首页 > 最新文献

IgMin Research最新文献

英文 中文
Levetiracetam-induced Rhabdomyolysis - A Rare Complication 左乙拉西坦引发的横纹肌溶解症--一种罕见并发症
Pub Date : 2024-07-22 DOI: 10.61927/igmin228
Khan Ayisha Farooq, Shaikh Naeemuddin, Abdy Faryal, Kanwar Dureshahwar
Background: Levetiracetam is an anti-epileptic drug that works by modulation of synaptic neurotransmitter release through binding to the synaptic vesicle protein 2A. Levetiracetam is generally well tolerated. Common side effects of levetiracetam include lethargy, drowsiness, headaches, and mood changes. Rhabdomyolysis and an increase in Creatine Kinase (CK) levels are one of the rarely reported effects of levetiracetam. Case presentation: We present a case of a 20-year-old patient with previously known epilepsy (non-compliant with medicine) who presented with a seizure. The patient was given 1 gram of levetiracetam in the emergency department and was kept at a maintenance dose of 500 mg twice a day. The workup revealed acute kidney injury and raised levels of creatinine kinase that peaked at 19,757 IU/L 72 hours after levetiracetam was started. Levetiracetam was later switched to lamotrigine and aggressive intravenous hydration was done. Gradual improvement of CK level was noted accompanied by improvement in renal function. Conclusion: Only a few cases of levetiracetam-induced rhabdomyolysis have been reported worldwide. Our case report highlights the importance of monitoring creatinine and CK levels while treating patients with levetiracetam as rhabdomyolysis can be asymptomatic with a rise in CK levels only.
背景:左乙拉西坦是一种抗癫痫药物,通过与突触小泡蛋白 2A 结合,调节突触神经递质的释放。左乙拉西坦的耐受性一般良好。左乙拉西坦常见的副作用包括昏睡、嗜睡、头痛和情绪变化。横纹肌溶解症和肌酸激酶(CK)水平升高是左乙拉西坦罕见的副作用之一。病例介绍:我们介绍了一例 20 岁患者的病例,该患者曾患有癫痫(不遵医嘱用药),并出现癫痫发作。患者在急诊科接受了 1 克左乙拉西坦治疗,维持剂量为 500 毫克,每天两次。检查结果显示患者出现急性肾损伤,肌酸激酶水平升高,在开始服用左乙拉西坦 72 小时后达到峰值 19,757 IU/L。后来将左乙拉西坦换成了拉莫三嗪,并进行了积极的静脉补液。随着肾功能的改善,肌酸激酶水平也逐渐得到改善。结论全球仅有几例左乙拉西坦诱发横纹肌溶解症的报道。我们的病例报告强调了在治疗左乙拉西坦患者时监测肌酐和肌酸激酶水平的重要性,因为横纹肌溶解症可能没有症状,只是肌酸激酶水平升高。
{"title":"Levetiracetam-induced Rhabdomyolysis - A Rare Complication","authors":"Khan Ayisha Farooq, Shaikh Naeemuddin, Abdy Faryal, Kanwar Dureshahwar","doi":"10.61927/igmin228","DOIUrl":"https://doi.org/10.61927/igmin228","url":null,"abstract":"Background: Levetiracetam is an anti-epileptic drug that works by modulation of synaptic neurotransmitter release through binding to the synaptic vesicle protein 2A. Levetiracetam is generally well tolerated. Common side effects of levetiracetam include lethargy, drowsiness, headaches, and mood changes. Rhabdomyolysis and an increase in Creatine Kinase (CK) levels are one of the rarely reported effects of levetiracetam. Case presentation: We present a case of a 20-year-old patient with previously known epilepsy (non-compliant with medicine) who presented with a seizure. The patient was given 1 gram of levetiracetam in the emergency department and was kept at a maintenance dose of 500 mg twice a day. The workup revealed acute kidney injury and raised levels of creatinine kinase that peaked at 19,757 IU/L 72 hours after levetiracetam was started. Levetiracetam was later switched to lamotrigine and aggressive intravenous hydration was done. Gradual improvement of CK level was noted accompanied by improvement in renal function. Conclusion: Only a few cases of levetiracetam-induced rhabdomyolysis have been reported worldwide. Our case report highlights the importance of monitoring creatinine and CK levels while treating patients with levetiracetam as rhabdomyolysis can be asymptomatic with a rise in CK levels only.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic Synthesis of Calcium Carbonate in Bile in the presence of Amino Acids 氨基酸存在下胆汁中碳酸钙的仿生合成
Pub Date : 2024-07-18 DOI: 10.61927/igmin227
Golovanova Olga
Thermodynamic and experimental modeling of calcium carbonate crystallization in a model solution of human bile has been carried out. The process of calcium carbonate (calcite and vaterite) crystallization from solutions containing bile has been studied. It is shown that differences in the phase and group composition of the samples arise depending on the synthesis parameters. It has been established that in the presence of 1 wt. % bile, calcite is formed, and an increase in the concentration of bile in the initial solution from 5 to 100 wt. % contributes to the crystallization of vaterite. It is shown that the mass of the solid phase increases with an increase in the concentration of bile in the initial solution. The dissolution of the synthesized samples was performed in 0.9 wt. % NaCl solution and 0.05 M EDTA solution. It was found that the presence of bile components in the composition of solid samples reduces the rate of their dissolutions.
对人体胆汁模型溶液中的碳酸钙结晶进行了热力学和实验建模。研究了含有胆汁的溶液中碳酸钙(方解石和钒酸盐)的结晶过程。结果表明,根据合成参数的不同,样品的相和基团组成也不同。研究确定,在含有 1 重量%胆汁的情况下,方解石会形成,而初始溶液中胆汁浓度从 5 重量%增加到 100 重量%时,会促进钒铁矿的结晶。研究表明,固相的质量随着初始溶液中胆汁浓度的增加而增加。合成样品在 0.9 重量 % 的 NaCl 溶液和 0.05 M EDTA 溶液中进行溶解。结果发现,固体样品成分中胆汁成分的存在会降低其溶解速度。
{"title":"Biomimetic Synthesis of Calcium Carbonate in Bile in the presence of Amino Acids","authors":"Golovanova Olga","doi":"10.61927/igmin227","DOIUrl":"https://doi.org/10.61927/igmin227","url":null,"abstract":"Thermodynamic and experimental modeling of calcium carbonate crystallization in a model solution of human bile has been carried out. The process of calcium carbonate (calcite and vaterite) crystallization from solutions containing bile has been studied. It is shown that differences in the phase and group composition of the samples arise depending on the synthesis parameters. It has been established that in the presence of 1 wt. % bile, calcite is formed, and an increase in the concentration of bile in the initial solution from 5 to 100 wt. % contributes to the crystallization of vaterite. It is shown that the mass of the solid phase increases with an increase in the concentration of bile in the initial solution. The dissolution of the synthesized samples was performed in 0.9 wt. % NaCl solution and 0.05 M EDTA solution. It was found that the presence of bile components in the composition of solid samples reduces the rate of their dissolutions.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Imperative for Modern Public Cloud Providers to Upgrade Their Data Centers 现代公共云提供商升级数据中心的必要性
Pub Date : 2024-07-17 DOI: 10.61927/igmin225
Sajid Taha
This study explores the imperative to modernize cloud computing in response to evolving technological landscapes and business demands. The research examines key areas requiring urgent attention to maintain competitive edge and operational efficiency in the digital era. We investigate the critical need for data center upgrades to accommodate emerging technologies and increased workloads. The study also delves into enhanced security measures and data privacy compliance protocols necessary to protect sensitive information in an increasingly complex threat environment. Furthermore, we analyze strategies to meet the growing demand for performance and scalability, ensuring that cloud infrastructure can adapt to fluctuating business needs. The research emphasizes the importance of maintaining system reliability to minimize downtime and maximize productivity. Additionally, we explore the potential of hybrid cloud integration to enable innovation and reduce costs. The purpose of this study is to provide a comprehensive overview of the challenges and opportunities in modernizing cloud computing, offering insights for organizations seeking to optimize their cloud strategies. Key findings highlight the significance of proactive infrastructure management, the adoption of advanced security frameworks, and the implementation of flexible, scalable architectures. This research contributes to the body of knowledge on cloud computing modernization, serving as a valuable resource for IT professionals, business leaders, and researchers in the field.
本研究探讨了根据不断变化的技术环境和业务需求实现云计算现代化的必要性。本研究探讨了在数字时代保持竞争优势和运营效率亟需关注的关键领域。我们调查了数据中心升级的关键需求,以适应新兴技术和增加的工作负载。研究还深入探讨了在日益复杂的威胁环境中保护敏感信息所需的强化安全措施和数据隐私合规协议。此外,我们还分析了满足日益增长的性能和可扩展性需求的策略,确保云基础设施能够适应不断变化的业务需求。研究强调了保持系统可靠性的重要性,以尽量减少停机时间,最大限度地提高生产率。此外,我们还探讨了混合云整合在实现创新和降低成本方面的潜力。本研究的目的是全面概述云计算现代化所面临的挑战和机遇,为寻求优化云战略的企业提供真知灼见。主要研究结果强调了积极主动的基础设施管理、采用先进的安全框架以及实施灵活、可扩展架构的重要性。这项研究为云计算现代化的知识体系做出了贡献,是该领域 IT 专业人士、企业领导者和研究人员的宝贵资源。
{"title":"The Imperative for Modern Public Cloud Providers to Upgrade Their Data Centers","authors":"Sajid Taha","doi":"10.61927/igmin225","DOIUrl":"https://doi.org/10.61927/igmin225","url":null,"abstract":"This study explores the imperative to modernize cloud computing in response to evolving technological landscapes and business demands. The research examines key areas requiring urgent attention to maintain competitive edge and operational efficiency in the digital era. We investigate the critical need for data center upgrades to accommodate emerging technologies and increased workloads. The study also delves into enhanced security measures and data privacy compliance protocols necessary to protect sensitive information in an increasingly complex threat environment. Furthermore, we analyze strategies to meet the growing demand for performance and scalability, ensuring that cloud infrastructure can adapt to fluctuating business needs. The research emphasizes the importance of maintaining system reliability to minimize downtime and maximize productivity. Additionally, we explore the potential of hybrid cloud integration to enable innovation and reduce costs. The purpose of this study is to provide a comprehensive overview of the challenges and opportunities in modernizing cloud computing, offering insights for organizations seeking to optimize their cloud strategies. Key findings highlight the significance of proactive infrastructure management, the adoption of advanced security frameworks, and the implementation of flexible, scalable architectures. This research contributes to the body of knowledge on cloud computing modernization, serving as a valuable resource for IT professionals, business leaders, and researchers in the field.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141830863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Low Pesticide Doses on Fusarium Molds 低剂量杀虫剂对镰刀菌霉菌的影响
Pub Date : 2024-07-17 DOI: 10.61927/igmin226
Ursan Mihaela, Boiu-Sicuia Oana-Alina, Crăinescu Ioana Irina, Cornea Călina Petruța
The agricultural sector is a large consumer of synthetic chemical products, especially fertilizers and plant protection products. Therefore, an emerging concern nowadays is to reduce chemicals’ use in agriculture. One of the approaches is to reduce the doses of plant protection products, as much as possible, while keeping the treatments’ efficacy. The present work presents the antifungal action of three commercial plant protection products, tested at recommended as well as reduced doses, against important phytopathogenic molds of the Fusarium genus. In vitro, results have shown that two of the tested products could be used at reduced doses while keeping their antifungal activity. The commercial pesticide containing prothioconazole 53 g/L, spiroxamine 224 g/L, and tebuconazole 148 g/L mixture was able to inhibit completely the growth of three virulent F. culmorum strains, even when fungicide treatment was applied in 25% reduced dose. Lower efficacy was seen on F. graminearum strains, however, there were no significant differences (p < 0.05) between the commercially recommended dose and the 25% reduced dose. Another efficient pesticide in Fusarium control contains triadimenol 43 g/L, spiroxamine 250 g/L, and tebuconazole 167 g/L. Tested in a reduced dose (28.6% less than the commercial recommended dose) it completely inhibited the F. graminearum Fg183 (DSM 4527) strain and inhibited the growth of various F. culmorum strains with at least 97.50% efficacy. However, there are some fungal strains, such as the aggressive F. graminearum Fg96 strains that were less susceptible to pesticide treatments even at commercially recommended doses of fungicides.
农业部门是合成化学产品,尤其是化肥和植物保护产品的消费大户。因此,如何减少化学品在农业中的使用成为了一个新的关注点。其中一个方法就是在保证疗效的前提下,尽可能减少植保产品的剂量。本研究介绍了三种商业植保产品的抗真菌作用,这些产品在推荐剂量和减量剂量下对镰刀菌属的重要植物病原霉菌进行了测试。体外试验结果表明,两种受试产品在保持其抗真菌活性的同时,可以减少使用剂量。含有丙硫菌唑 53 克/升、螺环菌胺 224 克/升和戊唑醇 148 克/升混合物的商用杀虫剂能够完全抑制三种烈性 F. culmorum 菌株的生长,即使杀菌剂的使用剂量减少了 25%。对禾谷镰孢菌株的药效较低,但商业推荐剂量和减少 25% 的剂量之间没有显著差异(p < 0.05)。另一种防治镰刀菌的高效杀虫剂含有三唑醇 43 克/升、螺环菌胺 250 克/升和戊唑醇 167 克/升。在减少剂量(比商业推荐剂量少 28.6%)的情况下进行试验,它能完全抑制禾本科镰刀菌 Fg183(DSM 4527)菌株,并以至少 97.50%的药效抑制多种镰刀菌菌株的生长。不过,也有一些真菌菌株,如攻击性强的禾谷镰孢 Fg96 菌株,即使使用了市场推荐剂量的杀菌剂,对杀虫剂的敏感性也较低。
{"title":"The Influence of Low Pesticide Doses on Fusarium Molds","authors":"Ursan Mihaela, Boiu-Sicuia Oana-Alina, Crăinescu Ioana Irina, Cornea Călina Petruța","doi":"10.61927/igmin226","DOIUrl":"https://doi.org/10.61927/igmin226","url":null,"abstract":"The agricultural sector is a large consumer of synthetic chemical products, especially fertilizers and plant protection products. Therefore, an emerging concern nowadays is to reduce chemicals’ use in agriculture. One of the approaches is to reduce the doses of plant protection products, as much as possible, while keeping the treatments’ efficacy. The present work presents the antifungal action of three commercial plant protection products, tested at recommended as well as reduced doses, against important phytopathogenic molds of the Fusarium genus. In vitro, results have shown that two of the tested products could be used at reduced doses while keeping their antifungal activity. The commercial pesticide containing prothioconazole 53 g/L, spiroxamine 224 g/L, and tebuconazole 148 g/L mixture was able to inhibit completely the growth of three virulent F. culmorum strains, even when fungicide treatment was applied in 25% reduced dose. Lower efficacy was seen on F. graminearum strains, however, there were no significant differences (p < 0.05) between the commercially recommended dose and the 25% reduced dose. Another efficient pesticide in Fusarium control contains triadimenol 43 g/L, spiroxamine 250 g/L, and tebuconazole 167 g/L. Tested in a reduced dose (28.6% less than the commercial recommended dose) it completely inhibited the F. graminearum Fg183 (DSM 4527) strain and inhibited the growth of various F. culmorum strains with at least 97.50% efficacy. However, there are some fungal strains, such as the aggressive F. graminearum Fg96 strains that were less susceptible to pesticide treatments even at commercially recommended doses of fungicides.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between Sustainable Development, Economy and Poverty 可持续发展、经济和贫困之间的关系
Pub Date : 2024-07-17 DOI: 10.61927/igmin224
Tenorio Antonio Oñate, del os Santos Oñate Tenorio María
Throughout this document, the opportunity is provided to show the relationship between sustainable development and economic growth, focusing on their definitions, their disparity, and their consequences, at the same time it gives us a vision of the evolution of the importance of economic development and of their inability to solve the problem of poverty. The satisfaction of the needs of the human being, would go through seeking a balance between economic growth, care for the environment, and social welfare, a breakdown of this balance has put into question the traditional model of economic development, in which they raise fundamental questions where the very accumulation of wealth creates poverty. The bibliographic search carried out has led us to obtain a series of conclusions on the proposed terms, in which a robust social solidarity economy would lead us to the eradication of poverty. This work takes us to a reflection on the sustainability of natural resources, the viability of the economic development model, and its rate of growth in a context of globalization in which localities are left behind, but without being forgotten, although they have no involvement in models that meet their development needs.
在整个文件中,我们有机会展示可持续发展与经济增长之间的关系,重点是它们的定义、它们之间的差距以及它们的后果,同时,它也让我们看到了经济发展重要性的演变,以及它们无法解决贫困问题。要满足人类的需求,就必须在经济增长、保护环境和社会福利之间寻求平衡,这种平衡的打破使传统的经济发展模式受到质疑。通过文献检索,我们得出了一系列关于拟议条款的结论,在这些条款中,强大的社会团结经济将带领我们消除贫困。这项工作使我们对自然资源的可持续性、经济发展模式的可行性及其在全球化背景下的增长速度进行了思考,在全球化背景下,地方被抛在后面,但没有被遗忘,尽管它们没有参与满足其发展需求的模式。
{"title":"Relationship between Sustainable Development, Economy and Poverty","authors":"Tenorio Antonio Oñate, del os Santos Oñate Tenorio María","doi":"10.61927/igmin224","DOIUrl":"https://doi.org/10.61927/igmin224","url":null,"abstract":"Throughout this document, the opportunity is provided to show the relationship between sustainable development and economic growth, focusing on their definitions, their disparity, and their consequences, at the same time it gives us a vision of the evolution of the importance of economic development and of their inability to solve the problem of poverty. The satisfaction of the needs of the human being, would go through seeking a balance between economic growth, care for the environment, and social welfare, a breakdown of this balance has put into question the traditional model of economic development, in which they raise fundamental questions where the very accumulation of wealth creates poverty. The bibliographic search carried out has led us to obtain a series of conclusions on the proposed terms, in which a robust social solidarity economy would lead us to the eradication of poverty. This work takes us to a reflection on the sustainability of natural resources, the viability of the economic development model, and its rate of growth in a context of globalization in which localities are left behind, but without being forgotten, although they have no involvement in models that meet their development needs.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141830858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lattice Boltzmann Method without Invoking the M << 1 Assumption 不引用 M << 1 假设的格子波尔兹曼法
Pub Date : 2024-07-16 DOI: 10.61927/igmin223
Ronald So
When a Maxwellian distribution is assumed for the distribution function in the BGK-type modelled BE, it will give rise to the Euler equations if it is the first-order approximation in the Chapman-Enskog method. Then the second-order equations will yield the N-S equations. Most LBM developed to date are formulated based on the second-order equations. Consequently, the assumption of a flow Mach number M << 1 is inherent in this formulation. This approach creates an unnecessary restriction on the LBM that should be avoided if possible. An alternative approach is to formulate a new LBM by considering an equilibrium distribution function where the first-order approximations give rise to the N-S equations. Adopting this approach, a new LBM has been formulated. This new LBM gives reliable results when applied to simulate aeroacoustics, incompressible flows, and compressible flows with and without shocks. Good agreement with measurements and numerical data derived from DAS/DNA calculations is obtained.
当假定 BGK 型建模 BE 的分布函数为 Maxwellian 分布时,如果它是 Chapman-Enskog 方法中的一阶近似值,则会产生欧拉方程。然后,二阶方程将产生 N-S 方程。迄今为止开发的大多数 LBM 都是基于二阶方程制定的。因此,流动马赫数 M << 1 的假设是这种公式的固有特点。这种方法对 LBM 造成了不必要的限制,应尽可能避免。另一种方法是通过考虑平衡分布函数来制定新的 LBM,其中一阶近似产生 N-S 方程。采用这种方法,我们提出了一种新的 LBM。当应用这种新的 LBM 模拟空气声学、不可压缩流以及有冲击和无冲击的可压缩流时,可以得到可靠的结果。它与通过 DAS/DNA 计算得出的测量结果和数值数据具有良好的一致性。
{"title":"Lattice Boltzmann Method without Invoking the M << 1 Assumption","authors":"Ronald So","doi":"10.61927/igmin223","DOIUrl":"https://doi.org/10.61927/igmin223","url":null,"abstract":"When a Maxwellian distribution is assumed for the distribution function in the BGK-type modelled BE, it will give rise to the Euler equations if it is the first-order approximation in the Chapman-Enskog method. Then the second-order equations will yield the N-S equations. Most LBM developed to date are formulated based on the second-order equations. Consequently, the assumption of a flow Mach number M << 1 is inherent in this formulation. This approach creates an unnecessary restriction on the LBM that should be avoided if possible. An alternative approach is to formulate a new LBM by considering an equilibrium distribution function where the first-order approximations give rise to the N-S equations. Adopting this approach, a new LBM has been formulated. This new LBM gives reliable results when applied to simulate aeroacoustics, incompressible flows, and compressible flows with and without shocks. Good agreement with measurements and numerical data derived from DAS/DNA calculations is obtained.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Power of Artificial Intelligence for Improved Patient Outcomes, Ethical Practices and Overcoming Challenges 人工智能在改善患者疗效、道德实践和克服挑战方面的力量
Pub Date : 2024-07-16 DOI: 10.61927/igmin222
Almasri Imad-Addin
Artificial Intelligence (AI) is revolutionizing healthcare by enhancing patient outcomes, reducing costs, and increasing the efficiency of medical professionals. This mini-review explores the diverse applications of AI in healthcare, including disease diagnosis, personalized treatment plans, and patient survival rate predictions. AI technologies such as Machine Learning (ML), deep learning, Natural Language Processing (NLP), and Robotic Process Automation (RPA) are becoming integral to modern healthcare practices. These technologies enable early disease detection, particularly in cases like cancer, by analyzing medical images and patient data, leading to more effective and personalized treatment strategies. Additionally, AI can predict patient outcomes by analyzing large datasets from electronic health records, providing valuable insights that can inform clinical decisions. However, the integration of AI in healthcare also presents significant ethical challenges. Issues such as data privacy, algorithmic bias, lack of transparency, and the potential for increased health inequalities need to be addressed. The World Health Organization (WHO) has provided guidelines emphasizing the ethical use of AI, highlighting the importance of designing AI systems that respect human rights and promote equity. As AI continues to advance, it is crucial to ensure its responsible and transparent use to maximize benefits and minimize risks. This review underscores the transformative potential of AI in healthcare while calling for vigilant ethical considerations to ensure that AI technologies are implemented in a manner that enhances patient care and upholds ethical standards.
人工智能(AI)正在通过提高患者疗效、降低成本和提高医疗专业人员的工作效率,彻底改变医疗保健行业。本微型综述探讨了人工智能在医疗保健领域的各种应用,包括疾病诊断、个性化治疗方案和患者存活率预测。机器学习 (ML)、深度学习、自然语言处理 (NLP) 和机器人流程自动化 (RPA) 等人工智能技术正在成为现代医疗实践中不可或缺的一部分。这些技术通过分析医学影像和患者数据,实现早期疾病检测,尤其是癌症等疾病的早期检测,从而制定出更有效、更个性化的治疗策略。此外,人工智能还可以通过分析电子健康记录中的大型数据集来预测患者的预后,从而为临床决策提供有价值的见解。然而,人工智能与医疗保健的结合也带来了重大的伦理挑战。数据隐私、算法偏见、缺乏透明度以及可能加剧健康不平等等问题都需要加以解决。世界卫生组织(WHO)提供了强调人工智能伦理使用的指南,强调了设计尊重人权和促进公平的人工智能系统的重要性。随着人工智能的不断进步,确保以负责任和透明的方式使用人工智能,以实现利益最大化和风险最小化至关重要。本综述强调了人工智能在医疗保健领域的变革潜力,同时呼吁对伦理问题保持警惕,以确保人工智能技术的实施方式既能加强对患者的护理,又能维护伦理标准。
{"title":"The Power of Artificial Intelligence for Improved Patient Outcomes, Ethical Practices and Overcoming Challenges","authors":"Almasri Imad-Addin","doi":"10.61927/igmin222","DOIUrl":"https://doi.org/10.61927/igmin222","url":null,"abstract":"Artificial Intelligence (AI) is revolutionizing healthcare by enhancing patient outcomes, reducing costs, and increasing the efficiency of medical professionals. This mini-review explores the diverse applications of AI in healthcare, including disease diagnosis, personalized treatment plans, and patient survival rate predictions. AI technologies such as Machine Learning (ML), deep learning, Natural Language Processing (NLP), and Robotic Process Automation (RPA) are becoming integral to modern healthcare practices. These technologies enable early disease detection, particularly in cases like cancer, by analyzing medical images and patient data, leading to more effective and personalized treatment strategies. Additionally, AI can predict patient outcomes by analyzing large datasets from electronic health records, providing valuable insights that can inform clinical decisions. However, the integration of AI in healthcare also presents significant ethical challenges. Issues such as data privacy, algorithmic bias, lack of transparency, and the potential for increased health inequalities need to be addressed. The World Health Organization (WHO) has provided guidelines emphasizing the ethical use of AI, highlighting the importance of designing AI systems that respect human rights and promote equity. As AI continues to advance, it is crucial to ensure its responsible and transparent use to maximize benefits and minimize risks. This review underscores the transformative potential of AI in healthcare while calling for vigilant ethical considerations to ensure that AI technologies are implemented in a manner that enhances patient care and upholds ethical standards.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Stacking Sequence and Ply Orientation with Central Hole on Tensile Behavior of Glass Fiber-polyester Composite 玻璃纤维-聚酯复合材料的堆叠顺序和带中心孔的纤维层方向对拉伸行为的影响
Pub Date : 2024-07-15 DOI: 10.61927/igmin221
Eladawi Ahmad E
An experimental investigation was carried out to study the effect of circular cross-holes on the failure behavior of unidirectional glass fiber reinforced with unsaturated polyester resin composites, varying cross-ply laminates that were subjected to axial tensile load. This paper deals with the effects of the circular notch and the number of plies on nominal tensile and net tensile strengths. Tensile strengths were investigated for composites with cross-ply([0/90]. [90°/0°/90°] and [0°/90°/0°].90°), orientation and varying the laminate layers with a central hole, and effects of volume fraction and number of ply on mechanical properties for un-notched (smooth) and notched specimens were also studied. The results showed that increasing the number of plies has a marginal effect on tensile strength values. The fraction of volume has significant effects and for increasing the number of plies about 9% decreases in nominal tensile strength and about 11% decrease in the net tensile strength was observed. The same results were obtained with finite element analysis.
本文进行了一项实验调查,研究了圆形交叉孔对单向玻璃纤维增强不饱和聚酯树脂复合材料失效行为的影响,这些复合材料是承受轴向拉伸载荷的不同交叉层压板。本文讨论了圆形凹槽和层数对标称拉伸强度和净拉伸强度的影响。研究了交叉层([0/90]、[90°/0°/90°] 和 [0°/90°/0°].90°)、取向和带中心孔的不同层压板的拉伸强度,还研究了未缺口(光滑)和缺口试样的体积分数和层数对机械性能的影响。结果表明,增加层数对拉伸强度值的影响微乎其微。体积分数的影响很大,增加层数会使名义抗拉强度降低约 9%,净抗拉强度降低约 11%。有限元分析也得到了相同的结果。
{"title":"The Effect of Stacking Sequence and Ply Orientation with Central Hole on Tensile Behavior of Glass Fiber-polyester Composite","authors":"Eladawi Ahmad E","doi":"10.61927/igmin221","DOIUrl":"https://doi.org/10.61927/igmin221","url":null,"abstract":"An experimental investigation was carried out to study the effect of circular cross-holes on the failure behavior of unidirectional glass fiber reinforced with unsaturated polyester resin composites, varying cross-ply laminates that were subjected to axial tensile load. This paper deals with the effects of the circular notch and the number of plies on nominal tensile and net tensile strengths. Tensile strengths were investigated for composites with cross-ply([0/90]. [90°/0°/90°] and [0°/90°/0°].90°), orientation and varying the laminate layers with a central hole, and effects of volume fraction and number of ply on mechanical properties for un-notched (smooth) and notched specimens were also studied. The results showed that increasing the number of plies has a marginal effect on tensile strength values. The fraction of volume has significant effects and for increasing the number of plies about 9% decreases in nominal tensile strength and about 11% decrease in the net tensile strength was observed. The same results were obtained with finite element analysis.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Access to Healthcare - A Prominent Challenge in Public Health 获得医疗保健--公共卫生面临的突出挑战
Pub Date : 2024-07-11 DOI: 10.61927/igmin220
Al-Khatib Inas, Awad Mahmoud, Ndiaye Malick
Among the important public health socioeconomic factors are Income and Social Status, Education, Occupation and Working Conditions, Access to Healthcare, Physical Environment, Social Support Network, Culture, and Community. A review was conducted based on other published articles and existing literature with an aim to identify what are the socioeconomic determinants of public health, in particular, determine the dimensions of access to healthcare determinants and outline strategies available to enhance access to healthcare. The results indicated that countries can adopt ten (10) key improvement strategies of public health that can support answering this main research question ‘How can Access to Healthcare socioeconomic determinants be improved?’
重要的公共卫生社会经济因素包括收入和社会地位、教育、职业和工作条件、获得医疗保健的机会、物质环境、社会支持网络、文化和社区。在其他已发表文章和现有文献的基础上进行了审查,目的是确定哪些是公共卫生的社会经济决定因素,特别是确定获得医疗保健决定因素的各个层面,并概述可用于提高获得医疗保健机会的战略。研究结果表明,各国可采取十(10)项关键的公共卫生改善战略,这些战略有助于回答 "如何改善获得医疗保健的社会经济决定因素?
{"title":"Access to Healthcare - A Prominent Challenge in Public Health","authors":"Al-Khatib Inas, Awad Mahmoud, Ndiaye Malick","doi":"10.61927/igmin220","DOIUrl":"https://doi.org/10.61927/igmin220","url":null,"abstract":"Among the important public health socioeconomic factors are Income and Social Status, Education, Occupation and Working Conditions, Access to Healthcare, Physical Environment, Social Support Network, Culture, and Community. A review was conducted based on other published articles and existing literature with an aim to identify what are the socioeconomic determinants of public health, in particular, determine the dimensions of access to healthcare determinants and outline strategies available to enhance access to healthcare. The results indicated that countries can adopt ten (10) key improvement strategies of public health that can support answering this main research question ‘How can Access to Healthcare socioeconomic determinants be improved?’","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141835204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Auxological Status of Modern Primary School Students of Nizhny Novgorod Region 下诺夫哥罗德州现代小学生的心理状况
Pub Date : 2024-07-11 DOI: 10.61927/igmin219
Aleksandrovich Kalyuzhny Evgeniy, Vasilievna Mukhina Irina, Sergeevna Bogomolova Elena, Anatolyevna Galova Elena, Andreevna Puzhak Svetlana, Sergeevna Baklanova Ekaterina
The article describes the characteristics of the resulting effector auxological morpho-functional status of primary school students, differentiated by gender and administrative-territorial characteristics. The objectives of the study included studying the auxological status of children adolescents, and primary school students in the Nizhny Novgorod region in the context of the peculiarities of the exoenvironment of residence in urban and rural areas. Materials and methods: Own data served as a source of anthropometry and physiometry indicators of the objective population of the region. The analysis of anthropological indicators was carried out by discretizing data sets that state an objective picture of auxological indicators at the regional level, taking into account the peculiarities of anthropogenic loads characteristic of the place of residence of the observed population groups. To quantify the values ​​and statistical differences in indicators by age, gender, and administrative characteristics, the median, standard deviation, and criteria were used: Fisher, Wilks, and Mahalanobis, with an error of differences at p < 0.05. Results: The stability of the age-sex evolution of auxological indicators is shown; the age-sex and territorial dimorphism of total body sizes is shown at 7-10 years of age, with residents of rural areas lagging in the observed indicators. Hemodynamic indicators in both boys and girls significantly prevail among students living in the metropolis relative to their rural counterparts, except diastolic blood pressure. Variance analytics shows differences in the distributions of anthropometry and hemodynamics, both by age and by the urbanization factor at p < 0.001. In the observed age period, at the initial stage, hemodynamic indicators act primarily as modifiers of the metropolis and rural groups. From the age of ten, according to the standardized coefficients of discriminant functions, according to the first canonical variable, the division of series also occurs according to anthropometric characteristics, among which the greatest contribution to the division of groups is made by body weight and body length, and the hemodynamic characteristic - diastolic blood pressure - has also proven to be decisive. Conclusion: Primary school students living in rural areas and in the metropolis of the Nizhny Novgorod region determine the observed indicators ambiguously; if residents of the metropolis state greater results for all observed auxological indicators, then rural peers demonstrate, while lagging in all observed indicators, greater indicators of diastolic blood pressure, which suggests a strain on adaptation mechanisms central character.
文章介绍了根据性别和行政区域特征区分的小学生辅助器官形态功能状况的特点。研究目标包括根据城市和农村地区居住外环境的特殊性,研究下诺夫哥罗德地区少年儿童和小学生的辅助机能状况。材料和方法该地区客观人口的人体测量和生理测量指标来源于自有数据。对人类学指标的分析是通过将数据集离散化来进行的,这些数据集反映了地区一级辅助指标的客观情况,同时考虑到了所观察人群居住地人为负荷的特殊性。为了量化不同年龄、性别和行政特征的指标值和统计差异,使用了中位数、标准差和标准:Fisher、Wilks 和 Mahalanobis,差异误差为 p <0.05。结果辅助生理指标的年龄-性别演变具有稳定性;总体型的年龄-性别和地区二态性表现在 7-10 岁,农村地区居民的观察指标落后。除舒张压外,男生和女生的血液动力学指标在居住在大都市的学生中明显优于居住在农村的学生。方差分析显示,人体测量和血液动力学指标的分布在不同年龄和城市化因素下存在差异,P < 0.001。在观察的年龄段中,在初始阶段,血液动力学指标主要是作为大都市组和农村组的调节因子。从 10 岁开始,根据判别函数的标准化系数,按照第一个标准变量,也会根据人体测量特征进行系列划分,其中体重和身长对组别划分的贡献最大,而血液动力学特征--舒张压--也被证明是决定性的。结论生活在农村地区和下诺夫哥罗德州大都市的小学生对观察指标的判断是模糊的;如果说大都市的居民在所有观察到的辅助指标上都取得了较好的成绩,那么农村的同龄人在所有观察指标上都落后的情况下,在舒张压指标上却取得了较好的成绩。
{"title":"Auxological Status of Modern Primary School Students of Nizhny Novgorod Region","authors":"Aleksandrovich Kalyuzhny Evgeniy, Vasilievna Mukhina Irina, Sergeevna Bogomolova Elena, Anatolyevna Galova Elena, Andreevna Puzhak Svetlana, Sergeevna Baklanova Ekaterina","doi":"10.61927/igmin219","DOIUrl":"https://doi.org/10.61927/igmin219","url":null,"abstract":"The article describes the characteristics of the resulting effector auxological morpho-functional status of primary school students, differentiated by gender and administrative-territorial characteristics. The objectives of the study included studying the auxological status of children adolescents, and primary school students in the Nizhny Novgorod region in the context of the peculiarities of the exoenvironment of residence in urban and rural areas. Materials and methods: Own data served as a source of anthropometry and physiometry indicators of the objective population of the region. The analysis of anthropological indicators was carried out by discretizing data sets that state an objective picture of auxological indicators at the regional level, taking into account the peculiarities of anthropogenic loads characteristic of the place of residence of the observed population groups. To quantify the values ​​and statistical differences in indicators by age, gender, and administrative characteristics, the median, standard deviation, and criteria were used: Fisher, Wilks, and Mahalanobis, with an error of differences at p < 0.05. Results: The stability of the age-sex evolution of auxological indicators is shown; the age-sex and territorial dimorphism of total body sizes is shown at 7-10 years of age, with residents of rural areas lagging in the observed indicators. Hemodynamic indicators in both boys and girls significantly prevail among students living in the metropolis relative to their rural counterparts, except diastolic blood pressure. Variance analytics shows differences in the distributions of anthropometry and hemodynamics, both by age and by the urbanization factor at p < 0.001. In the observed age period, at the initial stage, hemodynamic indicators act primarily as modifiers of the metropolis and rural groups. From the age of ten, according to the standardized coefficients of discriminant functions, according to the first canonical variable, the division of series also occurs according to anthropometric characteristics, among which the greatest contribution to the division of groups is made by body weight and body length, and the hemodynamic characteristic - diastolic blood pressure - has also proven to be decisive. Conclusion: Primary school students living in rural areas and in the metropolis of the Nizhny Novgorod region determine the observed indicators ambiguously; if residents of the metropolis state greater results for all observed auxological indicators, then rural peers demonstrate, while lagging in all observed indicators, greater indicators of diastolic blood pressure, which suggests a strain on adaptation mechanisms central character.","PeriodicalId":509147,"journal":{"name":"IgMin Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
IgMin Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1