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The Use of Umbilical Cord Blood Nucleated Cells in the Treatment of Regressive Autism: A Case Report. 使用脐带血核细胞治疗退行性自闭症:病例报告。
Pub Date : 2023-12-22 DOI: 10.17816/CP9300
Yana V Morozova, Vladimir N Smirnov, Igor V Makarov, Darya A Emelina

Background: Interest in the issue of childhood autism has surged in the recent decades. At the same time, despite the significant progress achieved in understanding the etiological and pathogenetic aspects of the condition, effective ways to treat it have continued to elude us. Stem cell therapy appears to hold great promise in the treatment and rehabilitation of patients with both neurological diseases (cerebral palsy, hydrocephalus) and mental disorders (autism, schizophrenia).

Methods: This article presents a case report describing the use of nucleated cord blood cells in a patient with regressive autism and resistance to standard therapies. The child's condition was assessed before treatment and 6 and 12 months after.

Results: Clinical observation, psychometric, and instrumental diagnostic methods led to a significant improvement in the child's condition in the form of perception development, reduction of somatosensory disorders, normalization of emotional status, and a development of social and communication skills.

Conclusion: We assume that the result obtained may be associated with the normalization of the immunological status of our patient thanks to the cord blood cells therapy and consider it necessary to conduct further studies into the effectiveness of the method, taking the pathogenic mechanisms of autism into account.

背景:近几十年来,人们对儿童自闭症问题的关注与日俱增。与此同时,尽管我们在了解自闭症的病因和发病机理方面取得了重大进展,但仍然无法找到有效的治疗方法。干细胞疗法似乎在神经系统疾病(脑瘫、脑积水)和精神障碍(自闭症、精神分裂症)患者的治疗和康复方面大有可为:本文是一份病例报告,描述了在一名自闭症退行性患者身上使用有核脐带血细胞治疗的情况。治疗前、治疗后6个月和12个月对患儿的病情进行了评估:临床观察、心理测量和仪器诊断方法使患儿在感知发展、躯体感觉障碍减少、情绪状态正常化、社交和沟通能力发展等方面的状况得到了显著改善:我们认为,所取得的结果可能与脐带血细胞疗法使患者的免疫状态恢复正常有关,并认为有必要在考虑自闭症发病机制的基础上,对该方法的有效性进行进一步研究。
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引用次数: 0
Schizophrenia: a Narrative Review of Etiological and Diagnostic Issues. 精神分裂症:病因和诊断问题的叙述性回顾。
Pub Date : 2022-09-30 eCollection Date: 2022-01-01 DOI: 10.17816/CP132
Sofia Oskolkova

Background: Despite the fact that schizophrenia has already been described historically and researched for a long time, this disorder remains unclear and controversial in many respects, including its etiology, pathogenesis, classification, diagnosis, and therapy.

Methods: Literature from the selected sources (elibrary.ru, Russian Science Citation Index and the Russian branch of the Cochrane Library) were searched and analyzed using the diachronic method. Priority was given to reviews, guidelines, and original research on schizophrenia written during the past 10 years.

Results: Historically, scientists have described schizophrenia as a single disorder, a group of disorders, or even as a combination of certain syndromes. The polymorphic symptoms and the most typical dynamics of various forms of schizophrenia have been systematized, but neither in Russia nor in other countries have the etiology and pathogenesis been proven. The reasons for the under- and overdiagnosis of schizophrenia cannot cover all possible objective and subjective difficulties arising in the diagnostic process.

Conclusion: The existing literature shows that the problem of schizophrenia may not be regarded as settled for a long time. This largely depends on the position of society, the development of biological sciences, and the pathomorphosis of the disorder itself. Many aspects of schizophrenia can become clearer and less controversial with systematic studies based on previous data, as well as data obtained using new research methods.

背景:尽管精神分裂症在历史上已有描述,研究也由来已久,但这种疾病在病因、发病机理、分类、诊断和治疗等许多方面仍不明确并存在争议:采用非同步法对选定来源(elibrary.ru、俄罗斯科学引文索引和 Cochrane 图书馆俄罗斯分馆)的文献进行了检索和分析。优先考虑过去 10 年中撰写的有关精神分裂症的综述、指南和原创研究:从历史上看,科学家们将精神分裂症描述为一种单一的疾病、一组疾病,甚至是某些综合症的组合。各种形式的精神分裂症的多态症状和最典型的动态变化已被系统化,但无论是在俄罗斯还是在其他国家,其病因和发病机制均未得到证实。精神分裂症诊断不足和诊断过度的原因无法涵盖诊断过程中可能出现的所有客观和主观困难:现有文献表明,精神分裂症的问题可能在很长时间内都不会得到解决。这在很大程度上取决于社会的立场、生物科学的发展以及精神分裂症本身的病理形态。通过基于以往数据的系统研究以及使用新的研究方法获得的数据,精神分裂症的许多方 面都会变得更加清晰,争议也会减少。
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引用次数: 0
Community Mental Health Services in Egypt. 埃及的社区心理健康服务。
Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.17816/CP165
Tarek Ahmed Okasha, Nermin Mahmoud Shaker, Dina Mohamed Aly Elgabry

As far back as the 14th Century, Egypt had already developed mental health care in a community-based sense in Kalaoon Hospital in Cairo, 600 years before similar institutions were founded across the globe. By 2001, an Egyptian-Finnish bilateral comprehensive reform program was incorporated. A few years later, in 2007, the Minister of Health and Population initiated a proper appraisal of the mental health services in Egypt, which was aimed at achieving better integration and coordination in the mental health sector, as well as supervision and training on the national, governmental, and primary care levels. By 2009, the Mental Health Act of 2009 (Law 71) brought basic conceptual changes to the care of people with a mental illness in Egyptian institutions, replacing the outdated 1944 law that had been used in Egypt for decades. However, despite all of the important steps Egypt is taking to move toward more integrated mental health services, more effort and resources are still needed to fight against stigma and to develop a comprehensive multidisciplinary approach that is approachable and effective to all those who need it.

早在 14 世纪,埃及就已经在开罗的 Kalaoon 医院发展了社区意义上的精神卫生保健,这比全球类似机构的建立还要早 600 年。2001 年,一项埃及-芬兰双边综合改革计划被纳入其中。几年后,即 2007 年,埃及卫生与人口部长启动了对埃及精神卫生服务的适当评估,旨在实现精神卫生部门更好的整合与协调,以及国家、政府和基层医疗机构层面的监督与培训。到 2009 年,《2009 年精神卫生法》(第 71 号法律)对埃及机构中精神疾病患者的护理工作进行了基本概念上的改革,取代了埃及沿用了几十年的过时的 1944 年法律。然而,尽管埃及正在采取各种重要措施来提供更加综合的心理健康服务,但仍然需要更多的努力和资源来消除耻辱感,并制定一种全面的多学科方法,使所有需要的人都能得到有效的服务。
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引用次数: 0
Experiences of Kyrgyzstani Frontline Healthcare Workers during the "Black July" of 2020: a Qualitative Study. 吉尔吉斯斯坦一线医护人员在 2020 年 "黑色七月 "期间的经历:一项定性研究。
Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.17816/CP154
Elena Molchanova, Veronika Kharsun, Zhibek Kenzhebaeva, Aigul Alikanova

Background: The peak of the pandemic in Kyrgyzstan occurred in July 2020 with highest infection rates, almost 1000 cases daily, compared to 100 cases prior to this date. The state health system was fatally unprepared to accommodate patients, mobilize medical staff, or provide clear instructions to the population. This study explores personal narratives of healthcare practitioners who were affected by and survived COVID-19 during the "Black July" of 2020 in Bishkek, Kyrgyzstan.

Method: Healthcare workers (n=10) were interviewed using a semi-structured interview protocol. Interviews were transcribed then analyzed in accordance with interpretative phenomenological study guidelines.

Results: The narratives demonstrated both post-traumatic depreciation and post-traumatic growth, resulting in changes of attitudes, lifestyle, and identity. An important aspect of identity shift included an emerging desire for increased self-care, which was characterized by resistance against a heroic Hippocratic ideal to "to save everybody".

Conclusion: COVID-19 is perceived as a psycho-socio-cultural phenomenon, which has transformed the identities of healthcare workers in the Kyrgyz Republic. Further research is recommended into developing rehabilitation programs for healthcare workers.

背景:吉尔吉斯斯坦的疫情高峰出现在 2020 年 7 月,感染率最高,每天近 1000 例,而在此之前只有 100 例。国家卫生系统在接待病人、动员医务人员或向民众提供明确指示方面准备不足,这是致命的。本研究探讨了 2020 年吉尔吉斯斯坦比什凯克 "黑色七月 "期间受 COVID-19 影响并幸存下来的医护人员的个人叙述:采用半结构化访谈协议对医护人员(n=10)进行了访谈。根据解释现象学研究指南对访谈内容进行转录和分析:叙述显示了创伤后贬值和创伤后成长,导致态度、生活方式和身份的改变。身份转变的一个重要方面包括新出现的加强自我护理的愿望,其特点是抵制 "拯救所有人 "的希波克拉底英雄主义理想:结论:COVID-19 被视为一种心理-社会-文化现象,它改变了吉尔吉斯共和国医护人员的身份。建议进一步开展研究,为医护人员制定康复计划。
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引用次数: 0
Formation of a New Paradigm of Social Interaction: On Touching and on not Touching. 社会互动新范式的形成:关于接触和不接触
Pub Date : 2022-07-05 eCollection Date: 2022-01-01 DOI: 10.17816/CP163
Roger Smith

The COVID-19 pandemic greatly accelerated the use of online technologies for communication, as opposed to contact involving physical presence and touch. This commentary further considers the consequences of this change in individual human terms, in everyday as well as medical situations. It is a kind of discussion paper, specially written for this journal. It develops two directions of argument, the first about the reality of embodiment, the second about figures of speech involving touch and movement, figures of speech about the actions of whole people rather than about mind (spirit) or body separately. The discussion reviews the nature of differences between communication involving physical proximity and physical distance (and electronic media), with comments on the positive and negative aspects of each. An emphasis on the significance of touch (and movement, since all touch involves movement) to people is linked to the basic aspects of the lifecycle in birth, reproduction, and death. In conclusion, the discussion emphasizes the traditional importance of touch and physical participation to people's feeling for reality. New digital forms of relations disturb this feel, with significant consequences.

COVID-19 大流行极大地加速了网络技术在交流中的应用,而不是通过身体接触来进行交流。本评论进一步探讨了这一变化在日常生活和医疗环境中对人类个体造成的影响。这是一篇专门为本刊撰写的讨论文章。它有两个论证方向,第一个方向是关于 "化身 "的现实,第二个方向是关于涉及触觉和运动的语言表达,这些语言表达是关于整个人的行为,而不是分别关于思想(精神)或身体。讨论回顾了身体近距离交流与身体远距离交流(以及电子媒体)之间的本质区别,并对两者的积极和消极方面进行了评论。强调触觉(和运动,因为所有触觉都涉及运动)对人的意义,并将其与出生、繁殖和死亡等生命周期的基本方面联系起来。总之,讨论强调了触觉和身体参与对人们感受现实的传统重要性。新的数字关系形式扰乱了这种感觉,造成了严重后果。
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引用次数: 0
Qatar Community Mental Health Care: Achievements and Challenges. 卡塔尔社区心理保健:成就与挑战。
Pub Date : 2021-05-25 eCollection Date: 2021-01-01 DOI: 10.17816/CP78
Mohamed Ali Ahmed, Suhaila Ali Ghuloum

Guided by international best practice and evidence-based medicine, the Qatar mental health service has undergone a major transformation in the last two decades, replacing the institution-based service with an accessible multidisciplinary community-based service. In this paper, we provide a brief historical background to mental health services in Qatar, and the progress and development towards community-based mental health-care provision. We also explore the challenges facing this new model of care in Qatar including social and cultural sensitivities, and the various solutions adopted to overcome these challenges. We outline the comprehensive plans envisaged to further develop Qatar community mental health services, including the provision of accessible, integrated and multimodal mental health care within primary care settings.

在国际最佳实践和循证医学的指导下,卡塔尔的精神卫生服务在过去二十年中经历了重大变革,以便捷的多学科社区服务取代了以机构为基础的服务。在本文中,我们将简要介绍卡塔尔精神卫生服务的历史背景,以及以社区为基础的精神卫生保健服务的进步和发展。我们还探讨了这种新的护理模式在卡塔尔所面临的挑战,包括社会和文化敏感性,以及为克服这些挑战所采取的各种解决方案。我们概述了为进一步发展卡塔尔社区精神保健服务而设想的全面计划,包括在初级保健环境中提供便捷、综合和多模式的精神保健服务。
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引用次数: 0
Gender Identity Disorders: Current Medical and Social Paradigm and the ICD-11 Innovations. 性别认同障碍:当前的医学和社会范式以及 ICD-11 的创新。
Pub Date : 2021-05-25 eCollection Date: 2021-01-01 DOI: 10.17816/CP68
Anton V Dyachenko, Alexey Y Perekhov, Victor A Soldatkin, Olga A Bukhanovskaya

Introduction: This article presents a review of current concepts of gender identity under normal and pathological conditions.

Aim: To analyse the impact of the medical and social paradigm shift for clinical practice.

Results and discussion: The modern academic literature devoted to gender identity disorders is characterized by a variety of terminology, a shift in emphasis from clinical judgement to a socially beneficial normocentric approach and a relatively few advanced, evidence-based research. There is also a lack of evidence for the gender theory underlying the new approach, which raises serious doubts about the validity of the medical and social paradigm revision. In the same time, the position of Russian psychiatrists remains to be more clinically oriented.

Conclusion: Patients who declare the desire to reassign their gender have to be assessed by psychiatrists for differential diagnosis to exclude a mental disorder. In such cases, the destigmatization of mental disorders is more critical than the depathologization of gender identity disorders.

引言:本文对正常和病理情况下的性别认同概念进行了综述:目的:分析医学和社会范式转变对临床实践的影响。结果与讨论:专门研究性别认同障碍的现代学术文献的特点是术语繁多,重点从临床判断转向以社会效益为中心的规范方法,先进的循证研究相对较少。新方法所依据的性别理论也缺乏证据,这让人严重怀疑医学和社会范式修正的有效性。与此同时,俄罗斯精神科医生的立场仍然是更加以临床为导向:结论:宣称希望重新分配性别的患者必须接受精神科医生的鉴别诊断,以排除精神障碍。在这种情况下,精神障碍的去污名化比性别认同障碍的去病理化更为重要。
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引用次数: 0
Toward ICD-11 Implementation: Attitudes and Expectations of the Russian Psychiatric Community. 迈向 ICD-11 的实施:俄罗斯精神病学界的态度和期望。
Pub Date : 2021-05-25 eCollection Date: 2021-01-01 DOI: 10.17816/CP80
Maya A Kulygina, Timur S Syunyakov, Ilya A Fedotov, George P Kostyuk

Background: ICD-11 implementation will start in early 2022 in WHO member countries, including Russia. This process should be preceded not only by the official translation and wide distribution of ICD-11 statistical classification and diagnostic guidelines but also by clinicians' training. For recent years ICD-11 development and innovations in the diagnosis of mental disorders were in the focus of attention of mental health professionals in all over the world.

Objectives: This online survey aimed to identify the current views of the Russian psychiatric community on the upcoming implementation of ICD-11.

Methods: A survey was composed in a Google form and circulated through the website of the Russian Society of Psychiatrists and other professional networks. Statistical and narrative analysis was provided. The sample was represented by 148 psychiatrists working in inpatient or outpatient clinical settings.

Results: Expectations for the classification of mental disorders reported by the respondents were wider than the current purpose of ICD-10. In general, the Russian psychiatrists expressed their interests to forthcoming ICD-11 implementation. Positive attitudes to ICD-11 innovations were associated with the familiarity with the ICD-11 draft. Conservative or negative views were related to longer years of clinical experience. Early carrier psychiatrists were more practically oriented than 'old school' clinicians.

Conclusion: This survey may help to promote the ICD-11 by focusing on its advantages for clinical practice and develop targeted training programs.

背景:包括俄罗斯在内的世界卫生组织成员国将于 2022 年初开始实施 ICD-11。在此之前,不仅要对 ICD-11 统计分类和诊断指南进行正式翻译和广泛传播,还要对临床医生进行培训。近年来,ICD-11 的发展和精神障碍诊断的创新一直是全世界精神卫生专业人员关注的焦点:本在线调查旨在了解俄罗斯精神医学界目前对即将实施的 ICD-11 的看法:方法:采用谷歌表格编制调查问卷,并通过俄罗斯精神病学家协会网站和其他专业网络进行传播。提供了统计和叙述分析。调查样本由 148 名在住院或门诊临床环境中工作的精神科医生组成:结果:受访者对精神障碍分类的期望比当前 ICD-10 的目的更广泛。总体而言,俄罗斯精神科医生对即将实施的 ICD-11 表示感兴趣。对 ICD-11 创新的积极态度与熟悉 ICD-11 草案有关。保守或消极的观点则与较长的临床经验有关。与 "老派 "临床医生相比,早期载体的精神科医生更注重实践:这项调查有助于宣传 ICD-11 在临床实践中的优势,并制定有针对性的培训计划。
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引用次数: 0
Depathologizing Sexual Orientation and Transgender Identities in Psychiatric Classifications. 精神病学分类中的性取向和变性身份去病理化。
Pub Date : 2021-05-25 eCollection Date: 2021-01-01 DOI: 10.17816/CP61
Rebeca Robles, Tania Real, Geoffrey M Reed

Introduction: This article presents the history and rationales of conceptualization and classification of homosexuality and transgender identity in both ICD and DSM. We review the efforts that have been made (and those that remain pending) to improve psychiatric classifications with new scientific knowledge, changing social attitudes and human rights standards.

Method: We conducted a literature search of the classification of homosexuality and transgender identity as mental disorders.

Result: We provide a historical description of these concepts in ICD and DSM, including fundamental points of disagreement as well as arguments that have been effective in achieving changes in both classifications.

Conclusions: Fundamental changes have been made in the International Classification of Diseases Eleventh Revision (ICD-11) in terms of the classification of sexual orientation and gender identity based on scientific evidence and the ICD's public health objectives. These changes might support the provision of accessible and high-quality healthcare services, and are responsive to the needs, experience and human rights of the populations involved.

导言:本文介绍了《国际疾病分类》(ICD)和《疾病分类》(DSM)对同性恋和变性者身份进行概念化和分类的历史和原理。我们回顾了根据新的科学知识、不断变化的社会态度和人权标准,为改进精神病学分类所做的努力(以及仍在进行中的努力):方法:我们对同性恋和变性人身份作为精神疾病的分类进行了文献检索:结果:我们对 ICD 和 DSM 中的这些概念进行了历史性描述,包括基本的分歧点,以及在改变这两种分类法方面行之有效的论据:基于科学证据和国际疾病分类的公共卫生目标,国际疾病分类第十一次修订版(ICD-11)对性取向和性别认同的分类进行了根本性的修改。这些变化可能有助于提供可获得的高质量医疗保健服务,并对相关人群的需求、经验和人权做出回应。
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引用次数: 0
ICD-11 as a Paradigm Shift Phase in the Classification of Mental Disorders. 作为精神疾病分类范式转变阶段的 ICD-11。
Pub Date : 2021-05-25 eCollection Date: 2021-01-01 DOI: 10.17816/CP70
Valery N Krasnov

Classifications of mental disorders change regularly. This fact requires analysis, taking into account changes in the epidemiological situation and changes in the organizational structure of mental health service, and development of its technical and human resources. The preliminary analysis of these changes presented in the article using the example of ICD-11 gives us reason to believe that they are almost unrelated to the diagnostic process improvement. On the contrary, each new classification is characterized by an increasing formalization and simplification of the criteria for separate clinical forms. The inevitable losses of clinical accuracy in psychopathological assessment of disorder are compensated for increasing opportunities to deliver care to a significantly greater number of patients.

精神障碍的分类经常发生变化。这一事实需要结合流行病学情况的变化、精神卫生服务组织结构的变化及其技术和人力资源的发展进行分析。本文以 ICD-11 为例对这些变化进行的初步分析使我们有理由相信,这些变化几乎与诊断程序的改进无关。恰恰相反,每一种新分类法的特点都是对不同临床形式的标准日益正规化和简化。在精神病理学失调评估中,临床准确性不可避免地会受到损失,但为更多患者提供护理的机会却在不断增加,从而弥补了这一损失。
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引用次数: 0
期刊
Consortium psychiatricum
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