首页 > 最新文献

South Asian Journal of Health Sciences最新文献

英文 中文
Mapping the landscape of COVID-19 research from Bangladesh: A bibliometric analysis of highly cited papers 绘制孟加拉国 COVID-19 研究图景:高被引论文的文献计量分析
Pub Date : 2024-08-10 DOI: 10.25259/sajhs_7_2024
Raju Vaishya, Brij Mohan Gupta, G. M. Mamdapur, Mallikarjun M. Kappi, K. S. Ali
We aimed to analyse the highly-cited papers on COVID-19 research from Bangladesh. This study used bibliometric methods to examine the characteristics and trends of COVID-19 research in the country.To source publication data for the study, the Scopus database was used, until 26th July 2023, employing a specific search strategy. The search yielded 4124 papers, which were then rearranged based on the frequency of citations to obtain the highly cited papers (HCPs), which received 100 or more citations.The 110 (2.67%) HCPs registered citations ranging from 100 to 1502, with an average of 236.21 Citations per Paper (CPP). Only 30.9% of the publications received external funding and and received an average CPP of 332.0. Similarly, 80% of the HCPs were involved in international collaboration, and and received an average of 249.89 CPP. The major international contributors were the USA, Australia, U.K., and China. The most productive organisations were Jahangirnagar University, International Centre for Diarrhoeal Disease Research, and University Of Dhaka. The most impactful organisations were Neurogen Children’s Healthcare, Bangabandhu Sheikh Mujib Medical University, and Begum Rokeya University. Three most productive authors were Mamun, M.A. (n=8), Saiful Islam, M. (n=6), Tajuddin Sikder, Md. and Bodrud-Doza, Md. (n=4 each).This study provides the current status of research on COVID-19, including its trends and the most significant contributions from Bangladesh. It has highlighted the top authors, organisations, journals, and research hotspots in the field of COVID-19 research. This information can also help researchers identify potential collaborators, relevant papers, and important research questions in their areas of expertise.
我们旨在分析孟加拉国有关 COVID-19 研究的高被引论文。本研究采用文献计量学方法研究了孟加拉国 COVID-19 研究的特点和趋势。为获取本研究的出版数据,我们使用了 Scopus 数据库,并采用特定的检索策略,检索期至 2023 年 7 月 26 日。通过检索,共获得 4124 篇论文,然后根据论文被引用的频率对这些论文进行重新排列,以获得被引用 100 次或以上的高被引论文(HCPs)。只有 30.9% 的论文获得了外部资助,平均 CPP 为 332.0。同样,80% 的高级专业人员参与了国际合作,平均每篇论文获得 249.89 CPP。主要的国际捐助者是美国、澳大利亚、英国和中国。最有成果的组织是贾汉吉尔纳格尔大学、国际腹泻病研究中心和达卡大学。最具影响力的机构是 Neurogen 儿童医疗保健机构、班加班杜-谢赫-穆吉布医科大学和 Begum Rokeya 大学。三位最有成果的作者分别是 Mamun, M.A. (n=8), Saiful Islam, M. (n=6), Tajuddin Sikder, Md. 和 Bodrud-Doza, Md. (n=4 each.)。本研究介绍了 COVID-19 的研究现状,包括其发展趋势和孟加拉国最重要的贡献。本研究提供了 COVID-19 的研究现状,包括其发展趋势和孟加拉国最重要的贡献。本研究强调了 COVID-19 研究领域的顶级作者、组织、期刊和研究热点。这些信息还可以帮助研究人员确定潜在的合作者、相关论文以及其专业领域的重要研究问题。
{"title":"Mapping the landscape of COVID-19 research from Bangladesh: A bibliometric analysis of highly cited papers","authors":"Raju Vaishya, Brij Mohan Gupta, G. M. Mamdapur, Mallikarjun M. Kappi, K. S. Ali","doi":"10.25259/sajhs_7_2024","DOIUrl":"https://doi.org/10.25259/sajhs_7_2024","url":null,"abstract":"\u0000\u0000We aimed to analyse the highly-cited papers on COVID-19 research from Bangladesh. This study used bibliometric methods to examine the characteristics and trends of COVID-19 research in the country.\u0000\u0000\u0000\u0000To source publication data for the study, the Scopus database was used, until 26th July 2023, employing a specific search strategy. The search yielded 4124 papers, which were then rearranged based on the frequency of citations to obtain the highly cited papers (HCPs), which received 100 or more citations.\u0000\u0000\u0000\u0000The 110 (2.67%) HCPs registered citations ranging from 100 to 1502, with an average of 236.21 Citations per Paper (CPP). Only 30.9% of the publications received external funding and and received an average CPP of 332.0. Similarly, 80% of the HCPs were involved in international collaboration, and and received an average of 249.89 CPP. The major international contributors were the USA, Australia, U.K., and China. The most productive organisations were Jahangirnagar University, International Centre for Diarrhoeal Disease Research, and University Of Dhaka. The most impactful organisations were Neurogen Children’s Healthcare, Bangabandhu Sheikh Mujib Medical University, and Begum Rokeya University. Three most productive authors were Mamun, M.A. (n=8), Saiful Islam, M. (n=6), Tajuddin Sikder, Md. and Bodrud-Doza, Md. (n=4 each).\u0000\u0000\u0000\u0000This study provides the current status of research on COVID-19, including its trends and the most significant contributions from Bangladesh. It has highlighted the top authors, organisations, journals, and research hotspots in the field of COVID-19 research. This information can also help researchers identify potential collaborators, relevant papers, and important research questions in their areas of expertise.\u0000","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young woman with high fever and a massive rise in N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) 年轻女性高烧不退,N-末端前 B 型利钠肽 (NT-pro-BNP) 大量升高
Pub Date : 2024-07-02 DOI: 10.25259/sajhs_8_2024
M. K. Sundarka, A. Sundarka, Krishna Kumar Lohani
A 33-year-old lady presented with acute symptoms suggestive of pneumonia. She rapidly deteriorated and needed intensive care unit care. She was found to have an enormous rise in N-terminal pro-B-type natriuretic peptide (NT-Pro-BNP), nearly in six digits without any previous co-morbidity. NT-Pro-BNP high levels could be reflective of cardiac injury, heart failure (HF), or chronic kidney disease (CKD), and a few other medical conditions. The final diagnosis was for acute on chronic kidney disease.
一位 33 岁的女士出现急性肺炎症状。她的病情迅速恶化,需要接受重症监护。她被发现N-末端前B型钠尿肽(NT-Pro-BNP)急剧升高,接近六位数,且之前没有任何并发症。NT-Pro-BNP的高水平可能反映了心脏损伤、心力衰竭(HF)或慢性肾病(CKD)以及其他一些疾病。最终诊断为急性慢性肾病。
{"title":"Young woman with high fever and a massive rise in N-terminal pro-B-type natriuretic peptide (NT-pro-BNP)","authors":"M. K. Sundarka, A. Sundarka, Krishna Kumar Lohani","doi":"10.25259/sajhs_8_2024","DOIUrl":"https://doi.org/10.25259/sajhs_8_2024","url":null,"abstract":"A 33-year-old lady presented with acute symptoms suggestive of pneumonia. She rapidly deteriorated and needed intensive care unit care. She was found to have an enormous rise in N-terminal pro-B-type natriuretic peptide (NT-Pro-BNP), nearly in six digits without any previous co-morbidity. NT-Pro-BNP high levels could be reflective of cardiac injury, heart failure (HF), or chronic kidney disease (CKD), and a few other medical conditions. The final diagnosis was for acute on chronic kidney disease.","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":"7 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141684961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical profile and risk factors for type-2 diabetes – A cross-sectional study 2 型糖尿病的临床概况和风险因素 - 一项横断面研究
Pub Date : 2024-06-03 DOI: 10.25259/sajhs_2_2023
P. N. Okoro, Kola Olarinoye, A. Esan
Type 2 diabetes is a chronic metabolic disorder characterised by elevated blood glucose levels due to insulin resistance or insufficient insulin production. Understanding the prevalence, characteristics, and markers of this disease is essential for effective prevention, management and treatment. The study aims to explore the association between type 2 diabetes and, its prevalence, characteristics and markers.Adults with type 2 diabetes and matched healthy controls were enrolled in the study. Statistical calculations were used to establish the sample size. Information on demographics, physical examinations and lab tests were collected. We assessed plasma glucose, glycated haemoglobin (HbA1c), serum lipids and serum DPP4.The mean age (SD) of the population under research was 55.7 (6.12) years for the study subjects and 55.7 (6.11) years for the controls. A positive family history of diabetes was present in 34 (or 33%) of the diabetes patients compared to 11 (or 11%) of the non-diabetic patients (p 0.001). The mean HbA1c in the diabetic group was substantially greater than that of the non-diabetic controls (5.47 1.89%), as expected (7.23 2.69%), p 0.001. It’s interesting to note that total cholesterol was markedly higher in the diabetes participants (5.59 2.24 mmol/L) than in the non-diabetic controls (6.48 1.54 mmol/L), p = 0.001.Due to common risk factors and underlying mechanisms, type 2 diabetes and hypertension may be related, as suggested by the high prevalence of hypertension in the diabetic group. Type 2 diabetes was substantially related to elevated HbA1c and fasting plasma glucose levels, indicating poor glycaemic control. The higher mean serum Dipeptidyl peptidase-4 (DPP4) level in the group with type 2 diabetes shows a link between high DPP4 levels and the disease, which may have an effect on incretin hormone activity, insulin resistance and therapeutic options.
2 型糖尿病是一种慢性代谢性疾病,其特点是由于胰岛素抵抗或胰岛素分泌不足导致血糖升高。了解这种疾病的发病率、特征和标志物对于有效预防、管理和治疗至关重要。本研究旨在探讨 2 型糖尿病及其发病率、特征和标志物之间的关联。统计计算用于确定样本量。我们收集了人口统计学、体格检查和实验室检测的相关信息。我们评估了血浆葡萄糖、糖化血红蛋白(HbA1c)、血脂和血清 DPP4。研究对象的平均年龄(标清)为 55.7(6.12)岁,对照组为 55.7(6.11)岁。有阳性糖尿病家族史的糖尿病患者有 34 人(占 33%),而非糖尿病患者有 11 人(占 11%)(P 0.001)。糖尿病组的 HbA1c 平均值(5.47 1.89%)大大高于非糖尿病对照组(7.23 2.69%),符合预期(P 0.001)。值得注意的是,糖尿病参与者的总胆固醇(5.59 2.24 mmol/L)明显高于非糖尿病对照组(6.48 1.54 mmol/L),P = 0.001。由于存在共同的风险因素和潜在机制,2 型糖尿病和高血压可能存在关联,糖尿病组的高血压患病率也说明了这一点。2 型糖尿病与 HbA1c 和空腹血浆葡萄糖水平升高密切相关,表明血糖控制不佳。2 型糖尿病组的平均血清二肽基肽酶-4(DPP4)水平较高,这表明高 DPP4 水平与该疾病有关,可能会对增量素激素活性、胰岛素抵抗和治疗方案产生影响。
{"title":"Clinical profile and risk factors for type-2 diabetes – A cross-sectional study","authors":"P. N. Okoro, Kola Olarinoye, A. Esan","doi":"10.25259/sajhs_2_2023","DOIUrl":"https://doi.org/10.25259/sajhs_2_2023","url":null,"abstract":"\u0000\u0000Type 2 diabetes is a chronic metabolic disorder characterised by elevated blood glucose levels due to insulin resistance or insufficient insulin production. Understanding the prevalence, characteristics, and markers of this disease is essential for effective prevention, management and treatment. The study aims to explore the association between type 2 diabetes and, its prevalence, characteristics and markers.\u0000\u0000\u0000\u0000Adults with type 2 diabetes and matched healthy controls were enrolled in the study. Statistical calculations were used to establish the sample size. Information on demographics, physical examinations and lab tests were collected. We assessed plasma glucose, glycated haemoglobin (HbA1c), serum lipids and serum DPP4.\u0000\u0000\u0000\u0000The mean age (SD) of the population under research was 55.7 (6.12) years for the study subjects and 55.7 (6.11) years for the controls. A positive family history of diabetes was present in 34 (or 33%) of the diabetes patients compared to 11 (or 11%) of the non-diabetic patients (p 0.001). The mean HbA1c in the diabetic group was substantially greater than that of the non-diabetic controls (5.47 1.89%), as expected (7.23 2.69%), p 0.001. It’s interesting to note that total cholesterol was markedly higher in the diabetes participants (5.59 2.24 mmol/L) than in the non-diabetic controls (6.48 1.54 mmol/L), p = 0.001.\u0000\u0000\u0000\u0000Due to common risk factors and underlying mechanisms, type 2 diabetes and hypertension may be related, as suggested by the high prevalence of hypertension in the diabetic group. Type 2 diabetes was substantially related to elevated HbA1c and fasting plasma glucose levels, indicating poor glycaemic control. The higher mean serum Dipeptidyl peptidase-4 (DPP4) level in the group with type 2 diabetes shows a link between high DPP4 levels and the disease, which may have an effect on incretin hormone activity, insulin resistance and therapeutic options. \u0000","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":"17 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141271926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial infarction in non-obstructive coronary artery (MINOCA) in a young girl with multidrug poisoning 一名多种药物中毒少女的非阻塞性冠状动脉心肌梗死(MINOCA)
Pub Date : 2024-05-23 DOI: 10.25259/sajhs_3_2024
Md Moniruzzaman, Amal Krishna Paul, K M Adnan Bulbul, Md Shariful Islam, Md Nahid Hasan
A 24-year-old girl was admitted to the emergency room with chest pain, abdominal discomfort and excessive sleeping tendency after taking some unprescribed medications. She had no risk factors for cardiovascular disease. On query, she gives a history of taking multiple medications available in her room due to some emotional outbreak. Her relatives give a history of taking paracetamol 1000 mg, cephradine 2500 mg, propranolol 100 mg, bilastine 160 mg and hydroxyzine 200 mg. None of these drugs have proven to cause myocardial infarction (MI) at this dosage. Initial ECG showed sinus bradycardia which can be because of taking propranolol. But 2 hours after admission, she developed severe chest pain and at that time ECG showed gross segment (ST) depression. Troponin-i was found to be raised. After initial management, a coronary angiogram was done which revealed normal epicardial coronaries. Patient was managed symptomatically and she recovered completely.
一名 24 岁的女孩因胸痛、腹部不适和过度睡眠而被送进急诊室。她没有心血管疾病的危险因素。经询问,她曾因情绪激动而服用过房间里的多种药物。她的亲属提供了服用扑热息痛 1000 毫克、头孢拉定 2500 毫克、普萘洛尔 100 毫克、比拉斯汀 160 毫克和羟嗪 200 毫克的病史。事实证明,这些药物在此剂量下均不会导致心肌梗死(MI)。最初的心电图显示为窦性心动过缓,这可能与服用普萘洛尔有关。但入院 2 小时后,她出现了剧烈胸痛,当时的心电图显示为 ST 段压低。发现肌钙蛋白-i升高。经过初步治疗后,进行了冠状动脉造影,结果显示心外膜冠状动脉正常。患者经过对症治疗后完全康复。
{"title":"Myocardial infarction in non-obstructive coronary artery (MINOCA) in a young girl with multidrug poisoning","authors":"Md Moniruzzaman, Amal Krishna Paul, K M Adnan Bulbul, Md Shariful Islam, Md Nahid Hasan","doi":"10.25259/sajhs_3_2024","DOIUrl":"https://doi.org/10.25259/sajhs_3_2024","url":null,"abstract":"A 24-year-old girl was admitted to the emergency room with chest pain, abdominal discomfort and excessive sleeping tendency after taking some unprescribed medications. She had no risk factors for cardiovascular disease. On query, she gives a history of taking multiple medications available in her room due to some emotional outbreak. Her relatives give a history of taking paracetamol 1000 mg, cephradine 2500 mg, propranolol 100 mg, bilastine 160 mg and hydroxyzine 200 mg. None of these drugs have proven to cause myocardial infarction (MI) at this dosage. Initial ECG showed sinus bradycardia which can be because of taking propranolol. But 2 hours after admission, she developed severe chest pain and at that time ECG showed gross segment (ST) depression. Troponin-i was found to be raised. After initial management, a coronary angiogram was done which revealed normal epicardial coronaries. Patient was managed symptomatically and she recovered completely.","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advocacy for neonates: Will respiratory syncytial virus monoclonal antibodies and maternal vaccine be made available in India? 新生儿宣传:印度能否获得呼吸道合胞病毒单克隆抗体和母体疫苗?
Pub Date : 2024-05-03 DOI: 10.25259/sajhs_1_2024
Mohamed Muneer Varikkottil, Divya Ajith, Femitha Pournami, Jyothi Prabhakar, Naveen Jain
Respiratory syncytial virus (RSV)-related morbidity in children has been widely described. Research has led to the availability of palivizumab for decades in high-income countries. Ongoing research underlines the high priority given to this conundrum. Nirsevimab, a long-acting monoclonal antibody, and a maternal vaccine have been developed and approved for RSV. Neither of these are available in India. Improving the survival of extreme preterm neonates in our country should parallel other strategies to protect them from diseases that affect these high-risk neonates. This case series comprises sick RSV-infected infants from our centre over a single season. Of 187 young infants who presented to the Neonatology Department with features of viral lower respiratory infections, 9 (4.8%) required intensive care. All of them were positive for RSV by nasopharyngeal polymerase chain reaction. A total of 25 (13%) required hospitalisation. Preterm infants presented with apnea or severe respiratory distress. All 9 in the intensive care unit required respiratory support, and 8 needed invasive ventilation. The median duration of hospital stay for these infants was 18 (7–37) days. This report is an appeal to stakeholders towards making these evidence-based prophylactic methods available in India. A preventable problem in high-risk neonates could be reduced. Improving neonatal survival and outcomes calls for our country to be at par with high-income countries for RSV prevention. RSV-related morbidity is an endemic conundrum with a high disease burden. We could take prompt action, akin to efforts taken during the COVID-19 pandemic.
与呼吸道合胞病毒(RSV)相关的儿童发病率已被广泛描述。经过研究,帕利珠单抗已在高收入国家上市数十年。正在进行的研究强调了对这一难题的高度重视。针对 RSV 开发并批准了长效单克隆抗体 Nirsevimab 和母体疫苗。但这两种药物在印度均未获得批准。在改善我国早产新生儿存活率的同时,还应采取其他策略保护他们免受影响这些高危新生儿的疾病的侵袭。本病例系列包括我们中心一个季度内感染 RSV 的患病婴儿。在新生儿科就诊的 187 名患有病毒性下呼吸道感染的婴儿中,有 9 名(4.8%)需要接受重症监护。经鼻咽聚合酶链反应检测,这些婴儿均对 RSV 呈阳性反应。共有 25 人(13%)需要住院治疗。早产儿出现呼吸暂停或严重呼吸困难。重症监护室的所有 9 名婴儿都需要呼吸支持,其中 8 名需要侵入性通气。这些婴儿的中位住院时间为 18(7-37)天。本报告呼吁相关各方在印度推广这些循证预防方法。可以减少高危新生儿中可预防的问题。为了提高新生儿的存活率和预后,我国需要在 RSV 预防方面与高收入国家看齐。RSV 相关发病率是一个地方性难题,疾病负担沉重。我们可以迅速采取行动,就像在 COVID-19 大流行期间所做的努力一样。
{"title":"Advocacy for neonates: Will respiratory syncytial virus monoclonal antibodies and maternal vaccine be made available in India?","authors":"Mohamed Muneer Varikkottil, Divya Ajith, Femitha Pournami, Jyothi Prabhakar, Naveen Jain","doi":"10.25259/sajhs_1_2024","DOIUrl":"https://doi.org/10.25259/sajhs_1_2024","url":null,"abstract":"Respiratory syncytial virus (RSV)-related morbidity in children has been widely described. Research has led to the availability of palivizumab for decades in high-income countries. Ongoing research underlines the high priority given to this conundrum. Nirsevimab, a long-acting monoclonal antibody, and a maternal vaccine have been developed and approved for RSV. Neither of these are available in India. Improving the survival of extreme preterm neonates in our country should parallel other strategies to protect them from diseases that affect these high-risk neonates. This case series comprises sick RSV-infected infants from our centre over a single season. Of 187 young infants who presented to the Neonatology Department with features of viral lower respiratory infections, 9 (4.8%) required intensive care. All of them were positive for RSV by nasopharyngeal polymerase chain reaction. A total of 25 (13%) required hospitalisation. Preterm infants presented with apnea or severe respiratory distress. All 9 in the intensive care unit required respiratory support, and 8 needed invasive ventilation. The median duration of hospital stay for these infants was 18 (7–37) days. This report is an appeal to stakeholders towards making these evidence-based prophylactic methods available in India. A preventable problem in high-risk neonates could be reduced. Improving neonatal survival and outcomes calls for our country to be at par with high-income countries for RSV prevention. RSV-related morbidity is an endemic conundrum with a high disease burden. We could take prompt action, akin to efforts taken during the COVID-19 pandemic.","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":"83 S2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141016288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the neuroprotective potential of chrysin on the pre-frontal cortex of adult male Wistar rats 揭示菊黄素对成年雄性 Wistar 大鼠前额叶皮层的神经保护潜力
Pub Date : 2024-03-22 DOI: 10.25259/sajhs_15_2023
Ifeanyi Anthony Egwuatu, C. Ozoemena, Fortune Kasiemobi Onuorah
Excessive free radicals in the human body predispose cells within the various systems to an imbalance and accumulation of oxygen-reactive species, known as oxidative stress. The central nervous system is not spared when it comes to these cell and tissue damages. Oxidative stress on the central nervous system may be responsible for anxiety, spatial memory impairment, neuronal cell depletion, and vacuole-tissue degeneration resulting from neurotoxicity. The use of chemotherapeutic agents such as doxorubicin has been implicated in the build-up of this imbalance between oxygen-reactive species and antioxidants. Therefore, it has become an area of research interest to seek antioxidant supplements that may offer neuroprotective effects. This study is aimed to evaluate the protective potential of chrysin on the pre-frontal cortex of male Wistar rats with doxorubicin-induced cognitive impairment.Thirty-five adult Wistar rats (180–200 g) were grouped into seven (1–7; n = 5). Group 1, the normal control, received normal saline treatment only throughout the study. Group 2 was administered with doxorubicin only for 21 days by intraperitoneal injection. Groups 3 and 4 were administered with chrysin in low and high doses for 21 days orally. Groups 5, 6 and 7 were exposed to doxorubicin and chrysin for 21 days intra-peritoneally and orally with low, medium and high doses, respectively.Anti-oxidative biomarkers analysed in Group 2 (doxorubicin-only) demonstrated a significant difference when compared to other groups. This corresponded to significant elevations in apoptotic indicators, inflammatory markers and histological lesions, which were indicative of cognitive impairment. 5, 7-dihydroxyflavone (chrysin) significantly mitigated and also reversed cognitive impairment caused by doxorubicin.The data showed that chrysin protected against doxorubicin-induced cognitive impairment. This effect is probably made possible by suppressing oxidative stress, inflammation and apoptosis.
人体内过多的自由基会使各个系统中的细胞失衡,并导致氧反应物的积累,即氧化应激。中枢神经系统也不能幸免于这些细胞和组织损伤。中枢神经系统的氧化应激可能是造成焦虑、空间记忆障碍、神经细胞耗竭和神经毒性导致的空泡组织变性的原因。多柔比星等化疗药物的使用与氧反应物和抗氧化剂之间的失衡有关。因此,寻找具有神经保护作用的抗氧化剂补充剂已成为一个研究热点。本研究旨在评估菊黄素对多柔比星诱发认知障碍的雄性 Wistar 大鼠前额叶皮层的保护潜力。35 只成年 Wistar 大鼠(180-200 克)被分为七组(1-7;n = 5)。第 1 组为正常对照组,在整个研究过程中只接受生理盐水治疗。第 2 组仅腹腔注射多柔比星 21 天。第 3 组和第 4 组分别口服低剂量和高剂量的金霉素 21 天。第 5 组、第 6 组和第 7 组分别腹腔注射和口服低、中、高剂量的多柔比星和金霉素 21 天。这与凋亡指标、炎症标志物和组织学病变的显著升高相对应,而这些都是认知障碍的表现。5,7-二羟基黄酮(金丝桃苷)能明显减轻和逆转多柔比星引起的认知障碍。这种作用可能是通过抑制氧化应激、炎症和细胞凋亡实现的。
{"title":"Unveiling the neuroprotective potential of chrysin on the pre-frontal cortex of adult male Wistar rats","authors":"Ifeanyi Anthony Egwuatu, C. Ozoemena, Fortune Kasiemobi Onuorah","doi":"10.25259/sajhs_15_2023","DOIUrl":"https://doi.org/10.25259/sajhs_15_2023","url":null,"abstract":"\u0000\u0000Excessive free radicals in the human body predispose cells within the various systems to an imbalance and accumulation of oxygen-reactive species, known as oxidative stress. The central nervous system is not spared when it comes to these cell and tissue damages. Oxidative stress on the central nervous system may be responsible for anxiety, spatial memory impairment, neuronal cell depletion, and vacuole-tissue degeneration resulting from neurotoxicity. The use of chemotherapeutic agents such as doxorubicin has been implicated in the build-up of this imbalance between oxygen-reactive species and antioxidants. Therefore, it has become an area of research interest to seek antioxidant supplements that may offer neuroprotective effects. This study is aimed to evaluate the protective potential of chrysin on the pre-frontal cortex of male Wistar rats with doxorubicin-induced cognitive impairment.\u0000\u0000\u0000\u0000Thirty-five adult Wistar rats (180–200 g) were grouped into seven (1–7; n = 5). Group 1, the normal control, received normal saline treatment only throughout the study. Group 2 was administered with doxorubicin only for 21 days by intraperitoneal injection. Groups 3 and 4 were administered with chrysin in low and high doses for 21 days orally. Groups 5, 6 and 7 were exposed to doxorubicin and chrysin for 21 days intra-peritoneally and orally with low, medium and high doses, respectively.\u0000\u0000\u0000\u0000Anti-oxidative biomarkers analysed in Group 2 (doxorubicin-only) demonstrated a significant difference when compared to other groups. This corresponded to significant elevations in apoptotic indicators, inflammatory markers and histological lesions, which were indicative of cognitive impairment. 5, 7-dihydroxyflavone (chrysin) significantly mitigated and also reversed cognitive impairment caused by doxorubicin.\u0000\u0000\u0000\u0000The data showed that chrysin protected against doxorubicin-induced cognitive impairment. This effect is probably made possible by suppressing oxidative stress, inflammation and apoptosis.\u0000","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":" 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140213330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphangioma circumscriptum – The “Frog Spawn” dermatosis 周身淋巴管瘤--"蛙卵 "皮肤病
Pub Date : 2024-03-22 DOI: 10.25259/sajhs_29_2023
V. Vijay, Yogindher Singh
{"title":"Lymphangioma circumscriptum – The “Frog Spawn” dermatosis","authors":"V. Vijay, Yogindher Singh","doi":"10.25259/sajhs_29_2023","DOIUrl":"https://doi.org/10.25259/sajhs_29_2023","url":null,"abstract":"","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140217455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the gut–brain axis on neurodegenerative diseases and potential benefits of probiotics 肠脑轴对神经退行性疾病的影响以及益生菌的潜在益处
Pub Date : 2024-03-22 DOI: 10.25259/sajhs_17_2023
S. Samanta, Saswati Parua Mondal
Gut microbiota are an essential community for human health. They produce different bioactive components and short-chain fatty acids for physiological benefits. Intestinal flora elicits an immune response and maintains a balance between inflammatory and anti-inflammatory cytokines during the inflammatory response. The intricate relationship between the activities of gut microbes and brain functions creates the gut–brain axis. Microbial metabolites of the gut reach the brain through blood and lymphatic circulation. The bioactive components from gut microorganisms regulate oxidative stress, cytokine profiles, neuroinflammation, apoptotic reactions and neurodegeneration. Dysbiosis alters the activity of gut microbiota, which causes gastrointestinal disorders, neurodegenerative diseases, metabolic syndrome and cancers. Probiotic bacteria (Lactobacillus spp., Bifidobacterium spp.) have different health promotional effects and exhibit a significant role in immunomodulation. These bacteria display some protective role against various diseases, including neurodegenerative disorders.
肠道微生物群是人类健康的重要群落。它们产生不同的生物活性成分和短链脂肪酸,具有生理益处。肠道菌群可引起免疫反应,并在炎症反应期间维持炎症细胞因子和抗炎细胞因子之间的平衡。肠道微生物的活动与大脑功能之间错综复杂的关系形成了肠道-大脑轴。肠道微生物代谢物通过血液和淋巴循环到达大脑。肠道微生物的生物活性成分可调节氧化应激、细胞因子谱、神经炎症、细胞凋亡反应和神经变性。菌群失调会改变肠道微生物群的活性,导致胃肠道疾病、神经退行性疾病、代谢综合征和癌症。益生菌(乳酸杆菌属、双歧杆菌属)具有不同的健康促进作用,并在免疫调节中发挥重要作用。这些细菌对包括神经退行性疾病在内的各种疾病具有一定的保护作用。
{"title":"Impact of the gut–brain axis on neurodegenerative diseases and potential benefits of probiotics","authors":"S. Samanta, Saswati Parua Mondal","doi":"10.25259/sajhs_17_2023","DOIUrl":"https://doi.org/10.25259/sajhs_17_2023","url":null,"abstract":"Gut microbiota are an essential community for human health. They produce different bioactive components and short-chain fatty acids for physiological benefits. Intestinal flora elicits an immune response and maintains a balance between inflammatory and anti-inflammatory cytokines during the inflammatory response. The intricate relationship between the activities of gut microbes and brain functions creates the gut–brain axis. Microbial metabolites of the gut reach the brain through blood and lymphatic circulation. The bioactive components from gut microorganisms regulate oxidative stress, cytokine profiles, neuroinflammation, apoptotic reactions and neurodegeneration. Dysbiosis alters the activity of gut microbiota, which causes gastrointestinal disorders, neurodegenerative diseases, metabolic syndrome and cancers. Probiotic bacteria (Lactobacillus spp., Bifidobacterium spp.) have different health promotional effects and exhibit a significant role in immunomodulation. These bacteria display some protective role against various diseases, including neurodegenerative disorders.","PeriodicalId":512351,"journal":{"name":"South Asian Journal of Health Sciences","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140217084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
South Asian Journal of Health Sciences
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1