLD patients, the low and high-risk EV subgroups were significant different in SS values with cut-off value of 15.125 KPa. Compared with splenic size and platelet count, SS had the highest accuracy (93.3%) in predicting high-grade EV. Conclusion. Patients with CLD showed higher SS values than control with stepwise increase in SS with increasing grade of EV. SS can accurately predict high-risk groups of EV hence may help decrease patients' burden by avoiding unnecessary endoscopy.
背景:慢性肝病(CLD)是一个全球性的公共卫生问题,也是导致全球死亡的主要原因之一,并伴有许多并发症,如门脉高压症(PH)和食管静脉曲张(EV)。研究人员已经研究了剪切波弹性成像(SWE)作为一种无创方法对肝硬化和门静脉高压患者进行评估的作用。然而,评估脾脏硬度(SS)作用的研究结果却不尽相同。研究目的 本研究旨在评估与对照病例相比,CLD 患者的脾脏硬度,并评估其在预测 EV 分级中的作用。材料与方法。该研究包括 60 名参与者:30 名通过临床、实验室和放射学检查确诊为 CLD 的患者,他们接受了上消化道内窥镜检查;以及 30 名对照健康人。研究人员测量了所有参与者的平均脾脏大小、SS 和血小板计数。比较两组的平均 SS,然后评估其在区分 EV 低危和高危人群方面的有效性。结果显示以 12.49 Kpa 为临界值,CLD 患者和对照组在 SS 值上存在显著差异。在 CLD 患者中,以 15.125 KPa 为临界值,低风险和高风险 EV 亚组的 SS 值差异显著。与脾脏大小和血小板计数相比,SS 预测高级别 EV 的准确率最高(93.3%)。结论CLD患者的SS值高于对照组,且随着EV等级的增加,SS值呈阶梯状增加。 SS能准确预测EV的高危人群,因此可避免不必要的内镜检查,从而减轻患者的负担。
{"title":"Shear-Wave Elastographic Evaluation of Splenic Stiffness in Patients with Chronic Liver Diseases as A Predictor of the Oesophageal Varices Grade","authors":"Ahmed Faaz Nasser, H. Al-Tameemi","doi":"10.36330/kmj.v20i1.15362","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.15362","url":null,"abstract":"Background: Chronic Liver disease (CLD) is a global public health problem and one of the leading causes of mortality worldwide with many complications like portal hypertension (PH) and esophageal varices (EV). Researchers have investigated the role of shear-wave elastography (SWE) as a non-invasive method to assess patients with cirrhosis and PH. However, studies evaluating the role of splenic stiffness (SS) have shown variable results. Aim of the study: This study aims to assess the SS in a patient with CLD compared to controlled cases and to evaluate its role in the prediction of EV grade. Material and Methods. The study included 60 participants; 30 patients diagnosed with CLD by the clinical, laboratory, and radiological investigation, who underwent upper gastrointestinal endoscopy; and 30 control health individuals. The mean splenic size, SS, and platelet counts were measured for all participants. Mean SS was compared between two groups, and then its validity in differentiated between low and high-risk groups of EV was assessed. Results. Patients with CLD and controls were significantly different in SS values with cut-off value of 12.49 Kpa. Among CLD patients, the low and high-risk EV subgroups were significant different in SS values with cut-off value of 15.125 KPa. Compared with splenic size and platelet count, SS had the highest accuracy (93.3%) in predicting high-grade EV. Conclusion. Patients with CLD showed higher SS values than control with stepwise increase in SS with increasing grade of EV. SS can accurately predict high-risk groups of EV hence may help decrease patients' burden by avoiding unnecessary endoscopy.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"17 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.16222
Mohammed Abbas Mohammed, Salam Jasim Mohammed
Background: Obesity and major depression disorder are two of the most common diseases in the world. They are also big problems because they have a very strong effect on people's health and well-being, but also because of their high morbidity and mortality rates and socioeconomic effect. Aim of the study: This study to study the association between obesity and depression, and to explore the link between body mass index and socio-demographic characteristics. Patients and methods: A case-control study utilized a random sample of 300 subjects (100 obese group and 200 normal weight group) attending diabetes and endocrinology center at Al- Najaf province. All subjects have been taken randomly from adult individuals with age range between (18-60) years in Al-Najaf province. The data were collected from October to the February. The obtained data analyzed by Version 28 of the Statistical Package for the Social Sciences (SPSS). Results: The current study found a significant association between obesity and depression, indicates that those with moderate/severe depression scores are more likely to be obese than those with mild depression or no depression (odds ratio = 2.306 times, 95% CI: 1.360-3.910). With (p = 0.002). The relationship between obesity and socio-demographic factors, this study found positive association between obesity and exercise (p = 0.001) and family history of obesity (p = 0.037), while the other characteristics were not significant. Conclusions: The current study concluded that those who had moderate or severe depression symptoms were more likely for developing obesity than those who had a mild or no depression symptoms.
{"title":"Effect of Depressive Symptoms on Weight among Adults at Al-Najaf Province: A case-control Study","authors":"Mohammed Abbas Mohammed, Salam Jasim Mohammed","doi":"10.36330/kmj.v20i1.16222","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.16222","url":null,"abstract":"Background: Obesity and major depression disorder are two of the most common diseases in the world. They are also big problems because they have a very strong effect on people's health and well-being, but also because of their high morbidity and mortality rates and socioeconomic effect. Aim of the study: This study to study the association between obesity and depression, and to explore the link between body mass index and socio-demographic characteristics. Patients and methods: A case-control study utilized a random sample of 300 subjects (100 obese group and 200 normal weight group) attending diabetes and endocrinology center at Al- Najaf province. All subjects have been taken randomly from adult individuals with age range between (18-60) years in Al-Najaf province. The data were collected from October to the February. The obtained data analyzed by Version 28 of the Statistical Package for the Social Sciences (SPSS). Results: The current study found a significant association between obesity and depression, indicates that those with moderate/severe depression scores are more likely to be obese than those with mild depression or no depression (odds ratio = 2.306 times, 95% CI: 1.360-3.910). With (p = 0.002). The relationship between obesity and socio-demographic factors, this study found positive association between obesity and exercise (p = 0.001) and family history of obesity (p = 0.037), while the other characteristics were not significant. Conclusions: The current study concluded that those who had moderate or severe depression symptoms were more likely for developing obesity than those who had a mild or no depression symptoms.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"5 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.14270
Baneen Ali Diab, Rana Fadhil Obaid
Background: Rheumatoid arthritis is an inflammatory illness that affects the entire body but its cause is unknown. There has been a considerable debate about the relation between thyroid gland and Rheumatoid arthritis. Aim of the study: To determine the frequency of Hashimoto's thyroiditis in patients with Rheumatoid Arthritis and determine whether patients with Rheumatoid arthritis are at higher risk of Hashimoto's thyroiditis. Patients and methods: This study is a cross-sectional observational study done in the governorate of Najaf from September 2022 to February 2023 involving 140 participants diagnosed with Rheumatoid arthritis, determined by rheumatologist doctors in line with ACR/EULAR 2010 Criteria and serological testing. Patients including 16 males and 124 females, ranging between the ages of 20 and 60. All participants underwent complete clinical and laboratory assessments. The data were collected during the direct patient interview and the information from the questionnaire, verbal approval has been received from the study participant. Results: The frequency of Hashimoto's disease in the selected patients of rheumatoid arthritis (N=140), was 45 (32.14%), While euthyroidism (Rheumatoid arthritis patients without Hashimoto’s) was 95(67.9%). Hashimoto's disease included subclinical 9 (6.4%) and overt Hashimoto's thyroiditis 36(25.7%). Conclusions: HT is frequent among patients with RA. Therefore, there is a need of screening of thyroid hormone dysfunction as well as presence of Anti-TPO antibodies as markers of HT in RA patients particularly in young patients, females, and those with high disease activity. The association was a significance among RA patients with HT and ACCP, BMI, and ESR.
{"title":"The Prevalence of Hashimoto's Thyroiditis among Rheumatoid Arthritis Patients","authors":"Baneen Ali Diab, Rana Fadhil Obaid","doi":"10.36330/kmj.v20i1.14270","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.14270","url":null,"abstract":"Background: Rheumatoid arthritis is an inflammatory illness that affects the entire body but its cause is unknown. There has been a considerable debate about the relation between thyroid gland and Rheumatoid arthritis. Aim of the study: To determine the frequency of Hashimoto's thyroiditis in patients with Rheumatoid Arthritis and determine whether patients with Rheumatoid arthritis are at higher risk of Hashimoto's thyroiditis. Patients and methods: This study is a cross-sectional observational study done in the governorate of Najaf from September 2022 to February 2023 involving 140 participants diagnosed with Rheumatoid arthritis, determined by rheumatologist doctors in line with ACR/EULAR 2010 Criteria and serological testing. Patients including 16 males and 124 females, ranging between the ages of 20 and 60. All participants underwent complete clinical and laboratory assessments. The data were collected during the direct patient interview and the information from the questionnaire, verbal approval has been received from the study participant. Results: The frequency of Hashimoto's disease in the selected patients of rheumatoid arthritis (N=140), was 45 (32.14%), While euthyroidism (Rheumatoid arthritis patients without Hashimoto’s) was 95(67.9%). Hashimoto's disease included subclinical 9 (6.4%) and overt Hashimoto's thyroiditis 36(25.7%). Conclusions: HT is frequent among patients with RA. Therefore, there is a need of screening of thyroid hormone dysfunction as well as presence of Anti-TPO antibodies as markers of HT in RA patients particularly in young patients, females, and those with high disease activity. The association was a significance among RA patients with HT and ACCP, BMI, and ESR.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.14459
Ahmed Jameel Mashloosh, Faiza M. Abdul-Ameer
Background: Maxillofacial defects may arise from congenital, developmental, traumatic, or surgical procedures. The presence of such defects may adversely affect an individual's appearance and function, resulting in an inability to lead a typical life and impacting their psychological well-being. Surgical reconstruction is often regarded as the primary therapeutic option in such instances. However, it may not be feasible in numerous cases due to various unfavorable conditions. Consequently, the need for maxillofacial prosthesis reconstruction becomes obligatory. Purpose: This study assesses the antibacterial efficacy of copper oxide nanoparticles at different rates against Staphylococcus epidermidis after incorporation into maxillofacial silicone. Methods: A pilot study was first conducted in Iraq and copper oxide nanoparticles were added to VST50F silicone elastomer in different five percentages (0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, and 0.05 wt%). Thirty specimens were prepared and grouped into six groups: one control group and five experimental groups, and then the best effective two percentages (0.03 wt% and 0.04 wt%) were selected for the main study. Thirty specimens for the main study were divided into three groups: control group (A) and two experimental groups (B and C). A statistical analysis was done with an ANOVA and the Games-Howell multiple comparison test (P < 0.05). The data's normal distribution and homogeneity were assessed. Field emission scanning electron microscopy (FES-EM) and Fourier transform infrared spectroscopy (FTIR) were also conducted. Results: The statistical analysis showed a significant difference between all groups with P < 0.05. There was a significant difference between control group A and experimental groups B and C with P < 0.05, as well as between experimental groups B and C (P < 0.05). FESEM showed that nanoparticles were distributed well within the silicone matrix. FTIR spectra proved no chemical reaction to occurr between the copper oxide nanoparticles and VST50F silicone. Conclusion: Incorporating copper oxide nanoparticles into VST50F maxillofacial silicone improved their antibacterial efficacy against Staphylococcus epidermidis.
背景:颌面部缺陷可能源于先天、发育、外伤或外科手术。这些缺陷的存在可能会对患者的外观和功能造成不利影响,导致其无法过正常生活,并影响其心理健康。在这种情况下,手术重建通常被视为主要的治疗方案。然而,在许多情况下,由于各种不利条件,手术可能并不可行。因此,必须进行颌面部假体重建。目的:本研究评估了氧化铜纳米颗粒加入颌面硅胶后对表皮葡萄球菌的不同抗菌率。研究方法:首先在伊拉克进行了一项试验性研究,在 VST50F 硅树脂弹性体中添加了不同比例的纳米氧化铜(0.01 wt%、0.02 wt%、0.03 wt%、0.04 wt% 和 0.05 wt%)。制备了 30 个试样并将其分为六组:一组对照组和五组实验组,然后选择效果最好的两个百分比(0.03 wt% 和 0.04 wt%)作为主要研究对象。主要研究的 30 个试样分为三组:对照组(A)和两个实验组(B 和 C)。统计分析采用方差分析和 Games-Howell 多重比较检验(P < 0.05)。对数据的正态分布和均匀性进行了评估。此外,还进行了场发射扫描电子显微镜(FES-EM)和傅立叶变换红外光谱(FTIR)分析。结果显示统计分析显示,各组间差异显著(P < 0.05)。对照组 A 与实验组 B 和 C 之间存在显著差异(P < 0.05),实验组 B 和 C 之间也存在显著差异(P < 0.05)。FESEM 显示,纳米颗粒在硅胶基质中分布良好。傅立叶变换红外光谱证明氧化铜纳米颗粒与 VST50F 硅胶之间没有发生化学反应。结论在 VST50F 颌面硅胶中加入纳米氧化铜颗粒可提高其对表皮葡萄球菌的抗菌效果。
{"title":"Evaluating the Effect of Copper Oxide Nanoparticles after Added to the Maxillofacial Silicone on the Adherence of Staphylococcus Epidermidis","authors":"Ahmed Jameel Mashloosh, Faiza M. Abdul-Ameer","doi":"10.36330/kmj.v20i1.14459","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.14459","url":null,"abstract":"Background: Maxillofacial defects may arise from congenital, developmental, traumatic, or surgical procedures. The presence of such defects may adversely affect an individual's appearance and function, resulting in an inability to lead a typical life and impacting their psychological well-being. Surgical reconstruction is often regarded as the primary therapeutic option in such instances. However, it may not be feasible in numerous cases due to various unfavorable conditions. Consequently, the need for maxillofacial prosthesis reconstruction becomes obligatory. Purpose: This study assesses the antibacterial efficacy of copper oxide nanoparticles at different rates against Staphylococcus epidermidis after incorporation into maxillofacial silicone. Methods: A pilot study was first conducted in Iraq and copper oxide nanoparticles were added to VST50F silicone elastomer in different five percentages (0.01 wt%, 0.02 wt%, 0.03 wt%, 0.04 wt%, and 0.05 wt%). Thirty specimens were prepared and grouped into six groups: one control group and five experimental groups, and then the best effective two percentages (0.03 wt% and 0.04 wt%) were selected for the main study. Thirty specimens for the main study were divided into three groups: control group (A) and two experimental groups (B and C). A statistical analysis was done with an ANOVA and the Games-Howell multiple comparison test (P < 0.05). The data's normal distribution and homogeneity were assessed. Field emission scanning electron microscopy (FES-EM) and Fourier transform infrared spectroscopy (FTIR) were also conducted. Results: The statistical analysis showed a significant difference between all groups with P < 0.05. There was a significant difference between control group A and experimental groups B and C with P < 0.05, as well as between experimental groups B and C (P < 0.05). FESEM showed that nanoparticles were distributed well within the silicone matrix. FTIR spectra proved no chemical reaction to occurr between the copper oxide nanoparticles and VST50F silicone. Conclusion: Incorporating copper oxide nanoparticles into VST50F maxillofacial silicone improved their antibacterial efficacy against Staphylococcus epidermidis.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"9 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.15055
Elham Hussien Manhal Al-Obaidi, Asaad Hasan Noaman Al-Aboodi
Background: In a wide range of clinical settings, comprehensive evaluation of the right ventricle has become increasingly essential. Measures of right ventricle systolic function, including fractional area change, tissue Doppler, S velocity, tricuspid annular plane systolic excursion, show a significant variation in previous studies and different data known regarding how these measurements change with age. Aim of the study: The aim of this study is to evaluate the effects of age on right ventricle systolic function by using conventional 2D echocardiographic assessment. Patients and methods: Comprehensive transthoracic echocardiography examinations were performed on 103 healthy adult volunteers, mean age 37.1±11.9 years (range: 20-66), to determine age related changes in right ventricle dimensions and function. Results: The assessment of right ventricle function demonstrates slightly significant differences in tricuspid annular plane systolic excursion (r= -.197, p = .047), and FAC (r= -.241, p = .015), among age groups, with a non-significant very small negative relationship between age and tissue Dopplers (r= -.0925, p = .355). Conclusions: This study has demonstrated that age-adjusted measures are required for the evaluation of right ventricle function. Further, the conventional techniques may ignore mild or slight changes leading to underestimated assessment which regarded as a fundamental challenge for their use; so, the use of advanced techniques which allow early identification of right ventricle dysfunction are recommended since they can detect subclinical dysfunction before anomalies revealed by traditional echocardiography occur.
{"title":"The Effect of Age on Right Ventricular Systolic Function Using Traditional Echocardiographic Measures","authors":"Elham Hussien Manhal Al-Obaidi, Asaad Hasan Noaman Al-Aboodi","doi":"10.36330/kmj.v20i1.15055","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.15055","url":null,"abstract":"Background: In a wide range of clinical settings, comprehensive evaluation of the right ventricle has become increasingly essential. Measures of right ventricle systolic function, including fractional area change, tissue Doppler, S velocity, tricuspid annular plane systolic excursion, show a significant variation in previous studies and different data known regarding how these measurements change with age. Aim of the study: The aim of this study is to evaluate the effects of age on right ventricle systolic function by using conventional 2D echocardiographic assessment. Patients and methods: Comprehensive transthoracic echocardiography examinations were performed on 103 healthy adult volunteers, mean age 37.1±11.9 years (range: 20-66), to determine age related changes in right ventricle dimensions and function. Results: The assessment of right ventricle function demonstrates slightly significant differences in tricuspid annular plane systolic excursion (r= -.197, p = .047), and FAC (r= -.241, p = .015), among age groups, with a non-significant very small negative relationship between age and tissue Dopplers (r= -.0925, p = .355). Conclusions: This study has demonstrated that age-adjusted measures are required for the evaluation of right ventricle function. Further, the conventional techniques may ignore mild or slight changes leading to underestimated assessment which regarded as a fundamental challenge for their use; so, the use of advanced techniques which allow early identification of right ventricle dysfunction are recommended since they can detect subclinical dysfunction before anomalies revealed by traditional echocardiography occur. ","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"5 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.16115
Zahraa M. Hussein AL-Khaqani, Thanaa Shams Al-Deen Al-Turaihi
Background: Diabetes is a chronic disease characterized by high blood sugar levels, resulting from insulin resistance and the destruction of pancreatic beta cells. This disease is associated with several serious complications that are sometimes life-threatening to patients. One of these complications is that it can depression accompanies patients with type 2 diabetes, as it is a Major Depressive Disorder (MDD), and the most important symptoms are social isolation, sleep disturbances, lack of appetite, loss of desire, and passion for daily activities. Opinions differed about the origin of the emergence of this psychological disorder in terms of the involvement of multiple factors, including internal, and some of them are external to causing this disorder. In this study, we will shed light on one of the complications associated with diabetes, which is depression. Method and Results: This cross-sectional study included the selection of 128 individuals diagnosed with type 2 diabetes from the Diabetes and Endocrinology Center located in Najaf, Iraq from July 2023 to January 2024. The study included 43 men and 85 women. The ages of the participants ranged from 30 to 75 years. Patients were randomly selected during their visit to the center. Results: 31(24.2%) individuals did not manifest any symptoms of depression 75.78% suffered from depression, most of the depressed people were women, and the difference between the sexes was statistically significant p-value (0. 002). Conclusion; Our study highlights a striking connection between type 2 diabetes and depression, with a significantly higher incidence of depression in diabetic patients. Additionally, the fact that females are more likely to suffer from depression compared to males also calls for further research into other factors that could potentially exacerbate mental health issues in type 2 diabetes women.
{"title":"Estimate the Prevalence of Depression in Type 2 Diabetes Patients","authors":"Zahraa M. Hussein AL-Khaqani, Thanaa Shams Al-Deen Al-Turaihi","doi":"10.36330/kmj.v20i1.16115","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.16115","url":null,"abstract":"Background: Diabetes is a chronic disease characterized by high blood sugar levels, resulting from insulin resistance and the destruction of pancreatic beta cells. This disease is associated with several serious complications that are sometimes life-threatening to patients. One of these complications is that it can depression accompanies patients with type 2 diabetes, as it is a Major Depressive Disorder (MDD), and the most important symptoms are social isolation, sleep disturbances, lack of appetite, loss of desire, and passion for daily activities. Opinions differed about the origin of the emergence of this psychological disorder in terms of the involvement of multiple factors, including internal, and some of them are external to causing this disorder. In this study, we will shed light on one of the complications associated with diabetes, which is depression. Method and Results: This cross-sectional study included the selection of 128 individuals diagnosed with type 2 diabetes from the Diabetes and Endocrinology Center located in Najaf, Iraq from July 2023 to January 2024. The study included 43 men and 85 women. The ages of the participants ranged from 30 to 75 years. Patients were randomly selected during their visit to the center. Results: 31(24.2%) individuals did not manifest any symptoms of depression 75.78% suffered from depression, most of the depressed people were women, and the difference between the sexes was statistically significant p-value (0. 002). Conclusion; Our study highlights a striking connection between type 2 diabetes and depression, with a significantly higher incidence of depression in diabetic patients. Additionally, the fact that females are more likely to suffer from depression compared to males also calls for further research into other factors that could potentially exacerbate mental health issues in type 2 diabetes women.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"4 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.14672
Mais Almumen, Liqaa Mohammed Muslim, Ammar Saeed Rasheed
Background: The most common extra axial primary central nervous system (CNS) tumor is meningioma, accounting for 36% of all CNS tumors. On neuroradiologic and gross assessment, the typical meningioma is lobulated. Cystic variants, although uncommon, are well recognized, and possibly be confused with metastatic or glial tumors. Case presentation: A 40-year-old female patient complaining of headache, Magnetic resonance imaging (MRI) revealed frontoparietal brain cystic lesion with intracystic nodule, given the differential diagnosis of low-grade gliomas, hemangioblastoma, pleomorphic xanthoastrocytoma, pilocytic astrocytoma and rarely meningioma. The histopathological slides showed the diagnosis of meningothelial meningioma (WHO/Mayo Clinic_ Grade I). Immunohistochemistry (IHC) was performed for epithelial membrane antigen (EMA) showing positive membranous stain but IHC staining for glial fibrillary acetic protein (GFAP) was negative for the cytoplasm. Conclusions: Patient with cystic meningioma was reported. There is no absolute test for preoperatively distinguishing it from the most prevalent other gliomas. So avoiding any extra cost and time loss, angiographic assessment and cooperation with a histopathologist are of clinical importance for the identification of these possibly curable neoplasms.
{"title":"Meningioma as a Rare Presentation","authors":"Mais Almumen, Liqaa Mohammed Muslim, Ammar Saeed Rasheed","doi":"10.36330/kmj.v20i1.14672","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.14672","url":null,"abstract":"Background: The most common extra axial primary central nervous system (CNS) tumor is meningioma, accounting for 36% of all CNS tumors. On neuroradiologic and gross assessment, the typical meningioma is lobulated. Cystic variants, although uncommon, are well recognized, and possibly be confused with metastatic or glial tumors. Case presentation: A 40-year-old female patient complaining of headache, Magnetic resonance imaging (MRI) revealed frontoparietal brain cystic lesion with intracystic nodule, given the differential diagnosis of low-grade gliomas, hemangioblastoma, pleomorphic xanthoastrocytoma, pilocytic astrocytoma and rarely meningioma. The histopathological slides showed the diagnosis of meningothelial meningioma (WHO/Mayo Clinic_ Grade I). Immunohistochemistry (IHC) was performed for epithelial membrane antigen (EMA) showing positive membranous stain but IHC staining for glial fibrillary acetic protein (GFAP) was negative for the cytoplasm. Conclusions: Patient with cystic meningioma was reported. There is no absolute test for preoperatively distinguishing it from the most prevalent other gliomas. So avoiding any extra cost and time loss, angiographic assessment and cooperation with a histopathologist are of clinical importance for the identification of these possibly curable neoplasms.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"4 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.36330/kmj.v20i1.15052
Fatima Ali Abdulwahed Alkyoon, Falah Mahdi Dananah
Back ground: the Chronic Obstructive Pulmonary Disease (COPD) is a chronic Inflammatory disease of the airways and/ or parenchyma usually characterized by progressive irreversible airflow with accompanying respiratory symptoms like dyspnea, cough, production of sputum, and/or exacerbations. The pathophysiology Of COPD involves bronchitis and /or emphysema, the effect of inflammation occurs in the lung and also have systemic effect, most common causes is tobacco smoking, occupational pollution, indoor pollution. Progranulin (PGRN) is defined as precursor of pleiotropic glycosylated protein, it has significant role in process of inflammation, angiogenesis, neoplasia, cell development, cell cycle, embryogenesis, wound healing, modification of autoimmune process, highly found in several type of cells like respiratory epithelial cells. Objective: The aim is to study relationship between serum level of PGRN and inflammatory markers in COPD patients. Material and method: A case control study composed of 40 patients with COPD and 45 controls, demographic characteristic, pulmonary function test, blood investigation include CRP-titer, WBC and plasma PGRN were measured and made comparison of data in cases with controls, data collected were statically analysis by SPSS. Result: The study showed that, there was no significant correlation between serum progranulin level, WBC and C-Reactive Protein titer in COPD patients (P value >0.05). Conclusions: It was concluded that PGRN level in COPD patients don’t correlate with CRP titer level or with WBC.
{"title":"The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease","authors":"Fatima Ali Abdulwahed Alkyoon, Falah Mahdi Dananah","doi":"10.36330/kmj.v20i1.15052","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.15052","url":null,"abstract":"Back ground: the Chronic Obstructive Pulmonary Disease (COPD) is a chronic Inflammatory disease of the airways and/ or parenchyma usually characterized by progressive irreversible airflow with accompanying respiratory symptoms like dyspnea, cough, production of sputum, and/or exacerbations. The pathophysiology Of COPD involves bronchitis and /or emphysema, the effect of inflammation occurs in the lung and also have systemic effect, most common causes is tobacco smoking, occupational pollution, indoor pollution. Progranulin (PGRN) is defined as precursor of pleiotropic glycosylated protein, it has significant role in process of inflammation, angiogenesis, neoplasia, cell development, cell cycle, embryogenesis, wound healing, modification of autoimmune process, highly found in several type of cells like respiratory epithelial cells. Objective: The aim is to study relationship between serum level of PGRN and inflammatory markers in COPD patients. Material and method: A case control study composed of 40 patients with COPD and 45 controls, demographic characteristic, pulmonary function test, blood investigation include CRP-titer, WBC and plasma PGRN were measured and made comparison of data in cases with controls, data collected were statically analysis by SPSS. Result: The study showed that, there was no significant correlation between serum progranulin level, WBC and C-Reactive Protein titer in COPD patients (P value >0.05). Conclusions: It was concluded that PGRN level in COPD patients don’t correlate with CRP titer level or with WBC.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}