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Developing Student Heuristic Characterizations to Help Them “Bond” with Organic Chemistry 开发学生启发式特征,帮助他们与有机化学 "结合"
Pub Date : 2024-03-01 DOI: 10.1525/abt.2024.86.3.167
Philip Mirkin
The volume of content and abstract nature of organic chemistry is challenging and potentially intimidating for students. I describe a strategy for facilitating student development of heuristic tools for engaging with the subject. By using experimental and researched data on carbon, oxygen, nitrogen, and hydrogen, the bulk chemical elements of organic chemistry, my students were encouraged to develop a “character reference” for each. The heuristics of characterization enabled them to relate more easily and engage more creatively with the work, including when working with complex organic molecules later on. I used this approach when teaching carbohydrates, alcohols, fats and proteins to 12- to 14-year-old students.
有机化学的内容繁多,性质抽象,对学生来说具有挑战性和潜在的恐吓性。我介绍了一种促进学生开发启发式工具的策略,以帮助他们更好地学习这门学科。通过使用有关碳、氧、氮和氢(有机化学的主要化学元素)的实验和研究数据,我鼓励学生为每种元素开发 "特征参考"。特征描述的启发式方法使他们能够更容易地与工作联系起来,更有创造性地参与工作,包括在以后处理复杂的有机分子时。在向 12 至 14 岁的学生讲授碳水化合物、醇、脂肪和蛋白质时,我采用了这种方法。
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引用次数: 0
The Master Builder 建筑大师
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.120
K. Milks, F. Cloud, Mark Terry
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引用次数: 0
Of Phylogenies and Tumors 关于系统发育和肿瘤
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.62
C. Babaian, Sudhir Kumar
When students think of evolution, they might imagine T. rex, or perhaps an abiotic scene of sizzling electrical storms and harsh reducing atmospheres, an Earth that looks like a lunar landscape. Natural selection automatically elicits responses that include “survival of the fittest,” and “descent with modification,” and with these historical biological catch phrases, one conjures up images of large animals battling it out on the Mesozoic plane. Rarely do teachers or students apply these same ideas to cancer and the evolution of somatic cells, which have accrued mutations and epigenetic imprinting and relentlessly survive and proliferate. Our questions in this paper include the following: Can cancer become an important teaching model for students to explore fundamental hypotheses about evolutionary process? Can the multi- step somatic cancer model encourage visualizations that enable students to revisit and reenter previous primary concepts in general biology such as the cell, mitosis, chromosomes, genetic diversity, ecological diversity, immune function, and of course evolution, continually integrating their biology knowledge into process and pattern knowledge? Can the somatic cancer model expose similar patterns and protagonists, linking Darwinian observations of the natural world to our body? And, can the cancer clone model excite critical thinking and student hypotheses about what cancer is as a biological process? Does this visually simple model assist students in recognizing patterns, connecting their biological curriculum dots into a more coherent learning experience? These biological dynamics and intercepting aptitudes of cells are amplified through the cancer model and can help shape the way biology students begin to appreciate the interrelatedness of all biological systems while they continue to explore pivotal points of biological fuzziness, such as the microbiome, limitations of models, and the complex coordination of genomic networks required for the function of even a single cell and the realization of phenotypes. In this paper we use clonal evolution of cancer as a model experience for students to recreate how a single, non-germline cell appears to shadow the classic pattern of natural selection in body cells that have gone awry. With authentic STEAM activities students can easily crossover and revisit previous biological topics and the ubiquitous nature of natural selection as seen in the example of somatic cells that result in a metastasizing tumor, giving students insight into natural selection’s accommodating and tractable patterns throughout the planet.
一提到进化,学生们可能会联想到霸王龙,或者是炙热的电风暴和严酷的还原大气层的非生物场景,或者是宛如月球景观的地球。自然选择会自动引起包括 "适者生存 "和 "后裔改良 "在内的反应,有了这些历史悠久的生物学术语,人们就会联想到大型动物在中生代平面上搏斗的画面。教师或学生很少将这些观点应用到癌症和体细胞的进化中,因为体细胞已经积累了突变和表观遗传印记,并在不断地生存和增殖。本文提出的问题如下:癌症能否成为学生探索进化过程基本假设的重要教学模型?多步骤体细胞癌症模型能否鼓励可视化,使学生能够重温和重新进入以前的普通生物学基本概念,如细胞、有丝分裂、染色体、遗传多样性、生态多样性、免疫功能,当然还有进化,不断将他们的生物学知识整合到过程和模式知识中?体细胞癌症模型能否揭示类似的模式和主角,将达尔文对自然界的观察与我们的身体联系起来?癌症克隆模型能否激发学生的批判性思维,让他们对癌症作为一种生物过程提出假设?这种视觉上简单的模型是否有助于学生识别模式,将他们的生物课程点连接成更连贯的学习体验?通过癌症模型,这些生物动态和细胞的截取能力被放大,并有助于塑造生物系学生开始理解所有生物系统相互关联性的方式,同时他们继续探索生物模糊性的关键点,如微生物群、模型的局限性以及即使是单个细胞的功能和表型的实现所需的基因组网络的复杂协调。在本文中,我们将癌症的克隆进化作为学生的示范体验,让他们再现单个非种系细胞是如何在出了问题的体细胞中出现自然选择的经典模式。通过真实的 STEAM 活动,学生可以很容易地交叉和重温以前的生物主题,以及从体细胞导致肿瘤转移的例子中看到的自然选择无处不在的性质,让学生深入了解自然选择在整个地球上的包容和可控模式。
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引用次数: 0
Considering Explanatory Diversity and Holistic Understanding of Biological Phenomena 考虑生物现象的解释多样性和整体理解
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.55
Ross H. Nehm
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引用次数: 0
Elephant Tusks and Natural Selection 象牙与自然选择
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.94
Aaron E. Kidd, Daniel J. De Jesús, Sarah V. Poor
Evolutionary theory is foundational to the life sciences because it unifies complex ecological principles and explains variation observed between and within species. Students at the secondary level often lack deep conceptual understanding of evolutionary theory, which is crucial to grasp topics related to primary drivers within populations such as inter- and intra-specific competition, predation, and reproductive success. Nonetheless, evolution remains a contentious topic in the United States. The prevalence of pseudoscientific belief among the U.S. populace warrants a calculated approach to deconstructing student misconceptions. This article puts forth an action-research-supported instructional strategy through which educators can identify and address core student misconceptions regarding evolutionary theory and other complex scientific phenomena, utilizing real-world and student-generated models to drive instruction.
进化理论是生命科学的基础,因为它统一了复杂的生态学原理,并解释了物种之间和物种内部的变异。中学阶段的学生往往对进化理论缺乏深刻的概念性理解,而进化理论对于掌握与种群内部主要驱动因素(如种群间和种群内竞争、捕食和繁殖成功)相关的主题至关重要。尽管如此,进化论在美国仍然是一个有争议的话题。伪科学信仰在美国民众中盛行,这就要求我们采取精心策划的方法来消除学生的误解。本文提出了一种以行动研究为支撑的教学策略,通过这种策略,教育工作者可以识别并解决学生对进化论和其他复杂科学现象的核心误解,利用现实世界和学生生成的模型来推动教学。
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引用次数: 0
A Tool to Teach Evolution of Protein Sequences and Structures 蛋白质序列和结构进化教学工具
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.108
Agnieszka Szarecka, Christopher Dobson
Computer modeling and protein structure visualization tools are effective and engaging ways of presenting various molecular biology concepts to high school and college students. Here, we describe a series of activities and exercises that use online bioinformatics databases and programs to search for and obtain protein sequence and structure data and use it to build homology models of proteins. Exercises in homology modeling can serve the pedagogical purpose of introducing and illustrating the concept of homology within gene and protein families, which results in conservation of the 3D structures of proteins and allows us to predict structures when experimental data are not available.
计算机建模和蛋白质结构可视化工具是向高中生和大学生介绍各种分子生物学概念的有效且引人入胜的方法。在此,我们介绍了一系列利用在线生物信息学数据库和程序搜索和获取蛋白质序列和结构数据,并利用这些数据建立蛋白质同源模型的活动和练习。同源建模练习的教学目的是介绍和说明基因和蛋白质家族内同源的概念,这导致蛋白质三维结构的保持,并使我们能够在没有实验数据的情况下预测结构。
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引用次数: 0
Considering Explanatory Diversity and Holistic Understanding of Biological Phenomena 考虑生物现象的解释多样性和整体理解
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.55
Ross H. Nehm
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引用次数: 0
The Master Builder 建筑大师
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.120
K. Milks, F. Cloud, Mark Terry
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引用次数: 0
Reconciling Evolution 协调进化
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.117
Jeffrey D. Sack, Daniel G. Ferguson
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引用次数: 0
A Comparison of Measured Outcomes across Tree-Thinking Interventions 不同树思维干预措施的测量结果比较
Pub Date : 2024-02-01 DOI: 10.1525/abt.2024.86.2.71
Kristy L Daniel, Daniel Ferguson, E. A. Leone, C. Bucklin
Phylogenetic tree diagrams are commonly found in introductory biology curricula and represent the evolutionary relationships of organisms. Tree-thinking, or the ability to accurately interpret, use, and generate these phylogenetic representations, involves a challenging set of skills for students to learn. Although many introductory biology courses incorporate tree-thinking instruction, few studies have identified which instructional methods provide the best learning gains for students. We gathered data from 884 introductory biology students using the Basic Evolutionary Tree-Thinking Skills Inventory (BETTSI) to measure tree-thinking learning gains. We measured tree-thinking differences across five sections of introductory biology, each offering a different instructional intervention, and compared differences among STEM majors and non-STEM majors. After calculating paired differences, we performed a two-way repeated measure analysis of variance (ANOVA) and Scheffe’s post hoc test to identify significant differences among and between the different interventions. We found that students who engaged in active tree-thinking instruction had significantly higher tree-thinking learning gains than students who participated in passive or no instruction. Furthermore, these learning gains became even more significant as active-learning became more multifaceted. These active-learning approaches also removed knowledge gaps between STEM majors and non-majors. Instructors must select explicit and active pedagogical approaches to support student tree-thinking to accomplish positive learning gains for all students.
系统发生树图通常出现在生物入门课程中,表示生物的进化关系。树状思维,或者说准确解释、使用和生成这些系统发生图的能力,对学生来说是一系列具有挑战性的技能。尽管许多生物入门课程都包含了 "树状思维 "教学,但很少有研究能确定哪种教学方法能让学生获得最佳学习效果。我们收集了 884 名生物入门学生的数据,使用 "基本进化树木思维技能量表"(BETTSI)来测量树木思维的学习效果。我们测量了生物入门课程五个部分的树木思考差异,每个部分都提供了不同的教学干预,并比较了 STEM 专业和非 STEM 专业之间的差异。计算配对差异后,我们进行了双向重复测量方差分析(ANOVA)和Scheffe事后检验,以确定不同干预措施之间的显著差异。我们发现,主动参与 "树木思考 "教学的学生的 "树木思考 "学习收获明显高于被动参与或未参与教学的学生。此外,随着主动学习变得更加多元,这些学习收获也变得更加显著。这些主动学习方法还消除了 STEM 专业和非专业学生之间的知识差距。教师必须选择明确和积极的教学方法来支持学生的树状思维,以实现所有学生的积极学习收获。
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引用次数: 0
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The American Biology Teacher
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