Pub Date : 2025-12-20DOI: 10.1186/s12963-025-00441-6
Tallys Feldens, Chiara Seghieri, Andrea Fontana, Paolo Berta
Background: Social capital, in its broad definitions, has been linked to improved health outcomes, yet the scarce consistency of social capital measurements and its further effects on healthcare utilization remain less clear. Particularly in Italy, where regional disparities and an aging population challenge the healthcare system, understanding these dynamics is crucial. This study proposes two population-based indicators of social capital and investigates whether they influence health itself and healthcare utilization.
Method: Italian population data from 2014 to 2023 was used to develop two social capital measurements: Social support and Social participation, applying Item Response Theory (IRT). Hence, we applied structural equation modeling (SEM) to explore the pathways between social capital, self-reported health status, and healthcare utilization. The analysis includes control variables for demographic and behavioral factors.
Results: Our main findings contribute with the current literature by identifying that population-based measures for social support and social participation may be useful for empirical research, and both direct and indirect effects of social constructs were found significantly associated with health and health utilization outcomes. Both social participation and social support were found to exert significant positive effects on self-perceived health and health utilization. The model suggests that while better social connections contribute to improved health, such increased support and participation can also lead to increased healthcare-seeking behavior.
Conclusion: Social capital plays a dual role in shaping both health outcomes and healthcare utilization in Italy. Our findings highlight the relevance of social resources as population-level determinants of health and access, suggesting that strengthening community networks and health literacy can reduce inequities and enhance the efficiency of healthcare systems.
{"title":"Mediating effects between social capital and health care utilization in Italy-a structural equation model analysis.","authors":"Tallys Feldens, Chiara Seghieri, Andrea Fontana, Paolo Berta","doi":"10.1186/s12963-025-00441-6","DOIUrl":"10.1186/s12963-025-00441-6","url":null,"abstract":"<p><strong>Background: </strong>Social capital, in its broad definitions, has been linked to improved health outcomes, yet the scarce consistency of social capital measurements and its further effects on healthcare utilization remain less clear. Particularly in Italy, where regional disparities and an aging population challenge the healthcare system, understanding these dynamics is crucial. This study proposes two population-based indicators of social capital and investigates whether they influence health itself and healthcare utilization.</p><p><strong>Method: </strong>Italian population data from 2014 to 2023 was used to develop two social capital measurements: Social support and Social participation, applying Item Response Theory (IRT). Hence, we applied structural equation modeling (SEM) to explore the pathways between social capital, self-reported health status, and healthcare utilization. The analysis includes control variables for demographic and behavioral factors.</p><p><strong>Results: </strong>Our main findings contribute with the current literature by identifying that population-based measures for social support and social participation may be useful for empirical research, and both direct and indirect effects of social constructs were found significantly associated with health and health utilization outcomes. Both social participation and social support were found to exert significant positive effects on self-perceived health and health utilization. The model suggests that while better social connections contribute to improved health, such increased support and participation can also lead to increased healthcare-seeking behavior.</p><p><strong>Conclusion: </strong>Social capital plays a dual role in shaping both health outcomes and healthcare utilization in Italy. Our findings highlight the relevance of social resources as population-level determinants of health and access, suggesting that strengthening community networks and health literacy can reduce inequities and enhance the efficiency of healthcare systems.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":" ","pages":"75"},"PeriodicalIF":2.5,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12750791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1186/s12963-025-00439-0
Jonathan M Samet
{"title":"Reflections from a departing editor-in-chief.","authors":"Jonathan M Samet","doi":"10.1186/s12963-025-00439-0","DOIUrl":"10.1186/s12963-025-00439-0","url":null,"abstract":"","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":"23 1","pages":"74"},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1186/s12963-025-00443-4
Takashi Oshio, Ruru Ping, Ayako Honda
Background: Japan has experienced widening income disparity in recent years, raising concerns about income inequality in health. This study aims to investigate trends in income-related concentration and inequality in key health outcomes between 2001 and 2022.
Methods: This study utilized repeated cross-sectional data from 500,580 individuals (238,746 men and 261,834 women) aged ≥ 6 years, obtained from eight waves of population-based national surveys conducted between 2001 and 2022. The study examined trends in the concentration index and the relative and slope indices of inequality for key health outcomes, including self-rated health, subjective symptoms, limitations in undertaking activities of daily living, and experience of stress/anxiety, as well as the number of physician visits and incidence of selected non-communicable diseases (NCDs). All measures were standardized by age and sex.
Results: Increasing concentrations of poor health status among low-income individuals and rising income-related health inequality were observed over the study period, although a greater pro-poor concentration was noted for physician visits. Additionally, income-related inequality increased for persons with hypertension, diabetes, and at least one type of NCD.
Conclusions: The results indicate persistent income-related inequalities in health within a context of universal health coverage.
{"title":"Trends in income-related concentration and inequality in health in Japan: evidence from population-based National surveys from 2001 to 2022.","authors":"Takashi Oshio, Ruru Ping, Ayako Honda","doi":"10.1186/s12963-025-00443-4","DOIUrl":"10.1186/s12963-025-00443-4","url":null,"abstract":"<p><strong>Background: </strong>Japan has experienced widening income disparity in recent years, raising concerns about income inequality in health. This study aims to investigate trends in income-related concentration and inequality in key health outcomes between 2001 and 2022.</p><p><strong>Methods: </strong>This study utilized repeated cross-sectional data from 500,580 individuals (238,746 men and 261,834 women) aged ≥ 6 years, obtained from eight waves of population-based national surveys conducted between 2001 and 2022. The study examined trends in the concentration index and the relative and slope indices of inequality for key health outcomes, including self-rated health, subjective symptoms, limitations in undertaking activities of daily living, and experience of stress/anxiety, as well as the number of physician visits and incidence of selected non-communicable diseases (NCDs). All measures were standardized by age and sex.</p><p><strong>Results: </strong>Increasing concentrations of poor health status among low-income individuals and rising income-related health inequality were observed over the study period, although a greater pro-poor concentration was noted for physician visits. Additionally, income-related inequality increased for persons with hypertension, diabetes, and at least one type of NCD.</p><p><strong>Conclusions: </strong>The results indicate persistent income-related inequalities in health within a context of universal health coverage.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":" ","pages":"6"},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-14DOI: 10.1186/s12963-025-00442-5
Jayra Usmany, Dennis G Barten, Krzysztof Goniewicz, Fredrik Granholm, Danielle N Poole, Derrick Tin, Frits H M van Osch
Background: The Geneva Conventions form the core of International Humanitarian Law (IHL), safeguarding healthcare and protecting civilians from the brutality of war. Unfortunately, these conventions are often disregarded. Attacks on healthcare have devastating effects on healthcare systems, and it is therefore vital to document such attacks and detect possible temporal patterns. This study aims to assess temporal trends in attacks on healthcare in five conflict-affected countries: Lebanon, Myanmar, occupied Palestinian territory (oPt), Sudan and Ukraine.
Methods: This study used two publicly available databases: the World Health Organization Surveillance System for Attacks on Health Care (WHO SSA) and the Insecurity Insight Safeguarding Health in Conflict Coalition (SHCC). Start dates and key events were determined for each conflict based on grey literature searches. From the start dates onward, data on attacks on healthcare were collected. The data collection ended on December 31, 2024. Statistical analysis entailed chi-square tests for temporal trends.
Results: The WHO SSA and SHCC database reported a total of 4,289 and 5,454 attacks, respectively, in the five investigated conflict-affected countries. For all conflict-affected countries except Lebanon, there were significant differences between the databases regarding the reported number of attacks. Temporal trend analyses revealed that, in Myanmar, oPt, Sudan and Ukraine, the highest number of attacks occurred during the 0-2 month period. In Lebanon, the highest number of attacks was observed in the 9-11-month period. All peaks in the number of attacks were associated with either the immediate or early phase of the conflict or with major conflict escalations.
Conclusions: Temporal trend analyses of five ongoing armed conflicts revealed that spikes in attacks on healthcare were either associated with the immediate or early phases of the conflict or with major conflict escalations. Although major differences exist between the WHO SSA and SHCC database, particularly regarding the reported number of attacks, the observed patterns were largely similar.
{"title":"Attacks on healthcare in conflict-affected countries: a comparison of temporal trends in ongoing conflicts in Lebanon, Myanmar, occupied Palestinian territory, Sudan and Ukraine using WHO SSA and SHCC data, 2018-2024.","authors":"Jayra Usmany, Dennis G Barten, Krzysztof Goniewicz, Fredrik Granholm, Danielle N Poole, Derrick Tin, Frits H M van Osch","doi":"10.1186/s12963-025-00442-5","DOIUrl":"10.1186/s12963-025-00442-5","url":null,"abstract":"<p><strong>Background: </strong>The Geneva Conventions form the core of International Humanitarian Law (IHL), safeguarding healthcare and protecting civilians from the brutality of war. Unfortunately, these conventions are often disregarded. Attacks on healthcare have devastating effects on healthcare systems, and it is therefore vital to document such attacks and detect possible temporal patterns. This study aims to assess temporal trends in attacks on healthcare in five conflict-affected countries: Lebanon, Myanmar, occupied Palestinian territory (oPt), Sudan and Ukraine.</p><p><strong>Methods: </strong>This study used two publicly available databases: the World Health Organization Surveillance System for Attacks on Health Care (WHO SSA) and the Insecurity Insight Safeguarding Health in Conflict Coalition (SHCC). Start dates and key events were determined for each conflict based on grey literature searches. From the start dates onward, data on attacks on healthcare were collected. The data collection ended on December 31, 2024. Statistical analysis entailed chi-square tests for temporal trends.</p><p><strong>Results: </strong>The WHO SSA and SHCC database reported a total of 4,289 and 5,454 attacks, respectively, in the five investigated conflict-affected countries. For all conflict-affected countries except Lebanon, there were significant differences between the databases regarding the reported number of attacks. Temporal trend analyses revealed that, in Myanmar, oPt, Sudan and Ukraine, the highest number of attacks occurred during the 0-2 month period. In Lebanon, the highest number of attacks was observed in the 9-11-month period. All peaks in the number of attacks were associated with either the immediate or early phase of the conflict or with major conflict escalations.</p><p><strong>Conclusions: </strong>Temporal trend analyses of five ongoing armed conflicts revealed that spikes in attacks on healthcare were either associated with the immediate or early phases of the conflict or with major conflict escalations. Although major differences exist between the WHO SSA and SHCC database, particularly regarding the reported number of attacks, the observed patterns were largely similar.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":" ","pages":"5"},"PeriodicalIF":2.5,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12822187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1186/s12963-025-00438-1
Hervé Bassinga, Alexandra Tebkieta Tapsoba, Bruno Yempabou Lankoandé, Nabié Douba, Mamadou Soura, Roch Modeste Millogo, Yacouba Compaoré, Soumaïla Ouedraogo, Daniel Mwanga
Background: Since 2015, recurrent terrorist attacks in Burkina Faso have caused large-scale displacement, impacting the psychological health of affected populations. This study explores the effects of migration forced or voluntary on depression and anxiety among adolescents and young people aged 15-24, in line with SDG 3, which aims to "ensure healthy lives and promote well-being for all at all ages".
Methods: The analysis is based on data from the baseline survey conducted by the Institut Supérieur des Sciences de la Population (ISSP) for the Sahel Resilience Building Program. A total of 1,911 adolescents and young people aged 15-24 living in four regions were interviewed. We measured mental health using two tools: the Patient Health Questionnaire-9 (PHQ-9) for depression and the Generalised Anxiety Disorder-7 (GAD-7) for anxiety. We used multinomial regressions to test the effects of migration status on depression and anxiety.
Findings: Forced migrants report higher symptoms of moderate or severe depression (11.1%) and anxiety (15.7%) compared to non-forced migrants (6.8% and 14.4%) and non-migrants (6.6% and 9.5%). Forced migrants were 2.16 times more likely (RRR = 2.16; p < 5%) than non-migrants to experience moderate or severe depression, and non-forced migrants were 2.12 times more likely (RRR = 2.12; p < 5%) than non-migrants to experience moderate or severe anxiety. Youth aged 20-24 and urban residents were also more likely to face these mental health issues.
Contributions: These findings call for more attention to the needs of both forced and non-forced migrants in terms of mental health. Psychological care mechanisms are needed in destination areas.
{"title":"The migration experience and mental health in the context of insecurity: evidence from Burkina Faso.","authors":"Hervé Bassinga, Alexandra Tebkieta Tapsoba, Bruno Yempabou Lankoandé, Nabié Douba, Mamadou Soura, Roch Modeste Millogo, Yacouba Compaoré, Soumaïla Ouedraogo, Daniel Mwanga","doi":"10.1186/s12963-025-00438-1","DOIUrl":"10.1186/s12963-025-00438-1","url":null,"abstract":"<p><strong>Background: </strong>Since 2015, recurrent terrorist attacks in Burkina Faso have caused large-scale displacement, impacting the psychological health of affected populations. This study explores the effects of migration forced or voluntary on depression and anxiety among adolescents and young people aged 15-24, in line with SDG 3, which aims to \"ensure healthy lives and promote well-being for all at all ages\".</p><p><strong>Methods: </strong>The analysis is based on data from the baseline survey conducted by the Institut Supérieur des Sciences de la Population (ISSP) for the Sahel Resilience Building Program. A total of 1,911 adolescents and young people aged 15-24 living in four regions were interviewed. We measured mental health using two tools: the Patient Health Questionnaire-9 (PHQ-9) for depression and the Generalised Anxiety Disorder-7 (GAD-7) for anxiety. We used multinomial regressions to test the effects of migration status on depression and anxiety.</p><p><strong>Findings: </strong>Forced migrants report higher symptoms of moderate or severe depression (11.1%) and anxiety (15.7%) compared to non-forced migrants (6.8% and 14.4%) and non-migrants (6.6% and 9.5%). Forced migrants were 2.16 times more likely (RRR = 2.16; p < 5%) than non-migrants to experience moderate or severe depression, and non-forced migrants were 2.12 times more likely (RRR = 2.12; p < 5%) than non-migrants to experience moderate or severe anxiety. Youth aged 20-24 and urban residents were also more likely to face these mental health issues.</p><p><strong>Contributions: </strong>These findings call for more attention to the needs of both forced and non-forced migrants in terms of mental health. Psychological care mechanisms are needed in destination areas.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":" ","pages":"4"},"PeriodicalIF":2.5,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1186/s12963-025-00440-7
Mindaugas Stankūnas, Olga Meščeriakova, Snieguolė Kaselienė, Skirmantė Sauliūnė, Janina Petkevičienė, Ramunė Kalėdienė, Romualdas Gurevičius, Juozas Augutis, Algis Džiugys
The aim of the study was to analyze changes and demographic inequalities in the mortality of the Lithuanian population in 2020 and 2021 compared to the period of 2015-2019, assess the major causes of death that contributed to the changes, and identify the groups of the society that suffered most.
Methods: Mortality rates for 2015-2021 from all causes, cardiovascular diseases, malignant neoplasms, external causes, diseases of the digestive system, diseases of the respiratory system, and COVID-19 in Lithuania by sex and age were calculated per 100,000 population. Mortality changes compared with the previous year and between the average of 2015-2019 years were calculated. The average annual percentage change was calculated to determine the aggregated 2015-2019 change in mortality from the leading causes of death. Coefficients of linear regression multiplied by 100 were presented as average annual changes, which were statistically significant at p < 0.05. Mortality rate differences between 2020 and 2021 years and the average of 2015-2019 years were calculated.
Results: Lithuania has recorded 9.4% higher overall mortality among males in 2020 and 18% higher mortality in 2021 compared with a period unaffected by the COVID-19 pandemic (p < 0.05). Among females - 10.7% higher mortality in 2020 and 22.6% in 2021 (p < 0.05). Male and female mortality from COVID-19 in all age groups in 2021 was higher than that in 2020, and mortality rates increased with an increase in age. Negative changes in mortality from 2015 to 2019 to 2020 among males and females of all age groups were mainly determined by COVID-19. The most significant impact of COVID-19 in 2021 on the overall mortality changes was estimated in the 55-64 and 65-74 male age groups, while female overall mortality was in the 45-54 and 65-74 age groups.
Conclusions: Negative changes in mortality from 2015 to 2019 to 2020 among males and females of all age groups were mainly determined by COVID-19. The most significant impact of COVID-19 in 2021 on the overall mortality changes was estimated in the 55-74 male age group, while on female overall mortality in the 45-54 and 65-74 age groups.
{"title":"Trends and demographic inequalities in mortality of the Lithuanian population during the COVID-19 pandemic: who suffered most?","authors":"Mindaugas Stankūnas, Olga Meščeriakova, Snieguolė Kaselienė, Skirmantė Sauliūnė, Janina Petkevičienė, Ramunė Kalėdienė, Romualdas Gurevičius, Juozas Augutis, Algis Džiugys","doi":"10.1186/s12963-025-00440-7","DOIUrl":"10.1186/s12963-025-00440-7","url":null,"abstract":"<p><p>The aim of the study was to analyze changes and demographic inequalities in the mortality of the Lithuanian population in 2020 and 2021 compared to the period of 2015-2019, assess the major causes of death that contributed to the changes, and identify the groups of the society that suffered most.</p><p><strong>Methods: </strong>Mortality rates for 2015-2021 from all causes, cardiovascular diseases, malignant neoplasms, external causes, diseases of the digestive system, diseases of the respiratory system, and COVID-19 in Lithuania by sex and age were calculated per 100,000 population. Mortality changes compared with the previous year and between the average of 2015-2019 years were calculated. The average annual percentage change was calculated to determine the aggregated 2015-2019 change in mortality from the leading causes of death. Coefficients of linear regression multiplied by 100 were presented as average annual changes, which were statistically significant at p < 0.05. Mortality rate differences between 2020 and 2021 years and the average of 2015-2019 years were calculated.</p><p><strong>Results: </strong>Lithuania has recorded 9.4% higher overall mortality among males in 2020 and 18% higher mortality in 2021 compared with a period unaffected by the COVID-19 pandemic (p < 0.05). Among females - 10.7% higher mortality in 2020 and 22.6% in 2021 (p < 0.05). Male and female mortality from COVID-19 in all age groups in 2021 was higher than that in 2020, and mortality rates increased with an increase in age. Negative changes in mortality from 2015 to 2019 to 2020 among males and females of all age groups were mainly determined by COVID-19. The most significant impact of COVID-19 in 2021 on the overall mortality changes was estimated in the 55-64 and 65-74 male age groups, while female overall mortality was in the 45-54 and 65-74 age groups.</p><p><strong>Conclusions: </strong>Negative changes in mortality from 2015 to 2019 to 2020 among males and females of all age groups were mainly determined by COVID-19. The most significant impact of COVID-19 in 2021 on the overall mortality changes was estimated in the 55-74 male age group, while on female overall mortality in the 45-54 and 65-74 age groups.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":" ","pages":"3"},"PeriodicalIF":2.5,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1186/s12963-025-00435-4
Dan Kajungu, Betty Nabukeera, Jean Bashingwa, Chodziwadziwa Kabudula, Beth T Barr, Donald Ndyomugyenyi, Akello Mercy Consolate, Collins Gyezaho, Elizeus Rutebemberwa
Background: Efforts to track the mortality and public health impact of the coronavirus disease (COVID-19) in Uganda have been hampered by weak Civil registration and vital statistics (CRVS) system and suboptimal health seeking behaviors or patterns. Evaluating unexplained increases in all-cause mortality provides a complete picture of the impact of COVID-19 pandemic and guide public health policies and resource allocation to protect the most vulnerable populations.
Methods: The longitudinal population cohort data on demographic events and socioeconomic status collected from 2015 to 2021 within the Iganga Mayuge Health and Demographic Surveillance System (IMHDSS) was used. Number of deaths and person years at risk were counted for each quarter of the year from January 2015 to December 2021 and classified as "pre-pandemic" (before January 2020), and "during pandemic" (January 2020 to December 2021). Crude mortality rates were computed comparing the two periods. Time series model was used to estimate excess mortality and to locate the exact time when excess deaths occurred. Cox Proportional Hazard model was used to estimate the Hazard ratio associated with death.
Results: A total of 132,367 individuals were followed up from 2015 to 2021 and 3,424 deaths were registered. Slightly more than a half of all deaths (53%, n = 1,827) were male, and 65.4% (n = 2,238) were rural residents. Children under five years had a significantly higher CMR during COVID-19 period of 18.9, (95% CI 17.2-20.8) per 1000 person compared to 12.5 (95% CI 11.6-13.4) per 1000 person years before COVID-19. The risk of dying among children under 5 years compared to those aged between 5 and 14 years was higher during the COVID-19 pandemic period (aHR = 18.0, 95% CI 13.6-24.0) than pre-pandemic (aHR = 10.4, 95% CI 8.8-12.3).
Conclusion: The COVID-19 pandemic increased all-cause mortality in the Iganga Mayuge HDSS population cohort in Eastern Uganda, particularly among children under five, likely due to restricted healthcare access and economic disruptions. Pandemic response measures should prioritize vulnerable populations at higher risk of malnutrition and preventable diseases to mitigate future negative impacts.
背景:由于薄弱的民事登记和生命统计系统以及不理想的就医行为或模式,在乌干达追踪冠状病毒病(COVID-19)死亡率和公共卫生影响的工作受到阻碍。评估不明原因的全因死亡率上升,可以全面了解COVID-19大流行的影响,并指导公共卫生政策和资源分配,以保护最脆弱的人群。方法:利用伊甘加马伊格健康与人口监测系统(IMHDSS) 2015 - 2021年收集的人口事件和社会经济状况的纵向人口队列数据。从2015年1月至2021年12月,每年每个季度统计死亡人数和面临风险的人年数,并将其分为“大流行前”(2020年1月之前)和“大流行期间”(2020年1月至2021年12月)。计算了两个时期的粗死亡率。使用时间序列模型估计超额死亡率并确定超额死亡发生的确切时间。采用Cox比例风险模型估计与死亡相关的风险比。结果:2015年至2021年共随访132367人,登记死亡3424人。超过一半的死亡(53%,n = 1,827)是男性,65.4% (n = 2,238)是农村居民。5岁以下儿童在COVID-19期间的CMR显著高于每1000人18.9 (95% CI 17.2-20.8),而在COVID-19之前为每1000人12.5 (95% CI 11.6-13.4)。与5至14岁儿童相比,5岁以下儿童在COVID-19大流行期间的死亡风险(aHR = 18.0, 95% CI 13.6-24.0)高于大流行前(aHR = 10.4, 95% CI 8.8-12.3)。结论:COVID-19大流行增加了乌干达东部Iganga Mayuge HDSS人群的全因死亡率,特别是五岁以下儿童,这可能是由于医疗保健机会有限和经济中断。大流行应对措施应优先考虑营养不良和可预防疾病风险较高的弱势群体,以减轻未来的负面影响。
{"title":"Assessing the impact of COVID-19 pandemic on all-cause mortality and child mortality in a population cohort of Iganga Mayuge HDSS in Eastern Uganda (2015-2021).","authors":"Dan Kajungu, Betty Nabukeera, Jean Bashingwa, Chodziwadziwa Kabudula, Beth T Barr, Donald Ndyomugyenyi, Akello Mercy Consolate, Collins Gyezaho, Elizeus Rutebemberwa","doi":"10.1186/s12963-025-00435-4","DOIUrl":"10.1186/s12963-025-00435-4","url":null,"abstract":"<p><strong>Background: </strong>Efforts to track the mortality and public health impact of the coronavirus disease (COVID-19) in Uganda have been hampered by weak Civil registration and vital statistics (CRVS) system and suboptimal health seeking behaviors or patterns. Evaluating unexplained increases in all-cause mortality provides a complete picture of the impact of COVID-19 pandemic and guide public health policies and resource allocation to protect the most vulnerable populations.</p><p><strong>Methods: </strong>The longitudinal population cohort data on demographic events and socioeconomic status collected from 2015 to 2021 within the Iganga Mayuge Health and Demographic Surveillance System (IMHDSS) was used. Number of deaths and person years at risk were counted for each quarter of the year from January 2015 to December 2021 and classified as \"pre-pandemic\" (before January 2020), and \"during pandemic\" (January 2020 to December 2021). Crude mortality rates were computed comparing the two periods. Time series model was used to estimate excess mortality and to locate the exact time when excess deaths occurred. Cox Proportional Hazard model was used to estimate the Hazard ratio associated with death.</p><p><strong>Results: </strong>A total of 132,367 individuals were followed up from 2015 to 2021 and 3,424 deaths were registered. Slightly more than a half of all deaths (53%, n = 1,827) were male, and 65.4% (n = 2,238) were rural residents. Children under five years had a significantly higher CMR during COVID-19 period of 18.9, (95% CI 17.2-20.8) per 1000 person compared to 12.5 (95% CI 11.6-13.4) per 1000 person years before COVID-19. The risk of dying among children under 5 years compared to those aged between 5 and 14 years was higher during the COVID-19 pandemic period (aHR = 18.0, 95% CI 13.6-24.0) than pre-pandemic (aHR = 10.4, 95% CI 8.8-12.3).</p><p><strong>Conclusion: </strong>The COVID-19 pandemic increased all-cause mortality in the Iganga Mayuge HDSS population cohort in Eastern Uganda, particularly among children under five, likely due to restricted healthcare access and economic disruptions. Pandemic response measures should prioritize vulnerable populations at higher risk of malnutrition and preventable diseases to mitigate future negative impacts.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":"23 Suppl 2","pages":"72"},"PeriodicalIF":2.5,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1186/s12963-025-00436-3
Júlia Almeida Calazans, Iñaki Permanyer
Background: Cause of death (CoD) diversity indices measure the extent to which some populations die from more similar or variegated causes than others. Higher CoD diversity implies higher unpredictability of the causes of individuals dying and greater challenges for health systems. In this paper, we propose a novel method to decompose overall CoD diversity as the sum of two interpretable parts: the within- and between-group components.
Methods: The novel approach is applied to Latin America and the Caribbean (LAC) region to illustrate its usefulness. We decompose overall CoD diversity, measured by the Simpson index of diversity, into between-country and within-country components. In addition, we provide further decompositions assessing how each cause of death and each country contributes to overall CoD diversity in the region.
Results: The CoD diversity in the region followed a nonmonotonic trend. From 2000 to 2018, the CoD diversity increased from 0.81 to 0.83 for women, reaching approximately 0.84 for men. El Salvador, Peru, and Uruguay are the countries that contribute the most to explaining the differences in the mortality profile between countries, but for very different and opposing reasons. While the high diversity in El Salvador and Peru can be explained by causes of deaths related to the early stages of the epidemiological transition, such as communicable causes, respiratory causes, and external causes, Uruguay presents a high diversity because the deaths are very dispersed between chronic conditions. Cardiovascular deaths are the main contributor to both CoD diversity levels and their changes over time. As cardiovascular deaths decline, they give way to other chronic causes, which become more prominent and contribute to diversifying the corresponding mortality profiles. However, external causes also significantly contribute to forming uneven epidemiological profiles.
Conclusions: The decomposition proposed in this paper makes possible to assess whether some groups contribute more or less to the uncertainty around the causes of individuals' deaths and identify the sources of CoD diversity. In this way, this approach can contribute to a better understanding of contemporary mortality dynamics, especially in a context with large health inequalities.
{"title":"Cause of death diversity in multi-group settings: an application to Latin America and the Caribbean.","authors":"Júlia Almeida Calazans, Iñaki Permanyer","doi":"10.1186/s12963-025-00436-3","DOIUrl":"10.1186/s12963-025-00436-3","url":null,"abstract":"<p><strong>Background: </strong>Cause of death (CoD) diversity indices measure the extent to which some populations die from more similar or variegated causes than others. Higher CoD diversity implies higher unpredictability of the causes of individuals dying and greater challenges for health systems. In this paper, we propose a novel method to decompose overall CoD diversity as the sum of two interpretable parts: the within- and between-group components.</p><p><strong>Methods: </strong>The novel approach is applied to Latin America and the Caribbean (LAC) region to illustrate its usefulness. We decompose overall CoD diversity, measured by the Simpson index of diversity, into between-country and within-country components. In addition, we provide further decompositions assessing how each cause of death and each country contributes to overall CoD diversity in the region.</p><p><strong>Results: </strong>The CoD diversity in the region followed a nonmonotonic trend. From 2000 to 2018, the CoD diversity increased from 0.81 to 0.83 for women, reaching approximately 0.84 for men. El Salvador, Peru, and Uruguay are the countries that contribute the most to explaining the differences in the mortality profile between countries, but for very different and opposing reasons. While the high diversity in El Salvador and Peru can be explained by causes of deaths related to the early stages of the epidemiological transition, such as communicable causes, respiratory causes, and external causes, Uruguay presents a high diversity because the deaths are very dispersed between chronic conditions. Cardiovascular deaths are the main contributor to both CoD diversity levels and their changes over time. As cardiovascular deaths decline, they give way to other chronic causes, which become more prominent and contribute to diversifying the corresponding mortality profiles. However, external causes also significantly contribute to forming uneven epidemiological profiles.</p><p><strong>Conclusions: </strong>The decomposition proposed in this paper makes possible to assess whether some groups contribute more or less to the uncertainty around the causes of individuals' deaths and identify the sources of CoD diversity. In this way, this approach can contribute to a better understanding of contemporary mortality dynamics, especially in a context with large health inequalities.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":" ","pages":"1"},"PeriodicalIF":2.5,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1186/s12963-025-00433-6
Giuseppe Orlando, Michele Bufalo, Varvara Nazarova
The COVID-19 pandemic has disproportionately impacted vulnerable populations, such as low-income households, exacerbating existing health and economic challenges. In Cuba, the crisis exposed the effects of long-standing economic difficulties, worsened by sanctions, but the country's robust public health system and independent vaccine development enabled an effective response. This study addresses the gap in understanding how socio-economic factors and individual behaviors interact to influence disease spread. It proposes a hybrid, efficient, and parsimonious model combining ABM (Agent-Based Modeling) and ARIMAX (AutoRegressive Integrated Moving Average with eXogenous variables) time series analysis to forecast COVID-19 cases, offering valuable insights for policymakers to tailor interventions and enhance crisis management.
2019冠状病毒病大流行对低收入家庭等弱势群体的影响尤为严重,加剧了现有的卫生和经济挑战。在古巴,危机暴露了长期经济困难的影响,制裁加剧了经济困难,但该国强大的公共卫生系统和独立的疫苗开发使其能够有效应对。这项研究解决了在理解社会经济因素和个人行为如何相互作用影响疾病传播方面的差距。本文提出了一种结合ABM (Agent-Based Modeling)和ARIMAX (AutoRegressive Integrated Moving Average with外生变量)时间序列分析的混合、高效和简洁的模型来预测COVID-19病例,为政策制定者量身定制干预措施和加强危机管理提供了有价值的见解。
{"title":"Modeling COVID-19 response in Cuba: a hybrid approach combining agent-based modeling and time series analysis.","authors":"Giuseppe Orlando, Michele Bufalo, Varvara Nazarova","doi":"10.1186/s12963-025-00433-6","DOIUrl":"10.1186/s12963-025-00433-6","url":null,"abstract":"<p><p>The COVID-19 pandemic has disproportionately impacted vulnerable populations, such as low-income households, exacerbating existing health and economic challenges. In Cuba, the crisis exposed the effects of long-standing economic difficulties, worsened by sanctions, but the country's robust public health system and independent vaccine development enabled an effective response. This study addresses the gap in understanding how socio-economic factors and individual behaviors interact to influence disease spread. It proposes a hybrid, efficient, and parsimonious model combining ABM (Agent-Based Modeling) and ARIMAX (AutoRegressive Integrated Moving Average with eXogenous variables) time series analysis to forecast COVID-19 cases, offering valuable insights for policymakers to tailor interventions and enhance crisis management.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":" ","pages":"71"},"PeriodicalIF":2.5,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12679736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1186/s12963-025-00431-8
Ivan Nesic, Petar Vukovic, Marko Kaitovic, Petar Tomic, Milica Ludoski, Jelena Dotlic, Aleksandra Sljivic, Tatjana Gazibara
Background: The psychometric properties of Seattle Angina Questionnaire (SAQ) have not been assessed longitudinally among people who underwent coronary artery bypass grafting (CABG). The purpose of this study was to examine psychometric characteristics of the SAQ in Serbian language in a cohort of patients who underwent CABG.
Methods: Study participants were recruited at the Department of Preoperative Patient Preparation, Clinic of Cardiac Surgery, Institute for Cardiovascular Diseases "Dedinje" (Belgrade, Serbia) from July 1, 2021 to December 31, 2023. The SAQ was administered at four time points: just before having CABG, 1, 6 and 12 months post-CABG. Also, the general health-related quality of life questionnaire Short Form-36 (SF-36) and Depression, Anxiety and Stress Scale-21 (DASS-21) were administered. Clinical parameters were retrieved from medical records.
Results: The study cohort included 192 participants (80.2% male, on average 64.5 ± 11.0 years old). Most α coefficients were good (> 0.70) or acceptable (> 0.60). Based on the correlations with clinical parameters, the criterion validity was good. Correlations with the SF-36 and depression and anxiety scores supported convergent and divergent validity, respectively. Based on the confirmatory factor analysis, the construct validity of the SAQ varied before and after CABG with regards to the ability to participate in high intensity activities and the angina occurrence, which was in line with the expected effect of CABG to free patients from angina, prolong survival and improve quality of life.
Conclusions: The SAQ in Serbian has good psychometric properties. However, the SAQ domains of Angina frequency and Quality of life were most applicable in the first month post-CABG, while Physical limitations domain was most applicable at 6 months and 12 months post-CABG.
{"title":"Longitudinal analysis of psychometric properties of the Seattle Angina Questionnaire among patients who underwent coronary artery bypass grafting in Serbia.","authors":"Ivan Nesic, Petar Vukovic, Marko Kaitovic, Petar Tomic, Milica Ludoski, Jelena Dotlic, Aleksandra Sljivic, Tatjana Gazibara","doi":"10.1186/s12963-025-00431-8","DOIUrl":"10.1186/s12963-025-00431-8","url":null,"abstract":"<p><strong>Background: </strong>The psychometric properties of Seattle Angina Questionnaire (SAQ) have not been assessed longitudinally among people who underwent coronary artery bypass grafting (CABG). The purpose of this study was to examine psychometric characteristics of the SAQ in Serbian language in a cohort of patients who underwent CABG.</p><p><strong>Methods: </strong>Study participants were recruited at the Department of Preoperative Patient Preparation, Clinic of Cardiac Surgery, Institute for Cardiovascular Diseases \"Dedinje\" (Belgrade, Serbia) from July 1, 2021 to December 31, 2023. The SAQ was administered at four time points: just before having CABG, 1, 6 and 12 months post-CABG. Also, the general health-related quality of life questionnaire Short Form-36 (SF-36) and Depression, Anxiety and Stress Scale-21 (DASS-21) were administered. Clinical parameters were retrieved from medical records.</p><p><strong>Results: </strong>The study cohort included 192 participants (80.2% male, on average 64.5 ± 11.0 years old). Most α coefficients were good (> 0.70) or acceptable (> 0.60). Based on the correlations with clinical parameters, the criterion validity was good. Correlations with the SF-36 and depression and anxiety scores supported convergent and divergent validity, respectively. Based on the confirmatory factor analysis, the construct validity of the SAQ varied before and after CABG with regards to the ability to participate in high intensity activities and the angina occurrence, which was in line with the expected effect of CABG to free patients from angina, prolong survival and improve quality of life.</p><p><strong>Conclusions: </strong>The SAQ in Serbian has good psychometric properties. However, the SAQ domains of Angina frequency and Quality of life were most applicable in the first month post-CABG, while Physical limitations domain was most applicable at 6 months and 12 months post-CABG.</p>","PeriodicalId":51476,"journal":{"name":"Population Health Metrics","volume":"23 1","pages":"70"},"PeriodicalIF":2.5,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12673699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}