Objectives: This research is designed to analyze the relationship between Sayeok-tang(四逆湯) and systemic inflammatory response syndrome in literature.Methods: The main treatment symptoms of Sayeok-tang(四逆湯) presented in Sanghanron(傷寒論) and Geumgweyoryak (金匱要略), and the symptoms of Ju-hwang(走黃) and Nae-ham(內陷), which is a sepsis and systemic inflammatory response syndrome in Korean medicine were analyzed. The symptoms of systemic inflammatory response syndrome presented in the related researches including diagnosis criteria and international guideline presented at the consensus conference hosted by the American College of Chest Physicians and The Society of Critical Care Medicine were also compared and analyzed.Results: The main treatment symptoms of Sayeok-tang(四逆湯) and symptoms of systemic inflammatory response were very similar, and were almost identical to the symptoms of Nae-ham (內陷, especially Gun-ham (乾陷) and Heo-ham(虛陷)), which are the Korean medicine descriptions of sepsis and systemic inflammatory response syndrome.Conclusions: Based on the research results, Sayeok-tang(四逆湯) can be used as a treatment of systemic inflammatory response syndrome.
{"title":"A Study on the Relationship Between Sayeok-tang and Systemic Inflammatory Response Syndrome","authors":"Ju-Hyun Lee, Sang-Bae Lee, E. Jo, Min-Cheol Park","doi":"10.13048/jkm.24020","DOIUrl":"https://doi.org/10.13048/jkm.24020","url":null,"abstract":"Objectives: This research is designed to analyze the relationship between Sayeok-tang(四逆湯) and systemic inflammatory response syndrome in literature.Methods: The main treatment symptoms of Sayeok-tang(四逆湯) presented in Sanghanron(傷寒論) and Geumgweyoryak (金匱要略), and the symptoms of Ju-hwang(走黃) and Nae-ham(內陷), which is a sepsis and systemic inflammatory response syndrome in Korean medicine were analyzed. The symptoms of systemic inflammatory response syndrome presented in the related researches including diagnosis criteria and international guideline presented at the consensus conference hosted by the American College of Chest Physicians and The Society of Critical Care Medicine were also compared and analyzed.Results: The main treatment symptoms of Sayeok-tang(四逆湯) and symptoms of systemic inflammatory response were very similar, and were almost identical to the symptoms of Nae-ham (內陷, especially Gun-ham (乾陷) and Heo-ham(虛陷)), which are the Korean medicine descriptions of sepsis and systemic inflammatory response syndrome.Conclusions: Based on the research results, Sayeok-tang(四逆湯) can be used as a treatment of systemic inflammatory response syndrome.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"53 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aimed to identify the current status, satisfaction, obstacles, and improvement points of the School Doctor Program of Korean Medicine, while providing supporting data for its enhancement.Methods: A self-reporting online survey was conducted among doctors of the Seoul Korean Medicine Association who applied to participate in the 2023 School Doctor Program of Korean Medicine. The questionnaire assessed various aspects including program status, satisfaction, evaluation, advantages, obstacles, promotion plans for the 2023 program, and intention to participate in the 2024 program. The survey was conducted from March 5th to 12th, 2024.Results: A total of 60 doctors participated in the survey, with 57 respondents included in the analysis. Among them, 45 Korean medical doctors had actively engaged in the school doctor program. Main reasons for non-participation included lack of request from assigned schools or scheduling conflicts between the desired program time and the conditions of Korean medicine doctors. Participants who conducted the program reported its effectiveness in fostering positive perceptions of Korean medicine. Despite obstacles, the majority expressed willingness to participate in the 2024 program. To promote the program, there is a need for a structured system to facilitate school cooperation and promote the School Doctor Program of Korean Medicine.Conclusions: Promoting the School Doctor Program of Korean Medicine requires collaboration from schools, provision of standardized manuals and programs, and support from the Korean Medicine Association. Strengthening systems for school cooperation and program promotion is essential for its advancement.
{"title":"Survey of Korean Medicine Doctors Applying to Participate in the School Doctor Program of Korean Medicine","authors":"Jeong-Su Park, Seung Hwan Lee, Seon Mi Shin","doi":"10.13048/jkm.24028","DOIUrl":"https://doi.org/10.13048/jkm.24028","url":null,"abstract":"Objectives: This study aimed to identify the current status, satisfaction, obstacles, and improvement points of the School Doctor Program of Korean Medicine, while providing supporting data for its enhancement.Methods: A self-reporting online survey was conducted among doctors of the Seoul Korean Medicine Association who applied to participate in the 2023 School Doctor Program of Korean Medicine. The questionnaire assessed various aspects including program status, satisfaction, evaluation, advantages, obstacles, promotion plans for the 2023 program, and intention to participate in the 2024 program. The survey was conducted from March 5th to 12th, 2024.Results: A total of 60 doctors participated in the survey, with 57 respondents included in the analysis. Among them, 45 Korean medical doctors had actively engaged in the school doctor program. Main reasons for non-participation included lack of request from assigned schools or scheduling conflicts between the desired program time and the conditions of Korean medicine doctors. Participants who conducted the program reported its effectiveness in fostering positive perceptions of Korean medicine. Despite obstacles, the majority expressed willingness to participate in the 2024 program. To promote the program, there is a need for a structured system to facilitate school cooperation and promote the School Doctor Program of Korean Medicine.Conclusions: Promoting the School Doctor Program of Korean Medicine requires collaboration from schools, provision of standardized manuals and programs, and support from the Korean Medicine Association. Strengthening systems for school cooperation and program promotion is essential for its advancement.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"36 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141274147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aimed to investigate the attitudes towards blood tests (BT), the utilization of BT in clinical contexts, and the educational needs and experiences among Korean medicine doctors (KMDs).Methods: An anonymous online survey was conducted among KMDs over a two-week period in 2023. The survey data were subjected to basic statistical analysis and logistic regression.Results: A total of 773 respondents participated in the survey, yielding a response rate of approximately 3%. Most respondents recognized the necessity of BT in Korean medicine, with 74.77% reporting prior utilization. However, only 43.73% currently utilize BTs. Key barriers to BT utilization included insufficient legal and institutional safeguards and cost burdens. Although 77.62% reported receiving BT education, only 54.85% deemed it useful, yet 95.21% expressed intent for future education. Younger KMDs exhibited lower BT utilization and lower agreement rates on the usefulness of education but higher demand for education. The longer the training period in Korean medicine hospitals, the higher the rate of experience with BTs, related education and the agreement on the usefulness of the education. And they had relatively less need for further education.Conclusions: Efforts are needed to meet the demand for BT education among KMDs. In particular, it seems necessary to identify the higher demand among young KMDs and prepare for education at a level equivalent to a training course in Korean medicine hospitals rather than in a form that just follows past education practices.
{"title":"A Survey on Korean medicine doctors' attitudes toward blood tests, status of usage, and experience and demand for related education","authors":"Mikyung Kim, Chang-ho Han","doi":"10.13048/jkm.24021","DOIUrl":"https://doi.org/10.13048/jkm.24021","url":null,"abstract":"Objectives: This study aimed to investigate the attitudes towards blood tests (BT), the utilization of BT in clinical contexts, and the educational needs and experiences among Korean medicine doctors (KMDs).Methods: An anonymous online survey was conducted among KMDs over a two-week period in 2023. The survey data were subjected to basic statistical analysis and logistic regression.Results: A total of 773 respondents participated in the survey, yielding a response rate of approximately 3%. Most respondents recognized the necessity of BT in Korean medicine, with 74.77% reporting prior utilization. However, only 43.73% currently utilize BTs. Key barriers to BT utilization included insufficient legal and institutional safeguards and cost burdens. Although 77.62% reported receiving BT education, only 54.85% deemed it useful, yet 95.21% expressed intent for future education. Younger KMDs exhibited lower BT utilization and lower agreement rates on the usefulness of education but higher demand for education. The longer the training period in Korean medicine hospitals, the higher the rate of experience with BTs, related education and the agreement on the usefulness of the education. And they had relatively less need for further education.Conclusions: Efforts are needed to meet the demand for BT education among KMDs. In particular, it seems necessary to identify the higher demand among young KMDs and prepare for education at a level equivalent to a training course in Korean medicine hospitals rather than in a form that just follows past education practices.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"20 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seoyeon Kim, Dohyeon Lee, Hye-Won Jeong, K. Kim, Seung-hee Lee
Objectives: The purpose of this study is to review trends in Korean medical education research.Method: We searched Korean Medicine Education research in 4 domestic and 4 international datebases. The studies were analyzed with journal, year, keyword and detailed topic, word frequency in research context, divided into four categories: basic Korean medicine, clinical Korean medicine, medical humanities, education.Result: 128 Korean studies and 30 International studies, total 158 studies, published from 1993 to 2024 have been selected. Research on Korean medicine education has been consistently published every year since 2003, by 61 journals. The period when the most papers were published was 2020, with 16 papers. Journal of Physiology & Pathology in Korean Medicine published a relatively large number of studies, with 19. Among the keywords divided into 4 categories according to Institute of Korean Medicine Education & Evaluation, studies related to 'basic medicine' were the most with 45 cases. When classified into detailed topics, there were 40 papers related to 'subject', and 21 papers related to ‘awareness’.Discussion and Conclusion: The study suggests that Korean medicine education method and curriculum should be developed. As educational research and method progresses, the corresponding curriculum has to be improved and applied to the field. This study would contribute to the foundation of Korean medicine education.
{"title":"Trends in the Study of Korean Medicine Education : Based on domestic and international research","authors":"Seoyeon Kim, Dohyeon Lee, Hye-Won Jeong, K. Kim, Seung-hee Lee","doi":"10.13048/jkm.24031","DOIUrl":"https://doi.org/10.13048/jkm.24031","url":null,"abstract":"Objectives: The purpose of this study is to review trends in Korean medical education research.Method: We searched Korean Medicine Education research in 4 domestic and 4 international datebases. The studies were analyzed with journal, year, keyword and detailed topic, word frequency in research context, divided into four categories: basic Korean medicine, clinical Korean medicine, medical humanities, education.Result: 128 Korean studies and 30 International studies, total 158 studies, published from 1993 to 2024 have been selected. Research on Korean medicine education has been consistently published every year since 2003, by 61 journals. The period when the most papers were published was 2020, with 16 papers. Journal of Physiology & Pathology in Korean Medicine published a relatively large number of studies, with 19. Among the keywords divided into 4 categories according to Institute of Korean Medicine Education & Evaluation, studies related to 'basic medicine' were the most with 45 cases. When classified into detailed topics, there were 40 papers related to 'subject', and 21 papers related to ‘awareness’.Discussion and Conclusion: The study suggests that Korean medicine education method and curriculum should be developed. As educational research and method progresses, the corresponding curriculum has to be improved and applied to the field. This study would contribute to the foundation of Korean medicine education.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"69 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141280670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ga-Ram Yu, Hye-Lin Jin, Da-Hoon Kim, Jay Kyun Noah, Hyuck Kim, Dong-Woo Lim
Objectives: Cannabis root is a medicinal plant that has been used in traditional medicine around the world. However, in previous studies using simple extracts, the biological activity was not relatively prominent compared to other herbal medicines. The aim of the present study is to confirm the enhancement of anti-inflammatory activity and bioactive compound of Cannabis root extract prepared by combined processing process.Methods: A series of processes including repeated steam and dry, fermentation, hydrothermal extraction and ethanol extraction was applied to Cannabis root. The antioxidant content of cannabis root extracts obtained through a combined processing process was investigated by analyzing the total phenolic, tannin, and flavonoid contents. Anti-inflammatory effects were tested in LPS-treated RAW264.7 cells. The anti-inflammatory mechanism was examined by western blot. Finally, the component profile of Cannabis root extract was analyzed using High Performance Liquid Chromatography (HPLC) and Thin layer chromatography (TLC).Results: The cannabis root extract prepared by complex processing process had higher antioxidant and anti-inflammatory effects than simple extract. Total phenolic and tannin contents were significantly increased, and DPPH free radical inhibition activity was strengthened by combined processing process. Increased NO production and iNOS expression in LPS-treated RAW264.7 cells were decreased in a concentration-dependent manner upon extract treatment by complex processing process. Additionally, the Stigmasterol content of Cannabis root extract was increased through a complex processing process.Conclusions: Further research is needed on the mechanisms and substances that exhibit the anti-inflammatory effects of Cannabis roots extract prepared by complex processing process.
目的：大麻根是一种药用植物，一直被用于世界各地的传统医药中。然而，在以往使用简单提取物的研究中，其生物活性与其他草药相比并不突出。本研究的目的是确认通过联合加工工艺制备的大麻根提取物的抗炎活性和生物活性化合物的增强情况：方法：对大麻根进行了一系列处理，包括重复蒸干、发酵、水热萃取和乙醇萃取。通过分析总酚、单宁和黄酮类化合物的含量，研究了通过联合加工工艺获得的大麻根提取物的抗氧化剂含量。在经 LPS 处理的 RAW264.7 细胞中测试了抗炎效果。抗炎机制通过 Western 印迹进行了检验。最后，使用高效液相色谱法（HPLC）和薄层色谱法（TLC）分析了大麻根提取物的成分概况：结果：采用复杂加工工艺制备的大麻根提取物比简单提取物具有更高的抗氧化和抗炎效果。总酚和单宁含量明显增加，DPPH 自由基抑制活性在复合加工过程中得到加强。经 LPS 处理的 RAW264.7 细胞中 NO 生成量和 iNOS 表达量的增加在复合处理过程中以浓度依赖性的方式降低。此外，通过复合加工工艺，大麻根提取物中的豆固醇含量也有所增加：通过复杂加工工艺制备的大麻根提取物具有抗炎作用的机制和物质有待进一步研究。
{"title":"A comparative study on enhanced anti-inflammatory activity of Cannabis root extract prepared by combined processing process","authors":"Ga-Ram Yu, Hye-Lin Jin, Da-Hoon Kim, Jay Kyun Noah, Hyuck Kim, Dong-Woo Lim","doi":"10.13048/jkm.24023","DOIUrl":"https://doi.org/10.13048/jkm.24023","url":null,"abstract":"Objectives: Cannabis root is a medicinal plant that has been used in traditional medicine around the world. However, in previous studies using simple extracts, the biological activity was not relatively prominent compared to other herbal medicines. The aim of the present study is to confirm the enhancement of anti-inflammatory activity and bioactive compound of Cannabis root extract prepared by combined processing process.Methods: A series of processes including repeated steam and dry, fermentation, hydrothermal extraction and ethanol extraction was applied to Cannabis root. The antioxidant content of cannabis root extracts obtained through a combined processing process was investigated by analyzing the total phenolic, tannin, and flavonoid contents. Anti-inflammatory effects were tested in LPS-treated RAW264.7 cells. The anti-inflammatory mechanism was examined by western blot. Finally, the component profile of Cannabis root extract was analyzed using High Performance Liquid Chromatography (HPLC) and Thin layer chromatography (TLC).Results: The cannabis root extract prepared by complex processing process had higher antioxidant and anti-inflammatory effects than simple extract. Total phenolic and tannin contents were significantly increased, and DPPH free radical inhibition activity was strengthened by combined processing process. Increased NO production and iNOS expression in LPS-treated RAW264.7 cells were decreased in a concentration-dependent manner upon extract treatment by complex processing process. Additionally, the Stigmasterol content of Cannabis root extract was increased through a complex processing process.Conclusions: Further research is needed on the mechanisms and substances that exhibit the anti-inflammatory effects of Cannabis roots extract prepared by complex processing process.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: In this study, we used network-based systems pharmacology analysis and molecular docking methods to predict the therapeutic mechanism of Scutellariae Radix on viral pneumonia.Methods: We screened active components of Scutellariae Radix and its’ genes by TCMSP. Also, we extracted viral pneumonia related target genes through Gene Cards, CTD and DisGeNet. To construct Protein-protein Interaction, STRING database was used. For functional enrichment, using SRplot platform, genes were classified by 3 categories: cellular component (CC), molecular function (MF) and biological process (BP). Molecular docking was conducted by AutoDockTools (version 4.2.6).Results: 32 Network-based systematic pharmacology analysis identified 37 target genes associated with baicalein. Based on the network and gene ontology analysis of the active ingredient's target genes and disease target genes, we identified nine core genes (AKT1, BAX, BCL2, CASP3, HIF1A, PTGS2, RELA, TP53, VEGFA) and HSP90 as involved. Notably, HIF1A showed the highest relevance, overlapping with two or more utilized programs. Hypoxia-inducible factor 1-alpha (HIF-1α) has been implicated in the expression of inflammatory cytokines, the induction of hypoxia, and the triggering of cytokine storms. Baicalein, a major component of SR, binds to both HIF-1 α and HSP90, suggesting that it may be a possible targeted treatment for viral pneumonia.Conclusions: Baicalein may bind to HIF-1α to control inflammation caused by viral infectious diseases and may also regulate hypoxic conditions to prevent impairment of lung function caused by an overactive immune system. These findings suggest further research into the molecular mechanisms involved in hypoxia and provide a scientific basis for improving the treatment of viral infectious diseases.
{"title":"Prediction of Treatment Mechanisms of Scutellariae Radix on Viral Pneumonia Through Network Pharmacology: Focus on Hypoxic State Regulation Through HIF-1α and HSP90","authors":"J. Shon, Do Kyung Han, Youn Sook Kim, Won Gun An","doi":"10.13048/jkm.24024","DOIUrl":"https://doi.org/10.13048/jkm.24024","url":null,"abstract":"Objectives: In this study, we used network-based systems pharmacology analysis and molecular docking methods to predict the therapeutic mechanism of Scutellariae Radix on viral pneumonia.Methods: We screened active components of Scutellariae Radix and its’ genes by TCMSP. Also, we extracted viral pneumonia related target genes through Gene Cards, CTD and DisGeNet. To construct Protein-protein Interaction, STRING database was used. For functional enrichment, using SRplot platform, genes were classified by 3 categories: cellular component (CC), molecular function (MF) and biological process (BP). Molecular docking was conducted by AutoDockTools (version 4.2.6).Results: 32 Network-based systematic pharmacology analysis identified 37 target genes associated with baicalein. Based on the network and gene ontology analysis of the active ingredient's target genes and disease target genes, we identified nine core genes (AKT1, BAX, BCL2, CASP3, HIF1A, PTGS2, RELA, TP53, VEGFA) and HSP90 as involved. Notably, HIF1A showed the highest relevance, overlapping with two or more utilized programs. Hypoxia-inducible factor 1-alpha (HIF-1α) has been implicated in the expression of inflammatory cytokines, the induction of hypoxia, and the triggering of cytokine storms. Baicalein, a major component of SR, binds to both HIF-1 α and HSP90, suggesting that it may be a possible targeted treatment for viral pneumonia.Conclusions: Baicalein may bind to HIF-1α to control inflammation caused by viral infectious diseases and may also regulate hypoxic conditions to prevent impairment of lung function caused by an overactive immune system. These findings suggest further research into the molecular mechanisms involved in hypoxia and provide a scientific basis for improving the treatment of viral infectious diseases.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"39 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The purpose of this study is to review the dissolving microneedle patches literature, which is loaded with pharmacopuncture preparation. By exploring types of pharmacopuncture preparation applied to microneedle patches, we aim to develop new potential preparation.Methods: This review included both animal and human studies that published between February 2015 and March 2024. After searching, no RCTs were found, the final selected in-vivo and in-vitro studies were analyzed. A total of 13 articles were retrieved from the international database, and a total of 5 articles were retrieved from the domestic database. Finally, 7 studies were selected, and evaluated by the published year, country of publication, types of animal model, disease type, retention type, evaluation index, adverse effects.Conclusions: According to 7 studies, pharmacopuncture preparation coated dissolving microneedle patch include bee venom, placenta, and ginseng in osteoarthritis, rheumatoid arthritis, hypertrophic scar, psoriasis, and neurodegeneration. In the future, follow-up studies on the safety, retention time, and optimal effective dose of the microneedle patches are expected.
{"title":"Analysis of research trends on microneedle patches loaded pharmacopuncture preparation: A Literature Review","authors":"Minjeong Kim","doi":"10.13048/jkm.24032","DOIUrl":"https://doi.org/10.13048/jkm.24032","url":null,"abstract":"Objectives: The purpose of this study is to review the dissolving microneedle patches literature, which is loaded with pharmacopuncture preparation. By exploring types of pharmacopuncture preparation applied to microneedle patches, we aim to develop new potential preparation.Methods: This review included both animal and human studies that published between February 2015 and March 2024. After searching, no RCTs were found, the final selected in-vivo and in-vitro studies were analyzed. A total of 13 articles were retrieved from the international database, and a total of 5 articles were retrieved from the domestic database. Finally, 7 studies were selected, and evaluated by the published year, country of publication, types of animal model, disease type, retention type, evaluation index, adverse effects.Conclusions: According to 7 studies, pharmacopuncture preparation coated dissolving microneedle patch include bee venom, placenta, and ginseng in osteoarthritis, rheumatoid arthritis, hypertrophic scar, psoriasis, and neurodegeneration. In the future, follow-up studies on the safety, retention time, and optimal effective dose of the microneedle patches are expected.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"18 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141280823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yebin Lim, Bitna Kweon, Dong-Uk Kim, Do-Eun Lee, Jungtae Leem, Dong-Gu Kim, Hyung Won Kang, Gi-Sang Bae
Objectives: This study utilized a network pharmacology approach to investigate the potential therapeutic effects and underlying mechanisms of Daehwangmokdanpi-tang (DHMDPT) in diabetic cognitive disorder (DCD).Methods: The compounds of DHMDPT and their target genes were obtained from the OASIS and PubChem databases. These putative target genes were compared with known targets of DCD to identify potential correlations. Using Cytoscape 3.10.2, a network was constructed to highlight key target genes. To further elucidate the underlying mechanisms, functional enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, CB-DOCK was used to assess binding affinities and confirm the interactions.Results: The results showed that a total of 27 compounds and 439 related genes were identified from DHMDPT. Among these, 373 genes interacted with the DCD gene set, indicating a close relationship between the effects of DHMDPT and DCD. Through GO enrichment analysis and KEGG pathways, ‘Regulation of Apoptotic Process’, ‘Cytokine-Mediated signaling pathway’, and ‘AGE-RAGE signaling pathway in diabetic complications’ were identified as the functional pathways of the 18 key target genes of DHMDPT on DCD. Additionally, molecular docking was performed to assess the binding affinities of the six most highly associated key target genes of DCD with active compounds.Conclusions: Using a network pharmacology approach, which included molecular docking, DHMDPT was found to be highly relevant to DCD. This study could serve as a foundation for further research on the cognitive enhancement effects of DHMDPT in DCD.
{"title":"Exploration of the Potential and Mechanisms of Diabetic Cognitive Disorder Modulation by Daehwangmokdanpi-tang through a Network Pharmacological Approach","authors":"Yebin Lim, Bitna Kweon, Dong-Uk Kim, Do-Eun Lee, Jungtae Leem, Dong-Gu Kim, Hyung Won Kang, Gi-Sang Bae","doi":"10.13048/jkm.24022","DOIUrl":"https://doi.org/10.13048/jkm.24022","url":null,"abstract":"Objectives: This study utilized a network pharmacology approach to investigate the potential therapeutic effects and underlying mechanisms of Daehwangmokdanpi-tang (DHMDPT) in diabetic cognitive disorder (DCD).Methods: The compounds of DHMDPT and their target genes were obtained from the OASIS and PubChem databases. These putative target genes were compared with known targets of DCD to identify potential correlations. Using Cytoscape 3.10.2, a network was constructed to highlight key target genes. To further elucidate the underlying mechanisms, functional enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, CB-DOCK was used to assess binding affinities and confirm the interactions.Results: The results showed that a total of 27 compounds and 439 related genes were identified from DHMDPT. Among these, 373 genes interacted with the DCD gene set, indicating a close relationship between the effects of DHMDPT and DCD. Through GO enrichment analysis and KEGG pathways, ‘Regulation of Apoptotic Process’, ‘Cytokine-Mediated signaling pathway’, and ‘AGE-RAGE signaling pathway in diabetic complications’ were identified as the functional pathways of the 18 key target genes of DHMDPT on DCD. Additionally, molecular docking was performed to assess the binding affinities of the six most highly associated key target genes of DCD with active compounds.Conclusions: Using a network pharmacology approach, which included molecular docking, DHMDPT was found to be highly relevant to DCD. This study could serve as a foundation for further research on the cognitive enhancement effects of DHMDPT in DCD.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"127 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aimed to analyze the results and review the outcomes and satisfaction levels of the 2023 Busan Korean medicine infertility treatment support project.Methods: A total of 137 female and 26 male participated in the Korean medicine infertility treatment support project, which encompassed herbal medicine and pharmacopuncture treatment over 4-month period. Data pertaining to patients' general, demographic, and fertility-related characteristics were collected before treatment initiation. During treatment, information regarding the treatments administered by Korean medical doctors was recorded, along with post-treatment outcomes and satisfaction levels.Results: Out of 163 initially enrolled participants, data from 4 female participants were missing, data from 159 participants were analyzed. A total of 113 female and 22 male participants completed the treatment program (Completion rate 84.9%). Of these, 23 female participants achieved pregnancy (Pregnancy rate 20.4%). Participants reported a high level of satisfaction with the treatment support project, with an average satisfaction score of 9.4 out of 10.Conclusions: The study analyzed the clinical findings of the 2023 Busan Korean medicine infertility treatment support project. These findings provide a basis for developing Korean medicine infertility support projects and related research.
{"title":"Retrospective Analysis of Outcomes in the 2023 Busan Korean Medicine infertility Treatment Support Project","authors":"Su-Ji Choi, J. Won, Dong-Hee Lee, Hyun-Min Yoon","doi":"10.13048/jkm.24027","DOIUrl":"https://doi.org/10.13048/jkm.24027","url":null,"abstract":"Objectives: This study aimed to analyze the results and review the outcomes and satisfaction levels of the 2023 Busan Korean medicine infertility treatment support project.Methods: A total of 137 female and 26 male participated in the Korean medicine infertility treatment support project, which encompassed herbal medicine and pharmacopuncture treatment over 4-month period. Data pertaining to patients' general, demographic, and fertility-related characteristics were collected before treatment initiation. During treatment, information regarding the treatments administered by Korean medical doctors was recorded, along with post-treatment outcomes and satisfaction levels.Results: Out of 163 initially enrolled participants, data from 4 female participants were missing, data from 159 participants were analyzed. A total of 113 female and 22 male participants completed the treatment program (Completion rate 84.9%). Of these, 23 female participants achieved pregnancy (Pregnancy rate 20.4%). Participants reported a high level of satisfaction with the treatment support project, with an average satisfaction score of 9.4 out of 10.Conclusions: The study analyzed the clinical findings of the 2023 Busan Korean medicine infertility treatment support project. These findings provide a basis for developing Korean medicine infertility support projects and related research.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This case study aims to demonstrate the efficacy of ultrasound-guided hominis placenta pharmacopuncture in lateral epicondylitis.Methods: A 42-year-old male patient presented with lateral epicondylitis of the right arm of 4 months’ duration. Sonographic findings were tearing of the common extensor tendon at the lateral epicondyle. The patient was treated with ultrasound-guided hominis placenta pharmacopuncture and acupuncture for 9 weeks. The numeric rating scale (NRS) and patient-rated tennis elbow evaluation(PRTEE) were used to assess pain, function and progression. Ultrasound images were compared every 2 weeks.Results: After treatments, NRS and PRTEE were reduced from 7 to 1 and from 106 to 22, respectively. And improvement was observed in the torn region of the common extensor tendon on ultrasound imaging.Conclusion: This case demonstrates that ultrasound-guided hominis placenta pharmacopuncture could improve lateral epicondylitis and tear with minimally invasive methods.
{"title":"A Case Report of Ultrasound-guided Hominis Placenta Pharmacopuncture on Lateral epicondylitis","authors":"Seung-Yun Oh, Myung-Ho Kim, Soo-Jung Park","doi":"10.13048/jkm.24030","DOIUrl":"https://doi.org/10.13048/jkm.24030","url":null,"abstract":"Objectives: This case study aims to demonstrate the efficacy of ultrasound-guided hominis placenta pharmacopuncture in lateral epicondylitis.Methods: A 42-year-old male patient presented with lateral epicondylitis of the right arm of 4 months’ duration. Sonographic findings were tearing of the common extensor tendon at the lateral epicondyle. The patient was treated with ultrasound-guided hominis placenta pharmacopuncture and acupuncture for 9 weeks. The numeric rating scale (NRS) and patient-rated tennis elbow evaluation(PRTEE) were used to assess pain, function and progression. Ultrasound images were compared every 2 weeks.Results: After treatments, NRS and PRTEE were reduced from 7 to 1 and from 106 to 22, respectively. And improvement was observed in the torn region of the common extensor tendon on ultrasound imaging.Conclusion: This case demonstrates that ultrasound-guided hominis placenta pharmacopuncture could improve lateral epicondylitis and tear with minimally invasive methods.","PeriodicalId":509794,"journal":{"name":"Journal of Korean Medicine","volume":"23 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141280334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：