Pub Date : 2023-10-05DOI: 10.24060/2076-3093-2023-13-3-229-237
A. I. Sherifova, A. M. Parsadanyan
The present paper reviews current publications of Russian and foreign authors addressing the issues of liver pathology and associated consequences. Primary liver cancer is a malignant tumor originated from hepatocytes and epithelium of the biliary duct. It differs from other liver pathologies by rapid progression and low life expectancy of patients. The morphology of cancer and its carcinogenesis is particularly considered. The paper describes the carcinogenesis of liver cancer in detail. Numerous scientific papers consider liver cancer as a global health issue due to the late diagnosis and, consequently, the limited treatment options for patients with this disease. The analysis of recent publications revealed that the incidence of this pathology tends to increase worldwide. According to the available data provided by different experts who study cancer globally, about 906 thousand new cases of liver cancer are registered annually and the number of patients is expected to exceed 1.4 million by 2040. In the conclusion, the present paper briefly observes the reasons of the late diagnosis of liver cancer and its consequences.
{"title":"Predictors of Liver Cancer: a Review","authors":"A. I. Sherifova, A. M. Parsadanyan","doi":"10.24060/2076-3093-2023-13-3-229-237","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-229-237","url":null,"abstract":"The present paper reviews current publications of Russian and foreign authors addressing the issues of liver pathology and associated consequences. Primary liver cancer is a malignant tumor originated from hepatocytes and epithelium of the biliary duct. It differs from other liver pathologies by rapid progression and low life expectancy of patients. The morphology of cancer and its carcinogenesis is particularly considered. The paper describes the carcinogenesis of liver cancer in detail. Numerous scientific papers consider liver cancer as a global health issue due to the late diagnosis and, consequently, the limited treatment options for patients with this disease. The analysis of recent publications revealed that the incidence of this pathology tends to increase worldwide. According to the available data provided by different experts who study cancer globally, about 906 thousand new cases of liver cancer are registered annually and the number of patients is expected to exceed 1.4 million by 2040. In the conclusion, the present paper briefly observes the reasons of the late diagnosis of liver cancer and its consequences.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.24060/2076-3093-2023-13-3-244-248
A. R. Gilemkhanov, V. V. Plechev, A. A. Bakirov, R. F. Safin, R. E. Abdrakhmanov, S. I. Blagodarov, T. R. Ibragimov, I. M. Gilemkhanova
Introduction . Endovascular intervention was firstly introduced for repairing aortic aneurysms in the early 1990s. The greatest advantage of endovascular aneurysm repair (EVAR) is its minimally-invasive character, thus implying shorter post-operative period. The operative mortality rate comprises 3.3 % (95 % CI 2.9–3.6); however, according to recent studies, the rate has declined to 1.4 % due to a rapid improvement in outcomes. According to the DREAM-trial, the incidence of a branched endograft thrombosis accounts for 6.4% within the first 30 days. The EVAR trial reports an incidence of 2.6% after the first year of follow-up. Stent bending and small distal aortic diameters (less than 20 mm) are believed to be the most common causes of endograft thrombosis. Aim . To identify the causes of complications following the abdominal aortic stent-graft repair and to determine the optimal treatment strategy. Materials and methods . The paper presents a case of 71-year-old patient with late complication after endovascular abdominal aortic repair of an infrarenal aortic aneurysm. The patient was admitted to the hospital on January 05, 2020 as an emergency due to the pain in the left lower limb. On December 03, 2019 the patient underwent endovascular abdominal aortic repair. Angiography of January 06, 2020 revealed thrombosis of the left branch of the stent graft. Thrombectomy of the brunched left stent graft, left iliac artery and balloon dilatation of the brunched left stent-graft were performed.Results and discussion. Endovascular abdominal aortic repair stands as the first choice for patients with appropriate aortic anatomy and those with significant comorbidity. Despite the significant progress in endovascular abdominal aortic repairing, the EVAR procedure is followed by a nearly fivefold increase in the 30-day reintervention rate as compared to open surgery which comprises 9.8 % according to the EVAR-I, and 18 %, according to the EVAR-II trials. Conclusion . Our multidisciplinary team consisted of vascular and endovascular surgeons managed to perform hybrid surgery, thus eliminating the EVAR-associated complication together with its cause.
介绍。20世纪90年代初，血管内介入治疗首次被用于修复主动脉瘤。血管内动脉瘤修复术(EVAR)最大的优点是其微创性，因此意味着较短的术后时间。手术死亡率为3.3% (95% CI 2.9-3.6);然而，根据最近的研究，由于治疗效果的迅速改善，这一比率已降至1.4%。根据dream -试验，前30天内分支性移植物血栓的发生率为6.4%。EVAR试验报告第一年随访后的发生率为2.6%。支架弯曲和主动脉远端直径小(小于20mm)被认为是导致血管内血栓形成的最常见原因。的目标。目的探讨腹主动脉支架修复术后并发症的原因，并确定最佳治疗策略。材料和方法。本文报告一例71岁的患者，经血管内腹主动脉修复肾下主动脉瘤后出现晚期并发症。患者因左下肢疼痛，于2020年1月5日急诊入院。2019年12月3日，患者行腹主动脉腔内修复术。2020年1月6日血管造影显示支架左支血栓形成。行左支架、左髂动脉取栓、左支架球囊扩张术。结果和讨论。腹主动脉腔内修复是主动脉解剖结构合适及有明显合并症患者的首选。尽管在血管内腹主动脉修复方面取得了重大进展，但与开放手术相比，EVAR手术后30天的再干预率增加了近5倍，根据EVAR- i试验，再干预率为9.8%，根据EVAR- ii试验，再干预率为18%。结论。我们的多学科团队由血管和血管内外科医生组成，成功地进行了混合手术，从而消除了evar相关的并发症及其原因。
{"title":"Surgical Treatment for Branched Endograft Thrombosis of the Abdominal Aorta","authors":"A. R. Gilemkhanov, V. V. Plechev, A. A. Bakirov, R. F. Safin, R. E. Abdrakhmanov, S. I. Blagodarov, T. R. Ibragimov, I. M. Gilemkhanova","doi":"10.24060/2076-3093-2023-13-3-244-248","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-244-248","url":null,"abstract":"Introduction . Endovascular intervention was firstly introduced for repairing aortic aneurysms in the early 1990s. The greatest advantage of endovascular aneurysm repair (EVAR) is its minimally-invasive character, thus implying shorter post-operative period. The operative mortality rate comprises 3.3 % (95 % CI 2.9–3.6); however, according to recent studies, the rate has declined to 1.4 % due to a rapid improvement in outcomes. According to the DREAM-trial, the incidence of a branched endograft thrombosis accounts for 6.4% within the first 30 days. The EVAR trial reports an incidence of 2.6% after the first year of follow-up. Stent bending and small distal aortic diameters (less than 20 mm) are believed to be the most common causes of endograft thrombosis. Aim . To identify the causes of complications following the abdominal aortic stent-graft repair and to determine the optimal treatment strategy. Materials and methods . The paper presents a case of 71-year-old patient with late complication after endovascular abdominal aortic repair of an infrarenal aortic aneurysm. The patient was admitted to the hospital on January 05, 2020 as an emergency due to the pain in the left lower limb. On December 03, 2019 the patient underwent endovascular abdominal aortic repair. Angiography of January 06, 2020 revealed thrombosis of the left branch of the stent graft. Thrombectomy of the brunched left stent graft, left iliac artery and balloon dilatation of the brunched left stent-graft were performed.Results and discussion. Endovascular abdominal aortic repair stands as the first choice for patients with appropriate aortic anatomy and those with significant comorbidity. Despite the significant progress in endovascular abdominal aortic repairing, the EVAR procedure is followed by a nearly fivefold increase in the 30-day reintervention rate as compared to open surgery which comprises 9.8 % according to the EVAR-I, and 18 %, according to the EVAR-II trials. Conclusion . Our multidisciplinary team consisted of vascular and endovascular surgeons managed to perform hybrid surgery, thus eliminating the EVAR-associated complication together with its cause.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.24060/2076-3093-2023-13-3-260-265
D. A. Karpov, E. F. Shakurov, T. A. Farkhutdinov, L. A. Kulmanova, A. V. Antonov, E. V. Strepetkov
Introduction . Cervical spine injury is recognised as one of the most disabling types of vertebral column and spinal cord injuries. With a high level of disability, this type of injury remains quite rare among children. The main types of complications in this kind of injury include impaired regulations of the respiratory and cardiovascular systems, tetra- and paraparesis, and pelvic organ disorders. The analysis of recent publications indicated early surgery (in less than 24 hours) as the main condition for reducing post-traumatic complications. Materials and methods . The paper presents a clinical case of delayed surgery (in more than 24 hours) performed in a 17-year-old patient who was admitted to hospital after a traffic accident. After diagnostic measures, according to indications, a delayed surgery was performed on day 3: anterior spine fusion at the level of C5-Th1 with the installation of a vertebral body endoprosthesis and fixation with a bone plate. Results and discussion . The present case confirms the need for patients with combined spinal cord injury and mild traumatic brain injury to undergo a full range of diagnostic examinations including: brain and spine imaging, and, in the presence of compression and signs of spinal cord injury, MRI of the spinal cord (if necessary, the brain) at the level of injury. In the absence of gross structural damage to the brain, urgent decompression of the spinal cord and spine stabilization are indicated to eliminate the traumatic and spinal shock. Conclusion . Mild traumatic brain injury cannot be considered a contraindication for delayed cervical spine surgery. The present case is indicative of early surgical treatment of spinal injury, especially of the cervical spine, without neurological onset. All diagnostic measures were performed in full. Despite the surgical treatment and rehabilitation measures, the neurological deficit in the patient was not completely eliminated and persisted after 1 year.
{"title":"Delayed Surgical Treatment of Cervical Spine Injury in an Adolescent Patient","authors":"D. A. Karpov, E. F. Shakurov, T. A. Farkhutdinov, L. A. Kulmanova, A. V. Antonov, E. V. Strepetkov","doi":"10.24060/2076-3093-2023-13-3-260-265","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-260-265","url":null,"abstract":"Introduction . Cervical spine injury is recognised as one of the most disabling types of vertebral column and spinal cord injuries. With a high level of disability, this type of injury remains quite rare among children. The main types of complications in this kind of injury include impaired regulations of the respiratory and cardiovascular systems, tetra- and paraparesis, and pelvic organ disorders. The analysis of recent publications indicated early surgery (in less than 24 hours) as the main condition for reducing post-traumatic complications. Materials and methods . The paper presents a clinical case of delayed surgery (in more than 24 hours) performed in a 17-year-old patient who was admitted to hospital after a traffic accident. After diagnostic measures, according to indications, a delayed surgery was performed on day 3: anterior spine fusion at the level of C5-Th1 with the installation of a vertebral body endoprosthesis and fixation with a bone plate. Results and discussion . The present case confirms the need for patients with combined spinal cord injury and mild traumatic brain injury to undergo a full range of diagnostic examinations including: brain and spine imaging, and, in the presence of compression and signs of spinal cord injury, MRI of the spinal cord (if necessary, the brain) at the level of injury. In the absence of gross structural damage to the brain, urgent decompression of the spinal cord and spine stabilization are indicated to eliminate the traumatic and spinal shock. Conclusion . Mild traumatic brain injury cannot be considered a contraindication for delayed cervical spine surgery. The present case is indicative of early surgical treatment of spinal injury, especially of the cervical spine, without neurological onset. All diagnostic measures were performed in full. Despite the surgical treatment and rehabilitation measures, the neurological deficit in the patient was not completely eliminated and persisted after 1 year.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.24060/2076-3093-2023-13-3-254-259
M. M. Zamilov, K. V. Menshikov, Sh. I. Musin, A. V. Sultanbaev, G. I. Zamilova, A. H. Nguyen
Introduction . Hodgkin’s lymphoma is most commonly reported in the young age of 20 to 40 years. Radiation therapy remained the first-choice option before the advent of modern chemotherapy agents. Thereafter, the risk of radioinduced breast cancer after radiotherapy with total radiation dose of 38 Gy or more increased 4.5-fold. Materials and methods . The presented clinical case demonstrates aggressive breast cancer that developed 43 years after radiation therapy for Hodgkin's lymphoma. Results and discussion . In the 1990s, chemotherapy regimens for Hodgkin’s lymphoma were not effective enough to control the disease, therefore, radiotherapy was an indispensable measure. Secondary radioinduced tumors take the second place (26 %) in the structure of mortality from Hodgkin’s lymphoma. The emergence of new, more effective chemotherapy regimens reduced the risk of secondary tumors and, in particular, breast cancer. Conclusion . At present, up to 75 % of patients with Hodgkin’s lymphoma can be cured using modern methods of chemotherapy and radiation therapy. In follow-up care, it is necessary to consider the high risk of secondary malignant neoplasms, especially lung and breast cancer.
{"title":"Features of the Course of Radioinduced Breast Cancer. Clinical Observation","authors":"M. M. Zamilov, K. V. Menshikov, Sh. I. Musin, A. V. Sultanbaev, G. I. Zamilova, A. H. Nguyen","doi":"10.24060/2076-3093-2023-13-3-254-259","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-254-259","url":null,"abstract":"Introduction . Hodgkin’s lymphoma is most commonly reported in the young age of 20 to 40 years. Radiation therapy remained the first-choice option before the advent of modern chemotherapy agents. Thereafter, the risk of radioinduced breast cancer after radiotherapy with total radiation dose of 38 Gy or more increased 4.5-fold. Materials and methods . The presented clinical case demonstrates aggressive breast cancer that developed 43 years after radiation therapy for Hodgkin's lymphoma. Results and discussion . In the 1990s, chemotherapy regimens for Hodgkin’s lymphoma were not effective enough to control the disease, therefore, radiotherapy was an indispensable measure. Secondary radioinduced tumors take the second place (26 %) in the structure of mortality from Hodgkin’s lymphoma. The emergence of new, more effective chemotherapy regimens reduced the risk of secondary tumors and, in particular, breast cancer. Conclusion . At present, up to 75 % of patients with Hodgkin’s lymphoma can be cured using modern methods of chemotherapy and radiation therapy. In follow-up care, it is necessary to consider the high risk of secondary malignant neoplasms, especially lung and breast cancer.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.24060/2076-3093-2023-13-3-221-228
A. V. Sultanbaev, K. V. Menshikov, Sh. I. Musin, A. A. Izmailov, I. A. Menshikova, N. I. Sultanbaeva
The present paper considers the predictors of multiple primary malignancies. The multiple primary malignancies are often induced by genetic predisposition and familial cancer syndromes, environmental carcinogens and bad habits (e.g. tobacco and alcohol abuse), immunodeficiency and infectious diseases, carcinogens occurring as a result of various treatments, etc. Germinal mutations are considered to be one of the causes of primary cancer — they increase the risk of various multiple primary malignancies. Hereditary cancers are characterized by a strong family history, early age of onset and occurrence of multiple primary malignancies. The paper considers various mechanisms of multiple primary malignancies with an emphasis on the effect of carcinogens in carriers of pathogenic genes on cancer development. In proven cases, when patients are exposed to multiple carcinogens, they should be aware of possible late and long-term effects of treatment and their symptoms, as well as secondary malignancies that might occur. When the main predictors of carcinogenesis are manageable, and primary preventive measures can be taken, the hereditary malignancies require postexposure prophylaxis. In addition to specific recommendations for the prevention of primary cancers, it is essential to follow recommendations for the prevention of second primary cancers.
{"title":"Predictors of Multiple Primary Malignancies: Literature Review","authors":"A. V. Sultanbaev, K. V. Menshikov, Sh. I. Musin, A. A. Izmailov, I. A. Menshikova, N. I. Sultanbaeva","doi":"10.24060/2076-3093-2023-13-3-221-228","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-221-228","url":null,"abstract":"The present paper considers the predictors of multiple primary malignancies. The multiple primary malignancies are often induced by genetic predisposition and familial cancer syndromes, environmental carcinogens and bad habits (e.g. tobacco and alcohol abuse), immunodeficiency and infectious diseases, carcinogens occurring as a result of various treatments, etc. Germinal mutations are considered to be one of the causes of primary cancer — they increase the risk of various multiple primary malignancies. Hereditary cancers are characterized by a strong family history, early age of onset and occurrence of multiple primary malignancies. The paper considers various mechanisms of multiple primary malignancies with an emphasis on the effect of carcinogens in carriers of pathogenic genes on cancer development. In proven cases, when patients are exposed to multiple carcinogens, they should be aware of possible late and long-term effects of treatment and their symptoms, as well as secondary malignancies that might occur. When the main predictors of carcinogenesis are manageable, and primary preventive measures can be taken, the hereditary malignancies require postexposure prophylaxis. In addition to specific recommendations for the prevention of primary cancers, it is essential to follow recommendations for the prevention of second primary cancers.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.24060/2076-3093-2023-13-3-238-243
V. A. Pelts, V. E. Tropin, V. V. Pavlenko, A. O. Krasnov
The evolution of hepatic surgery at the present stage of medical development requires specialists to develop patient-oriented rational surgical tactics and use modern methods for the diagnosis and prediction of post-resection liver failure in the surgical treatment of liver tumors by resection, thereby forming approaches that reduce the risks of severe postoperative complications associated with insufficient liver remnants remaining after extensive resection. The paper reviews the problematic issues of diagnosis and treatment of liver tumors, as well as provides current views on the relevance of timely prevention of post-resection liver failure. The study considers methods for assessing the risks of complications and adverse outcome when planning and performing extensive liver resections, defines the concept of post-resection liver failure, and highlights the main mechanisms of vicarious hypertrophy. The paper examines the most commonly used methods for vicarious hypertrophy of the parenchyma remaining after extensive liver resection, their advantages, and disadvantages. The main possible causes of failures in developing a strategy for two-stage liver resections are analyzed. A critical analysis of available contemporary literature enabled the authors of the paper to identify possible ways to further improve the results of extensive liver resections.
{"title":"Staged Surgical Treatment for Patients with Liver Tumors and Optimal Method of Vicarious Hypertrophy of the Liver Remnant: Literature Review","authors":"V. A. Pelts, V. E. Tropin, V. V. Pavlenko, A. O. Krasnov","doi":"10.24060/2076-3093-2023-13-3-238-243","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-238-243","url":null,"abstract":"The evolution of hepatic surgery at the present stage of medical development requires specialists to develop patient-oriented rational surgical tactics and use modern methods for the diagnosis and prediction of post-resection liver failure in the surgical treatment of liver tumors by resection, thereby forming approaches that reduce the risks of severe postoperative complications associated with insufficient liver remnants remaining after extensive resection. The paper reviews the problematic issues of diagnosis and treatment of liver tumors, as well as provides current views on the relevance of timely prevention of post-resection liver failure. The study considers methods for assessing the risks of complications and adverse outcome when planning and performing extensive liver resections, defines the concept of post-resection liver failure, and highlights the main mechanisms of vicarious hypertrophy. The paper examines the most commonly used methods for vicarious hypertrophy of the parenchyma remaining after extensive liver resection, their advantages, and disadvantages. The main possible causes of failures in developing a strategy for two-stage liver resections are analyzed. A critical analysis of available contemporary literature enabled the authors of the paper to identify possible ways to further improve the results of extensive liver resections.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.24060/2076-3093-2023-13-3-249-253
V. S. Panteleev, M. A. Nartaylakov, A. S. Safonov, Yu. V. Petrov, M. P. Pogorelova, T. A. Shagabutdinov
Introduction . A comprehensive approach to restore the patency of the trachea and bronchi in stenoses of various origin consists in their endoscopic stenting, which can be both temporary and maximum continuous. Materials and methods . The study presents two clinical cases of successful endoscopic stenting of the lower lobar bronchi of the lungs with relief of respiratory failure. In the first case, the left inferior lobar bronchus was compressed from the outside by a hematoma from a ruptured false aortic aneurysm. Thus, the aneurysm was stented first, and the compressed bronchus — second. In the second case, the right inferior lobar bronchus was stented due to lung metastases. In both cases, bronchial stenosis was accompanied by pulmonary atelectasis. Results and discussion . In both cases, stenting was effective in restoring the patency of stenosed bronchi and expanding the lungs, which enabled respiratory failure to be stopped. In the first case, 3 months after the stenting, its outward migration was revealed, but no recurrence of bronchial narrowing was observed during further dynamic observation. In the second case, the follow-up of the patient for 6 months after stenting showed adequate functioning of the stent. Conclusion . The presented clinical cases demonstrate high efficacy and reliability of endoscopic stenting in bronchial stenoses of various origin to cope with the respiratory failure and thereby improve the quality of life.
{"title":"Clinical Cases of Successful Endoscopic Bronchial Stenting","authors":"V. S. Panteleev, M. A. Nartaylakov, A. S. Safonov, Yu. V. Petrov, M. P. Pogorelova, T. A. Shagabutdinov","doi":"10.24060/2076-3093-2023-13-3-249-253","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-249-253","url":null,"abstract":"Introduction . A comprehensive approach to restore the patency of the trachea and bronchi in stenoses of various origin consists in their endoscopic stenting, which can be both temporary and maximum continuous. Materials and methods . The study presents two clinical cases of successful endoscopic stenting of the lower lobar bronchi of the lungs with relief of respiratory failure. In the first case, the left inferior lobar bronchus was compressed from the outside by a hematoma from a ruptured false aortic aneurysm. Thus, the aneurysm was stented first, and the compressed bronchus — second. In the second case, the right inferior lobar bronchus was stented due to lung metastases. In both cases, bronchial stenosis was accompanied by pulmonary atelectasis. Results and discussion . In both cases, stenting was effective in restoring the patency of stenosed bronchi and expanding the lungs, which enabled respiratory failure to be stopped. In the first case, 3 months after the stenting, its outward migration was revealed, but no recurrence of bronchial narrowing was observed during further dynamic observation. In the second case, the follow-up of the patient for 6 months after stenting showed adequate functioning of the stent. Conclusion . The presented clinical cases demonstrate high efficacy and reliability of endoscopic stenting in bronchial stenoses of various origin to cope with the respiratory failure and thereby improve the quality of life.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.24060/2076-3093-2023-13-3-198-202
L. R. Akhmadeeva, V. V. Plechev, K. R. Izhbuldina, R. R. Gizatullin, M. O. Isrofilov
Introduction . Acute cerebrovascular accident is recognized as the leading pathology in the structure of cerebrovascular diseases (CVD). Annually 6 million cases of CVD are registered in the world. Fatal outcomes from this pathology in Russia occur 1.5–2 times more often than in developed countries. According to the All-Russian Center for Preventive Medicine, 25% of males and 39% of females die from CVD. The incidence of CVD in Russia ranges from 460 to 560 cases per 100 thousand people. This pathology may be caused by carotid artery stenosis resulting from atherosclerotic vascular lesions and plaque formation which lead to embolism and stroke. Materials and methods . The study analyzed 341 medical histories of patients hospitalized at the Bashkir State Medical University Clinic (BSMU Clinic) in 2022, who underwent carotid endarterectomy (CEE) (288 of them had a history of chronic cerebrovascular accident) and 278 medical histories of patients with acute cerebrovascular accident, hospitalized at the Neurologic Clinic of the Avicenna Tajik State Medical University in 2022. Results and discussion . Perioperative complications that occurred during CEE at BSMU Clinic in 2022 included 12 cases of acute cerebrovascular accident of ischemic type (3.52%) and 2 cases of transient ischemic attack (0.6%), which is lower than the same rates in previously published observations at the same clinic. Conclusion . The number of complications resulting from the CEE does not exceed the global rates. Quantitative and qualitative indicators of carotid reconstructions demonstrate positive trends. Acute cerebrovascular accident requires clarifying the cause of its occurrence and taking measures to prevent ischemic strokes, including angiosurgical interventions.
{"title":"Acute Cerebral Vascular Events after Carotid Endarterectomy","authors":"L. R. Akhmadeeva, V. V. Plechev, K. R. Izhbuldina, R. R. Gizatullin, M. O. Isrofilov","doi":"10.24060/2076-3093-2023-13-3-198-202","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-198-202","url":null,"abstract":"Introduction . Acute cerebrovascular accident is recognized as the leading pathology in the structure of cerebrovascular diseases (CVD). Annually 6 million cases of CVD are registered in the world. Fatal outcomes from this pathology in Russia occur 1.5–2 times more often than in developed countries. According to the All-Russian Center for Preventive Medicine, 25% of males and 39% of females die from CVD. The incidence of CVD in Russia ranges from 460 to 560 cases per 100 thousand people. This pathology may be caused by carotid artery stenosis resulting from atherosclerotic vascular lesions and plaque formation which lead to embolism and stroke. Materials and methods . The study analyzed 341 medical histories of patients hospitalized at the Bashkir State Medical University Clinic (BSMU Clinic) in 2022, who underwent carotid endarterectomy (CEE) (288 of them had a history of chronic cerebrovascular accident) and 278 medical histories of patients with acute cerebrovascular accident, hospitalized at the Neurologic Clinic of the Avicenna Tajik State Medical University in 2022. Results and discussion . Perioperative complications that occurred during CEE at BSMU Clinic in 2022 included 12 cases of acute cerebrovascular accident of ischemic type (3.52%) and 2 cases of transient ischemic attack (0.6%), which is lower than the same rates in previously published observations at the same clinic. Conclusion . The number of complications resulting from the CEE does not exceed the global rates. Quantitative and qualitative indicators of carotid reconstructions demonstrate positive trends. Acute cerebrovascular accident requires clarifying the cause of its occurrence and taking measures to prevent ischemic strokes, including angiosurgical interventions.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135646354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.24060/2076-3093-2023-13-3-215-220
M. V. Timerbulatov, A. F. Itkulov, D. E. Baikov, A. A. Ibatullin, M. M. Khafizov
Introduction . Colonic diverticular disease (colonic diverticulitis) is considered to be a serious medical and social problem of modern society, marked by a persistent decrease in the quality of life of patients and a steady growth in morbidity with a tendency to increase complications of the underlying disease in the form of inflammatory destructive changes in the intestinal wall. Materials and methods . The study involved 63 patients with colonic diverticulitis, males and females, aged 34 through 79 years. All participants were divided into 3 groups, depending on the damage to the intestinal wall. The first group included 11 patients with intact intestinal wall, the second group included 43 patients with diverticulitis, and the third group — 9 patients with adenocarcinoma of the large intestine. Results and discussion . When performing perfusion computed tomography (PCT) of the intestinal wall, it was found that BF values in acute diverticulitis, compared to the intact intestinal wall, increased on average by 1.7 times, while in malignancies — by 5.3 times. BV values in acute diverticulitis, as compared to the intact intestinal wall, increased by 9.2, and in malignancies — 13.6 times. MRI values in acute diverticulitis, as compared to the intact intestinal wall, increased by 2.5 times, and in malignancies — 3.9 times. PS values in acute diverticulitis, as compared to the intact intestinal wall, increased by 1.7 times, and in malignancies — 3.8 times. Conclusion . Since PCT is able to detect the difference of microcirculation parameters in inflammatory and malignant processes, it can be used in the diagnostic algorithm to determine further treatment strategy.
{"title":"Perfusion Computed Tomography in the Diagnosis of Colonic Diverticular Disease and its Complications","authors":"M. V. Timerbulatov, A. F. Itkulov, D. E. Baikov, A. A. Ibatullin, M. M. Khafizov","doi":"10.24060/2076-3093-2023-13-3-215-220","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-215-220","url":null,"abstract":"Introduction . Colonic diverticular disease (colonic diverticulitis) is considered to be a serious medical and social problem of modern society, marked by a persistent decrease in the quality of life of patients and a steady growth in morbidity with a tendency to increase complications of the underlying disease in the form of inflammatory destructive changes in the intestinal wall. Materials and methods . The study involved 63 patients with colonic diverticulitis, males and females, aged 34 through 79 years. All participants were divided into 3 groups, depending on the damage to the intestinal wall. The first group included 11 patients with intact intestinal wall, the second group included 43 patients with diverticulitis, and the third group — 9 patients with adenocarcinoma of the large intestine. Results and discussion . When performing perfusion computed tomography (PCT) of the intestinal wall, it was found that BF values in acute diverticulitis, compared to the intact intestinal wall, increased on average by 1.7 times, while in malignancies — by 5.3 times. BV values in acute diverticulitis, as compared to the intact intestinal wall, increased by 9.2, and in malignancies — 13.6 times. MRI values in acute diverticulitis, as compared to the intact intestinal wall, increased by 2.5 times, and in malignancies — 3.9 times. PS values in acute diverticulitis, as compared to the intact intestinal wall, increased by 1.7 times, and in malignancies — 3.8 times. Conclusion . Since PCT is able to detect the difference of microcirculation parameters in inflammatory and malignant processes, it can be used in the diagnostic algorithm to determine further treatment strategy.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135646355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.24060/2076-3093-2023-13-3-210-214
Sh. R. Kzyrgalin, R. S. Yamidanov, R. A. Amirov, Sh. Kh. Gantsev
Introduction . Ovarian cancer (OC) is recognized to be a pressing problem of modern oncology. Cytoreductive surgery and combined therapy based on platinum and taxanes play an important role in OC treatment. The response rate to first-line therapy accounts for about 80–90%. However, most patients relapse and develop resistance to therapy. Thus, the search for new effective drugs and new combinations for OC treatment is an urgent task of modern oncology. Aim . To evaluate in vivo the antitumor activity of dehydroxymethylepoxyquinomycin (DHMEQ) and cisplatin combination in an ovarian cancer model. Materials and methods . An experimental model of disseminated OC in rats was used to evaluate antitumor activity. A strain of ovarian tumor (OT) was transplanted into 200 female Wistar rats. The drugs were administered intraperitoneally. The “median life expectancy” was taken as a benchmark for the quality evaluation of experimental treatment. Results . It was found that DHMEQ and cisplatin combination increased the survival rate by 387% (p = 0.005, log-rank test) compared to the control group and by 91% compared to the group of animals treated with cisplatin (p = 0.003, log-rank test) in mono mode. More than 50% of the animals in the DHMEQ + cisplatin group remained alive on day 73 of the experiment. No animals remained alive in the cisplatin group, and only one rat remained in the DHMEQ group. Discussion . Thus, the obtained data demonstrate a potentiating antitumor effect of the DHMEQ + cisplatin combination by 387% compared to the control group. Conclusion. The results of the experiments demonstrated a potentiating antitumor effect of DHMEQ in combination with cisplatin. DHMEQ in combination with cisplatin manifests high efficacy in an in vivo model of ovarian cancer.
{"title":"Antitumor Activity of Dehydroxymethylepoxychinomycin (DHMEQ) and Cisplatin Combination in a Model of Disseminated Ovarian Cancer","authors":"Sh. R. Kzyrgalin, R. S. Yamidanov, R. A. Amirov, Sh. Kh. Gantsev","doi":"10.24060/2076-3093-2023-13-3-210-214","DOIUrl":"https://doi.org/10.24060/2076-3093-2023-13-3-210-214","url":null,"abstract":"Introduction . Ovarian cancer (OC) is recognized to be a pressing problem of modern oncology. Cytoreductive surgery and combined therapy based on platinum and taxanes play an important role in OC treatment. The response rate to first-line therapy accounts for about 80–90%. However, most patients relapse and develop resistance to therapy. Thus, the search for new effective drugs and new combinations for OC treatment is an urgent task of modern oncology. Aim . To evaluate in vivo the antitumor activity of dehydroxymethylepoxyquinomycin (DHMEQ) and cisplatin combination in an ovarian cancer model. Materials and methods . An experimental model of disseminated OC in rats was used to evaluate antitumor activity. A strain of ovarian tumor (OT) was transplanted into 200 female Wistar rats. The drugs were administered intraperitoneally. The “median life expectancy” was taken as a benchmark for the quality evaluation of experimental treatment. Results . It was found that DHMEQ and cisplatin combination increased the survival rate by 387% (p = 0.005, log-rank test) compared to the control group and by 91% compared to the group of animals treated with cisplatin (p = 0.003, log-rank test) in mono mode. More than 50% of the animals in the DHMEQ + cisplatin group remained alive on day 73 of the experiment. No animals remained alive in the cisplatin group, and only one rat remained in the DHMEQ group. Discussion . Thus, the obtained data demonstrate a potentiating antitumor effect of the DHMEQ + cisplatin combination by 387% compared to the control group. Conclusion. The results of the experiments demonstrated a potentiating antitumor effect of DHMEQ in combination with cisplatin. DHMEQ in combination with cisplatin manifests high efficacy in an in vivo model of ovarian cancer.","PeriodicalId":52846,"journal":{"name":"Kreativnaia khirurgiia i onkologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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