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Benign Lobular Inner Nuclear Layer Proliferation associated with Congenital Hypertrophy of the Retinal Pigment Epithelium 与视网膜色素上皮先天性肥大相关的良性叶状核内层增生
Pub Date : 2024-05-08 DOI: 10.1097/icb.0000000000001599
Tarquin Boca, Salomon Y. Cohen, Elsabeth Hermouet, M. Srour, A. Miere
To report two cases of benign intraretinal tumors of the inner nuclear layer (INL) associated with congenital hypertrophy of the retinal pigment epithelium (CHRPE). Multimodal imaging of two cases, including fundus color and autofluorescence photography, structural and en face spectral-domain optical coherence tomography (SD-OCT), OCT-angiography, fluorescein and indocyanine green angiography. During a routine examination, intraretinal tumors of the INL associated with several CHRPE lesions were observed in one eye of two male patients, aged 27 and 32 years, respectively. Multimodal imaging showed white multifocal lobulated lesions with arching extensions, located in the INL, which allowed diagnosing benign lobular inner nuclear layer proliferation (BLIP). BLIP is a rare benign tumor located in the INL with a unique pattern and only 4 cases have been reported to date. The present two cases allowed confirming that BLIP is associated with CHRPE, suggesting a concomitant developmental anomaly of the RPE and the inner retina.
报告两例伴有先天性视网膜色素上皮细胞肥大(CHRPE)的内核层(INL)视网膜内良性肿瘤。 对两例病例进行多模式成像,包括眼底彩色和自动荧光摄影、结构和全脸光谱域光学相干断层扫描(SD-OCT)、OCT 血管造影、荧光素和吲哚青绿血管造影。 在一次常规检查中,在两名分别为 27 岁和 32 岁的男性患者的一只眼睛中发现了 INL 视网膜内肿瘤,并伴有多个 CHRPE 病变。多模态成像显示,位于INL的白色多灶性分叶状病变呈拱形扩展,可诊断为良性分叶状核内层增生(BLIP)。 BLIP是一种位于INL的罕见良性肿瘤,具有独特的形态,迄今仅有4例报道。本病例证实BLIP与CHRPE有关,提示RPE和视网膜内层同时发育异常。
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引用次数: 0
Surgical repair of macular fold in X-linked retinoschisis initially misdiagnosed as familial exudative vitreoretinopathy 最初被误诊为家族性渗出性玻璃体视网膜病变的 X 连锁视网膜裂孔症黄斑皱褶手术修复术
Pub Date : 2024-05-07 DOI: 10.1097/icb.0000000000001600
Yasmine Alcibahy, Nicola Ghazi, Arif O. Khan, Aniruddha Agarwal
To describe the presentation and surgical management of a young boy initially thought to have familial exudative vitreoretinopathy who was ultimately diagnosed with an unusually aggressive form of X-linked retinoschisis that included rapidly progressive bullous retinoschisis and tractional macular fold. Retrospective case report A 19-month-old boy with straightening of major arcades, peripheral retinal ischemia, and in the left eye, a large macular fold was initially diagnosed as familial exudative vitreoretinopathy. During follow-up, he developed a rapidly progressive bullous retinoschisis in the left eye involving the inferior macula extending superiorly up to the macular fold. This revised the working diagnosis to X-linked retinoschisis, which was confirmed by genetic testing. Pars plana vitrectomy, inner flap retinectomy, unrolling of the macular fold and inner flap retinectomy, and C3F8 gas tamponade were performed. This resolved the macular fold. The patient showed good anatomical results without surgical complications up to 18 months of post-operative follow-up. X-linked retinoschisis can rarely present in young children with macular fold and peripheral ischemia, mimicking familial exudative vitreoretinopathy. Rapidly progressive bullous retinoschisis in this setting can be treated with pars plana vitrectomy, inner wall retinectomy, and removal of the vitreous traction to improve visual prognosis.
描述一名最初被认为患有家族性渗出性玻璃体视网膜病变的小男孩的表现和手术治疗情况,该男孩最终被诊断出患有一种异常侵袭性的X连锁视网膜裂孔症,包括快速进展的大泡性视网膜裂孔症和牵引性黄斑皱褶。 回顾性病例报告 一名 19 个月大的男孩,主要视网膜弧变直,周围视网膜缺血,左眼出现大片黄斑皱褶,最初被诊断为家族性渗出性玻璃体视网膜病变。在随访期间,他的左眼出现了快速进展的大泡性视网膜裂孔,累及黄斑下部,并向上延伸至黄斑皱褶。这将工作诊断改为 X 连锁视网膜裂孔症,并通过基因检测得到证实。患者接受了玻璃体旁切除术、内瓣网状切除术、黄斑皱褶展开和内瓣网状切除术以及 C3F8 气体填塞。这解决了黄斑皱褶问题。患者术后随访18个月,解剖效果良好,无手术并发症。 X连锁视网膜裂孔症极少出现在黄斑皱褶和周边缺血的幼童身上,与家族性渗出性玻璃体视网膜病变相似。在这种情况下,可通过平面玻璃体旁切除术、内壁网状切除术和玻璃体牵引去除术治疗快速进展的大疱性视网膜脱离,以改善视力预后。
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引用次数: 0
Clinical and Optical Coherence Tomography Features of Subretinal Fibrin Glue after Glue-Assisted Vitrectomy for Rhegmatogenous Retinal Detachment Repair. GUARD Study – Report 3: 用胶水辅助玻璃体切割术进行流变性视网膜脱离修复术后视网膜下纤维蛋白胶的临床和光学相干断层扫描特征。GUARD 研究 - 报告 3:
Pub Date : 2024-05-07 DOI: 10.1097/icb.0000000000001598
Aiswarya Ramachandran, SriniVas Sadda, Mudit Tyagi
To highlight the clinical and optical coherence tomography (OCT) features of subretinal fibrin glue and its resolution over time in patients who have undergone glue- assisted retinopexy for Rhegmatogenous Retinal Detachments (RRD). A report of 2 cases with subretinal migration of fibrin glue. Both the cases were assessed with clinical examination, serial fundus photos and serial OCT scans through the area of subretinal fibrin immediately after surgery, at 1 week, 2 weeks and at 6 weeks. In both the cases of intraoperative subretinal glue migration during glue-assisted vitrectomy for RRD repair, the subretinal glue had a characteristic appearance and course of evolution. On examination and color photography, the glue had an amorphous whitish appearance with wispy edges. This corresponded to subretinal hyperreflective material (SHRM) on OCT with a layered appearance. By two weeks after surgery, the subretinal glue demonstrated substantial regression on retinal examination and on OCT scans. At 6 weeks visit, the entire glue was noted to be resorbed along with an intact photoreceptor outer segments/Ellipsoid Zone layer In summary, this report describes the clinical and OCT appearance of subretinal migration of fibrin glue. Subretinal fibrin appears whitish on examination and corresponds to layered SHRM without shadowing on OCT. It appears to resorb spontaneously within weeks with apparent recovery of the overlying photoreceptors.
强调视网膜下纤维蛋白胶水的临床和光学相干断层扫描(OCT)特征,以及在接受胶水辅助视网膜整形术治疗风湿性视网膜脱离(RRD)的患者中随着时间推移纤维蛋白胶水的溶解情况。 报告两例视网膜下纤维蛋白胶移位病例。两例病例均在术后立即、1周、2周和6周通过视网膜下纤维蛋白区域的临床检查、连续眼底照片和连续OCT扫描进行评估。 在这两例胶水辅助玻璃体切除术修复 RRD 的术中视网膜下胶水移位病例中,视网膜下胶水的外观和演变过程均具有特征性。在检查和彩色照片中,胶水呈无定形的白色外观,边缘模糊不清。这与 OCT 上分层外观的视网膜下超反光材料(SHRM)相对应。术后两周,视网膜下胶水在视网膜检查和 OCT 扫描中显示出大量消退。总之,本报告描述了视网膜下纤维蛋白胶移位的临床和 OCT 外观。视网膜下纤维蛋白在检查时呈白色,在 OCT 上与分层的 SHRM 相对应,没有阴影。它似乎会在数周内自发吸收,上覆的光感受器也会明显恢复。
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引用次数: 0
Combined Amniotic Membrane Graft and Autologous Retinal Transplant for Repair of Refractory Chronic Myopic Macular Holes 联合羊膜移植和自体视网膜移植修复难治性慢性近视黄斑孔
Pub Date : 2024-05-02 DOI: 10.1097/icb.0000000000001588
Z. Tauqeer, Jong Park, Tamer H Mahmoud
To report a technique for reconstruction of large, persistent, chronic, myopic macular holes using a combined human amniotic membrane graft and autologous retinal transplant (AMN-ART). Three patients with large, myopic macular holes that failed prior surgical attempts and underwent subretinal amniotic membrane graft with overlying autologous retinal transplant and short-term perfluorocarbon tamponade. Pre- and postoperative visual acuity (VA) and images were analyzed at 3, 6, and 9 months. All 3 myopic macular holes remained closed at 9 months with resolution of central scotoma. The first case, a 69-year-old female, presented with a persistent macular hole whose minimum linear diameter was 1085 μm. Her pre-op VA of 20/200 improved by 9 months to 20/100. Secondly, a 72-year-old male with history of recurrent retinal detachment repair with silicone oil and persistent macular hole of 1134 μm presented with pre-op VA of 20/200, which was unchanged at 9 months. Lastly, a 76-year-old female with a persistent macular hole of 935 μm with preop VA of 20/80 improved by 9 months post-op to 20/50. No complications were encountered related to the grafts. Combined AMN-ART may provide a surgical option for repair of refractory, large, chronic myopic macular holes with underlying atrophy.
报告一种利用联合人羊膜移植和自体视网膜移植(AMN-ART)重建巨大、顽固、慢性近视黄斑孔的技术。 三位患者患有大型近视黄斑孔,之前的手术尝试均告失败,他们接受了视网膜下羊膜移植术,并在其上进行了自体视网膜移植和短期全氟碳填塞。对术前、术后 3 个月、6 个月和 9 个月的视力(VA)和图像进行了分析。 所有 3 个近视眼黄斑孔在 9 个月时都保持闭合,中心视网膜疤痕消退。第一个病例是一名 69 岁的女性,她的黄斑部有一个持续存在的孔,其最小线性直径为 1085 μm。术前视力为 20/200,9 个月后视力提高到 20/100。第二例患者是一名 72 岁的男性,曾反复使用硅油进行视网膜脱离修复,术前视力为 20/200,9 个月后视力保持不变。最后,一名 76 岁女性患者的黄斑孔为 935 μm,术前视力为 20/80,术后 9 个月视力改善至 20/50。移植手术未出现任何并发症。 AMN-ART联合术可为修复难治性、巨大、慢性近视性黄斑孔和潜在萎缩提供一种手术选择。
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引用次数: 0
A Novel Technique for scleral fixation of Carlevale Intraocular Lens without conjunctival opening utilizing Hoffman Pockets 利用霍夫曼袋在不打开结膜的情况下固定卡氏人工晶状体的巩膜固定新技术
Pub Date : 2024-04-12 DOI: 10.1097/icb.0000000000001584
E. Manousakis, P. Gartaganis, Emmanouil Manousakis, Efthymios Karmiris
To report a novel surgical technique for scleral fixation of Carlevale intraocular lens (IOL) without conjunctival dissection using Hoffman pockets. An 80-years-old female with IOL dislocation in her right eye required IOL exchange. After removing the dislocated IOL, a Carlevale IOL was implanted, securing the self-blocking harpoons within scleral pockets which were constructed using Hoffman technique. Surgical procedure was uneventful. During the next 3 months follow up, Carlevale IOL remained stable within the scleral pockets, and no signs of IOL dislocation or decentration were observed. Visual acuity significantly improved from 20/200 preoperatively up to 20/32 postoperatively due to corneal scaring from previous herpetic keratitis. No postoperative complications were recorded. Creating scleral pockets without conjunctival dissection using Hoffman pockets technique, represent a reliable and effective method for achieving both secure fixation and effective scleral covering of Carlevale IOL haptics. Absence of conjunctival opening, apart from patient postoperative comfort, reduces risk of postoperative complications, including conjunctival erosion and infection. The presented technique offers a promising alternative for Carlevale IOL scleral fixation.
报告一种无需结膜剥离、利用霍夫曼口袋固定卡氏人工晶体(IOL)的新型巩膜固定手术技术。 一位 80 岁的女性右眼人工晶体脱位,需要进行人工晶体置换。取出脱位的人工晶体后,植入了卡列维人工晶体,并将自阻断鱼叉固定在使用霍夫曼技术构建的巩膜袋中。 手术过程顺利。在接下来 3 个月的随访中,Carlevale 人工晶体在巩膜袋内保持稳定,没有发现人工晶体脱位或分散的迹象。由于之前疱疹性角膜炎造成的角膜疤痕,术后视力从术前的 20/200 明显提高到 20/32。术后未出现并发症。 使用霍夫曼口袋技术在不剥离结膜的情况下创建巩膜口袋,是实现卡氏人工晶体触点安全固定和有效覆盖巩膜的可靠而有效的方法。不切开结膜除了能让患者术后感觉舒适外,还能降低术后并发症的风险,包括结膜糜烂和感染。该技术为卡氏人工晶体巩膜固定提供了一种可行的替代方案。
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引用次数: 0
An Unusual Chorioretinal Manifestation of Relapsing Polychondritis Coexisting with Scleritis: A Case Report 复发性多软骨炎与巩膜炎并存的罕见脉络膜视网膜表现:病例报告
Pub Date : 2024-04-05 DOI: 10.1097/icb.0000000000001582
Masahiro Akada, Yuki Muraoka, Kenji Ishihara, S. Morooka, Masayuki Hata, A. Tsujikawa
To report an atypical chorioretinal manifestation concomitant with severe scleritis in a patient diagnosed with relapsing polychondritis. A 53-year-old male, with a six-month history of recurrent bilateral auricular cartilage inflammation was admitted to our hospital. Clinical and pathological examinations of the auricular cartilage led to the diagnosis of relapsing polychondritis. Ophthalmological examination revealed a localized elevation in the superonasal quadrant of the left fundus, where the scleritis was more severe than in other regions. B-mode ultrasonography revealed choroidal thickening and subretinal lesions in this area, along with a white retinal lesion identified during the fundus examination. Further investigation using optical coherence tomography (OCT) unveiled subretinal and retinal lesions in the same region, with dispersed cells into the vitreous cavity in a fountain-like pattern. After treatment with systemic corticosteroids and cyclophosphamide, there was an improvement in scleritis, conjunctivitis, and retinal vasculitis; however, the white retinal lesion progressed to retinal atrophy. Concurrently, a decrease in the number of vitreous cells emanating from the area of fountain-like leakage was noted. Retinal manifestations of relapsing polychondritis are underrepresented in the literature. This report presents a unique case of relapsing polychondritis with a localized retinal manifestation observed on OCT imaging, thereby broadening our understanding of the potential localized retinal presentations associated with this disease.
报告一名被诊断为复发性多软骨炎的患者在重度巩膜炎的同时出现的非典型脉络膜视网膜表现。 本院收治了一名双侧耳廓软骨炎反复发作 6 个月的 53 岁男性患者。经耳廓软骨的临床和病理检查,诊断为复发性多软骨炎。 眼科检查发现,左眼底的上鼻孔象限局部隆起,巩膜炎症较其他区域严重。B 型超声波检查显示,该区域脉络膜增厚,视网膜下有病变,眼底检查时还发现了白色视网膜病变。使用光学相干断层扫描(OCT)进行的进一步检查显示,同一区域存在视网膜下和视网膜病变,细胞呈喷泉状分散到玻璃体腔中。经过全身皮质类固醇和环磷酰胺治疗后,巩膜炎、结膜炎和视网膜血管炎有所好转,但视网膜白斑却发展为视网膜萎缩。与此同时,喷泉样渗漏区域的玻璃体细胞数量也有所减少。 复发性多软骨炎的视网膜表现在文献中并不多见。本报告介绍了一例独特的复发性多软骨炎病例,通过 OCT 成像观察到局部视网膜表现,从而拓宽了我们对这种疾病潜在的局部视网膜表现的认识。
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引用次数: 0
Perfluorocarbon Liquid-Silicone Oil Exchange: The Simplicity and Reliability of the Single Port Technique and a Review of Literature 全氟碳化物液体-硅油交换:单孔技术的简便性和可靠性及文献综述
Pub Date : 2024-04-04 DOI: 10.1097/icb.0000000000001579
Sukhum Silpa-archa, Variya Nganthavee
To report the “Single Port Technique” for perfluorocarbon liquid (PFCL)-silicone oil (SO) exchange for the management of giant retinal tear detachments (GRTD). The previously reported techniques of direct PFCL-SO exchange used 2 ports to achieve the influx and outflux of fluid. The term 'Single Port' refers to the use of only one port as the exclusive port for the inflow of SO and the outflow of fluid meniscus and PFCL, performed alternately. This technique is proposed, with illustrated instructions and a surgical video. The newly proposed “Single Port Technique” offers a straightforward step using a switch between active aspiration by the vitreous cutter and active silicone oil injection through a single port without the need for assistance. This method has been performed by the authors on 29 patients, including 22 GRTD patients and 7 patients with rhegmatogenous retinal detachment caused by dialysis, and it has demonstrated its simplicity and reliability for use with only standard vitrectomy tools and machine settings. The Single Port Technique for PFCL-SO exchange for the management of GRTD and rhegmatogenous retinal detachment caused by dialysis has been tried and tested, and it is a valuable tool that can be easily used by any vitreoretinal surgeon.
报告用于治疗巨大视网膜撕裂脱落(GRTD)的全氟碳化物(PFCL)-硅油(SO)交换 "单孔技术"。 之前报道的全氟碳化物-硅油直接交换技术使用两个端口来实现液体的流入和流出。单孔 "是指只使用一个孔作为专用孔,交替进行 SO 的流入和半月板及 PFCL 液体的流出。本文提出了这一技术,并附有图解说明和手术视频。 新提出的 "单孔技术 "提供了一个简单的步骤,即通过单孔在玻璃体切割器主动抽吸和硅油主动注射之间切换,无需辅助。作者已对 29 名患者实施了这种方法,其中包括 22 名 GRTD 患者和 7 名因透析引起的流变性视网膜脱离患者,并证明了这种方法的简便性和可靠性,只需使用标准的玻璃体切割工具和机器设置即可。 单孔 PFCL-SO 交换技术用于治疗 GRTD 和透析引起的流变性视网膜脱离已经过尝试和测试,它是一种有价值的工具,任何玻璃体视网膜外科医生都可以轻松使用。
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引用次数: 0
SPONTANEOUS RESOLUTION OF SUBFOVEAL PERFLUOROCARBON: CASE REPORT AND REVIEW OF THE LITERATURE 眼窝下全氟碳化物的自发消退:病例报告和文献综述
Pub Date : 2024-04-04 DOI: 10.1097/icb.0000000000001583
Hermosa A, Vela Ji, Loscos-Giménez I, Verdú A, Rego-Lorca D
To report a case of spontaneous resolution of subfoveal perfluorocarbon liquid (sPFCL). Methods: A 72-year-old male presented with poor vision in the left eye for two months. Ophthalmic examination revealed a visual acuity of counting fingers at 40 cm, pseudophakia, and rhegmatogenous retinal detachment in the left eye. The patient underwent 23G pars plana vitrectomy associated with a scleral buckle and silicone oil. Postoperatively, a retained sPFCL bubble was observed on OCT image. Results: Postoperatively, the sPFCL bubbles disappeared spontaneously by a full-thickness macular hole. Four weeks after surgery, the macular hole was closed, and visual acuity improved with preservation of foveal depression. Conclusion: Because spontaneous resolution rarely occurs, retinal surgeons prefer early evacuation of sPFCL. Herein, we report a new case of spontaneously resolved sPFCL and discuss the mechanisms for its resolution reported in the literature.
目的:报告一例眼窝下全氟化碳液体(sPFCL)自发消退的病例。方法:一名 72 岁的男性患者左眼视力下降两个月。眼科检查显示其左眼视力为 40 厘米处数手指的视力、假性角膜和流变性视网膜脱离。患者接受了 23G 角膜旁玻璃体切除术,术中使用了巩膜扣带和硅油。术后,在 OCT 图像上观察到保留的 sPFCL 气泡。结果:术后,sPFCL气泡因全厚黄斑孔而自动消失。术后四周,黄斑孔闭合,视力得到改善,保留了眼窝凹陷。结论:由于自发消退的情况很少发生,视网膜外科医生更倾向于早期撤除 sPFCL。在此,我们报告了一例新的自发消退的 sPFCL 病例,并讨论了文献中报道的其消退机制。
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引用次数: 0
CHOROIDAL NEOVASCULARIZATION IN A CHILD WITH DOWN SYNDROME 一名唐氏综合征患儿的脉络膜新生血管
Pub Date : 2023-12-15 DOI: 10.1097/icb.0000000000001541
Hazuki Morikawa, Tomoyo Yoshida, Emi Kashizuka, Shion Hayashi, T. Yokoi, Kaoru Tomita, N. Azuma, S. Nishina
To report a case of Down syndrome with myopic choroidal neovascularization (CNV) and the treatment outcome. Case report. Main outcome measures include refractive error, fundus examination, optical coherence tomography (OCT), OCT angiography (OCTA), fluorescein angiography (FA), anti-vascular endothelial growth factor (VEGF) injections. A 12-year-old boy with Down syndrome presented at a regular check-up with decreased visual acuity (VA) with macular degeneration in the left eye. The best-corrected VA was 0.6 in the right eye and 0.1 in the left eye, which decreased from 0.3 1 year ago. The refractive error (spherical equivalent) was -5.25 diopters (D) in the right eye and -8.00 D in the left eye. Detailed examinations were performed under general anesthesia. The fundus examination showed macular degeneration with retinal pigment epithelium (RPE) atrophy, pigmentary changes, and fibrous tissue in the left eye. OCT showed CNV at the macula with edema, and OCTA showed spreading CNV above the RPE at the macula in the left eye. FA showed hyperfluorescence in the early phase and late dye leakage from the CNV. Intravitreal ranibizumab injections were administered twice within 2 months, and he maintained a VA of 0.1 in the left eye. CNV and associated macular degeneration may occur in Down syndrome with high myopia possibly because of the abnormal choroidal structure. In children with Down syndrome, regular fundus examinations with OCT are important for early detection and treatment of CNV.
报告一例唐氏综合征近视眼脉络膜新生血管(CNV)病例及其治疗结果。 病例报告。主要结果指标包括屈光不正、眼底检查、光学相干断层扫描(OCT)、OCT 血管造影(OCTA)、荧光素血管造影(FA)、抗血管内皮生长因子(VEGF)注射。 一名患有唐氏综合征的 12 岁男孩在定期体检时发现左眼视力下降并伴有黄斑变性。右眼最佳矫正视力为 0.6,左眼为 0.1,比一年前的 0.3 有所下降。右眼屈光不正(球面等效)为-5.25屈光度(D),左眼屈光不正(球面等效)为-8.00屈光度(D)。详细检查在全身麻醉下进行。眼底检查显示左眼黄斑变性,伴有视网膜色素上皮(RPE)萎缩、色素变化和纤维组织。OCT 显示左眼黄斑处有 CNV,伴有水肿,OCTA 显示左眼黄斑处 RPE 上有扩散的 CNV。FA显示CNV早期高荧光和晚期染料渗漏。他在两个月内接受了两次雷尼单抗玻璃体内注射,左眼视力维持在 0.1。 可能由于脉络膜结构异常,患有高度近视的唐氏综合征患儿可能会出现 CNV 和相关的黄斑变性。对于唐氏综合征患儿,定期进行眼底检查和 OCT 对早期发现和治疗 CNV 非常重要。
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引用次数: 0
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