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New Horizons in Treatment of Knee Osteoarthritis: A Brief Look-up at Emerging Approaches 膝骨关节炎治疗的新视野:新方法简介
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14677
Afsaneh Zare, Aida Iraji, S. Zare, O. koohi-Hosseinabadi, Fateme Bagheri, Romina Tanideh, Nader Tanideh
Knee osteoarthritis (OA) is a chronic and prevalent musculoskeletal condition that is the underlying cause of disability in most patients worldwide. Even though the pathophysiology of KOA has not yet been fully understood and includes a wide range of risk factors, current therapeutic options are temporarily palliative rather than curative. In recent years, new strategies have focused on the curative agents. As part of this review, we highlight the latest treatment approaches for KOA.
膝关节骨关节炎(OA)是一种常见的慢性肌肉骨骼疾病,是导致全球大多数患者残疾的根本原因。尽管膝关节骨性关节炎的病理生理学尚未完全清楚,而且包括多种风险因素,但目前的治疗方案只是暂时缓解而非治疗。近年来,新策略的重点放在了治疗药物上。作为本综述的一部分,我们将重点介绍 KOA 的最新治疗方法。
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引用次数: 0
Subclinical Hypothyroidism and Functional Hemodynamics of the Heart 亚临床甲状腺功能减退症与心脏功能性血液动力学
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14685
Raisa A. Aringazina, Nurgul Abenova, Sajad Ahmad Bhat
Subclinical hyperthyroidism (SHyper), a laboratory decrease in thyroid-stimulating hormone levels with peripheral thyroid hormone levels within the reference interval, is considered a medical condition, especially its impact on cardiac hemodynamics among young women. To determine the effects of subclinical thyroid dysfunction on hemodynamics in young women. clinical observation included two groups of women: (1) the main group consisted of 30 patients with subclinical hyperthyroidism, which was examined at the Family Medicine Clinic of the West Kazakhstan Marat Ospanov Medical University (Aktobe, Kazakhstan) and (2) the control group consisted of 30 practically healthy women. The groups were comparable in age (30–42), mean age 36.2±7.0 years. Blood pressure (BP) was measured, heart rate (HR) was counted, and thyroid hormones were determined. in the examined patients, clinical symptoms of pathology were not observed; laboratory tests determined a decrease in thyroid-stimulating hormone (TSH) in the main group of patients to 2.48±0.23 mIU/L in comparison with the control group 3.65±1.3 mIU/L, which was significant (p0.05) increase in blood pressure SBP/DBP from 122.34±2.7/78.3±2.7 to 127.8±3.1/83.2±2.1 mmHg and HR from 77.7±1.9 to 82.2±2.6 in 1 minute. A significant (r2 =0.482) interaction was determined between TSH -0.236 mIU/L and HP +20.3 in 1 minute, this could be a predictor of an increase in heart rate greater than the reference value (60–80 per minute), and an increased heart rate is considered a predictor of an increase in blood pressure. Subclinical hyperthyroidism may produce a significant laboratory decrease in TSH, without significant clinical symptoms of increased blood pressure. In conclusion, current observational experience suggests that small decreases in laboratory values of thyroid-stimulating hormone may affect blood pressure and heart rate.
亚临床甲状腺功能亢进(SHyper)是指实验室促甲状腺激素水平下降,而外周甲状腺激素水平在参考区间内,被认为是一种病症,尤其是对年轻女性心脏血液动力学的影响。为了确定亚临床甲状腺功能障碍对年轻女性血液动力学的影响,临床观察包括两组女性:(1) 主组由 30 名亚临床甲状腺功能亢进症患者组成,在西哈萨克斯坦马拉特-奥斯帕诺夫医科大学(哈萨克斯坦,阿克托别)家庭医学诊所接受检查;(2) 对照组由 30 名身体健康的女性组成。两组年龄相当(30-42 岁),平均年龄为 36.2±7.0 岁。测量血压(BP),计算心率(HR),并测定甲状腺激素。受检患者未发现病理临床症状;实验室检查结果显示,主要组患者的促甲状腺激素(TSH)下降至 2.与对照组的 3.65±1.3 mIU/L 相比,主要组患者的促甲状腺激素(TSH)下降至 2.48±0.23 mIU/L,血压 SBP/DBP 在 1 分钟内从 122.34±2.7/78.3±2.7 升至 127.8±3.1/83.2±2.1 mmHg,心率从 77.7±1.9 升至 82.2±2.6。TSH -0.236 mIU/L 和 HP +20.3 在 1 分钟内有明显的交互作用(r2 =0.482),这可能是心率增加超过参考值(每分钟 60-80)的预测因素,而心率增加被认为是血压增加的预测因素。亚临床甲状腺功能亢进可能会导致实验室 TSH 显著下降,但没有明显的血压升高临床症状。总之,目前的观察经验表明,促甲状腺激素实验室值的小幅下降可能会影响血压和心率。
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引用次数: 0
Effect of Interventions on Informal Caregivers of Older Adults: A Scientific Mini Review 干预措施对老年人非正式照顾者的影响:科学微型综述
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14678
A. Zhylkybekova, Gulbakit K. Koshmaganbetova, Andrej M. Grjibovski, N. Glushkova
The growing number of older adults with long-term health issues has led to more family members becoming informal caregivers. These caregivers play a crucial role in providing care to their elderly loved ones. However, this caregiving can be physically and emotionally demanding, affecting the caregivers’ own well-being. This scientific mini-review examines various ways, known as “interventions,” that can help ease the challenges faced by informal caregivers and improve their quality of life. These interventions can include things like training programs, support groups, or using technology to assist caregivers. To get the most up-to-date information, we looked at the recent systematic reviews and studies published in the last 5 years. We searched for this information in three widely recognized electronic databases: PubMed, Web of Science, and Scopus with full text. These interventions show promise in making life easier for informal caregivers and improving their quality of life. This mini review intends to offer insights into how these interventions can be beneficial, serving as a resource for healthcare professionals, policymakers, and researchers working to enhance the well-being of both caregivers and the elderly individuals they care for.
有长期健康问题的老年人越来越多,导致越来越多的家庭成员成为非正式护理人员。这些照顾者在照顾他们所爱的老人方面发挥着至关重要的作用。然而,这种照顾可能会对身体和情感造成很大的负担,影响照顾者自身的健康。这篇科学小综述探讨了有助于缓解非正规护理人员所面临的挑战并提高其生活质量的各种方法,即所谓的 "干预措施"。这些干预措施包括培训计划、支持小组或使用技术来帮助照顾者。为了获得最新信息,我们查阅了最近的系统综述和过去 5 年中发表的研究报告。我们在三个广泛认可的电子数据库中搜索了这些信息:PubMed、Web of Science 和 Scopus 全文。这些干预措施有望为非正式照顾者的生活带来便利,并提高他们的生活质量。本微型综述旨在深入探讨这些干预措施的益处,为医疗保健专业人员、政策制定者和研究人员提供资源,以提高护理人员及其所护理的老年人的福祉。
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引用次数: 0
Embracing Change: The Transition of the West Kazakhstan Medical Journal to English 拥抱变化:西哈萨克斯坦医学杂志向英文版的过渡
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14676
A. Tamadon, Asset A. Kaliyev, Nadiar M. Mussin
For nearly two decades, the West Kazakhstan Medical Journal (WKMJ) has been a cornerstone of medical knowledge and research in the West Kazakhstan region, serving as a vital platform for local and regional healthcare communities. In a strategic move, the journal is transitioning to the English language, aligning itself with the global discourse in medical science. This transition aims to enhance accessibility, visibility, and impact, fostering international collaborations and contributing valuable insights to the broader medical community. The metamorphosis signifies a commitment to global integration without compromising the journal’s unwavering commitment to quality, ethical publishing, and rigorous peer review. The transformation invites researchers, practitioners, and institutions worldwide to participate in this journey, elevating the exchange of medical knowledge on a global scale
近二十年来,《西哈萨克斯坦医学杂志》(WKMJ)一直是西哈萨克斯坦地区医学知识和研究的基石,是当地和地区医疗界的重要平台。作为一项战略举措,该杂志正在向英语过渡,与全球医学科学话语保持一致。这一转变旨在提高可读性、知名度和影响力,促进国际合作,为更广泛的医学界贡献有价值的见解。这一转变标志着该杂志致力于全球一体化,同时又不影响其对质量、出版道德和严格同行评审的坚定承诺。这一转变邀请世界各地的研究人员、从业人员和机构参与其中,在全球范围内促进医学知识的交流。
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引用次数: 0
The Four Elements in Low-Vision Rehabilitation Service 低视力康复服务的四个要素
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14679
Suresh Subramaniam
This article addresses the critical issue of low-vision rehabilitation (LVR) services, focusing on the challenges faced by visually impaired patients, particularly those with central visual field limitations and visual acuity of 3/60 or worse in the better eye. Glaucoma, a chronic progressive optic neuropathy, poses a significant threat to vision and quality of life. Despite the absence of a definitive cure, various treatment modalities aim to control and slow down its progression. However, the impact of glaucoma-related structural and functional vision loss on patients’ quality of life is profound. Visual rehabilitation plays a pivotal role in guiding patient-centered therapeutic decisions, yet it remains underutilized for glaucoma patients. Understanding the available LVR is crucial in developing new tools and approaches. This article provides an overview of LVR options for visually impaired individuals and emphasizes the importance of comprehensively assessing and addressing their needs, both in terms of visual function and overall well-being.
本文探讨了低视力康复(LVR)服务的关键问题,重点关注视力受损患者所面临的挑战,尤其是那些中心视野受限、较好眼睛的视力为 3/60 或更差的患者。青光眼是一种慢性进行性视神经病变,对视力和生活质量构成严重威胁。尽管目前还没有根治的方法,但各种治疗方法都旨在控制和减缓其发展。然而,与青光眼相关的结构性和功能性视力丧失对患者的生活质量影响深远。视觉康复在指导以患者为中心的治疗决策方面发挥着举足轻重的作用,但它对青光眼患者的利用率仍然很低。了解可用的 LVR 对开发新的工具和方法至关重要。本文概述了视力受损者的视力康复选择,并强调了全面评估和满足他们在视觉功能和整体健康方面需求的重要性。
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引用次数: 0
Ureterocele in Combination with Urolithiasis in a Pregnant Woman 一名孕妇的输尿管鞘膜积液合并泌尿系结石
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14686
Gafour Khairli, U. Zhanbyrbekuly, Alexey Suchshenko, Almas Muralovich Kazhitaev, Ravshan Zulfugarogly Alnagiev, Orkhan Alyshanogly Ismailov, Abylaikhan Zhakiyauly Baigozha
This article is devoted to the description of the clinical picture, methods of laboratory and instrumental diagnostics, the choice of surgical treatment and postoperative rehabilitation of a patient with a rare urological pathology - ureterocele in combination with urolithiasis in a pregnant woman.
本文主要描述了一名罕见泌尿系统病变--孕妇输尿管膀胱合并尿路结石--患者的临床表现、实验室和仪器诊断方法、手术治疗选择和术后康复。
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引用次数: 0
Processed Foods and Gut Health: A Mini Review of Microbiome Responses 加工食品与肠道健康:微生物群反应小回顾
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14683
A. Baspakova, Kulyash R. Zhilisbayeva, Aigerim A. Umbetova, Anara Zh. Abitova
The present mini review delves into the intricate nexus between processed foods and gut health, with a focused exploration of the dynamic responses exhibited by the gut microbiome. The ubiquity of processed foods in contemporary diets has prompted inquiries into their potential ramifications for human physiological well-being. Given the acknowledged centrality of the gut microbiota in sustaining holistic health, deciphering the nuances of how processed foods impinge upon its constitution and functionality assumes critical significance. By methodically scrutinizing recent empirical investigations, this mini review elucidates the multifaceted manners through which processed foods interface with the complex web of the gut microbial consortium. It meticulously delineates alterations in microbial taxonomic diversity, community richness, and ecological equilibrium, thereby elucidating the putative mechanistic underpinnings driving the possible impact of processed food consumption on physiological equilibrium. Furthermore, the review cogitates upon the broader translational repercussions of these microbiome perturbations, cogently contemplating potential correlations with pathophysiologies encompassing but not limited to inflammation cascades, metabolic perturbations, and immune homeostasis dysregulation. By synthesizing the current compendium of empirical insights, this mini review proffers cogent perspectives into the intricate interplay between processed foods and gut health. It substantiates the exigency for augmented investigative endeavors, whilst advocating for judicious dietary selections that foster resilience and equilibrium within the intricate milieu of the gut microbiome.
本微型综述深入探讨了加工食品与肠道健康之间错综复杂的关系,重点探讨了肠道微生物组所表现出的动态反应。加工食品在当代饮食中无处不在,这促使人们探究其对人类生理健康的潜在影响。鉴于肠道微生物群在维持整体健康中的核心地位已得到公认,解读加工食品如何对其构成和功能产生影响的细微差别就显得至关重要。通过有条不紊地仔细研究近期的实证调查,这篇微型综述阐明了加工食品与肠道微生物群复杂网络的多方面联系。它细致地描述了微生物分类多样性、群落丰富度和生态平衡的变化,从而阐明了加工食品消费可能对生理平衡产生影响的潜在机理基础。此外,这篇综述还探讨了这些微生物群扰动所带来的更广泛的转化影响,深入思考了与病理生理的潜在关联,包括但不限于炎症级联、代谢扰动和免疫平衡失调。这篇小型综述综合了当前的经验见解,对加工食品与肠道健康之间错综复杂的相互作用提出了有说服力的观点。它证实了加强研究工作的必要性,同时倡导明智的饮食选择,以促进肠道微生物群复杂环境中的恢复力和平衡。
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引用次数: 0
Stem Cell- and Stem Cell-Free-Based Therapies: Pros and Cons 干细胞疗法和无干细胞疗法:利与弊
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14684
Halimeh Mobarak, Reza Rahbarghazi, M. Mahdipour
The efficiency of stem cell (SC)-based therapies has been proven in numerous animal and human studies. Along with the differentiation into several lineages, it is quite evident that SCs convey significant therapeutic effects in a paracrine manner via releasing various nano-sized extracellular vesicles (EVs) containing cytokines and bioactive factors. Notably, recent trials have stated the lack of stability and durability of the transplanted SCs at the site of injury for long periods, leading to the restrictions of SC in regenerative outcomes. Thus, EVs especially exosomes (Exos) gained much attention for therapeutic purposes and delivery purposes to the injury site. In contrast to whole-SC-based therapies, Exos can be used with fewer side effects. However, it should not be forgotten that both whole-SC- and cell-free-based options possess inherent pros and cons that necessitate being carefully evaluated before application in the clinical setting. Here, the effectiveness and limitations associated with whole-SCand SC-free-based therapies in the clinical setting are briefly discussed.
以干细胞(SC)为基础的疗法的有效性已在大量动物和人体研究中得到证实。干细胞在分化成多种细胞系的同时,还通过释放含有细胞因子和生物活性因子的各种纳米级细胞外囊泡(EV),以旁分泌方式传递显著的治疗效果。值得注意的是,最近的试验表明,移植的细胞外囊在损伤部位缺乏长期稳定性和持久性,导致细胞外囊在再生效果方面受到限制。因此,EVs,尤其是外泌体(Exos)因其治疗目的和向损伤部位输送的目的而备受关注。与基于全细胞的疗法相比,外泌体的副作用较小。然而,不应忘记的是,全SC 和无细胞疗法都有其固有的优缺点,因此在临床应用前必须进行仔细评估。在此,我们将简要讨论基于全SC和无SC的疗法在临床环境中的有效性和局限性。
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引用次数: 0
Future Prospects for Assessment of General Movements in Developing Countries 发展中国家一般性迁移评估的未来前景
Pub Date : 2023-12-21 DOI: 10.18502/wkmj.v65i4.14681
Zhanna Zhussupova, Dinmukhamed Ayaganov, Gulmira Zharmakhanova, Ayten Mamedbayli
The well-being of children is crucial for a nation’s demographic, economic, and intellectual prospects. Developing countries face an increasing number of children with disabilities, primarily attributed to congenital developmental defects, neurological disorders, and other health issues. Neurological disorders pose significant challenges to realizing the full potential of children and society. Early intervention is essential for improving functional outcomes in infants with neurological impairments. General Movements (GM) assessment, a predictor of subsequent neurological outcomes, plays a vital role in early detection. However, its widespread implementation in developing countries is limited. This article explores the history of GM assessment, its current state in developing countries, and the potential for mobile applications to revolutionize early assessments and interventions in developing countries.
儿童的福祉对一个国家的人口、经济和智力前景至关重要。发展中国家面临着越来越多的残疾儿童,主要原因是先天发育缺陷、神经系统疾病和其他健康问题。神经系统疾病对充分发挥儿童和社会的潜力构成了重大挑战。早期干预对于改善有神经障碍婴儿的功能结果至关重要。一般运动(GM)评估是预测后续神经系统结果的一个指标,在早期检测中起着至关重要的作用。然而,该方法在发展中国家的广泛应用还很有限。本文探讨了一般运动评估的历史、其在发展中国家的现状,以及移动应用在彻底改变发展中国家早期评估和干预措施方面的潜力。
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引用次数: 0
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West Kazakhstan Medical Journal
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