Pub Date : 2024-06-01DOI: 10.1024/1662-9647/a000339
D. De Leo, Jana Nikitin, Johannes Pantel, Marco Trabucchi
{"title":"Greetings from the New Editorial Team","authors":"D. De Leo, Jana Nikitin, Johannes Pantel, Marco Trabucchi","doi":"10.1024/1662-9647/a000339","DOIUrl":"https://doi.org/10.1024/1662-9647/a000339","url":null,"abstract":"","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"81 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-22DOI: 10.1024/1662-9647/a000338
B. Levy, S. Viali, T. Naseri, M. Reupena, Kima Faasalele-Savusa, Vaimoana Filipo, Erin E. Kershaw, Yuan Huang, Martin D. Slade
Abstract: We examined whether the A allele of CREBRF rs373863828, which is common in Samoans but rare in non-Pacific Islanders, predicts better cognition. Samoan interviewers interviewed participants who were 60 years and older, lived in the Independent State of Samoa, and had four Samoan grandparents. The AA genotype significantly predicted older Samoans’ better subjective and objective cognition; it also contributed 5.9 times more than APOE to subjective cognition and 12.3 times more than APOE to objective cognition, in effect-size analyses. Since CREBRF operates in the universal CREB system, the findings could inform general aging-cognition resilience.
{"title":"Advantage in Aging Cognition Associated with the CREBRF variant rs373863828 Among Samoans","authors":"B. Levy, S. Viali, T. Naseri, M. Reupena, Kima Faasalele-Savusa, Vaimoana Filipo, Erin E. Kershaw, Yuan Huang, Martin D. Slade","doi":"10.1024/1662-9647/a000338","DOIUrl":"https://doi.org/10.1024/1662-9647/a000338","url":null,"abstract":"Abstract: We examined whether the A allele of CREBRF rs373863828, which is common in Samoans but rare in non-Pacific Islanders, predicts better cognition. Samoan interviewers interviewed participants who were 60 years and older, lived in the Independent State of Samoa, and had four Samoan grandparents. The AA genotype significantly predicted older Samoans’ better subjective and objective cognition; it also contributed 5.9 times more than APOE to subjective cognition and 12.3 times more than APOE to objective cognition, in effect-size analyses. Since CREBRF operates in the universal CREB system, the findings could inform general aging-cognition resilience.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"83 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141111693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.1024/1662-9647/a000334
Karen L. Siedlecki, Veronika Kobrinsky, Elissa Aminoff
Abstract: Research has demonstrated associations between subjective age (i.e., the age that one feels) and cognitive performance, although the mechanisms underlying this relationship remain understudied. The current study examined the predictive validity of subjective age on objective and subjective cognition as well as depressive symptoms and self-rated health (SRH) as statistical mediators. We used secondary data analysis comprising the cross-sectional data of 247 adults (ages 50+) to conduct a series of hierarchical linear regressions and mediation analyses. Older subjective age was significantly associated with lower ratings of measures of subjective cognition, and depressive symptoms and SRH partially mediated these relationships. The malleability of depressive symptoms and SRH provide promising directions for future research aimed at enhancing or maintaining cognition in older adults.
{"title":"Examining Mediators of the Relationship Between Subjective Age and Cognition","authors":"Karen L. Siedlecki, Veronika Kobrinsky, Elissa Aminoff","doi":"10.1024/1662-9647/a000334","DOIUrl":"https://doi.org/10.1024/1662-9647/a000334","url":null,"abstract":"Abstract: Research has demonstrated associations between subjective age (i.e., the age that one feels) and cognitive performance, although the mechanisms underlying this relationship remain understudied. The current study examined the predictive validity of subjective age on objective and subjective cognition as well as depressive symptoms and self-rated health (SRH) as statistical mediators. We used secondary data analysis comprising the cross-sectional data of 247 adults (ages 50+) to conduct a series of hierarchical linear regressions and mediation analyses. Older subjective age was significantly associated with lower ratings of measures of subjective cognition, and depressive symptoms and SRH partially mediated these relationships. The malleability of depressive symptoms and SRH provide promising directions for future research aimed at enhancing or maintaining cognition in older adults.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"105 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-16DOI: 10.1024/1662-9647/a000333
Dovrat Harel
Abstract: This case study examines a therapeutic puppetry project conducted by a drama therapist in a dementia unit at a daycare center in Israel. Three people with dementia and three drama-therapy students participated. The intervention included three genres of puppetry. A qualitative case study was conducted following the project. The students’ and the therapist’s records and the photos of the puppetry were analyzed according to the case study design. Four themes were generated: (1) Puppetry encourages the flow of creativity; (2) puppetry encourages self-expression and authenticity; (3) puppetry supports memory and the sequence of the therapeutic process; (4) puppetry leads to a transformation of the inner experience. The findings point to the contribution of the project for people with dementia.
{"title":"Therapeutic Puppetry as a Drama-Therapy Intervention for People Living with Dementia","authors":"Dovrat Harel","doi":"10.1024/1662-9647/a000333","DOIUrl":"https://doi.org/10.1024/1662-9647/a000333","url":null,"abstract":"Abstract: This case study examines a therapeutic puppetry project conducted by a drama therapist in a dementia unit at a daycare center in Israel. Three people with dementia and three drama-therapy students participated. The intervention included three genres of puppetry. A qualitative case study was conducted following the project. The students’ and the therapist’s records and the photos of the puppetry were analyzed according to the case study design. Four themes were generated: (1) Puppetry encourages the flow of creativity; (2) puppetry encourages self-expression and authenticity; (3) puppetry supports memory and the sequence of the therapeutic process; (4) puppetry leads to a transformation of the inner experience. The findings point to the contribution of the project for people with dementia.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"17 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139960739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.1024/1662-9647/a000332
Jeremia Heinik
Abstract: We examined (1) the relationship between actual intelligence and the CAMCOG-R performance in cognitively normal elders and (2) the presumed impact of age and education on the relationship. Our retrospective study of 94 participants assessed in a specialized setting, measuring actual intelligence (general and specific) with the Wechsler Adult Intelligence Scale-III, the Full-Scale Intelligence Quotient (WAIS-III FSIQ), and the specific subtests thereof. The CAMCOG-R correlated largely with FSIQ (.629, p < .001; .708 when controlled for age). The CAMCOG-R’s scores increased across three different IQ levels as IQ increased. FSIQ accounted for 40% of the CAMCOG-R’s variability. Combined, FSIQ and age accounted for 59% of the CAMCOG-R’s variability. FSIQ had a stronger weight than age (β: .644 and −.439, respectively). Regression analyses with FSIQ’s subtests, age and education, found the best-equilibrated model to include Information, age, and Picture Completion. Combined, they accounted for 55% of the CAMCOG-R’s variability. Information received the strongest weight (β: .411). Overall, education was nonsignificant. Thus, a significant relationship existed primarily between general intelligence and the CAMCOG-R and, to a lesser extent, between the above-mentioned subtests of intelligence and the CAMCOG-R. Adding age increased the prediction rate. Actual intelligence and age should be considered when interpreting the CAMCOG-R’s scores. The practical implementation of the intelligence factor is complex.
{"title":"Relationship Between Actual Intelligence & the CAMCOG-R in Cognitively Normal Elders","authors":"Jeremia Heinik","doi":"10.1024/1662-9647/a000332","DOIUrl":"https://doi.org/10.1024/1662-9647/a000332","url":null,"abstract":"Abstract: We examined (1) the relationship between actual intelligence and the CAMCOG-R performance in cognitively normal elders and (2) the presumed impact of age and education on the relationship. Our retrospective study of 94 participants assessed in a specialized setting, measuring actual intelligence (general and specific) with the Wechsler Adult Intelligence Scale-III, the Full-Scale Intelligence Quotient (WAIS-III FSIQ), and the specific subtests thereof. The CAMCOG-R correlated largely with FSIQ (.629, p < .001; .708 when controlled for age). The CAMCOG-R’s scores increased across three different IQ levels as IQ increased. FSIQ accounted for 40% of the CAMCOG-R’s variability. Combined, FSIQ and age accounted for 59% of the CAMCOG-R’s variability. FSIQ had a stronger weight than age (β: .644 and −.439, respectively). Regression analyses with FSIQ’s subtests, age and education, found the best-equilibrated model to include Information, age, and Picture Completion. Combined, they accounted for 55% of the CAMCOG-R’s variability. Information received the strongest weight (β: .411). Overall, education was nonsignificant. Thus, a significant relationship existed primarily between general intelligence and the CAMCOG-R and, to a lesser extent, between the above-mentioned subtests of intelligence and the CAMCOG-R. Adding age increased the prediction rate. Actual intelligence and age should be considered when interpreting the CAMCOG-R’s scores. The practical implementation of the intelligence factor is complex.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139774447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.1024/1662-9647/a000332
Jeremia Heinik
Abstract: We examined (1) the relationship between actual intelligence and the CAMCOG-R performance in cognitively normal elders and (2) the presumed impact of age and education on the relationship. Our retrospective study of 94 participants assessed in a specialized setting, measuring actual intelligence (general and specific) with the Wechsler Adult Intelligence Scale-III, the Full-Scale Intelligence Quotient (WAIS-III FSIQ), and the specific subtests thereof. The CAMCOG-R correlated largely with FSIQ (.629, p < .001; .708 when controlled for age). The CAMCOG-R’s scores increased across three different IQ levels as IQ increased. FSIQ accounted for 40% of the CAMCOG-R’s variability. Combined, FSIQ and age accounted for 59% of the CAMCOG-R’s variability. FSIQ had a stronger weight than age (β: .644 and −.439, respectively). Regression analyses with FSIQ’s subtests, age and education, found the best-equilibrated model to include Information, age, and Picture Completion. Combined, they accounted for 55% of the CAMCOG-R’s variability. Information received the strongest weight (β: .411). Overall, education was nonsignificant. Thus, a significant relationship existed primarily between general intelligence and the CAMCOG-R and, to a lesser extent, between the above-mentioned subtests of intelligence and the CAMCOG-R. Adding age increased the prediction rate. Actual intelligence and age should be considered when interpreting the CAMCOG-R’s scores. The practical implementation of the intelligence factor is complex.
{"title":"Relationship Between Actual Intelligence & the CAMCOG-R in Cognitively Normal Elders","authors":"Jeremia Heinik","doi":"10.1024/1662-9647/a000332","DOIUrl":"https://doi.org/10.1024/1662-9647/a000332","url":null,"abstract":"Abstract: We examined (1) the relationship between actual intelligence and the CAMCOG-R performance in cognitively normal elders and (2) the presumed impact of age and education on the relationship. Our retrospective study of 94 participants assessed in a specialized setting, measuring actual intelligence (general and specific) with the Wechsler Adult Intelligence Scale-III, the Full-Scale Intelligence Quotient (WAIS-III FSIQ), and the specific subtests thereof. The CAMCOG-R correlated largely with FSIQ (.629, p < .001; .708 when controlled for age). The CAMCOG-R’s scores increased across three different IQ levels as IQ increased. FSIQ accounted for 40% of the CAMCOG-R’s variability. Combined, FSIQ and age accounted for 59% of the CAMCOG-R’s variability. FSIQ had a stronger weight than age (β: .644 and −.439, respectively). Regression analyses with FSIQ’s subtests, age and education, found the best-equilibrated model to include Information, age, and Picture Completion. Combined, they accounted for 55% of the CAMCOG-R’s variability. Information received the strongest weight (β: .411). Overall, education was nonsignificant. Thus, a significant relationship existed primarily between general intelligence and the CAMCOG-R and, to a lesser extent, between the above-mentioned subtests of intelligence and the CAMCOG-R. Adding age increased the prediction rate. Actual intelligence and age should be considered when interpreting the CAMCOG-R’s scores. The practical implementation of the intelligence factor is complex.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"429 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.1024/1662-9647/a000335
S. Ahmadboukani, Mohammad Rostami, Mahshid Foroughan, Azad Hemmati
Abstract: This psychometric study examined the psychometric characteristics of the shortened version of the Persian-Reasons for Living Inventory for Older Adults (the shortened P-RFL-OA) in a sample of 293 clinical and nonclinical community-dwelling older adults living in Sanandaj, Iran in 2023. We collected the data using the shortened P-RFL-OA Scale, the Beck Scale for Suicidal Ideation (BSSI), the Life Satisfaction Index (LSI-Z), the Geriatric Depression Scale (GDS), and the Short Form Health Survey (SF-12). Overall, the shortened P-RFL-OA has acceptable psychometric properties in terms of test-retest reliability, convergent validity with depression and suicidal ideation, and divergent validity with life satisfaction and quality of life. The findings of the present study confirmed that the shortened P-RFL-OA has acceptable psychometric properties for older adults.
摘要：本心理测量研究以 2023 年居住在伊朗萨南达季的 293 名临床和非临床社区老年人为样本，研究了波斯语-老年人生活原因量表（Persian-Reasons for Living Inventory for Older Adults，简称 P-RFL-OA）缩短版的心理测量特征。我们使用缩短版 P-RFL-OA 量表、贝克自杀意念量表 (BSSI)、生活满意度指数 (LSI-Z)、老年抑郁量表 (GDS) 和简表健康调查 (SF-12) 收集数据。总体而言，缩短的 P-RFL-OA 在测验重复信度、与抑郁和自杀意念的聚合效度以及与生活满意度和生活质量的发散效度方面具有可接受的心理测量学特性。本研究的结果证实，缩短的 P-RFL-OA 对老年人具有可接受的心理测量特性。
{"title":"A Shortened Version of the Reasons for Living Inventory for Older Iranian Adults","authors":"S. Ahmadboukani, Mohammad Rostami, Mahshid Foroughan, Azad Hemmati","doi":"10.1024/1662-9647/a000335","DOIUrl":"https://doi.org/10.1024/1662-9647/a000335","url":null,"abstract":"Abstract: This psychometric study examined the psychometric characteristics of the shortened version of the Persian-Reasons for Living Inventory for Older Adults (the shortened P-RFL-OA) in a sample of 293 clinical and nonclinical community-dwelling older adults living in Sanandaj, Iran in 2023. We collected the data using the shortened P-RFL-OA Scale, the Beck Scale for Suicidal Ideation (BSSI), the Life Satisfaction Index (LSI-Z), the Geriatric Depression Scale (GDS), and the Short Form Health Survey (SF-12). Overall, the shortened P-RFL-OA has acceptable psychometric properties in terms of test-retest reliability, convergent validity with depression and suicidal ideation, and divergent validity with life satisfaction and quality of life. The findings of the present study confirmed that the shortened P-RFL-OA has acceptable psychometric properties for older adults.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"58 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139775292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.1024/1662-9647/a000335
S. Ahmadboukani, Mohammad Rostami, Mahshid Foroughan, Azad Hemmati
Abstract: This psychometric study examined the psychometric characteristics of the shortened version of the Persian-Reasons for Living Inventory for Older Adults (the shortened P-RFL-OA) in a sample of 293 clinical and nonclinical community-dwelling older adults living in Sanandaj, Iran in 2023. We collected the data using the shortened P-RFL-OA Scale, the Beck Scale for Suicidal Ideation (BSSI), the Life Satisfaction Index (LSI-Z), the Geriatric Depression Scale (GDS), and the Short Form Health Survey (SF-12). Overall, the shortened P-RFL-OA has acceptable psychometric properties in terms of test-retest reliability, convergent validity with depression and suicidal ideation, and divergent validity with life satisfaction and quality of life. The findings of the present study confirmed that the shortened P-RFL-OA has acceptable psychometric properties for older adults.
摘要：本心理测量研究以 2023 年居住在伊朗萨南达季的 293 名临床和非临床社区老年人为样本，研究了波斯语-老年人生活原因量表（Persian-Reasons for Living Inventory for Older Adults，简称 P-RFL-OA）缩短版的心理测量特征。我们使用缩短版 P-RFL-OA 量表、贝克自杀意念量表 (BSSI)、生活满意度指数 (LSI-Z)、老年抑郁量表 (GDS) 和简表健康调查 (SF-12) 收集数据。总体而言，缩短的 P-RFL-OA 在测验重复信度、与抑郁和自杀意念的聚合效度以及与生活满意度和生活质量的发散效度方面具有可接受的心理测量学特性。本研究的结果证实，缩短的 P-RFL-OA 对老年人具有可接受的心理测量特性。
{"title":"A Shortened Version of the Reasons for Living Inventory for Older Iranian Adults","authors":"S. Ahmadboukani, Mohammad Rostami, Mahshid Foroughan, Azad Hemmati","doi":"10.1024/1662-9647/a000335","DOIUrl":"https://doi.org/10.1024/1662-9647/a000335","url":null,"abstract":"Abstract: This psychometric study examined the psychometric characteristics of the shortened version of the Persian-Reasons for Living Inventory for Older Adults (the shortened P-RFL-OA) in a sample of 293 clinical and nonclinical community-dwelling older adults living in Sanandaj, Iran in 2023. We collected the data using the shortened P-RFL-OA Scale, the Beck Scale for Suicidal Ideation (BSSI), the Life Satisfaction Index (LSI-Z), the Geriatric Depression Scale (GDS), and the Short Form Health Survey (SF-12). Overall, the shortened P-RFL-OA has acceptable psychometric properties in terms of test-retest reliability, convergent validity with depression and suicidal ideation, and divergent validity with life satisfaction and quality of life. The findings of the present study confirmed that the shortened P-RFL-OA has acceptable psychometric properties for older adults.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"534 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139834851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.1024/1662-9647/a000328
J. Regala, Pedro Costa, Rafael Costa, João Reis
Abstract: This article characterizes the clinical differences between bipolar disorder (BD) subtypes in 44 early-onset (EOBD), 32 late-onset (LOBD), and 30 very-late-onset (VLOBD) disorders. We considered vascular mania in five LOBD and 17 VLOBD, with an association with right-sided lesions for VLOBD. Other nonvascular-related brain injuries preceded the emergence of mania: traumatic brain injury (one LOBD, two VLOBD), epilepsy/brain tumor (one LOBD), multiple sclerosis (one LOBD), and HIV-encephalopathy/cerebral toxoplasmosis (two VLOBD). No secondary mania was identified in 21.4% of the VLOBD and 64% of the LOBDd, corresponding to presumptive idiopathic/primary BD. A transdiagnostic conversion within the affective disorder spectrum occurred in 50% of the VLOBD, 30.8% of the LOBD, and 20.5% of the EOBD across the lifespan. An interplay between genetics and age-specific processes may underlie the neurobiological underpinnings of late-life-onset idiopathic/primary BD.
{"title":"Late-Life Bipolar Disorder Subtypes According to Age Onset","authors":"J. Regala, Pedro Costa, Rafael Costa, João Reis","doi":"10.1024/1662-9647/a000328","DOIUrl":"https://doi.org/10.1024/1662-9647/a000328","url":null,"abstract":"Abstract: This article characterizes the clinical differences between bipolar disorder (BD) subtypes in 44 early-onset (EOBD), 32 late-onset (LOBD), and 30 very-late-onset (VLOBD) disorders. We considered vascular mania in five LOBD and 17 VLOBD, with an association with right-sided lesions for VLOBD. Other nonvascular-related brain injuries preceded the emergence of mania: traumatic brain injury (one LOBD, two VLOBD), epilepsy/brain tumor (one LOBD), multiple sclerosis (one LOBD), and HIV-encephalopathy/cerebral toxoplasmosis (two VLOBD). No secondary mania was identified in 21.4% of the VLOBD and 64% of the LOBDd, corresponding to presumptive idiopathic/primary BD. A transdiagnostic conversion within the affective disorder spectrum occurred in 50% of the VLOBD, 30.8% of the LOBD, and 20.5% of the EOBD across the lifespan. An interplay between genetics and age-specific processes may underlie the neurobiological underpinnings of late-life-onset idiopathic/primary BD.","PeriodicalId":513271,"journal":{"name":"GeroPsych","volume":"58 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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