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Assessing salivary innate immune responses in adolescents with dentofacial abnormalities and central precocious puberty 评估牙面畸形和中枢性性早熟青少年的唾液先天性免疫反应
Pub Date : 2024-04-15 DOI: 10.33925/1683-3031-2024-717
K. A. Kolesnik, A. M. Belousova
Relevance. Central precocious puberty (CPP), characterized by a high incidence of 60% among endocrinopathies during puberty, significantly influences dentofacial development and the local immune defense mechanisms in adolescents. However, the impact on saliva's innate immune function remains underexplored.This study aims to evaluate the innate immune function of saliva in individuals with CPP coexisting with dentofacial abnormalities.Materials and methods. An analysis of saliva biochemical markers was conducted on 59 adolescents diagnosed with CPP and dentofacial abnormalities, alongside a control group of 21 age-matched individuals with dentofacial abnormalities but without systemic conditions, aged 13-18 years. The evaluation focused on lysozyme and urease levels, dysbiosis markers indicating oral microbiota status, malondialdehyde (MDA) levels, and catalase activity to gauge the balance between pro-oxidant and antioxidant systems, alongside proteolytic enzyme elastase activity.Results. Adolescents with combined CPP and dentofacial abnormalities exhibited weakened antioxidant and antibacterial defenses, evidenced by decreased catalase activity (0.105 ± 0.020 mkat/l, p < 0.001) and lysozyme levels (54.7 ± 3.2 U/l, p < 0.02), against a backdrop of increased lipoperoxidation and microbial contamination (MDA levels at 0.48 ± 0.11 μmol/l, p < 0.05, urease levels at 0.713 ± 0.015 μkat/l, p < 0.01), and heightened inflammation (elastase activity up to 2.71 ± 0.12 μkat/l, p < 0.01).Conclusion. The diminished innate immune function in saliva necessitates the development of strategies to enhance it, serving as a preventive measure against gingivitis in patients with CPP.
相关性。中枢性性早熟(CPP)在青春期内分泌疾病中的发病率高达 60%,严重影响青少年的颌面部发育和局部免疫防御机制。本研究旨在评估 CPP 并发牙面畸形患者唾液的先天性免疫功能。研究人员对 59 名确诊为 CPP 和牙面异常的青少年进行了唾液生化指标分析,同时还对 21 名年龄匹配的牙面异常但无全身疾病的 13-18 岁对照组进行了唾液生化指标分析。评估的重点是溶菌酶和尿素酶水平、表明口腔微生物群状况的菌群失调标志物、丙二醛(MDA)水平、过氧化氢酶活性,以衡量促氧化系统和抗氧化系统之间的平衡,以及蛋白水解酶弹性蛋白酶活性。合并 CPP 和牙面畸形的青少年表现出抗氧化和抗菌防御功能减弱,这体现在过氧化氢酶活性降低(0.105 ± 0.020 mkat/l,p < 0.001)和溶菌酶水平降低(54.7 ± 3.2 U/l,p < 0.02)。02),脂肪过氧化和微生物污染增加(MDA 水平为 0.48 ± 0.11 μmol/l,p < 0.05,脲酶水平为 0.713 ± 0.015 μkat/l,p < 0.01),炎症加剧(弹性蛋白酶活性高达 2.71 ± 0.12 μkat/l,p < 0.01)。唾液中的先天性免疫功能减弱,因此有必要制定策略来增强唾液中的先天性免疫功能,以此作为预防 CPP 患者牙龈炎的措施。
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引用次数: 0
Functional and morphological evaluation of the dentofacial system in patients with distal occlusion using ultrasonic diagnostic methods 使用超声波诊断方法对远端咬合患者的颌面系统进行功能和形态评估
Pub Date : 2024-04-11 DOI: 10.33925/1683-3031-2024-713
N. Y. Oborotistov, A. A. Fokina, D. N. Vracheva, S. N. Ermoljev, O. Yanushevich, L. Persin, A. G. Sedoykin
Relevance. The integrity of the dentofacial system, significantly influenced by the functional condition of the masseter muscles (MM) and the morphological alterations in the alveolar bone, plays a crucial role in the outcome and duration of orthodontic treatment for distal occlusion. Ultrasonic diagnostic methods, due to their physiological compatibility, high information content, and ergonomic design, offer a preferable alternative for assessing and tracking these changes throughout orthodontic treatment.Materials and methods. This study included 55 individuals of both genders, aged 9-12, with either normal occlusions (NO) or distal occlusions (DO). Ultrasound examinations of the MM at rest and during maximum voluntary teeth clenching were conducted to evaluate MM thickness and echotexture. Ultrasonic densitometry measurements were conducted through the assessment of ultrasound transit velocity (UTV). This was carried out across the interalveolar bone with probes positioned on the buccal and oral sides between two neighboring teeth roots.Results. The findings indicated that DO patients had a notably thicker MM compared to their NO counterparts. Variations in MM echotexture were observed, with differences in the anechogenic and hyper echogenic zones. Recorded UTV values illustrated that the highest alveolar bone density in DO subjects was predominantly in the frontal regions of both jaws on the left side, whereas the lowest density was observed in the right lateral regions. For NO subjects, the highest density values were identified in the frontal region of the mandibular bone, with the lowest in the maxillary bone's lateral regions on both sides.Conclusion. The application of advanced ultrasonic diagnostic methods in this study facilitated a detailed functional and morphological analysis of the MM, as well as an evaluation of alveolar bone density in individuals with both distal and normal occlusions. The development of ultrasonic alveolar bone density chart from this research provides a valuable addition to dental examination protocols for patients undergoing orthodontic treatment.
相关性。颌面系统的完整性受咀嚼肌(MM)功能状况和牙槽骨形态改变的显著影响,对远端咬合正畸治疗的结果和持续时间起着至关重要的作用。超声波诊断方法因其生理兼容性、高信息含量和符合人体工程学的设计,为在整个正畸治疗过程中评估和跟踪这些变化提供了一种可取的替代方法。这项研究包括 55 名年龄在 9-12 岁之间、咬合正常(NO)或远端咬合(DO)的男女患者。研究人员对静止时和最大自主咬合时的牙周膜进行了超声波检查,以评估牙周膜的厚度和回声纹理。超声波密度测量是通过评估超声波传输速度(UTV)来进行的。测量时,探头位于两个相邻牙根之间的颊侧和口侧,横跨牙槽骨。研究结果表明,与无牙颌畸形患者相比,有牙颌畸形患者的牙槽骨明显较厚。观察到 MM 回声纹理的变化,无回声区和高回声区存在差异。记录的UTV值表明,DO受试者牙槽骨密度最高的部位主要在左侧两个颌骨的前部,而密度最低的部位在右侧。对于 NO 受试者,密度值最高的部位是下颌骨的正面区域,密度值最低的部位是两侧上颌骨的侧面区域。本研究应用先进的超声波诊断方法,对MM进行了详细的功能和形态分析,并对远端咬合和正常咬合者的牙槽骨密度进行了评估。这项研究开发的超声波牙槽骨密度图为正畸治疗患者的牙科检查方案提供了宝贵的补充。
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引用次数: 0
Oral health of children and adolescents with type 1 diabetes mellitus: a literature review 1 型糖尿病儿童和青少年的口腔健康:文献综述
Pub Date : 2024-04-05 DOI: 10.33925/1683-3031-2024-687
M. M. Scherbakova, O. Admakin, N. S. Morozova, I. A. Kozlitina, A. A. Saushkina
Relevance. Type 1 diabetes mellitus is a prevalent chronic metabolic autoimmune condition among children and adolescents. The compromised metabolic control associated with this endocrinopathy elevates the risk of various complications, including oral diseases. Establishing an interdisciplinary approach to enhance oral care for young patients with type 1 diabetes mellitus is crucial in contemporary dentistry.Objective. To synthesize information regarding the relationship between type 1 diabetes mellitus and oral health in children and adolescents.Materials and methods. The search strategy involved both electronic and manual searches, querying key databases like PubMed, eLibrary, MEDLINE, and Embase using specific keywords related to the subject. Additionally, a manual search was conducted in the references of relevant articles.Results. The literature review identified the most frequently occurring oral diseases in children and adolescents with type 1 diabetes mellitus. It highlighted key biomarkers for monitoring oral health in these patients. The review uncovered major gaps in understanding the oral manifestations of type 1 diabetes mellitus.Conclusion. Exploring the links between pathogenesis of type 1 diabetes mellitus in young populations and their oral health is pivotal for pediatric dentistry and endocrinology. Addressing this issue could lead to more effective treatment strategies, enhance preventive measures, and improve the diagnostic accuracy of oral diseases. Discrepancies among study findings underscores the imperative for ongoing research and substantiates the value of an interdisciplinary approach in investigating the dental manifestations associated with this endocrine disorder.
相关性。1 型糖尿病是儿童和青少年中普遍存在的一种慢性自身免疫代谢疾病。与这种内分泌病症相关的代谢控制受损会增加包括口腔疾病在内的各种并发症的风险。建立一种跨学科的方法来加强对 1 型糖尿病年轻患者的口腔护理在当代牙科医学中至关重要。综合儿童和青少年 1 型糖尿病与口腔健康之间关系的相关信息。检索策略包括电子检索和人工检索,使用与主题相关的特定关键词查询 PubMed、eLibrary、MEDLINE 和 Embase 等主要数据库。此外,还对相关文章的参考文献进行了人工检索。文献综述确定了 1 型糖尿病儿童和青少年最常见的口腔疾病。它强调了监测这些患者口腔健康的关键生物标志物。综述发现了在了解 1 型糖尿病口腔表现方面存在的主要差距。探索年轻群体中 1 型糖尿病发病机制与口腔健康之间的联系,对于儿童牙科和内分泌学至关重要。解决这一问题可以制定更有效的治疗策略,加强预防措施,并提高口腔疾病诊断的准确性。研究结果之间的差异强调了持续研究的必要性,并证明了采用跨学科方法调查与这种内分泌失调有关的牙科表现的价值。
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引用次数: 0
Orodental Manifestations of Noonan Syndrome: a Clinical Case Study 努南综合征的口腔表现:临床病例研究
Pub Date : 2024-02-29 DOI: 10.33925/1683-3031-2024-695
T. Modina, E. V. Mamaeva, M. V. Moseeva, L. R. Salimova, N. A. Musina, V. S. Lyamina
Relevance. Mutations in the PTPN11 gene, a hallmark of Noonan syndrome, disrupt the normal development of connective tissue structure, resulting in a range of manifestations, including orodental abnormalities.Clinical case description. This article presents a medical record of a 14-year-old patient diagnosed with Noonan syndrome who sought medical assistance due to exacerbated chronic generalized periodontitis. The authors implemented a two-stage treatment approach, resulting in satisfactory outcomes. They identified concurrent orodental symptoms and conducted analyses of orthopantomography and bone densitometry for both jaws. A personalized treatment schedule was devised, emphasizing the necessity for the patient's chronic periodontitis to be in a state of remission and the utilization of sedation for effective management. Following the implementation of a planned series of therapeutic interventions during the remission stage, including professional oral care, teeth splinting with orthodontic retainers, nonsurgical root debridement, and mandibular labial frenuloplasty, quarterly follow-up assessments were chosen as the preferred monitoring method.Conclusion. Patients with hereditary pathologies, such as Noonan syndrome, often exhibit significant orodental manifestations. Addressing such conditions necessitates specific treatment techniques that integrate a comprehensive approach, timely diagnostics, and collaboration between general practitioners and dentists. Given the unique needs of these patients, it is essential to develop personalized treatment protocols tailored to their individual requirements, including the duration and efficacy of chosen treatments, as well as considerations for anesthesia or sedation care.
相关性。PTPN11 基因突变是努南综合征的特征之一,会破坏结缔组织结构的正常发育,导致一系列表现,包括口腔异常。本文介绍了一名被诊断患有努南综合征的 14 岁患者的病历,该患者因慢性全身性牙周炎加重而求医。作者采用了两阶段治疗方法,取得了令人满意的疗效。他们确定了并发的口腔症状,并对双颌进行了正畸和骨密度测量分析。他们制定了个性化的治疗计划,强调患者的慢性牙周炎必须处于缓解状态,并使用镇静剂进行有效治疗。在缓解阶段实施了一系列有计划的治疗干预措施,包括专业口腔护理、使用正畸保持器进行牙齿夹板固定、非手术牙根清创和下颌唇裂成形术,之后选择每季度进行一次随访评估作为首选的监测方法。努南综合征等遗传性疾病患者通常会有明显的口腔表现。治疗这类疾病需要特殊的治疗技术,包括综合方法、及时诊断以及全科医生和牙科医生之间的合作。鉴于这些患者的独特需求,必须根据他们的个人要求制定个性化的治疗方案,包括所选治疗方法的持续时间和疗效,以及麻醉或镇静护理的注意事项。
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引用次数: 0
Findings of an orthodontic and osteopathic diagnostic of individuals with an asymmetric narrowing of maxilla 上颌骨不对称狭窄患者的正畸和整骨诊断结果
Pub Date : 2024-01-30 DOI: 10.33925/1683-3031-2023-690
M. Vasilyeva, G. S. Perevezentsev, T. Kosyreva
Relevance. Postural disorders and their connection to dentofacial abnormalities represent a prominent subject in modern medicine, establishing a new diagnostic standard within the emerging fields of orthodontic and osteopathic diagnostic techniques.Objective. Establish a correlation between asymmetric narrowing of maxilla and postural disorders in children and teens aged 6 to 15 years. Substantiate the necessity for a combined approach involving both orthodontic and osteopathic diagnostics in this age group, aiming to develop a comprehensive treatment algorithm.Materials and methods. Orthodontists and an osteopathic physician conducted diagnostic procedures for 320 subjects. Verification methods included standardized questionnaires for orthodontics and osteopathy, digital photography, radiological analysis using cone beam computer tomography (CBCT) of the head, electromyography (EMG), and computer-aided optical postural topography with the DIERS formetric 4D motion system.Results. Among the 320 subjects examined, the study revealed that 65% presented with an asymmetric narrowing of maxilla. Digital photography illustrated deviations from the norm in the total width of the maxilla for all subjects, a critical factor influencing proper tongue posture, swallowing, and breathing patterns. Facial asymmetry and temporomandibular disorders (TMD) were prevalent among the majority of patients, with a reported mandibular deviation observed in 100% of cases. Based on CBCT data, the transverse dimension of the asymmetrically narrow maxilla, relative to the mid-sagittal axis, was found to be reduced, along with a concomitant displacement of the greater wings of the sphenoid bone. The measured electric activity of masticatory and temporal muscles supported the diagnosis of asymmetric muscular dysfunction. Additionally, irregularities in the sphenobasilar synchondrosis (SBS) were identified. Moreover, patients with asymmetric maxillary narrowing exhibited static and dynamic imbalance in the body, along with disorders of body posture and foot profile. These observations were made through visual assessment, manual testing, and the DIERS formetric 4D motion optical posture topography system.Conclusion. Asymmetric maxillary narrowing strongly correlated with posture disorders, static and dynamic imbalances in the body, and dysfunctions in primary activities such as chewing, swallowing, breathing, and gait patterns. To achieve a predictable outcome without complications, it is recommended to pursue both orthodontic and osteopathic treatments for cases involving an asymmetric narrowing of maxilla.
相关性。姿势失调及其与颌面部异常的联系是现代医学的一个重要课题,在新兴的正畸和整骨诊断技术领域确立了新的诊断标准。在 6 至 15 岁的儿童和青少年中,建立上颌骨不对称狭窄与姿势失调之间的相关性。证明对这一年龄段的儿童采用正畸和整骨诊断相结合的方法的必要性,从而制定出一套全面的治疗算法。正畸医师和一名整骨医师对 320 名受试者进行了诊断。验证方法包括正畸和整骨疗法标准问卷、数码照片、头部锥形束计算机断层扫描(CBCT)放射学分析、肌电图(EMG)以及使用 DIERS formetric 4D 运动系统的计算机辅助光学姿势地形图。研究显示,在接受检查的 320 名受试者中,65% 的人上颌骨不对称狭窄。数字摄影显示,所有受试者的上颌骨总宽度都与正常值有偏差,而这是影响正确的舌头姿势、吞咽和呼吸模式的关键因素。面部不对称和颞下颌关节紊乱症(TMD)在大多数患者中普遍存在,据报告,100% 的病例都存在下颌骨偏斜。根据 CBCT 数据,不对称狭窄的上颌骨相对于中矢状轴的横向尺寸减小,同时鼻骨大翼也发生移位。咀嚼肌和颞肌的电活动测量结果支持不对称肌肉功能障碍的诊断。此外,还发现了鼻基底滑膜(SBS)的不规则性。此外,上颌不对称缩窄患者表现出身体的静态和动态失衡,以及身体姿势和足部轮廓失调。这些观察结果是通过视觉评估、手动测试和 DIERS formetric 4D 运动光学姿势地形图系统得出的。上颌不对称狭窄与姿势障碍、身体的静态和动态失衡以及咀嚼、吞咽、呼吸和步态等主要活动的功能障碍密切相关。为了达到可预测的效果,避免并发症,建议对涉及上颌不对称狭窄的病例同时采用正畸和整骨疗法。
{"title":"Findings of an orthodontic and osteopathic diagnostic of individuals with an asymmetric narrowing of maxilla","authors":"M. Vasilyeva, G. S. Perevezentsev, T. Kosyreva","doi":"10.33925/1683-3031-2023-690","DOIUrl":"https://doi.org/10.33925/1683-3031-2023-690","url":null,"abstract":"Relevance. Postural disorders and their connection to dentofacial abnormalities represent a prominent subject in modern medicine, establishing a new diagnostic standard within the emerging fields of orthodontic and osteopathic diagnostic techniques.Objective. Establish a correlation between asymmetric narrowing of maxilla and postural disorders in children and teens aged 6 to 15 years. Substantiate the necessity for a combined approach involving both orthodontic and osteopathic diagnostics in this age group, aiming to develop a comprehensive treatment algorithm.Materials and methods. Orthodontists and an osteopathic physician conducted diagnostic procedures for 320 subjects. Verification methods included standardized questionnaires for orthodontics and osteopathy, digital photography, radiological analysis using cone beam computer tomography (CBCT) of the head, electromyography (EMG), and computer-aided optical postural topography with the DIERS formetric 4D motion system.Results. Among the 320 subjects examined, the study revealed that 65% presented with an asymmetric narrowing of maxilla. Digital photography illustrated deviations from the norm in the total width of the maxilla for all subjects, a critical factor influencing proper tongue posture, swallowing, and breathing patterns. Facial asymmetry and temporomandibular disorders (TMD) were prevalent among the majority of patients, with a reported mandibular deviation observed in 100% of cases. Based on CBCT data, the transverse dimension of the asymmetrically narrow maxilla, relative to the mid-sagittal axis, was found to be reduced, along with a concomitant displacement of the greater wings of the sphenoid bone. The measured electric activity of masticatory and temporal muscles supported the diagnosis of asymmetric muscular dysfunction. Additionally, irregularities in the sphenobasilar synchondrosis (SBS) were identified. Moreover, patients with asymmetric maxillary narrowing exhibited static and dynamic imbalance in the body, along with disorders of body posture and foot profile. These observations were made through visual assessment, manual testing, and the DIERS formetric 4D motion optical posture topography system.Conclusion. Asymmetric maxillary narrowing strongly correlated with posture disorders, static and dynamic imbalances in the body, and dysfunctions in primary activities such as chewing, swallowing, breathing, and gait patterns. To achieve a predictable outcome without complications, it is recommended to pursue both orthodontic and osteopathic treatments for cases involving an asymmetric narrowing of maxilla.","PeriodicalId":509861,"journal":{"name":"Pediatric dentistry and dental prophylaxis","volume":"187 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140481151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence and severity of malocclusion in foster home children 寄养家庭儿童牙齿畸形的发生率和严重程度
Pub Date : 2024-01-25 DOI: 10.33925/1683-3031-2023-682
O. Malanova, N. S. Morozova, V. M. Grinin, O. Admakin, A. Maltseva, E. T. Savenko
Relevance. Malocclusions in children present a pressing concern in the field of dentistry. Timely diagnostics and treatment of these conditions are crucial for children aged 6 to 18, residing in foster homes, where incidence tend to be higher compared to children raised in family settings. This heightened incidence is often attributed to the lack of timely examinations by pediatric dentist or orthodontists. Such examinations could have potentially prevented the development of malocclusions or facilitated the administration of appropriate orthodontic treatments.Materials and methods. The study included 200 children aged 6 to 18, categorized into two groups: 100 children residing in foster homes or orphanages and 100 living with families (control group). Various malocclusions were identified using the Dental Aesthetic Index (DAI) dental aesthetic index and Angle's classification.Results. Malocclusions were identified in 89.3% of the children from foster home, compared to 66.6% of children from family households. The most prevalent types of malocclusions observed were crowding of front teeth and incisor cross-bite. The DAI dental aesthetic index was higher in children from foster home (DAI = 30.4) than in those from family (DAI = 27.8). Additionally, it was observed that none of the children from foster homes had undergone orthodontic treatment, in contrast to the children in the control group.Conclusion. The study underscores the significance of diagnosing and treating malocclusions in children, with particular emphasis on those residing in foster homes. The results highlight the necessity of implementing effective methods to prevent and address malocclusions in such environments, aiming to enhance the dental health of the children.
相关性。儿童牙颌畸形是牙科领域亟待解决的问题。对于寄养家庭中的 6 至 18 岁儿童来说,及时诊断和治疗这些疾病至关重要,因为与家庭环境中的儿童相比,寄养家庭中的儿童发病率更高。这种高发病率通常是由于缺乏儿童牙医或正畸医生的及时检查。这种检查有可能预防畸形的发生,或有助于进行适当的正畸治疗。这项研究包括 200 名 6 至 18 岁的儿童,分为两组:100 名儿童住在寄养家庭或孤儿院,100 名儿童与家人住在一起(对照组)。采用牙齿美学指数(DAI)和安格尔分类法对各种畸形进行鉴定。结果显示,89.3%的寄养儿童存在牙齿畸形,而家庭寄养儿童的这一比例为66.6%。最常见的畸形类型是门牙拥挤和门牙交叉咬合。寄养家庭儿童的 DAI 牙齿美学指数(DAI = 30.4)高于家庭儿童(DAI = 27.8)。此外,研究还发现,与对照组儿童相比,寄养家庭的儿童均未接受过牙齿矫正治疗。这项研究强调了诊断和治疗儿童畸形的重要性,尤其是寄养家庭中的儿童。研究结果突出表明,有必要采取有效的方法来预防和解决这类环境中儿童的错颌畸形问题,从而提高儿童的牙齿健康水平。
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引用次数: 0
Screening as a stage in the prevention of oral mucosal diseases in patients undergoing chemotherapy for malignant growths 作为恶性肿瘤化疗患者口腔黏膜疾病预防阶段的筛查
Pub Date : 2024-01-24 DOI: 10.33925/1683-3031-2023-689
Y. Makedonova, V. V. Shkarin, O. S. Emelyanova, T. V. Chizhikova, I. V. Venskel, L. A. Devyatchenko
Relevance. The incidence of malignant growths in the maxillofacial area has consistently increased over the years. Chemotherapy stands out as one of the most effective treatments for cancerous tumors. Chemotherapeutic drugs possess the capability to either inhibit the proliferation of malignant cells or cause damage to them. However, while acting on abnormal cells, cytostatic drugs also impact actively dividing cells in normal tissues, including the mucous membranes in the oral cavity. As a result, various complications are observed in every patient undergoing treatment for malignant neoplasms (MN), particularly chemotherapy (CT). The nature and severity of side effects undergo changes based on the specific drugs and cytostatic treatment regimen employed. Adverse reactions and side effects inherent to each drug category manifest at different points throughout a chemotherapy course and its aftermath. Oral mucosal (OM) complications, such as oral mucositis, may ensue as a consequence of CT side effects.Materials and methods. In order to assess the effectiveness of screening for OM disorders arising as side effects of chemotherapy, a study involving 37 patients undergoing chemotherapy for an underlying condition was conducted. The screening study comprised two stages: Stage I involved a quality-of-life assessment utilizing questionnaires developed by the authors, while Stage II entailed a clinical examination of the oral mucosa. The obtained data were subjected to statistical analysis methods. Variation statistics were employed to assess the likelihood of data errors.Results. Comprehensive OM diagnostics in patients undergoing chemotherapy for an underlying oncology condition enable the early identification of oral mucosal diseases and the prevention of complications. It is recommended to conduct a thorough clinical examination and employ toluidine blue staining during each follow-up visit. Any observed clinical or stained tissue changes, the emergence of new erythematous lesions, erosions, or ulcers may serve as indicators of malignant transformation.Conclusion. It is advisable to incorporate screening diagnostics into each patient's dental visit to proactively prevent the onset of various pathological conditions.
相关性。近年来,颌面部恶性肿瘤的发病率持续上升。化疗是治疗癌症肿瘤最有效的方法之一。化疗药物具有抑制恶性细胞增殖或对其造成损害的能力。然而,细胞抑制药物在作用于异常细胞的同时,也会影响正常组织中活跃分裂的细胞,包括口腔黏膜。因此,每位接受恶性肿瘤(MN)治疗,尤其是化疗(CT)的患者都会出现各种并发症。副作用的性质和严重程度会根据采用的特定药物和细胞抑制治疗方案而发生变化。每类药物固有的不良反应和副作用会在整个化疗过程及其后的不同阶段表现出来。口腔粘膜(OM)并发症,如口腔粘膜炎,可能是 CT 副作用的结果。为了评估化疗副作用引起的口腔粘膜疾病筛查的有效性,我们开展了一项涉及 37 名因潜在疾病接受化疗的患者的研究。筛查研究包括两个阶段:第一阶段是利用作者编制的问卷进行生活质量评估,第二阶段是对口腔黏膜进行临床检查。获得的数据均采用统计分析方法。采用变异统计来评估数据错误的可能性。对因潜在肿瘤疾病接受化疗的患者进行全面的口腔粘膜诊断,可及早发现口腔粘膜疾病并预防并发症。建议在每次随访时进行全面的临床检查和甲苯胺蓝染色。任何观察到的临床或染色组织变化、新出现的红斑病变、糜烂或溃疡都可能是恶性转化的指标。建议将筛查诊断纳入每位患者的牙科检查中,以积极预防各种病症的发生。
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引用次数: 0
Prevalence of periodontal diseases in children under 6 years old in the Republic of Tatarstan: impact of age and family structure 鞑靼斯坦共和国 6 岁以下儿童牙周病患病率:年龄和家庭结构的影响
Pub Date : 2024-01-22 DOI: 10.33925/1683-3031-2023-659
M. Khadyeva, S. L. Blashkova, A. Galiullin
Relevance. This article addresses the prevalence of periodontal diseases in infants and preschool-aged children, considering factors such as the child's age and family structure within the region of the Republic of Tatarstan. Periodontal diseases, in conjunction with dental caries and dental abnormalities, represent the most frequently observed oral health conditions among children and adolescents.Materials and methods. The research involved 2429 families and 2556 preschool-aged children representing diverse family structures within Kazan, Arsk, and Pestrechinsky districts in the Republic of Tatarstan. During the survey, five primary family classifications emerged: complete, incomplete, extended, reconstituted, and foster families. The research methodology involved conducting interviews with parents, close relatives, or guardians, coupled with comprehensive examinations of the children, documenting both systemic disease and general health information using specifically tailored charts. Data analysis included determining mean values (M), mean error of the score (m), and Student's t-test criterion (t). Significance among group disparities was established at a probability of error less than 5% (p < 0.05). The gathered data underwent interpretation, considering both family structure and the spectrum of periodontal diseases.Results. Periodontal diseases were found to affect children from foster and incomplete families most significantly, with prevalence rates exceeding 90% in certain age groups. Children from complete and extended families exhibited lower prevalence rates of periodontal diseases, at 9.8% and 22.2%, respectively. Notably, within all age brackets, the highest occurrence of periodontal diseases was observed among children aged 4.6-6 years, constituting 57.0% of cases. Infants under one year old displayed the lowest susceptibility, with only 16.3% affected. Upon analyzing disease prevalence among children in the Republic of Tatarstan, a significant disparity emerged: children residing in rural areas demonstrated a higher susceptibility to periodontal diseases in comparison to their urban counterparts.Conclusion. The findings reveal a clear correlation between a child's family structure and the occurrence of periodontal diseases. Establishing the family structure and implementing tailored preventive measures specific to periodontal diseases, while considering both the child's family structure and age, plays a significant role in averting the onset and progression of this condition.
相关性。本文探讨了鞑靼斯坦共和国地区婴儿和学龄前儿童牙周疾病的流行情况,并考虑了儿童年龄和家庭结构等因素。牙周疾病与龋齿和牙齿畸形是儿童和青少年中最常见的口腔健康问题。研究涉及鞑靼斯坦共和国喀山、阿尔斯克和佩斯特雷钦斯基地区的 2429 个家庭和 2556 名学龄前儿童,他们代表了不同的家庭结构。在调查过程中,出现了五种主要的家庭分类:完整家庭、不完整家庭、扩大家庭、重组家庭和寄养家庭。研究方法包括对父母、近亲或监护人进行访谈,同时对儿童进行全面检查,使用专门定制的图表记录系统疾病和一般健康信息。数据分析包括确定平均值(M)、平均分误差(m)和学生 t 检验标准(t)。组间差异的显著性以误差概率小于 5%(P < 0.05)为标准。对收集的数据进行解释,同时考虑家庭结构和牙周疾病谱。结果发现,牙周病对寄养家庭和不完整家庭的儿童影响最大,在某些年龄组的患病率超过 90%。完整家庭和大家庭的儿童牙周病患病率较低,分别为 9.8%和 22.2%。值得注意的是,在所有年龄段中,4.6-6 岁儿童的牙周病发病率最高,占 57.0%。一岁以下婴儿的患病率最低,仅占 16.3%。在分析鞑靼斯坦共和国儿童的患病率时,发现了一个显著的差异:与城市儿童相比,居住在农村地区的儿童更容易患牙周病。研究结果表明,儿童的家庭结构与牙周病的发生有明显的相关性。在考虑儿童的家庭结构和年龄的同时,建立家庭结构和实施有针对性的牙周病预防措施,对于避免牙周病的发生和发展具有重要作用。
{"title":"Prevalence of periodontal diseases in children under 6 years old in the Republic of Tatarstan: impact of age and family structure","authors":"M. Khadyeva, S. L. Blashkova, A. Galiullin","doi":"10.33925/1683-3031-2023-659","DOIUrl":"https://doi.org/10.33925/1683-3031-2023-659","url":null,"abstract":"Relevance. This article addresses the prevalence of periodontal diseases in infants and preschool-aged children, considering factors such as the child's age and family structure within the region of the Republic of Tatarstan. Periodontal diseases, in conjunction with dental caries and dental abnormalities, represent the most frequently observed oral health conditions among children and adolescents.Materials and methods. The research involved 2429 families and 2556 preschool-aged children representing diverse family structures within Kazan, Arsk, and Pestrechinsky districts in the Republic of Tatarstan. During the survey, five primary family classifications emerged: complete, incomplete, extended, reconstituted, and foster families. The research methodology involved conducting interviews with parents, close relatives, or guardians, coupled with comprehensive examinations of the children, documenting both systemic disease and general health information using specifically tailored charts. Data analysis included determining mean values (M), mean error of the score (m), and Student's t-test criterion (t). Significance among group disparities was established at a probability of error less than 5% (p < 0.05). The gathered data underwent interpretation, considering both family structure and the spectrum of periodontal diseases.Results. Periodontal diseases were found to affect children from foster and incomplete families most significantly, with prevalence rates exceeding 90% in certain age groups. Children from complete and extended families exhibited lower prevalence rates of periodontal diseases, at 9.8% and 22.2%, respectively. Notably, within all age brackets, the highest occurrence of periodontal diseases was observed among children aged 4.6-6 years, constituting 57.0% of cases. Infants under one year old displayed the lowest susceptibility, with only 16.3% affected. Upon analyzing disease prevalence among children in the Republic of Tatarstan, a significant disparity emerged: children residing in rural areas demonstrated a higher susceptibility to periodontal diseases in comparison to their urban counterparts.Conclusion. The findings reveal a clear correlation between a child's family structure and the occurrence of periodontal diseases. Establishing the family structure and implementing tailored preventive measures specific to periodontal diseases, while considering both the child's family structure and age, plays a significant role in averting the onset and progression of this condition.","PeriodicalId":509861,"journal":{"name":"Pediatric dentistry and dental prophylaxis","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139607643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the impact of kallikrein 4 gene polymorphism on caries severity and development in divers age groups of pregnant women during caries prevention 在预防龋齿过程中,调查卡利克林 4 基因多态性对不同年龄组孕妇龋齿严重程度和发展的影响
Pub Date : 2024-01-22 DOI: 10.33925/1683-3031-2023-639
I. Lukashevich, I. Gorbunova, G. Skripkina, L. V. Lukashevich
Relevance. The progression of caries during pregnancy is significantly influenced by the resistance of dental tissues against demineralization. The degree of resistance in dental enamel is influenced by its genetic determinants, encompassing structural and morphological properties. The kallikrein 4 (KLK4) gene plays a pivotal role as a primary enzyme in dental enamel formation. Consequently, evaluating the effectiveness of various preventive measures on dental enamel necessitates consideration of KLK4 gene mutations.Material and methods. An examination was conducted on a cohort of 322 pregnant women. Key indices assessed included OHI-S, DMF, DMFs, ∆DMF, and ∆DMFs. Oral fluid analysis encompassed parameters such as Ca, P, Ca/P-molar ratio, рН, Ca2+, pK+, pNa+. The sediment of oral fluid was examined for ∆рН and ∆Ca. DNA sample was isolated from venous blood obtained from the participants.Results. The G/G polymorphism of the KLK4 gene at positions G2664153A and G2142А did not exhibit a statistically significant association with an increase in the ∆DMFs index during caries prevention, a finding consistent across both discussed tools for exogenous caries prevention in this study. In case of heterozygous KLK4 G/A polymorphism with the dominant G allele, the application of Enamel Sealing Liquid showed a tendency towards higher ∆DMF and ∆DMFs indices over a 12-month follow-up period. When pregnant patients with heterozygous dominant G allele mutations were treated with the triple-component calcium-fluorine-phosphate-containing gel, there were no observed elevations in these indices. The amplified production of KLK4 A/A polymorphism was associated with a statistically significant rise in ∆DMF and ∆DMFs indices, accompanied by alterations in certain oral fluid parameters. These changes included reduced active calcium levels and Ca/P molar ratio, along with elevated levels of phosphates and electrolytes. Enhanced demineralizing activity was observed in the oral fluid sediment.Conclusion. The effectiveness of caries prevention tools during pregnancy is contingent upon the genotypic diversity of KLK4 gene polymorphism at the G2664153A and G2142А mutation points.
相关性。妊娠期龋病的发展在很大程度上受到牙齿组织抗脱矿化能力的影响。牙釉质的抗性程度受其遗传决定因素的影响,包括结构和形态特性。Kallikrein 4(KLK4)基因作为牙釉质形成过程中的一种主要酶,发挥着举足轻重的作用。因此,要评估各种预防措施对牙釉质的效果,就必须考虑 KLK4 基因突变的情况。对 322 名孕妇进行了检查。评估的主要指标包括 OHI-S、DMF、DMFs、∆DMF 和 ∆DMFs。口腔液分析包括 Ca、P、Ca/P 摩尔比、рН、Ca2+、pK+、pNa+ 等参数。对口腔液沉淀物进行∆рН和∆Ca检测。从参与者的静脉血中分离出 DNA 样本。KLK4基因在G2664153A和G2142А位置上的G/G多态性与预防龋齿期间∆DMFs指数的增加没有统计学意义,这一发现与本研究中讨论的两种外源性预防龋齿工具一致。对于具有显性 G 等位基因的 KLK4 G/A 多态性杂合子,在 12 个月的随访期间,使用珐琅质封闭液会导致 ∆DMF 和 ∆DMFs 指数升高。当杂合显性 G 等位基因突变的孕妇使用含钙-氟-磷酸三组份凝胶治疗时,没有观察到这些指数的升高。KLK4 A/A 多态性的扩增与 ∆DMF 和 ∆DMFs 指数的上升有统计学意义,同时伴随着某些口腔液参数的改变。这些变化包括活性钙水平和钙/磷摩尔比降低,磷酸盐和电解质水平升高。在口腔液沉淀物中观察到脱矿物质活性增强。孕期防龋工具的有效性取决于 KLK4 基因多态性 G2664153A 和 G2142А 突变点的基因型多样性。
{"title":"Investigating the impact of kallikrein 4 gene polymorphism on caries severity and development in divers age groups of pregnant women during caries prevention","authors":"I. Lukashevich, I. Gorbunova, G. Skripkina, L. V. Lukashevich","doi":"10.33925/1683-3031-2023-639","DOIUrl":"https://doi.org/10.33925/1683-3031-2023-639","url":null,"abstract":"Relevance. The progression of caries during pregnancy is significantly influenced by the resistance of dental tissues against demineralization. The degree of resistance in dental enamel is influenced by its genetic determinants, encompassing structural and morphological properties. The kallikrein 4 (KLK4) gene plays a pivotal role as a primary enzyme in dental enamel formation. Consequently, evaluating the effectiveness of various preventive measures on dental enamel necessitates consideration of KLK4 gene mutations.Material and methods. An examination was conducted on a cohort of 322 pregnant women. Key indices assessed included OHI-S, DMF, DMFs, ∆DMF, and ∆DMFs. Oral fluid analysis encompassed parameters such as Ca, P, Ca/P-molar ratio, рН, Ca2+, pK+, pNa+. The sediment of oral fluid was examined for ∆рН and ∆Ca. DNA sample was isolated from venous blood obtained from the participants.Results. The G/G polymorphism of the KLK4 gene at positions G2664153A and G2142А did not exhibit a statistically significant association with an increase in the ∆DMFs index during caries prevention, a finding consistent across both discussed tools for exogenous caries prevention in this study. In case of heterozygous KLK4 G/A polymorphism with the dominant G allele, the application of Enamel Sealing Liquid showed a tendency towards higher ∆DMF and ∆DMFs indices over a 12-month follow-up period. When pregnant patients with heterozygous dominant G allele mutations were treated with the triple-component calcium-fluorine-phosphate-containing gel, there were no observed elevations in these indices. The amplified production of KLK4 A/A polymorphism was associated with a statistically significant rise in ∆DMF and ∆DMFs indices, accompanied by alterations in certain oral fluid parameters. These changes included reduced active calcium levels and Ca/P molar ratio, along with elevated levels of phosphates and electrolytes. Enhanced demineralizing activity was observed in the oral fluid sediment.Conclusion. The effectiveness of caries prevention tools during pregnancy is contingent upon the genotypic diversity of KLK4 gene polymorphism at the G2664153A and G2142А mutation points.","PeriodicalId":509861,"journal":{"name":"Pediatric dentistry and dental prophylaxis","volume":"71 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive management of Pindborg tumor in childhood: a case report 儿童平堡肿瘤的综合治疗:病例报告
Pub Date : 2024-01-17 DOI: 10.33925/1683-3031-2023-710
D. R. Minnakhmetova, O. Z. Topolnitsky, O. A. Solodovnik, I. V. Tikhonova
Relevance. The calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a locally aggressive neoplasm characterized by strands and medullary formations of flat and clear cells, often accompanied by spherical calcifications and amyloid-stained hyaline deposits. The Pindborg tumor is rare, representing less than 1% of odontogenic tumors, and typically manifests in individuals aged 20 to 60 years. However, there is a growing incidence of neoplasms of diverse origins in childhood. This article presents a clinical case detailing the comprehensive multi-stage treatment of a pediatric patient with a Pindborg tumor, facilitating complete rehabilitation before reaching adulthood.Clinical case description. This article presents a clinical case detailing the comprehensive management of a patient with a Pindborg tumor. The individual initially sought treatment at the Department of Pediatric Maxillofacial Surgery of A.I. Evdokimov Moscow State Medical and Dental University in 2020, undergoing complete combined treatment until November 2023. Full rehabilitation was successfully achieved by the time of adulthood through a series of four consecutive surgeries, including dental implantation, followed by prosthetics utilizing a non-removable orthopedic structure in the final stage.Conclusion. Initiating comprehensive rehabilitation at an early stage, including dental implantation before reaching adulthood, facilitates complete social adaptation in society and contributes to the patient's harmonious development.
相关性。钙化上皮性牙源性肿瘤又称平堡瘤,是一种局部侵袭性肿瘤,其特征是扁平透明细胞的股状和髓质形成,常伴有球形钙化和淀粉样染色的透明沉积。平德博格瘤十分罕见,在牙源性肿瘤中所占比例不到 1%,通常出现在 20 至 60 岁的人群中。然而,儿童时期各种来源肿瘤的发病率也在不断上升。本文通过一个临床病例,详细介绍了对一名患有平德博格肿瘤的儿童患者进行的多阶段综合治疗,帮助患者在成年前完全康复。本文介绍了一个临床病例,详细介绍了对一名平堡肿瘤患者的综合治疗。患者最初于2020年在莫斯科国立埃夫多基莫夫医科牙科大学小儿颌面外科就诊,直到2023年11月才接受了完整的综合治疗。通过连续四次手术,包括种植牙,最后阶段使用不可拆卸的矫形结构进行修复,成功实现了成年后的全面康复。结论:在成年之前尽早开始全面康复治疗,包括种植牙,有助于患者完全适应社会,促进其和谐发展。
{"title":"Comprehensive management of Pindborg tumor in childhood: a case report","authors":"D. R. Minnakhmetova, O. Z. Topolnitsky, O. A. Solodovnik, I. V. Tikhonova","doi":"10.33925/1683-3031-2023-710","DOIUrl":"https://doi.org/10.33925/1683-3031-2023-710","url":null,"abstract":"Relevance. The calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a locally aggressive neoplasm characterized by strands and medullary formations of flat and clear cells, often accompanied by spherical calcifications and amyloid-stained hyaline deposits. The Pindborg tumor is rare, representing less than 1% of odontogenic tumors, and typically manifests in individuals aged 20 to 60 years. However, there is a growing incidence of neoplasms of diverse origins in childhood. This article presents a clinical case detailing the comprehensive multi-stage treatment of a pediatric patient with a Pindborg tumor, facilitating complete rehabilitation before reaching adulthood.Clinical case description. This article presents a clinical case detailing the comprehensive management of a patient with a Pindborg tumor. The individual initially sought treatment at the Department of Pediatric Maxillofacial Surgery of A.I. Evdokimov Moscow State Medical and Dental University in 2020, undergoing complete combined treatment until November 2023. Full rehabilitation was successfully achieved by the time of adulthood through a series of four consecutive surgeries, including dental implantation, followed by prosthetics utilizing a non-removable orthopedic structure in the final stage.Conclusion. Initiating comprehensive rehabilitation at an early stage, including dental implantation before reaching adulthood, facilitates complete social adaptation in society and contributes to the patient's harmonious development.","PeriodicalId":509861,"journal":{"name":"Pediatric dentistry and dental prophylaxis","volume":" March","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Pediatric dentistry and dental prophylaxis
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