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O–O Bond Activation in Cu- and Fe-Based Coordination Complexes: Breaking It Makes the Difference 铜和铁基配位配合物中的O-O键活化:破坏它会产生差异
4区 化学 Q2 Chemistry Pub Date : 2017-01-01 DOI: 10.1016/BS.ADIOCH.2017.04.001
J. Serrano-Plana, M. Costas
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引用次数: 1
The Role of Nonheme Transition Metal-Oxo, -Peroxo, and -Superoxo Intermediates in Enzyme Catalysis and Reactions of Bioinspired Complexes 非血红素过渡金属-氧、-过氧和-超氧中间体在酶催化和生物激发复合物反应中的作用
4区 化学 Q2 Chemistry Pub Date : 2017-01-01 DOI: 10.1016/BS.ADIOCH.2017.01.002
Abayomi S Faponle, S. P. Visser
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引用次数: 2
Oxygen–Isotope Exchange and Metastable Dissociation in Oxides 氧同位素交换和氧化物的亚稳态解离
4区 化学 Q2 Chemistry Pub Date : 2017-01-01 DOI: 10.1016/BS.ADIOCH.2016.12.007
W. Casey
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引用次数: 2
μ-Nitrido Diiron Phthalocyanine and Porphyrin Complexes: Unusual Structures With Interesting Catalytic Properties μ-硝基二铁酞菁与卟啉配合物:具有有趣催化性质的特殊结构
4区 化学 Q2 Chemistry Pub Date : 2017-01-01 DOI: 10.1016/BS.ADIOCH.2017.02.003
A. Sorokin
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引用次数: 11
Development of Trackable Anticancer Agents Based on Metal Complexes 基于金属配合物的可追踪抗癌药物的开发
4区 化学 Q2 Chemistry Pub Date : 2016-01-01 DOI: 10.1016/BS.ADIOCH.2015.09.004
E. Bodio, P. Gendre, F. Denat, C. Goze
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引用次数: 10
Opportunities and challenges for metal chemistry in molecular imaging: from gamma camera imaging to PET and multimodality imaging. 金属化学在分子成像中的机遇和挑战:从伽马相机成像到PET和多模态成像。
4区 化学 Q2 Chemistry Pub Date : 2016-01-01 Epub Date: 2015-11-16 DOI: 10.1016/bs.adioch.2015.09.001
Richard Southworth, Rafael Torres Martin de Rosales, Levente K Meszaros, Michelle T Ma, Gregory E D Mullen, Gilbert Fruhwirth, Jennifer D Young, Cinzia Imberti, Julia Bagunya-Torres, Erica Andreozzi, Philip J Blower

The development of medical imaging is a highly multidisciplinary endeavor requiring the close cooperation of clinicians, physicists, engineers, biologists and chemists to identify capabilities, conceive challenges and solutions and apply them in the clinic. The chemistry described in this article illustrates how synergistic advances in these areas drive the technology and its applications forward, with each discipline producing innovations that in turn drive innovations in the others. The main thread running through the article is the shift from single photon radionuclide imaging towards PET, and in turn the emerging shift from PET/CT towards PET/MRI and further, combination of these with optical imaging. Chemistry to support these transitions is exemplified by building on a summary of the status quo, and recent developments, in technetium-99m chemistry for SPECT imaging, followed by a report of recent developments to support clinical application of short lived (Ga-68) and long-lived (Zr-89) positron emitting isotopes, copper isotopes for PET imaging, and combined modality imaging agents based on radiolabelled iron oxide based nanoparticles.

医学成像的发展是一项高度多学科的努力,需要临床医生、物理学家、工程师、生物学家和化学家的密切合作,以确定能力,构思挑战和解决方案,并将其应用于临床。本文中描述的化学说明了这些领域的协同进步是如何推动技术及其应用向前发展的,每个学科都产生了创新,反过来又推动了其他学科的创新。贯穿本文的主线是从单光子放射性核素成像向PET的转变,以及从PET/CT向PET/MRI的新转变,以及这些与光学成像的结合。支持这些转变的化学是通过总结SPECT成像的锝-99m化学的现状和最新发展来举例说明的,随后是支持短寿命(Ga-68)和长寿命(Zr-89)正电子发射同位素、PET成像的铜同位素、,以及基于放射性标记的基于氧化铁的纳米颗粒的组合模态成像剂。
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引用次数: 0
Macrocyclic Bifunctional Chelators and Conjugation Strategies for Copper-64 Radiopharmaceuticals 铜-64放射性药物的大环双功能螯合剂及其偶联策略
4区 化学 Q2 Chemistry Pub Date : 2016-01-01 DOI: 10.1016/BS.ADIOCH.2015.09.005
Brett M. Paterson, P. Donnelly
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引用次数: 5
Labeling of Graphene, Graphene Oxides, and of Their Congeners: Imaging and Biosensing Applications of Relevance to Cancer Theranostics 石墨烯、氧化石墨烯及其同系物的标记:与癌症治疗相关的成像和生物传感应用
4区 化学 Q2 Chemistry Pub Date : 2016-01-01 DOI: 10.1016/BS.ADIOCH.2015.09.007
J. Tyson, D. G. Calatayud, V. Mirabello, Boyang Mao, S. Pascu
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引用次数: 7
Radiometallo-Labeled Peptides in Tumor Diagnosis and Targeted Radionuclide Therapy 放射性金属标记肽在肿瘤诊断和靶向放射性核素治疗中的应用
4区 化学 Q2 Chemistry Pub Date : 2016-01-01 DOI: 10.1016/BS.ADIOCH.2015.11.003
S. Okarvi, H. Maecke
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引用次数: 6
Molecular Magnetic Resonance Imaging Probes Based on Ln3 + Complexes 基于Ln3 +配合物的分子磁共振成像探针
4区 化学 Q2 Chemistry Pub Date : 2016-01-01 DOI: 10.1016/BS.ADIOCH.2015.09.002
C. Bonnet, É. Tóth
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引用次数: 11
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