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Correlation between allergic rhinitis or hay fever and lung cancer: A systematic review and meta-analysis 过敏性鼻炎或花粉症与肺癌之间的相关性：系统回顾与荟萃分析

Medicine

Pub Date : 2024-05-17 DOI: 10.1097/MD.0000000000038197

Qudsia Umaira Khan, Muneeb Ur Rehman, Mohammad Ali Arshad Abbasi, Rubina Rafique Shiekh, Munazza Nazir, S. Raja, Amna Akbar, Sabahat Tasneem, S. K. Jadoon, S. Alvi

Background: The association between allergies and cancer is contradictory, whereas some forms of cancer have inverse associations with allergies. Allergic rhinitis (AR) is the most prevalent form of allergy, and lung cancer is one of the most prevalent forms of cancer with the highest mortality rate. Recent studies have reported a positive association between asthma and lung cancer; however, this association is inconclusive. Furthermore, AR is positively associated with asthma; therefore, our research question was to explore whether there is any correlation between AR and lung cancer epidemiologically. Methods: After a rigorous search of PubMed, Google Scholar, and ScienceDirect, 7 eligible articles were included in this systematic review and meta-analysis, including 4724 cases and 9059 controls, 5 from the USA, and one each from Canada and Germany. Results: Pooled analysis (OR, 0.55; 95% CI: 0.45–0.68; P value < .00001) showed a strong inverse relationship between AR and lung cancer. Conclusion: The current meta-analysis suggests an inverse relationship between AR and lung cancer; however, new epidemiological studies are required to observe the current scenario more comprehensively.

背景：过敏与癌症之间的关系是矛盾的，有些癌症与过敏呈反向关系。过敏性鼻炎（AR）是最普遍的过敏形式，而肺癌是死亡率最高的癌症形式之一。最近有研究报告称，哮喘与肺癌之间存在正相关关系，但这种关系尚无定论。此外，AR 与哮喘呈正相关；因此，我们的研究问题是探讨 AR 与肺癌之间是否存在流行病学上的相关性。研究方法在对 PubMed、Google Scholar 和 ScienceDirect 进行严格检索后，本系统综述和荟萃分析纳入了 7 篇符合条件的文章，包括 4724 例病例和 9059 例对照，其中 5 篇来自美国，加拿大和德国各一篇。研究结果汇总分析（OR，0.55；95% CI：0.45-0.68；P 值 < .00001）显示 AR 与肺癌之间存在密切的反向关系。结论目前的荟萃分析表明，AR 与肺癌之间存在反向关系；然而，要更全面地观察目前的情况，还需要新的流行病学研究。

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引用次数: 0

The prognostic value of prognostic nutritional index and renal function indicators for mortality prediction in severe COVID-19 elderly patients: A retrospective study 预后营养指数和肾功能指标对重症 COVID-19 老年患者死亡率预测的预后价值：一项回顾性研究

Medicine

Pub Date : 2024-05-17 DOI: 10.1097/MD.0000000000038213

Angyang Cao, Wenjun Luo, Long Wang, Jianhua Wang, Yanling Zhou, Changshun Huang, Binbin Zhu

Identifying prognostic factors in elderly patients with severe coronavirus disease 2019 (COVID-19) is crucial for clinical management. Recent evidence suggests malnutrition and renal dysfunction are associated with poor outcome. This study aimed to develop a prognostic model incorporating prognostic nutritional index (PNI), estimated glomerular filtration rate (eGFR), and other parameters to predict mortality risk. This retrospective analysis included 155 elderly patients with severe COVID-19. Clinical data and outcomes were collected. Logistic regression analyzed independent mortality predictors. A joint predictor “L” incorporating PNI, eGFR, D-dimer, and lactate dehydrogenase (LDH) was developed and internally validated using bootstrapping. Decreased PNI (OR = 1.103, 95% CI: 0.78–1.169), decreased eGFR (OR = 0.964, 95% CI: 0.937–0.992), elevated D-dimer (OR = 1.001, 95% CI: 1.000–1.004), and LDH (OR = 1.005, 95% CI: 1.001–1.008) were independent mortality risk factors (all P < .05). The joint predictor “L” showed good discrimination (area under the curve [AUC] = 0.863) and calibration. The bootstrapped area under the curve was 0.858, confirming model stability. A combination of PNI, eGFR, D-dimer, and LDH provides useful prognostic information to identify elderly patients with severe COVID-19 at highest mortality risk for early intervention. Further external validation is warranted.

确定2019年严重冠状病毒病（COVID-19）老年患者的预后因素对临床管理至关重要。最近的证据表明，营养不良和肾功能障碍与不良预后有关。本研究旨在建立一个预后模型，将预后营养指数（PNI）、估计肾小球滤过率（eGFR）和其他参数结合起来，以预测死亡风险。这项回顾性分析纳入了 155 名患有严重 COVID-19 的老年患者。收集了临床数据和结果。逻辑回归分析了独立的死亡率预测因素。我们开发了一个包含 PNI、eGFR、D-二聚体和乳酸脱氢酶（LDH）的联合预测因子 "L"，并通过引导法进行了内部验证。PNI 降低（OR = 1.103，95% CI：0.78-1.169）、eGFR 降低（OR = 0.964，95% CI：0.937-0.992）、D-二聚体升高（OR = 1.001，95% CI：1.000-1.004）和 LDH 升高（OR = 1.005，95% CI：1.001-1.008）是独立的死亡风险因素（所有 P < .05）。联合预测因子 "L "显示出良好的区分度（曲线下面积 [AUC] = 0.863）和校准性。引导曲线下面积为 0.858，证实了模型的稳定性。PNI、eGFR、D-二聚体和 LDH 的组合提供了有用的预后信息，可用于识别死亡风险最高的严重 COVID-19 老年患者，以便进行早期干预。还需要进一步的外部验证。

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引用次数: 0

Gastro-oesophageal reflux disease and hiatus hernia 胃食管反流病和食管裂孔疝

Medicine

Pub Date : 2024-02-01 DOI: 10.1016/j.mpmed.2023.12.005

Estefania Moreno, Philip Woodland

引用次数: 0

Coeliac disease 乳糜泻

Medicine

Pub Date : 2024-02-01 DOI: 10.1016/j.mpmed.2023.12.003

Jeffrey Butterworth, Louis Los

引用次数: 0

Helicobacter pylori infection and peptic ulcers 幽门螺杆菌感染与消化性溃疡

Medicine

Pub Date : 2024-02-01 DOI: 10.1016/j.mpmed.2023.12.006

Debabrata Majumdar, Shi Looi

引用次数: 0

Eosinophilic oesophagitis: practical management and novel therapeutics 嗜酸性粒细胞食管炎：实用管理和新疗法

Medicine

Pub Date : 2024-02-01 DOI: 10.1016/j.mpmed.2023.12.011

Radu Rusu, Terry Wong

引用次数: 0

Disorders of the mouth 口腔疾病

Medicine

Pub Date : 2024-02-01 DOI: 10.1016/j.mpmed.2023.12.002

S. Nayee, Martyn Ormond, Jeremy D. Sanderson, Michael P. Escudier

引用次数: 0

Accuracy and reproducibility of shear wave elastography according to the size and elasticity of lesions: A phantom study. 根据病变的大小和弹性，剪切波弹性成像的准确性和可重复性:一项幻影研究。

IF 1.6

Medicine

Pub Date : 2022-10-14 DOI: 10.1097/MD.0000000000031095

Harim Kim, Haejung Kim, Boo-Kyung Han, Ji Soo Choi, Eun Sook Ko, Eun Young Ko

While the extrinsic factors affecting reproducibility of shear wave elastography (SWE) have been well documented, there are few resources assessing intrinsic characteristics of the lesion affecting the reproducibility and accuracy of SWE. In this regard, this study aimed to evaluate the accuracy of measured elasticity and the reproducibility of SWE according to the lesion size and stiffness. Two breast radiologists examined 20 targets of 4 different levels of stiffness and 5 different sizes (2.5, 4, 7, 11, and 18 mm) in a customized elasticity phantom. The B-mode image, color elastography image, and kPa measurement were obtained twice by each examiner with a 1-week interval. Inter- and intra-observer reproducibility and the accuracy of measured kPa were analyzed using intraclass correlation coefficient (ICC) and Bland-Altman analysis. Subgroup analysis was run to evaluate the effect of lesion size and stiffness on the reproducibility and accuracy of measured kPa. Inter- and intraobserver reproducibility for measuring kPa showed excellent agreement (ICC: 0.9742 and 0.9582; ICC: 0.9932 and 0.9294). The size and stiffness of the targets did not affect reproducibility. The overall accuracy of measured kPa was very high (ICC: 0.8049). In the subgroup analysis, targets that were ≤4 mm in size showed lower accuracy (ICC: 0.542), whereas targets that were 7 and 11 mm in size showed higher accuracy (ICC: 0.9832 and 0.9656, respectively). SWE shows excellent reproducibility regardless of lesion size or stiffness in phantom targets. The accuracy of measured kPa is high in lesions that are 7 and 11 mm in size but is low in lesions that are ≤4 mm in size.

虽然影响剪切波弹性成像(SWE)再现性的外在因素已经被很好地记录下来，但很少有资源评估影响剪切波弹性成像再现性和准确性的病变的内在特征。因此，本研究旨在根据病变的大小和刚度来评估弹性测量的准确性和SWE的重复性。两名乳腺放射科医生在定制的弹性模型中检查了20个4种不同硬度水平和5种不同尺寸(2.5、4、7、11和18毫米)的目标。每个审查员每隔一周获得两次b型图像、彩色弹性成像和kPa测量。使用类内相关系数(ICC)和Bland-Altman分析分析观察者间和观察者内的重复性和测量kPa的准确性。亚组分析评估病变大小和刚度对测量kPa的重复性和准确性的影响。测量kPa的观察者间和观察者内重现性表现出极好的一致性(ICC: 0.9742和0.9582;ICC: 0.9932和0.9294)。靶材的尺寸和刚度不影响再现性。所测kPa的总体精度非常高(ICC: 0.8049)。在亚组分析中，尺寸≤4 mm的靶精度较低(ICC: 0.542)，尺寸为7 mm和11 mm的靶精度较高(ICC: 0.9832和0.9656)。SWE显示了极好的再现性，无论病变大小或刚度的幻影目标。对于尺寸为7和11mm的病变，测量kPa的准确性较高，但对于尺寸≤4mm的病变，测量kPa的准确性较低。

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引用次数: 0

A comparative study of four Bowie-Dick test under the condition of pressure steam sterilizer simulating gas leakage. 压力蒸汽灭菌器模拟气体泄漏条件下4种鲍伊-迪克试验的对比研究。

IF 1.6

Medicine

Pub Date : 2020-12-11 DOI: 10.1097/MD.0000000000023653

Xiaomei Yu, Qing Zhang, Xingling Deng, Jinxiu Liang, Shuqin Hao, Jianling Chen, Heying Du

We aimed to understand the evaluation of different Bowie-Dick test (B-D test) on the performance of pressure steam sterilization equipment in the case of simulated gas leakage, and we selected a pulsating vacuum steam sterilizer to set 4 different gas leakage levels: 1.1, 1.3, 1.5, and 1.7 mbar/min during the B-D test phase. In terms of methods, 4 different brands of B-D test kits (devices) were tested at 4 different leakage rates, and a total of 48 experiments were conducted. The results from univariate analysis revealed that there are statistically significant differences in the judgment of test results among different personnel and brands. The results from multivariate logistic regression analysis displayed that the difference between different personnel was statistically significant (χ = 45.34, P < .001); the difference between different products was statistically significant (χ = 129.37, P < .001); and there was no statistically significant difference between different degree of leakage (χ = 6.99, P > .05). Result judgments of brand 1 and brand 2 are susceptible to subjective factors. The judgment of brand 3 is intuitive and consistent with the evaluation result of brand 4. In conclusion, the order of capacity to evaluate air leakage from best to worst is brand 4→brand 3→brand 1→brand 2.

为了了解不同鲍伊-迪克试验(B-D试验)在模拟气体泄漏情况下对压力蒸汽灭菌设备性能的评价，我们选择了脉动真空蒸汽灭菌器，在B-D试验阶段设置了1.1、1.3、1.5和1.7 mbar/min 4种不同的气体泄漏水平。在方法上，采用4种不同品牌的B-D检测试剂盒(装置)在4种不同的泄漏率下进行检测，共进行48次实验。单变量分析结果显示，不同人员、不同品牌对检验结果的判断存在统计学差异。多因素logistic回归分析结果显示，不同人员间差异有统计学意义(χ = 45.34, P .05)。品牌1和品牌2的结果判断容易受到主观因素的影响。品牌3的判断直观，与品牌4的评价结果一致。综上所述，评价漏风能力从好到坏的顺序为:品牌4→品牌3→品牌1→品牌2。

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引用次数: 0

Aerobic, resistance and combined training for adults with chronic kidney disease: A protocol for a systematic review and network meta-analysis. 成人慢性肾脏疾病的有氧、阻力和联合训练：一项系统评价和网络荟萃分析方案

Medicine

Pub Date : 2020-12-04 DOI: 10.1097/MD.0000000000023518

Rong Zeng, Honghao Lai, Zhuoyan Li, Beibei Chen, Lu Wang, Yali Zhang

Background: Chronic kidney disease (CKD) as a disease that poses a great threat to human health, which has become a public health issue of great concern. Studies have found that exercise training has a positive effect on improving the condition of chronic kidney disease. We will conduct a network meta-analysis to assess the effects of aerobic training, resistance training and combined aerobic and resistance training in treating CKD patients.

Methods: We will search PubMed, EMBASE, Medline, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of science to identify randomized control trails (RCTs) that assessed the effect of different exercise training for CKD patients. Cochrane Handbook will be used to evaluate the risk of bias of included articles. We will use Stata or R software to perform data analysis.

Results and conclusion: Our systematic review and network meta-analysis will be the first study that investigates the effect of different exercise training for CKD patients, and will provide evidence for management of chronic kidney disease.

Ethics and dissemination: The data involved in this study are from published articles. For this reason, there is no need for ethical approval or patient consent.

Trial registration: the registration number was: CRD42020157280.

背景：慢性肾脏疾病（CKD）作为一种严重威胁人类健康的疾病，已成为备受关注的公共卫生问题。研究发现，运动训练对改善慢性肾脏疾病的病情有积极作用。我们将进行一项网络荟萃分析，以评估有氧训练、阻力训练以及有氧和阻力联合训练在治疗CKD患者中的效果。方法：我们将检索PubMed、EMBASE、Medline、Cochrane Central Register of Controlled Trials （Central）和Web of science，以确定评估不同运动训练对CKD患者影响的随机对照试验（RCTs）。将使用Cochrane手册评估纳入文章的偏倚风险。我们将使用Stata或R软件进行数据分析。结果和结论：我们的系统综述和网络荟萃分析将是第一个调查不同运动训练对CKD患者影响的研究，并将为慢性肾脏疾病的治疗提供证据。伦理与传播：本研究涉及的数据来自已发表的文章。出于这个原因，不需要伦理批准或患者同意。试验注册：注册号为：CRD42020157280。

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引用次数: 0

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