Pub Date : 2024-03-15DOI: 10.22270/ijmspr.v10i1.85
Aswathy Ramesh, R. Jat, R. Arunkumar
Here new eight derivatives of 1,3,4-oxadiazole were synthesised from salicylic acid and phenyl acetic acid by ring condensation mechanism. The synthesized derivatives were characterized and structures were confirmed by various spectral analysis. Antifungal activity studies revealed that Ox1, Ox2 and Ox4 exhibit promising activity. Keywords: 1,3,4-oxadiazole, antifungal activity, Disc diffusion method, MIC,
本文以水杨酸和苯乙酸为原料，通过环缩合机制合成了八种新的 1,3,4-噁二唑衍生物。对合成的衍生物进行了表征，并通过各种光谱分析确认了其结构。抗真菌活性研究表明，Ox1、Ox2 和 Ox4 具有良好的活性：1,3,4-恶二唑 抗真菌活性 盘扩散法 MIC
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Pub Date : 2024-03-15DOI: 10.22270/ijmspr.v10i1.92
Nida Mehraj, Mahboob Alam
Agrimonia eupatoria, commonly known as Ghafis, holds a significant role in traditional herbal medicine across different regions. This perennial plant, part of the Rosaceae family, has been used in Unani medicine for its various healing properties since ancient times. Ghafis is known for its abilities as a demulcent, stomachic, blood purifier, diuretic, emmenagogue, anti-inflammatory, and astringent agent. Traditionally, it has been employed to treat liver and spleen inflammation, fevers, ulcers, jaundice, wounds, and gastrointestinal disorders. Ethnopharmacological practices have also recognized its antioxidant, antimicrobial, and diuretic effects. Recent scientific studies have further explored its potential in managing diabetes, neuropathic pain, oxidative stress-related disorders, and protecting the liver. This review aims to provide an overview of Ghafis, covering its description, habitat, traditional uses, and recent scientific studies. Ghafis emerges as a valuable herbal remedy with ongoing relevance in herbal medicine and Unani pharmacotherapy. Keywords: Ghafis, Agrimonia eupatoria, Agrimony, Unani Medicine
{"title":"Ghafis (Agrimonia eupatoria): An In-depth Review of its Historical Context, Therapeutic properties, Ethnopharmacological applications, and Scientific research","authors":"Nida Mehraj, Mahboob Alam","doi":"10.22270/ijmspr.v10i1.92","DOIUrl":"https://doi.org/10.22270/ijmspr.v10i1.92","url":null,"abstract":"Agrimonia eupatoria, commonly known as Ghafis, holds a significant role in traditional herbal medicine across different regions. This perennial plant, part of the Rosaceae family, has been used in Unani medicine for its various healing properties since ancient times. Ghafis is known for its abilities as a demulcent, stomachic, blood purifier, diuretic, emmenagogue, anti-inflammatory, and astringent agent. Traditionally, it has been employed to treat liver and spleen inflammation, fevers, ulcers, jaundice, wounds, and gastrointestinal disorders. Ethnopharmacological practices have also recognized its antioxidant, antimicrobial, and diuretic effects. Recent scientific studies have further explored its potential in managing diabetes, neuropathic pain, oxidative stress-related disorders, and protecting the liver. This review aims to provide an overview of Ghafis, covering its description, habitat, traditional uses, and recent scientific studies. Ghafis emerges as a valuable herbal remedy with ongoing relevance in herbal medicine and Unani pharmacotherapy.\u0000Keywords: Ghafis, Agrimonia eupatoria, Agrimony, Unani Medicine","PeriodicalId":509624,"journal":{"name":"International Journal of Medical Sciences and Pharma Research","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/ijmspr.v10i1.88
Aswathy Ramesh, R. Jat, R. Arunkumar
A series of 2, 5- disubstituted- 1, 3, 4-oxadiazole derivatives (Ox1-Ox10) are synthesized by the ring condensation reaction followed by rearrangement of salicylic acid and phenyl acetic acid with various aromatic acids in presence of phosphorous oxychloride as cyclizing agent. Structure of the new derivatives are confirmed by spectral analysis. Those derivatives having high Pa value in PASS software are subjected to antibacterial, anticancer and antidiabetic studies which yield promising reports. This study helps and stimulate the researcher to exploit the oxadiazole nuclei for the development of more active less harmful drugs. Keywords: 1,3,4-oxadiazole, antibacterial activity, anticancer activity, antidiabetic activity
水杨酸和苯乙酸与各种芳香酸在氧氯化磷作为环化剂存在下发生环缩合反应，然后进行重排，合成了一系列 2，5-二取代-1，3，4-噁二唑衍生物（Ox1-Ox10）。新衍生物的结构通过光谱分析得到了证实。对 PASS 软件中 Pa 值较高的衍生物进行了抗菌、抗癌和抗糖尿病研究，结果令人鼓舞。这项研究有助于并激励研究人员利用噁二唑核来开发活性更强、危害更小的药物：1,3,4-噁二唑；抗菌活性；抗癌活性；抗糖尿病活性
{"title":"Pharmacological Evaluation of Novel 1,3,4-Oxadiazole Derivatives","authors":"Aswathy Ramesh, R. Jat, R. Arunkumar","doi":"10.22270/ijmspr.v10i1.88","DOIUrl":"https://doi.org/10.22270/ijmspr.v10i1.88","url":null,"abstract":"A series of 2, 5- disubstituted- 1, 3, 4-oxadiazole derivatives (Ox1-Ox10) are synthesized by the ring condensation reaction followed by rearrangement of salicylic acid and phenyl acetic acid with various aromatic acids in presence of phosphorous oxychloride as cyclizing agent. Structure of the new derivatives are confirmed by spectral analysis. Those derivatives having high Pa value in PASS software are subjected to antibacterial, anticancer and antidiabetic studies which yield promising reports. This study helps and stimulate the researcher to exploit the oxadiazole nuclei for the development of more active less harmful drugs.\u0000Keywords: 1,3,4-oxadiazole, antibacterial activity, anticancer activity, antidiabetic activity","PeriodicalId":509624,"journal":{"name":"International Journal of Medical Sciences and Pharma Research","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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