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Effect of Extracorporeal Shock Wave Therapy on Different Types of Lumbar Disc Herniation 体外冲击波疗法对不同类型腰椎间盘突出症的影响
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01012
Ganggang Xiang, Jiankun Chen, Taiyou Li, Shuai Xu, Qilong Gao
Objective To explore the effect of extracorporeal shock wave (ESW) therapy on different types of lumbar disc herniation (LDH). Methods A total of 3,454 patients with LDH admitted to the Department of Orthopedics and Traumatology of the Third Affiliated Hospital of
目的 探讨体外冲击波(ESW)疗法对不同类型腰椎间盘突出症(LDH)的影响。方法 对中国医学科学院第三附属医院骨伤科收治的 3 454 名腰椎间盘突出症患者进行体外冲击波治疗。
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引用次数: 0
Introduction to Neuromodulation-Based Therapies for Chronic Pain 基于神经调控的慢性疼痛疗法简介
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01001
Wen Wu
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引用次数: 0
Effects of Repetitive Transcranial Magnetic Stimulation Combined with Balance Acupuncture Treatment on Sleep Quality and Psychology in Patients after Stroke 重复经颅磁刺激联合平衡针灸治疗对脑卒中后患者睡眠质量和心理的影响
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01010
Huazhong Yang, Jinlong Cui, Hexin Fan, Zhonghui Xiong, Yuanmian Yao, Shasha Zhou, Wenxiu Cui, Tianbao Sun
Objective To observe the clinical effects of repetitive transcranial magnetic stimulation (rTMS) combined with bal‐ ance acupuncture treatment on sleep quality and psychology in patients after stroke. Methods A total of 60 patients with post-stroke sleep disorder admitted at Xiangya Boai Rehabilitation Hospital were selected and randomly divided into three groups: rTMS group (psychotherapy+rTMS), balance acupuncture group (psychotherapy+balance acupuncture treatment), and combination group (psychotherapy +rTMS+balance acupuncture), with 20 cases in each group. All patients were treated for 4 weeks. The overall clini‐ cal efficacy was assessed at the end of the treatment
目的 观察重复经颅磁刺激联合平衡针刺治疗对脑卒中后患者睡眠质量及心理的临床影响。方法 选择湘雅博爱康复医院收治的脑卒中后睡眠障碍患者60例,随机分为三组:经颅磁刺激组(心理治疗+经颅磁刺激)、平衡针刺组(心理治疗+平衡针刺治疗)、联合治疗组(心理治疗+经颅磁刺激+平衡针刺),每组20例。所有患者均接受为期 4 周的治疗。治疗结束后评估总体临床疗效
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引用次数: 0
Mechanism of Bushen Zhuangjin Decoction to Promote BMSCs Homing and Protect Articular Cartilage in Mice by the SDF-1/CXCR4 Axis 布参壮骨煎丸通过SDF-1/CXCR4轴促进小鼠BMSCs归巢并保护关节软骨的机制
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01007
Yanfeng Huang, Dezun Ma, Changlong Fu, Jinxia Ye, Yunmei Huang, Xihai Li
Objective To investigate the mechanism by which Bushen Zhuangjin Decoction (BZD) regulates the SDF-1/CX‐ CR4 axis to promote the homing of bone marrow mesenchymal stem cells (BMSCs) and protect articular cartilage in mice, thereby providing experimental basis for the rehabilitation treatment of knee osteoarthritis (KOA). Methods (1) In the animal experiment, 30 SPF male C57BL/6 mice, 8 weeks old, were selected and randomly divided into sham group, model group and BZD group, with 10 mice in each group. Intervention in each group lasted for 12 weeks. The morphological changes of the cartilage in each group were observed by micro-CT and hematoxylin-eosin staining. The fluorescence intensity of SDF-1 in bone tissue was observed by laser confocal microscopy. qPCR and Western blot were used to detect mRNA transcription level and protein relative expression level of homing-related regulatory factors in each group. (2) In the cell experiment, 4-week-old SPF male C57BL/6 mice were selected and the primary BMSCs were extracted by the whole bone marrow adherence method. After the extracted cells were identified by flow cytometry, the optimal lentivirus MOI value was screened. The cells were randomly divided into five groups: blank group, empty vector group, BZD group, sh-SDF-1 group and sh-SDF-1+BZD group. The migration of BMSCs in each group was observed by cell scratch test. The chondrogenic differentiation ability of cells in each group was observed by immunocytological staining of Collagen Ⅱ and Alcian blue. The fluorescence intensity of SDF-1 and CXCR4 in each group was observed by confocal laser microscope. mRNA transcription level of homing-related regulatory factors were detected by qPCR. Results (1) In the animal experiment, the joint histomorphologic findings (micro-CT and hematoxylin-eosin staining) showed that compared with the sham group, there was a circular defect between the femoral condyles, with cortical separation and loss of chondrocytes in the model group ( P <0.05); com‐ pared with the model group, the annular defect between the femoral condyles was improved and the arrangement of chondrocytes was slightly disordered in the BZD group. The immunofluorescence staining of joint tissues showed that compared with the sham group, the relative expression of SDF-1 protein increased in the model group ( P <0.05); compared with the model group, the relative expression level of SDF-1 increased in the BZD group ( P <0.05). qPCR and Western blot results showed that compared with the sham group, the mRNA transcription level and protein relative expression level of key homing regulatory factors (SDF-1, CXCR4, MIP-1α, MCP-1, MIP-1β, RANTES, VEGF, G-CSF, NCAM-1, MMP-2) increased in the model group ( P <0.05); compared with the model group, the mRNA transcription level and relative protein expression level of key homing regulatory factors increased in the BZD group ( P <0.05). (2) In the cell experiment, BMSCs were identified by flow cytometry: CD44 and
摘要】 目的 探讨炙甘草汤(BZD)调节SDF-1/CX- CR4轴促进骨髓间充质干细胞(BMSCs)归巢和保护小鼠关节软骨的机制,为膝关节骨性关节炎(KOA)的康复治疗提供实验依据。方法 (1) 在动物实验中,选择 30 只 SPF 雄性 C57BL/6 小鼠(8 周龄),随机分为假组、模型组和 BZD 组,每组 10 只。每组干预12周。通过显微 CT 和苏木精-伊红染色观察各组小鼠软骨的形态学变化。用 qPCR 和 Western blot 检测各组与同种异体相关的调节因子的 mRNA 转录水平和蛋白相对表达水平。(2)在细胞实验中,选择 4 周龄 SPF 雄性 C57BL/6 小鼠,采用全骨髓粘附法提取原代 BMSCs。提取的细胞经流式细胞仪鉴定后,筛选出最佳慢病毒 MOI 值。将细胞随机分为五组:空白组、空载体组、BZD 组、sh-SDF-1 组和 sh-SDF-1+BZD 组。通过细胞划痕试验观察各组 BMSCs 的迁移情况。通过免疫细胞学染色胶原Ⅱ和阿尔新蓝观察各组细胞的软骨分化能力。用激光共聚焦显微镜观察各组细胞中 SDF-1 和 CXCR4 的荧光强度。结果 (1) 动物实验中,关节组织形态学结果(micro-CT和苏木精-伊红染色)显示,与假组相比,模型组股骨髁间有环形缺损,皮质分离,软骨细胞缺失(P<0.05);与模型组相比,BZD组股骨髁间环形缺损改善,软骨细胞排列稍紊乱。关节组织免疫荧光染色显示,与假组相比,模型组SDF-1蛋白相对表达量增加(P<0.05);与模型组相比,BZD组SDF-1相对表达量增加(P<0.05)。qPCR和Western blot结果显示,与假组相比,模型组主要归巢调节因子(SDF-1、CXCR4、MIP-1α、MCP-1、MIP-1β、RANTES、VEGF、G-CSF、NCAM-1、MMP-2)的mRNA转录水平和蛋白相对表达水平均升高(P<0.05);与模型组相比,BZD组主要归巢调节因子的mRNA转录水平和蛋白相对表达水平均升高(P<0.05)。(2)在细胞实验中,BMSCs 被流式细胞术鉴定:CD44和CD105呈阳性表达,而CD34呈阴性表达。当 MOI 值为 100 时,SDF-1 基因的感染率最高。BMSCs 迁移和软骨分化结果显示,与空白组相比,sh-SDF-1 细胞迁移到划痕区的细胞数、胶原蛋白Ⅱ和酸性粘多糖的相对表达量明显减少。BZD组和sh-SDF-1+BZD组迁移细胞数、Alcian蓝染色和胶原Ⅱ蛋白相对表达量均明显增加(P <0.05)。免疫荧光结果显示,与空白组相比,sh-SDF-1组SDF-1和CXCR4的相对蛋白表达量明显减少(P <0.05),而BZD组和sh-SDF-1+BZD组SDF-1和CXCR4的相对蛋白表达量明显增加(P <0.qPCR结果显示,与空白组相比,sh-SDF-1组关键归巢调节因子的mRNA转录水平降低(P <0.05),而BZD组则升高(P <0.05)。结论 BZD可通过上调SDF-1/CXCR4轴促进BMSCs归巢,保护小鼠关节软骨。
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引用次数: 0
Influence of Interactive Scalp Acupuncture Combined with Upper Limb Exoskeleton Robot on Upper Limb Function in Stroke Patients 交互式头皮针结合上肢外骨骼机器人对中风患者上肢功能的影响
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01005
Zihao Wang, Chuan Hu, Haiquan Zhang, Xin Wang
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引用次数: 0
Effect of Intelligent Selection Training Strategies by Cognitive Impairment Diagnosis and Treatment Instrument on Cognitive Function in Stroke Patients 认知障碍诊断与治疗工具的智能选择训练策略对脑卒中患者认知功能的影响
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01008
Qiuli Huang, Jianlin Ou, Jiajian Yan, Zhuoming Chen
Objective To analyze the effect of intelligent selection training strategies by cognitive impairment diagnosis and treatment instrument (early dementia intervention system) on cognitive function recovery in stroke patients. Methods A total of 100 post-stroke patients with cognitive impairment hospitalized in the Rehabilitation Department of the First Affiliated Hospital of
目的 分析认知障碍诊疗仪(早期痴呆干预系统)智能选择训练策略对脑卒中患者认知功能恢复的影响。方法 选取 100 例在北京大学第一医院康复科住院治疗的脑卒中后认知功能障碍患者作为研究对象。
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引用次数: 0
Research Progress of Common Rehabilitation Training Methods in Mild Cognitive Impairment 轻度认知障碍常见康复训练方法的研究进展
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01013
Yiyuan Wang, Chenyu Fan, Nianhong Wang, Yi Wu
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引用次数: 0
Eye Collateral Channel Characteristic Analysis and Identification Model Construction of Mild Cognitive Impairment 轻度认知障碍的眼侧通道特征分析与识别模型构建
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01011
Tiecheng Wu, Lei Cao, Lianhua YIN, Youze He, Zhizhen Liu, Minguang Yang, Ying Xu, Jinsong Wu
{"title":"Eye Collateral Channel Characteristic Analysis and Identification Model Construction of Mild Cognitive Impairment","authors":"Tiecheng Wu, Lei Cao, Lianhua YIN, Youze He, Zhizhen Liu, Minguang Yang, Ying Xu, Jinsong Wu","doi":"10.3724/sp.j.1329.2024.01011","DOIUrl":"https://doi.org/10.3724/sp.j.1329.2024.01011","url":null,"abstract":"","PeriodicalId":516006,"journal":{"name":"Rehabilitation Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140465833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperactive Behavior Screening and Its Influencing Factors in Preschool Children Based on a Computer Cloud Platform 基于计算机云平台的学龄前儿童多动行为筛查及其影响因素
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01003
Xiaona Yin, Longbin Shen, Nan Wang, Jinyu Zhang, Jianbo Wu, Shuangyan Qiu, Haiyan Lei, Zhuoming Chen
{"title":"Hyperactive Behavior Screening and Its Influencing Factors in Preschool Children Based on a Computer Cloud Platform","authors":"Xiaona Yin, Longbin Shen, Nan Wang, Jinyu Zhang, Jianbo Wu, Shuangyan Qiu, Haiyan Lei, Zhuoming Chen","doi":"10.3724/sp.j.1329.2024.01003","DOIUrl":"https://doi.org/10.3724/sp.j.1329.2024.01003","url":null,"abstract":"","PeriodicalId":516006,"journal":{"name":"Rehabilitation Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140470129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Lymphatic Drainage Manipulation on Knee Joint Swelling after Anterior Cruciate Ligament Reconstruction 淋巴引流手法对前交叉韧带重建术后膝关节肿胀的影响
Pub Date : 2024-02-01 DOI: 10.3724/sp.j.1329.2024.01009
Cong Meng, Yong Bao, Weiming Zhang
Objective To analyze the effect of lymphatic drainage manipulation on knee joint swelling after anterior cruciate ligament (ACL) reconstruction. Methods This prospective study was conducted to select patients with ACL injury admitted to the Orthopaedics Department of Shanghai Ruijin Rehabilitation Hospital from February 2020 to February 2023. The participants were divided into the observation group and control group according to the random number table method, with 120 cases in each group. ACL reconstruction was performed in both groups. Postoperatively, the control group was treated with ice compression, and the ob‐ servation group was treated with lymphatic drainage manipulation. Both groups received continuous intervention for 4 weeks. The swelling degree and skin temperature of knee joint were observed at different time points (postoperative day, 1 week, 2 weeks and 4 weeks postoperatively). Range of motion (ROM) and knee function [Lysholm knee score scale (LKSS)] before and after intervention for both groups were observed, as well as changes in pain substances [substance P, 5-hydroxytryptamine (5-HT)] and inflammatory markers [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)]. Results The
目的 分析淋巴引流手法对前交叉韧带(ACL)重建术后膝关节肿胀的影响。方法 本前瞻性研究选取 2020 年 2 月至 2023 年 2 月期间上海瑞金康复医院骨科收治的前交叉韧带损伤患者为研究对象。按照随机数字表法分为观察组和对照组,每组 120 例。两组均进行前交叉韧带重建术。术后,对照组采用冰敷治疗,观察组采用淋巴引流手法治疗。两组均持续干预 4 周。在不同时间点(术后 1 天、1 周、2 周和 4 周)观察膝关节的肿胀程度和皮肤温度。观察两组患者干预前后的活动范围(ROM)和膝关节功能[Lysholm 膝关节评分量表(LKSS)],以及疼痛物质[P 物质、5-羟色胺(5-HT)]和炎症标志物[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]的变化。结果
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Rehabilitation Medicine
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