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Geographic distribution of pancreaticobiliary malignancy in central South Africa presenting to the Universitas Academic Hospital Complex 南非中部胰胆管恶性肿瘤的地理分布呈现给大学学术医院综合体
4区 医学 Q4 SURGERY Pub Date : 2023-09-01 DOI: 10.36303/sajs.3903
R J Mthunzi, C B Noel
There is limited data on the epidemiology, determination of risk factors and geographical variation of pancreatic cancer in South Africa. The aim of this study is to describe these parameters within central South Africa and compare to national and international reports.A retrospective review of all patients with newly diagnosed pancreatic cancer on clinical and radiological grounds admitted to Universitas Academic Hospital from 1st January 2015 to 31st December 2019 was performed. Patients were grouped into geographical regions based on their district municipality to identify clusters of pancreatic cancer. Demographic information and details of family history, diabetes and smoking status, and chronic pancreatitis were recorded and analysed in conjuction with the geographical and census data to provided estimates of disease incidence.The mean age of the the 382 patients with pancreatic cancer in the study period was 62.8 years ± 11.06. Two hundred and twelve (55.5%) were females. The Frances Baard district in the Northern Cape had the highest estimated rate of 3.5/100 000 and the Thabo Mofutsanyana district the lowest at 1.0/100 000. Of the cohort 132 (34.5%) were active smokers, 71 (18.6%) had diabetes mellitus, four (1%) had a history of chronic pancreatitis and two (0.5%) had a family history of pancreatic cancer.The incidence of pancreatic cancer in central South Africa is higher than that reported nationally with a female gender bias, marked regional variation and lack of a family history. These observations merit further evalualtion in the South African context.
关于南非胰腺癌的流行病学、危险因素的确定和地理差异的数据有限。本研究的目的是描述南非中部的这些参数,并与国内和国际报告进行比较。回顾性分析2015年1月1日至2019年12月31日在Universitas学术医院收治的所有临床和放射学原因新诊断的胰腺癌患者。研究人员根据患者所在的地区将患者分组,以确定胰腺癌的聚集性。结合地理和人口普查数据,记录和分析了人口统计信息和家族史、糖尿病和吸烟状况以及慢性胰腺炎的详细情况,以提供疾病发病率的估计数。研究期间382例胰腺癌患者的平均年龄为62.8岁±11.06岁。122例(55.5%)为女性。北开普省的Frances Baard区估计发病率最高,为3.5/10万,Thabo Mofutsanyana区最低,为1.0/10万。在该队列中,132人(34.5%)是活跃吸烟者,71人(18.6%)患有糖尿病,4人(1%)有慢性胰腺炎病史,2人(0.5%)有胰腺癌家族史。南非中部胰腺癌的发病率高于全国报告的发病率,存在女性性别偏见、明显的地区差异和缺乏家族史。这些意见值得在南非的情况下进一步评价。
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引用次数: 1
An audit of traumatic haemothoraces in a regional hospital in KwaZulu-Natal, South Africa 南非夸祖鲁-纳塔尔省一家地区医院外伤性血胸的审计
4区 医学 Q4 SURGERY Pub Date : 2023-09-01 DOI: 10.36303/sajs.3986
C M Kithuka, V C Ntola, W Sibanda
Haemothorax occurs in approximately 60% of all thoracic and polytrauma cases and is responsible for 15-30% of all trauma mortalities. Penetrating injuries to the thorax are a common presentation in South African hospitals. This study aims to audit the traumatic haemothoraces and their outcomes in regional hospitals in Durban, KwaZulu-Natal, South Africa.In this study, patient characteristics were grouped as either continuous or categorical variables. Continuous variables, such as age were summarised as means (with standard deviations) or medians (interquartile range [IQR]), as appropriate. Categorical variables such as sex were summarised as proportions. Fisher's exact test was used to compare proportions. All analyses were performed using the Statistical Package for Social Sciences.A total of 118 patients were included comprising 110 (93%) males and eight (7%) females, with an average age of 29.7 years. Stab-chest was the most frequent mechanism of injury (76; 64.4%), followed by gunshot wound (GSW)- chest (27; 22.9%) and isolated blunt chest trauma (9; 7.6%). Other mechanisms of injury were stab-neck (3; 2.5%), stab-shoulder (2; 1.7%) and blunt chest trauma in the context of polytrauma (1; 0.8%). The most frequent type of injury was penetrating (108; 91.5%), with only 10 (8.5%) cases of blunt injury. This study found that there was a statistically significant association between patient age groups and type of injury.Haemothorax is a common sequela of chest trauma. Retained haemothorax (RH) results in worsened patient outcomes including increased hospital length of stay (LOS). This study points to the need for auditing of proper intercostal chest drain (ICD) positioning, which is crucial for the successful drainage of haemothorax.
在所有胸部和多发创伤病例中,约60%的病例发生血性胸,在所有创伤死亡率中占15-30%。胸部穿透性损伤是南非医院常见的症状。本研究的目的是审计创伤性胸出血和他们的结果在德班地区医院夸祖鲁-纳塔尔省,南非。在这项研究中,患者的特征分为连续变量和分类变量。连续变量,如年龄,酌情汇总为平均值(带标准差)或中位数(四分位数间距[IQR])。诸如性别之类的分类变量被总结为比例。费雪精确检验被用来比较比例。所有分析均使用社会科学统计软件包进行。纳入118例患者,其中男性110例(93%),女性8例(7%),平均年龄29.7岁。刺胸是最常见的损伤机制(76;64.4%),其次是枪伤(GSW)-胸部(27;22.9%)和孤立性钝性胸外伤(9;7.6%)。其他损伤机制包括刺颈(3;2.5%),刺肩(2;1.7%)和钝性胸外伤在多发伤的背景下(1;0.8%)。最常见的伤害类型是穿透性(108;91.5%),而钝性损伤只有10例(8.5%)。本研究发现,患者年龄组和损伤类型之间存在统计学上显著的关联。血胸是胸部外伤的常见后遗症。残留的血胸(RH)导致患者预后恶化,包括住院时间(LOS)的增加。本研究指出需要对正确的肋间胸引流(ICD)定位进行审计,这对于成功引流血胸至关重要。
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引用次数: 0
Surgical exploration for penetrating neck trauma - an audit of results in 145 patients. 穿透性颈部创伤的外科探查——145例患者的结果审计。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-09-01
N Laher, B Monzon-Torres, M Mauser

Background: Selective non-operative management (SNOM) is the current gold standard for the treatment of patients with penetrating neck trauma. The policy revolves around the liberal use of computed tomography angiography (CTA) in those patients who are haemodynamically stable, irrespective of the anatomical zone of injury, aiming at reducing the incidence of negative and non-therapeutic interventions and their potential complications.

Methods: A retrospective audit of results of patients who underwent immediate surgical exploration at the Chris Hani Baragwanath Academic Hospital in Soweto between January 2010 and December 2015 was performed.

Results: One-hundred and forty-five (145) patients, with a median age of 28 years (range 18-67 years), predominantly males (93.8%), underwent immediate exploration. Most injuries were caused by stab wounds (92.4%) and affected zone 2 (54.1%) on the left side of the neck (69.6%). The most common presentations were active haemorrhage (29.4%), shock (24.1%) and expanding haematoma (15.1%). A major vascular injury was found in 40%, and aero-digestive organ injury in 19.3%. The rate of negative-non-therapeutic exploration in this cohort was 4.1%. Complications were recorded in 7.6%, and the overall mortality was 9.6% secondary to early uncontrolled haemorrhage, sepsis and occlusive strokes.

Conclusions: The utilisation of SNOM with strict criteria for selection of patients who require immediate surgical exploration versus investigations with CTA results in a low rate of non-therapeutic interventions.

背景:选择性非手术治疗(SNOM)是目前治疗穿透性颈部创伤患者的金标准。该政策围绕着在血流动力学稳定的患者中自由使用计算机断层造影(CTA)展开,无论损伤的解剖区域如何,旨在降低阴性和非治疗性干预的发生率及其潜在并发症。方法:对2010年1月至2015年12月期间在索韦托Chris Hani Baragwanath学术医院接受即时手术探查的患者的结果进行回顾性审计。结果:145名患者,中位年龄28岁(18-67岁),主要为男性(93.8%),立即接受了探查。大多数损伤是由颈部左侧的刺伤(92.4%)和受累区2(54.1%)(69.6%)引起的。最常见的表现是活动性出血(29.4%)、休克(24.1%)和扩张性血肿(15.1%)。40%的患者出现严重的血管损伤,该队列中非治疗性探索阴性率为4.1%。并发症记录为7.6%,早期失控出血、败血症和闭塞性中风的总死亡率为9.6%。结论:与CTA检查相比,在选择需要立即手术探查的患者时,使用SNOM具有严格的标准,导致非治疗性干预的发生率较低。
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引用次数: 0
An audit of traumatic haemothoraces in a regional hospital in KwaZulu-Natal, South Africa. 南非夸祖鲁-纳塔尔省一家地区医院的创伤性血胸审计。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-09-01
C M Kithuka, V C Ntola, W Sibanda

Background: Haemothorax occurs in approximately 60% of all thoracic and polytrauma cases and is responsible for 15-30% of all trauma mortalities. Penetrating injuries to the thorax are a common presentation in South African hospitals. This study aims to audit the traumatic haemothoraces and their outcomes in regional hospitals in Durban, KwaZulu-Natal, South Africa.

Methods: In this study, patient characteristics were grouped as either continuous or categorical variables. Continuous variables, such as age were summarised as means (with standard deviations) or medians (interquartile range [IQR]), as appropriate. Categorical variables such as sex were summarised as proportions. Fisher's exact test was used to compare proportions. All analyses were performed using the Statistical Package for Social Sciences.

Results: A total of 118 patients were included comprising 110 (93%) males and eight (7%) females, with an average age of 29.7 years. Stab-chest was the most frequent mechanism of injury (76; 64.4%), followed by gunshot wound (GSW)- chest (27; 22.9%) and isolated blunt chest trauma (9; 7.6%). Other mechanisms of injury were stab-neck (3; 2.5%), stab-shoulder (2; 1.7%) and blunt chest trauma in the context of polytrauma (1; 0.8%). The most frequent type of injury was penetrating (108; 91.5%), with only 10 (8.5%) cases of blunt injury. This study found that there was a statistically significant association between patient age groups and type of injury.

Conclusion: Haemothorax is a common sequela of chest trauma. Retained haemothorax (RH) results in worsened patient outcomes including increased hospital length of stay (LOS). This study points to the need for auditing of proper intercostal chest drain (ICD) positioning, which is crucial for the successful drainage of haemothorax.

背景:大约60%的胸部和多发性创伤病例会发生血栓,并导致15-30%的创伤死亡。胸部穿透性损伤是南非医院常见的表现。本研究旨在审计南非夸祖鲁-纳塔尔州德班地区医院的创伤性血胸及其结果。方法:在本研究中,将患者特征分为连续变量或分类变量。连续变量,如年龄,视情况总结为平均值(带标准差)或中位数(四分位间距[IQR])。性别等分类变量被概括为比例。Fisher精确检验用于比较比例。所有分析均使用社会科学统计软件包进行。结果:共有118名患者,包括110名(93%)男性和8名(7%)女性,平均年龄为29.7岁。胸部刺伤是最常见的损伤机制(76;64.4%),其次是胸部枪伤(GSW)(27;22.9%)和孤立性钝性胸部创伤(9;7.6%)。其他损伤机制是颈部刺伤(3;2.5%)、肩部刺伤(2;1.7%)和多发伤背景下的钝性胸部损伤(1;0.8%)。最常见的伤害类型是穿透性损伤(108;91.5%),钝性损伤10例(8.5%)。这项研究发现,患者年龄组和损伤类型之间存在统计学上显著的相关性。结论:胸腔出血是胸部创伤后常见的后遗症。保留性血胸(RH)导致患者预后恶化,包括住院时间增加(LOS)。这项研究指出,需要对正确的肋间胸腔引流管(ICD)定位进行审计,这对成功引流血胸至关重要。
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引用次数: 0
Hydrothorax and air fluid levels in the right chest - a diagnostic dilemma. 胸腔积液和右胸的空气液位-诊断难题。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-09-01
M Morar, T B Rangaka, A B Ogunrombi, A Abd Elrahman

Summary: A diaphragmatic defect that permits abdominal contents to herniate into the right side of the chest is rare. In adults with right-sided diaphragmatic hernias, few occur without a history of trauma, and even fewer are symptomatic. This case report illustrates such a case and the rare entity of an anterolaterally located hernia. Although uncommon and easily missed, consequences of diaphragmatic hernias can be disastrous. The importance of a combination of high clinical suspicion and the use of computed tomography (CT) to aid diagnosis, and the dangers of a surgical condition being incorrectly assessed and admitted to a non-surgical specialty are highlighted in this case.

摘要:允许腹部内容物疝入胸部右侧的膈肌缺损是罕见的。在患有右侧膈疝的成年人中,很少有人没有外伤史,有症状的人更少。本病例报告说明了这样一个病例和罕见的前外侧疝。尽管膈疝不常见且容易被遗漏,但其后果可能是灾难性的。本例强调了高度临床怀疑和使用计算机断层扫描(CT)辅助诊断的重要性,以及手术条件被错误评估和进入非手术专业的危险。
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引用次数: 0
Implementing robotic surgery in South African training institutions: fiddling while Rome burns 在南非培训机构实施机器人手术:玩火自焚
4区 医学 Q4 SURGERY Pub Date : 2023-09-01 DOI: 10.36303/sajs.4142
JJ Fagan
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引用次数: 0
The clinical utility of PET/CT scan and tissue biopsy in the management and follow-up of paediatric Hodgkin lymphoma in South Africa. PET/CT扫描和组织活检在南非儿童霍奇金淋巴瘤治疗和随访中的临床应用。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-09-01
K Heyman, G Hyman, R Kolia, K Nicholaides, V Govender, J McMaster, D Harrison

Background: In low- to middle-income countries (LMICs) like South Africa, there is a need to understand the clinical practices surrounding diagnosis and surveillance of paediatric Hodgkin lymphoma (HL) to reduce the burden on health systems. Understanding the clinical utility of PET/CT scans may decrease repeated tissue biopsies during disease surveillance.

Methods: This is a retrospective cohort study of patients aged less than 18 years treated for HL at Chris Hani Baragwanath Academic Hospital from 1 January 2009 to 31 December 2018.

Results: Fifty-four patients were included in the study; male-to-female ratio was 5:1 with a mean age of 9 years. Seventy per cent of patients (n = 38) received a PET/CT and tissue biopsy during their initial diagnostic workup, whereas 20.4% (n = 11) of patients received a PET/CT and tissue biopsy during surveillance. Tissue biopsy and PET/CT showed slight agreement (κ = 0.14) in diagnosing relapsed disease during surveillance. The false negative rate for tissue biopsy during surveillance was 42.9%. Surveillance PET/CT showed a positive predictive value (PPV) of 66.7% and negative predictive value (NPV) of 100% when compared to tissue biopsy.

Conclusion: This study is the first cohort to explore the clinical utility of PET/CT scans and tissue biopsies in a lowresourced setting. Our findings showed slight agreement between the modalities in diagnosing relapsed disease during surveillance. A portion of this discordance can be attributed to false negative tissue biopsy results. While the sample is limited, our findings are consistent with the high NPV of PET/CT scans of > 95% as is reported in the literature.

背景:在南非等中低收入国家,有必要了解儿科霍奇金淋巴瘤(HL)的诊断和监测的临床实践,以减轻卫生系统的负担。了解PET/CT扫描的临床实用性可以减少疾病监测期间的重复组织活检。方法:这是一项对2009年1月1日至2018年12月31日在Chris Hani Baragwanath学术医院接受HL治疗的18岁以下患者的回顾性队列研究。结果:54名患者纳入研究;男女比例为5:1,平均年龄9岁。70%的患者(n=38)在最初的诊断检查期间接受了PET/CT和组织活检,而20.4%(n=11)的患者在监测期间接受了PET/CT和组织活检。在监测期间,组织活检和PET/CT在诊断复发性疾病方面显示出轻微的一致性(κ=0.14)。监测期间组织活检的假阴性率为42.9%。与组织活检相比,监测PET/CT显示阳性预测值(PPV)为66.7%,阴性预测值(NPV)为100%。结论:本研究是第一个探索PET/CT扫描和组织活检在低资源环境中的临床实用性的队列研究。我们的研究结果显示,在监测期间,诊断复发性疾病的模式略有一致。这种不一致的一部分可以归因于假阴性的组织活检结果。虽然样本有限,但我们的发现与文献中报道的PET/CT扫描的高NPV(>95%)一致。
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引用次数: 0
A tragedy of albinism 白化病的悲剧
4区 医学 Q4 SURGERY Pub Date : 2023-09-01 DOI: 10.36303/sajs.3989
FB Aboo, MP Kgagudi, M Jingo
{"title":"A tragedy of albinism","authors":"FB Aboo, MP Kgagudi, M Jingo","doi":"10.36303/sajs.3989","DOIUrl":"https://doi.org/10.36303/sajs.3989","url":null,"abstract":"","PeriodicalId":51161,"journal":{"name":"South African Journal of Surgery","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135691214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mortality rate of patients with open abdomen and contributing factors - a three-year audit in a major academic trauma unit. 腹部开放患者的死亡率及其影响因素——一项在主要学术创伤单位进行的为期三年的审计。
IF 0.5 4区 医学 Q4 SURGERY Pub Date : 2023-09-01
E van der Merwe, M S Moeng, M Joubert, M Nel

Background: Damage control surgery (DCS) is a widely used approach in trauma. An open abdomen carries complications, increased morbidity and mortality. This study aims to quantify the mortality rate, determine contributory factors and factors influencing the decision to perform DCS and assess morbidity in patients undergoing open abdomen.

Methods: A retrospective review was conducted on 205 patients in Charlotte Maxeke Johannesburg Academic Hospital Trauma Unit. The mortality rate was evaluated over a 24-hour, 7-day and 28-day period. Data were collected by a data collection sheet from 1 January 2016 to 31 December 2018.

Results: Of the 205 patients, 193 were male and the median age was 34.34 years. Penetrating trauma was the most predominant mechanism of injury in 162 (79%), with gunshot injuries seen in the majority (130/162). The mortality rate was 55/205 (26.8%) for open abdomen patients, 19/55 (34.5%) within the first 24 hours, 22/55 (40%) in the 24-hours to 7-days period, and 14/55 (25.4%) in the 8-day to 28-day period. Statistically significant factors contributing to mortality were haemodynamic instability, hypothermia, coagulopathy, massive transfusion, vasopressors, and significant associated injuries. Morbidities were entero-atmospheric fistula (EAF) in 7.3% (Clavien-Dindo grade IIIa), surgical site infection in 45.3% (Clavien-Dindo grade I) and ventral hernia in 10.24% (Clavien-Dindo grade IIIb).

Conclusion: Most open abdomens were performed in males, with gunshot injuries being the most common mechanism. The majority of mortalities were within the 24-hours to 7-days period. The most common morbidity associated with an open abdomen was surgical site infection.

背景:损伤控制手术(DCS)是一种广泛应用于创伤治疗的方法。腹部开放会带来并发症,增加发病率和死亡率。本研究旨在量化死亡率,确定促成因素和影响决定进行DCS的因素,并评估腹部开放患者的发病率。方法:对Charlotte Maxeke Johannesburg学术医院创伤科的205名患者进行回顾性分析。死亡率在24小时、7天和28天内进行评估。数据通过2016年1月1日至2018年12月31日的数据收集表收集。结果:205名患者中,193人为男性,中位年龄为34.34岁。穿透性创伤是162例(79%)中最主要的损伤机制,枪伤占大多数(130/162)。开腹患者的死亡率为55/205(26.8%),前24小时内为19/55(34.5%),24小时至7天为22/55(40%),8天至28天为14/55(25.4%)。在统计学上,导致死亡率的重要因素是血液动力学不稳定、体温过低、凝血障碍、大量输血、血管升压药和严重的相关损伤。发病率为肠-大气瘘7.3%(Clavien-DindoⅢa级),手术部位感染45.3%(Clavien DindoⅠ级),腹疝10.24%(Clavien-DindoⅢb级)。大多数死亡发生在24小时至7天内。与腹部开放相关的最常见的发病率是手术部位感染。
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引用次数: 0
The clinical utility of PET/CT scan and tissue biopsy in the management and follow-up of paediatric Hodgkin lymphoma in South Africa PET/CT扫描和组织活检在南非儿童霍奇金淋巴瘤的治疗和随访中的临床应用
4区 医学 Q4 SURGERY Pub Date : 2023-09-01 DOI: 10.36303/sajs.3930
K Heyman, G Hyman, R Kolia, K Nicholaides, V Govender, J McMaster, D Harrison
In low- to middle-income countries (LMICs) like South Africa, there is a need to understand the clinical practices surrounding diagnosis and surveillance of paediatric Hodgkin lymphoma (HL) to reduce the burden on health systems. Understanding the clinical utility of PET/CT scans may decrease repeated tissue biopsies during disease surveillance.This is a retrospective cohort study of patients aged less than 18 years treated for HL at Chris Hani Baragwanath Academic Hospital from 1 January 2009 to 31 December 2018.Fifty-four patients were included in the study; male-to-female ratio was 5:1 with a mean age of 9 years. Seventy per cent of patients (n = 38) received a PET/CT and tissue biopsy during their initial diagnostic workup, whereas 20.4% (n = 11) of patients received a PET/CT and tissue biopsy during surveillance. Tissue biopsy and PET/CT showed slight agreement (κ = 0.14) in diagnosing relapsed disease during surveillance. The false negative rate for tissue biopsy during surveillance was 42.9%. Surveillance PET/CT showed a positive predictive value (PPV) of 66.7% and negative predictive value (NPV) of 100% when compared to tissue biopsy.This study is the first cohort to explore the clinical utility of PET/CT scans and tissue biopsies in a lowresourced setting. Our findings showed slight agreement between the modalities in diagnosing relapsed disease during surveillance. A portion of this discordance can be attributed to false negative tissue biopsy results. While the sample is limited, our findings are consistent with the high NPV of PET/CT scans of > 95% as is reported in the literature.
在南非等中低收入国家,有必要了解儿科霍奇金淋巴瘤诊断和监测的临床实践,以减轻卫生系统的负担。了解PET/CT扫描的临床应用可以减少疾病监测期间重复的组织活检。这是一项回顾性队列研究,研究对象为2009年1月1日至2018年12月31日在Chris Hani Baragwanath学术医院接受HL治疗的18岁以下患者。54名患者被纳入研究;男女比例为5:1,平均年龄9岁。70%的患者(n = 38)在最初的诊断检查中接受了PET/CT和组织活检,而20.4% (n = 11)的患者在监测期间接受了PET/CT和组织活检。监测期间组织活检与PET/CT对疾病复发的诊断略有一致(κ = 0.14)。监测期间组织活检假阴性率为42.9%。与组织活检相比,PET/CT监测显示阳性预测值为66.7%,阴性预测值为100%。本研究是首个在资源匮乏地区探索PET/CT扫描和组织活检的临床应用的队列研究。我们的研究结果显示,在监测期间诊断复发疾病的方式之间存在轻微的一致性。这种不一致的一部分可归因于假阴性组织活检结果。虽然样本有限,但我们的发现与文献中报道的PET/CT扫描> 95%的高净现值一致。
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引用次数: 0
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South African Journal of Surgery
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