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Late-onset multiple sclerosis initially presenting with acute psychiatric symptomatology: A case report. 迟发性多发性硬化症最初表现为急性精神症状:1例报告。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-08-01 DOI: 10.12788/acp.0038
Hassan Alfanharawi, Prabhpreet S Bassi, Christina D Enescu, Siri S Sarvepalli, Victor Ajluni
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引用次数: 0
Measurement-based care training curriculum in psychiatry residency programs: I: Description of the curriculum and demonstration of implementation. 精神病学住院医师项目中基于测量的护理培训课程:1:课程描述和实施演示。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-08-01 DOI: 10.12788/acp.0039
Ahmed Aboraya, Henry A Nasrallah, Daniel Elswick, Yasha Rastgar, James Berry, Cheryl Hill, John Justice, Wanhong Zheng, Nathan Pearson, Gerard Gallucci, Patricia Figgs, Jeremy Hustead, Joel Vogt, Jawad Zafar, Sheena Dohar, Robert Looper, Danielle Guinan, Akram Elawady, Omar Shah, Mei Wai Lam, Shanila Shagufta, Noah Schwartzman, Eddie Hamric, Lauren Mayle, Mark Miller, Dilip Chandran, Patrick Marshalek, Rachel Moreland, Tenchee Lama Tamang, Sunny Mattancheril, Sara Berzingi

Background: Recent literature shows that most practicing psychiatrists do not receive training in measurement-based care (MBC). Among the primary barriers to MBC implementation are the lack of formal training and curriculums. We present the first comprehensive MBC curriculum for use in adult psychiatric practice, and describe how the curriculum is adapted and implemented in psychiatry residency training programs.

Methods: The Standard for Clinicians' Interview in Psychiatry (SCIP) was developed as a measurement-based care tool for clinicians' use. The SCIP is the only instrument that includes 18 reliable and validated clinician-rated scales covering most adult psychiatric disorders. The SCIP has simple, unified rules of measurement that apply to the 18 scales. The MBC curriculum includes 2 instruction manuals, 4 didactic lectures, and 12 videotaped interviews. We describe the annual learning and implementation of MBC curriculum in residency programs.

Results: The curriculum implementation at West Virginia University and Delaware Psychiatric Center began in 2019 and is ongoing. We present 3 case demonstrations of the implementation of MBC in clinical settings.

Conclusions: Comprehensive implementation of MBC curriculum in residency programs has the potential to facilitate research and create a "culture" of MBC in future generations of psychiatrists.

背景:最近的文献显示,大多数执业精神科医生没有接受过以测量为基础的护理(MBC)的培训。实施MBC的主要障碍之一是缺乏正规培训和课程。我们提出了第一个用于成人精神病学实践的综合MBC课程,并描述了如何在精神病学住院医师培训计划中调整和实施课程。方法:制定临床医生精神病学访谈标准(SCIP),作为临床医生使用的基于测量的护理工具。SCIP是唯一包含了18个可靠且有效的临床评定量表的工具,涵盖了大多数成人精神疾病。SCIP有简单、统一的测量规则,适用于18个量表。MBC的课程包括2本教学手册、4个教学讲座和12个访谈录像。我们描述了每年的学习和实施MBC课程在住院医师计划。结果:西弗吉尼亚大学和特拉华精神病学中心的课程实施始于2019年,目前正在进行中。我们提出了在临床环境中实施MBC的3个案例演示。结论:在住院医师项目中全面实施MBC课程有可能促进研究,并在未来几代精神科医生中创造MBC“文化”。
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引用次数: 1
Psychiatry Update 2021 Spring Abstract Compendium. 精神病学更新2021春季摘要纲要。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-08-01 DOI: 10.12788/10.12788/acp.0059
No abstract available.
没有摘要。
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引用次数: 0
An exploration of parental awareness, knowledge, and concerns related to COVID-19. 探讨父母对COVID-19的认识、知识和担忧。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-08-01 DOI: 10.12788/acp.0040
Eyüp Sarı, Harun Terin, Sadettin Burak Açıkel, Bilge Akkaya, Saliha Şenel

Background: COVID-19 rapidly spread worldwide with high morbidity and mortality. In this study, we aimed to detect parental concerns along with their awareness of and attitudes towards COVID-19 among patients admitted to our inpatient and outpatient clinics.

Methods: This study was conducted at a children's hospital with 141 parents of children who were patients in the inpatient and outpatient clinics. Parents were asked to complete an anonymous questionnaire and psychiatric scales that included the Beck Depression Inventory, Beck Anxiety Inventory (BAI), and Impact of Events Scale-Revised form (IES-R).

Results: The study sample consisted of 141 parents, of which 59 were parents of inpatients and 82 were parents of outpatients. The most known COVID-19 symptoms were fever, difficulty in breathing, and cough, respectively. The most preferred precaution was "staying at home." We found a significant positive correlation between the number of precautions and BAI score (R = .169, P = .046). Inpatients' parents IES-R scores were significantly higher than outpatients' parents IES-R scores.

Conclusions: Parents were found to be aware of the COVID-19 pandemic regardless of education status and family income. Participants' IES-R scores revealed significant differences in terms of COVID-19 impact on psychological health between the parents of inpatient and outpatient children; inpatients' parents were more concerned about COVID-19.

背景:COVID-19在全球范围内迅速传播,发病率和死亡率高。在本研究中,我们旨在了解住院和门诊患者中父母的担忧以及他们对COVID-19的认识和态度。方法:本研究在某儿童医院对141名住院和门诊儿童的家长进行研究。父母被要求完成一份匿名问卷和精神病学量表,包括贝克抑郁量表、贝克焦虑量表(BAI)和事件影响量表修订表(IES-R)。结果:研究样本共141名家长,其中住院患者家长59名,门诊患者家长82名。最常见的新冠肺炎症状分别是发烧、呼吸困难和咳嗽。最受欢迎的预防措施是“待在家里”。我们发现预防措施数量与BAI评分呈显著正相关(R = 0.169, P = 0.046)。住院患者父母IES-R得分显著高于门诊患者父母IES-R得分。结论:无论受教育程度和家庭收入如何,家长对COVID-19大流行的了解程度都不高。参与者的IES-R得分显示,住院和门诊儿童的父母在COVID-19对心理健康的影响方面存在显著差异;住院患者家长更关心新冠肺炎。
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引用次数: 2
Student leadership in medical school and its implications for health care and policy-making. 医学院学生领导力及其对医疗保健和政策制定的影响。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-08-01 DOI: 10.12788/acp.0027
Nagy A Youssef, Isha Dabke

Background: Approximately 5% of hospital chief executive officers are physicians, and that number is growing. Leadership is a vital skill for future physicians.

Methods: We conducted a narrative review of the literature on student leadership in medical school and its implications for health care and policy-making.

Results: Qualities a good leader should possess include accountability, empathy, positivity, teamwork, and organization. Leadership skills need to be taught to students in their formative pre-clinical years so they can build upon this foundation during their clinical and residency years. Leadership is a multifaceted quality because unlike other lessons, it cannot be measured on a scale or under the microscope; it is largely developed through practice. Furthermore, among physicians, psychiatrists are especially well-trained to serve in active leadership roles because psychiatry training emphasizes interpersonal dynamics and emotional intelligence, qualities that are vital to the skill set of an effective leader.

Conclusions: Medical leadership is essential because physicians relate best to other physicians, and those adept in administrative skills can help bridge the gap between administration and clinicians. There is a need for teaching an evidence-based leadership curriculum and training techniques that will fill a recognized educational void in medical student education (as well as for residents and junior faculty).

背景:大约5%的医院首席执行官是医生,而且这个数字还在增长。领导能力对未来的医生来说是一项至关重要的技能。方法:我们对有关医学院学生领导能力及其对医疗保健和政策制定的启示的文献进行了叙述性回顾。结果:一个好的领导者应该具备的品质包括责任心、同理心、积极向上、团队合作和组织能力。领导技能需要在学生的临床前阶段教授,这样他们就可以在临床和住院医师阶段建立在这个基础上。领导力是一种多方面的品质,因为与其他课程不同,它无法用天平或显微镜来衡量;它在很大程度上是通过实践发展起来的。此外,在内科医生中,精神科医生尤其训练有素,能够担任积极的领导角色,因为精神病学培训强调人际关系动态和情商,这些品质对一个有效的领导者的技能组合至关重要。结论:医疗领导是必不可少的,因为医生与其他医生关系最好,那些擅长管理技能的人可以帮助弥合行政部门和临床医生之间的差距。有必要教授以证据为基础的领导力课程和培训技术,以填补医科学生(以及住院医生和初级教师)教育中公认的教育空白。
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引用次数: 2
Less is more: Deprescribing anticholinergic medications in persons with severe mental illness. 少即是多:严重精神疾病患者的抗胆碱能药物处方。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-05-01 DOI: 10.12788/acp.0019
Ana M Lupu, Kathryn L MacCamy, Jessica M Gannon, Jaspreet S Brar, K N Roy Chengappa

Background: Long-term prescribing of anticholinergic medications (ACM) for antipsychotic-associated extrapyramidal symptoms (EPS) is not recommended, yet is widely prevalent. Adverse effects of ACM include memory impairment, dry mouth, constipation, blurred vision, urinary retention, and tachycardia, which can seriously impact quality of life. This quality improvement deprescription project sought to reduce chronic ACM use in patients with serious mental illness (SMI).

Methods: Education directed at psychiatrists combined with clinical pharmacy support for deprescription was used to target clinically stable patients diagnosed with schizophrenia, schizoaffective disorder, or bipolar disorder with no EPS and ACM prescriptions of ≥6 months. Scales were used to assess anticholinergic adverse effects, memory impairment, and quality of life. ACMs were tapered and discontinued over 1 to 6 months.

Results: More than 75% of targeted patients successfully tapered or discontinued ACM, which coincided with significant improvements in anticholinergic adverse effects, memory impairment, and quality of life. Approximately 10% of patients were restarted on ACM for re-emergent EPS.

Conclusions: For most clinically stable patients with SMI without EPS, our findings suggest that gradual deprescription of chronic ACM is clinically appropriate, well tolerated, and improves quality of life. A randomized trial could provide more definitive answers.

背景:抗精神病相关锥体外系症状(EPS)的长期处方抗胆碱能药物(ACM)是不推荐的,但广泛流行。ACM的副作用包括记忆障碍、口干、便秘、视力模糊、尿潴留和心动过速,这些都会严重影响生活质量。这个质量改进去处方项目旨在减少严重精神疾病(SMI)患者的慢性ACM使用。方法:针对临床稳定的精神分裂症、分裂情感性障碍或双相情感障碍患者,采用精神科医生指导教育结合临床药学支持去处方的方法,且未使用EPS和ACM处方≥6个月。使用量表评估抗胆碱能不良反应、记忆障碍和生活质量。ACMs在1至6个月内逐渐减少并停止使用。结果:超过75%的目标患者成功地逐渐减少或停止使用ACM,这与抗胆碱能不良反应、记忆障碍和生活质量的显著改善相一致。大约10%的患者因再次出现EPS而重新开始ACM治疗。结论:对于大多数临床稳定的SMI患者,我们的研究结果表明,慢性ACM的逐渐去处方在临床上是合适的,耐受性良好,并改善了生活质量。随机试验可以提供更明确的答案。
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引用次数: 2
Race and ethnicity in pediatric OCD: An exploratory study of a clinical North American sample. 儿童强迫症的种族和民族:一项北美临床样本的探索性研究。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-02-01 DOI: 10.12788/acp.0007
Joanne Jf Wang, Sarah Lin, John R Best, Robert R Selles, S Evelyn Stewart

Background: Influences of race and ethnicity have received limited attention in pediatric obsessive-compulsive disorder (OCD), despite noted importance in other psychiatric diseases. We sought to compare racially defined groups presenting to a North American tertiary care pediatric OCD subspecialty clinic.

Methods: Clinician-rated and parent/child-reported information was extracted from a research data registry comprising OCD-affected youth assessed between 2011 and 2018. The study population was aggregated into racial groups, defined as Caucasian, Asian, and "other." Country of origin and spoken language were used as ethnicity proxies. Obsessivecompulsive disorder phenotype, clinical course, and family environment were compared, with inclusion of mixed Asian-Caucasians in post-hoc analyses.

Results: Asian youth reported significantly later ages of OCD symptom onset, clinical diagnosis, and treatment compared with Caucasian youth and were significantly less likely to have participated in OCD-specific treatment, despite similar clinician recommendation rates. Obsessivecompulsive disorder severity and comorbidities did not differ across groups. Asian parents reported significantly higher levels of family blame and conflict than Caucasian parents, but similar prevalence of OCD family history.

Conclusions: Clinically relevant differences were identified between Asians and Caucasians, highlighting the need for individualized care that respects the influences of ethnicity and race in pediatric OCD. Replication and future study of additional racial groups is warranted.

背景:种族和民族的影响在儿童强迫症(OCD)中受到的关注有限,尽管在其他精神疾病中很重要。我们试图比较在北美三级保健儿科强迫症亚专科诊所就诊的按种族划分的人群。方法:从2011年至2018年评估的受强迫症影响的青少年的研究数据注册表中提取临床医生评价和家长/儿童报告的信息。研究人群按种族分组,定义为白种人、亚洲人和“其他”人种。原籍国和口语被用作种族代理。比较强迫症的表型、临床病程和家庭环境,并在事后分析中纳入亚洲-高加索混血儿。结果:与高加索青年相比,亚洲青年报告的强迫症症状发作,临床诊断和治疗年龄明显晚于白人青年,尽管临床医生推荐率相似,但参加强迫症特异性治疗的可能性也明显较低。强迫症的严重程度和合并症在各组间没有差异。亚裔父母报告的家庭责备和冲突程度明显高于白种人父母,但强迫症家族史的患病率相似。结论:亚洲人和白种人之间存在临床相关差异,强调需要个性化护理,尊重种族和种族对儿童强迫症的影响。对其他种族群体的复制和未来研究是有必要的。
{"title":"Race and ethnicity in pediatric OCD: An exploratory study of a clinical North American sample.","authors":"Joanne Jf Wang,&nbsp;Sarah Lin,&nbsp;John R Best,&nbsp;Robert R Selles,&nbsp;S Evelyn Stewart","doi":"10.12788/acp.0007","DOIUrl":"https://doi.org/10.12788/acp.0007","url":null,"abstract":"<p><strong>Background: </strong>Influences of race and ethnicity have received limited attention in pediatric obsessive-compulsive disorder (OCD), despite noted importance in other psychiatric diseases. We sought to compare racially defined groups presenting to a North American tertiary care pediatric OCD subspecialty clinic.</p><p><strong>Methods: </strong>Clinician-rated and parent/child-reported information was extracted from a research data registry comprising OCD-affected youth assessed between 2011 and 2018. The study population was aggregated into racial groups, defined as Caucasian, Asian, and \"other.\" Country of origin and spoken language were used as ethnicity proxies. Obsessivecompulsive disorder phenotype, clinical course, and family environment were compared, with inclusion of mixed Asian-Caucasians in post-hoc analyses.</p><p><strong>Results: </strong>Asian youth reported significantly later ages of OCD symptom onset, clinical diagnosis, and treatment compared with Caucasian youth and were significantly less likely to have participated in OCD-specific treatment, despite similar clinician recommendation rates. Obsessivecompulsive disorder severity and comorbidities did not differ across groups. Asian parents reported significantly higher levels of family blame and conflict than Caucasian parents, but similar prevalence of OCD family history.</p><p><strong>Conclusions: </strong>Clinically relevant differences were identified between Asians and Caucasians, highlighting the need for individualized care that respects the influences of ethnicity and race in pediatric OCD. Replication and future study of additional racial groups is warranted.</p>","PeriodicalId":50770,"journal":{"name":"Annals of Clinical Psychiatry","volume":"33 1","pages":"4-17"},"PeriodicalIF":1.3,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38546656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rapid expansion of direct-to-consumer telemental health during the COVID-19 pandemic: A case series. 在2019冠状病毒病大流行期间,直接面向消费者的远程卫生服务迅速扩大:一个病例系列。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-02-01 DOI: 10.12788/acp.0020
Jessica M Gannon, Abigail Schlesinger, Jody Glance, Mandayam Sujata, Noreen Fredrick, James Wyler, Gina Perez

Background: The coronavirus disease 2019 (COVID-19) pandemic brought many challenges to patient care delivery. The need for social distancing and relaxing of federal and state telemental health regulations paved the way for widespread adoption of direct-to-consumer (DTC) ambulatory mental health video visits.

Methods: We present cases that demonstrate the use of video visits across 6 clinical areas, each serving a unique population of patients, in a large behavioral health system. The benefits and limitations of this modality are illustrated in children, adults, and older adults with mood disorders, anxiety disorders, intellectual disability, substance use disorders, neurocognitive disorders, and schizophrenia.

Results: Although telephone visits were acceptable and necessary to serve some patients, there are many advantages to video visits in providing best patient care. Education and support for telemental health-delivered to both patients and clinicians-is critical to the success of the DTC model.

Conclusions: DTC telemental health is a widespread clinical tool used during the COVID-19 pandemic. Because this model has many strengths and advantages compared with traditional telemental health delivered in a clinic, regulators and insurers should be open to its continued use postpandemic when clinically appropriate.

背景:2019冠状病毒病(COVID-19)大流行给患者护理服务带来了许多挑战。保持社会距离的必要性以及放宽联邦和州远程心理健康法规,为广泛采用直接面向消费者(DTC)的动态心理健康视频就诊铺平了道路。方法:我们提出的案例展示了在一个大型行为健康系统中,在6个临床领域使用视频访问,每个临床领域服务于独特的患者群体。这种治疗方法的益处和局限性在患有情绪障碍、焦虑症、智力残疾、物质使用障碍、神经认知障碍和精神分裂症的儿童、成人和老年人中都有体现。结果:虽然电话就诊是可接受的和必要的,但视频就诊在提供最佳患者护理方面有许多优势。向患者和临床医生提供远程心理健康教育和支持,是DTC模式成功的关键。结论:DTC远程心理健康是COVID-19大流行期间广泛使用的临床工具。由于这种模式与在诊所提供的传统远程心理健康相比具有许多优势和优势,监管机构和保险公司应在临床适当的情况下,对大流行后继续使用这种模式持开放态度。
{"title":"Rapid expansion of direct-to-consumer telemental health during the COVID-19 pandemic: A case series.","authors":"Jessica M Gannon,&nbsp;Abigail Schlesinger,&nbsp;Jody Glance,&nbsp;Mandayam Sujata,&nbsp;Noreen Fredrick,&nbsp;James Wyler,&nbsp;Gina Perez","doi":"10.12788/acp.0020","DOIUrl":"https://doi.org/10.12788/acp.0020","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic brought many challenges to patient care delivery. The need for social distancing and relaxing of federal and state telemental health regulations paved the way for widespread adoption of direct-to-consumer (DTC) ambulatory mental health video visits.</p><p><strong>Methods: </strong>We present cases that demonstrate the use of video visits across 6 clinical areas, each serving a unique population of patients, in a large behavioral health system. The benefits and limitations of this modality are illustrated in children, adults, and older adults with mood disorders, anxiety disorders, intellectual disability, substance use disorders, neurocognitive disorders, and schizophrenia.</p><p><strong>Results: </strong>Although telephone visits were acceptable and necessary to serve some patients, there are many advantages to video visits in providing best patient care. Education and support for telemental health-delivered to both patients and clinicians-is critical to the success of the DTC model.</p><p><strong>Conclusions: </strong>DTC telemental health is a widespread clinical tool used during the COVID-19 pandemic. Because this model has many strengths and advantages compared with traditional telemental health delivered in a clinic, regulators and insurers should be open to its continued use postpandemic when clinically appropriate.</p>","PeriodicalId":50770,"journal":{"name":"Annals of Clinical Psychiatry","volume":"33 1","pages":"27-34"},"PeriodicalIF":1.3,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25322592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Retrospective review of use of adjunctive psychostimulants in patients with schizophrenia. 精神分裂症患者使用辅助精神兴奋剂的回顾性分析。
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-02-01 DOI: 10.12788/acp.0015
Naista Zhand, Philip Harvey, Roisin Osborne, Anna Hatko, Marika Stuyt, Alain Labelle

Background: Adjunctive psychostimulants have been proposed as a potential treatment option for the management of cognitive and/or negative symptoms of schizophrenia.

Methods: The present study is a retrospective review of use of adjunctive psychostimulants among outpatients enrolled in our tertiary Schizophrenia Program between 2014 and 2019. We assessed response to treatment, adverse effects, and the impact of various clinical factors on treatment outcome.

Results: Of the 77 (out of 1,300) participants prescribed psychostimulants during the study period, 42.22% had chart-based evidence of significant improvement, 27.77% had minimal improvement, and 25.55% reported no change. The majority (61.9%) demonstrated improvement in attention, concentration, and/or other cognitive symptoms. Approximately one-third of cases had evidence of emergence of psychosis. Of the factors assessed, comorbid attention-deficit/hyperactivity disorder was associated with an increased likelihood of response, and higher doses of stimulants were associated with likelihood of emergence of psychosis.

Conclusions: Adjunctive psychostimulants could be a potential treatment consideration to address cognitive deficits in selected patients with schizophrenia.

背景:辅助精神兴奋剂已被提出作为精神分裂症认知和/或阴性症状管理的潜在治疗选择。方法:本研究是对2014年至2019年参加我们的三级精神分裂症项目的门诊患者使用辅助精神兴奋剂的回顾性研究。我们评估了对治疗的反应、不良反应以及各种临床因素对治疗结果的影响。结果:在研究期间,77名(1300名)参与者服用了精神兴奋剂,42.22%的人有明显改善的证据,27.77%的人有轻微改善,25.55%的人没有变化。大多数(61.9%)表现出注意力、注意力集中和/或其他认知症状的改善。大约三分之一的病例有精神病出现的证据。在评估的因素中,共病性注意力缺陷/多动障碍与反应的可能性增加有关,而高剂量的兴奋剂与出现精神病的可能性有关。结论:辅助精神兴奋剂可能是解决精神分裂症患者认知缺陷的潜在治疗考虑。
{"title":"Retrospective review of use of adjunctive psychostimulants in patients with schizophrenia.","authors":"Naista Zhand,&nbsp;Philip Harvey,&nbsp;Roisin Osborne,&nbsp;Anna Hatko,&nbsp;Marika Stuyt,&nbsp;Alain Labelle","doi":"10.12788/acp.0015","DOIUrl":"https://doi.org/10.12788/acp.0015","url":null,"abstract":"<p><strong>Background: </strong>Adjunctive psychostimulants have been proposed as a potential treatment option for the management of cognitive and/or negative symptoms of schizophrenia.</p><p><strong>Methods: </strong>The present study is a retrospective review of use of adjunctive psychostimulants among outpatients enrolled in our tertiary Schizophrenia Program between 2014 and 2019. We assessed response to treatment, adverse effects, and the impact of various clinical factors on treatment outcome.</p><p><strong>Results: </strong>Of the 77 (out of 1,300) participants prescribed psychostimulants during the study period, 42.22% had chart-based evidence of significant improvement, 27.77% had minimal improvement, and 25.55% reported no change. The majority (61.9%) demonstrated improvement in attention, concentration, and/or other cognitive symptoms. Approximately one-third of cases had evidence of emergence of psychosis. Of the factors assessed, comorbid attention-deficit/hyperactivity disorder was associated with an increased likelihood of response, and higher doses of stimulants were associated with likelihood of emergence of psychosis.</p><p><strong>Conclusions: </strong>Adjunctive psychostimulants could be a potential treatment consideration to address cognitive deficits in selected patients with schizophrenia.</p>","PeriodicalId":50770,"journal":{"name":"Annals of Clinical Psychiatry","volume":"33 1","pages":"45-52"},"PeriodicalIF":1.3,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25322594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migraine and adult-onset stuttering: A proposed autoimmune phenomenon. 偏头痛和成人发作的口吃:一种被提出的自身免疫现象
IF 1.3 4区 医学 Q3 PSYCHIATRY Pub Date : 2021-02-01 DOI: 10.12788/acp.0016
Stephanie M Wong, Joyce Y Kim, Gerald A Maguire
TO THE EDITOR: We report a case of a 40-year-old female patient with a medical history of chronic refractory urticaria who presented with intractable migraine and adult-onset stuttering. The patient’s stuttering was characterized by a sudden onset and prolonging of words with repetition of beginning syllables, and it was associated with anxiety and migraine. There was no personal or known family history of stuttering. The patient reported her stuttering began more than 2 years ago, when she was prescribed cyproheptadine, 12 mg/d, for autoimmune urticaria flares. This medication was discontinued approximately 5 months later due to weight gain and possible contribution to stuttering, but the stuttering did not improve. Multiple other treatment options had been previously explored, including propranolol, topiramate, IV steroids, dihydroergotamine, and butalbital-acetaminophen-caffeine combination medication, but these were ineffective. Magnetic resonance imaging and venography of the brain demonstrated a partially visualized left multispacial vascular malformation, but were otherwise unremarkable. Given the patient's extensive history of migraine medication failures, the patient’s neurologist administered erenumab, 70 mg, a new autoimmune treatment for migraine. Erenumab is a monoclonal antibody that antagonizes the calcitonin gene-related peptide (CGRP) receptor and is approved for use as migraine prophylaxis. The patient reported relief of migraine and stuttering within 2 days of treatment and remained free of symptoms for 1 month. The stuttering returned by the time of the next erenumab dose, which the patient had delayed to better understand the treatment’s effects on her migraine and stuttering. After the second dose of erenumab was administered, she again experienced improvements in both the prevention of her migraine and treatment of her stuttering symptoms.
{"title":"Migraine and adult-onset stuttering: A proposed autoimmune phenomenon.","authors":"Stephanie M Wong,&nbsp;Joyce Y Kim,&nbsp;Gerald A Maguire","doi":"10.12788/acp.0016","DOIUrl":"https://doi.org/10.12788/acp.0016","url":null,"abstract":"TO THE EDITOR: We report a case of a 40-year-old female patient with a medical history of chronic refractory urticaria who presented with intractable migraine and adult-onset stuttering. The patient’s stuttering was characterized by a sudden onset and prolonging of words with repetition of beginning syllables, and it was associated with anxiety and migraine. There was no personal or known family history of stuttering. The patient reported her stuttering began more than 2 years ago, when she was prescribed cyproheptadine, 12 mg/d, for autoimmune urticaria flares. This medication was discontinued approximately 5 months later due to weight gain and possible contribution to stuttering, but the stuttering did not improve. Multiple other treatment options had been previously explored, including propranolol, topiramate, IV steroids, dihydroergotamine, and butalbital-acetaminophen-caffeine combination medication, but these were ineffective. Magnetic resonance imaging and venography of the brain demonstrated a partially visualized left multispacial vascular malformation, but were otherwise unremarkable. Given the patient's extensive history of migraine medication failures, the patient’s neurologist administered erenumab, 70 mg, a new autoimmune treatment for migraine. Erenumab is a monoclonal antibody that antagonizes the calcitonin gene-related peptide (CGRP) receptor and is approved for use as migraine prophylaxis. The patient reported relief of migraine and stuttering within 2 days of treatment and remained free of symptoms for 1 month. The stuttering returned by the time of the next erenumab dose, which the patient had delayed to better understand the treatment’s effects on her migraine and stuttering. After the second dose of erenumab was administered, she again experienced improvements in both the prevention of her migraine and treatment of her stuttering symptoms.","PeriodicalId":50770,"journal":{"name":"Annals of Clinical Psychiatry","volume":"33 1","pages":"56-57"},"PeriodicalIF":1.3,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25322595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Annals of Clinical Psychiatry
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