Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-b04
Bharat Ashok Nikam, A. Gayke
The objective of this research work was to formulate, develop and evaluate immediate release tablet of paracetamol and orphenadrine citrate by direct compression method. Paracetamol which is antipyretic and orphenadrine citrate is skeletal muscle relaxant. The drug paracetamol and orphenadrine citrate was taken and formulated with different concentration of cross-povidone, mannitol, micro-crystalline cellulose, magnesium stearate and talc. Where cross-povidone as a superdisintegrant, mannitol as diluent, micro-crystalline cellulose as binder, magnesium stearate as lubricant and talc as a glidant used. the preformulation parameters such as bulk density, tapped density, compressibility index and hausner’s ratio were analysed. The thickness, hardness, friability, weight variation, disintegration time & drug content uniformity was evaluated. the in-vitro drug release studied were performed in the usp type (ii) paddle using 0.1N HCl as a dissolution media at 75 rpm speed and temperature of 37±0.5ºC. The % drug release at different time interval was estimated using UV method. Based on the evaluation result f9 trial was selected as the best formulation. The in-vitro drug release profile of the drugs was compared with marketed reference product. All the evaluated result was found to be satisfied with the reference products.
{"title":"FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET OF PARACETAMOL AND ORPHENADRINE CITRATE BY DIRECT COMPRESSION METHOD","authors":"Bharat Ashok Nikam, A. Gayke","doi":"10.46939/j.sci.arts-22.3-b04","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-b04","url":null,"abstract":"The objective of this research work was to formulate, develop and evaluate immediate release tablet of paracetamol and orphenadrine citrate by direct compression method. Paracetamol which is antipyretic and orphenadrine citrate is skeletal muscle relaxant. The drug paracetamol and orphenadrine citrate was taken and formulated with different concentration of cross-povidone, mannitol, micro-crystalline cellulose, magnesium stearate and talc. Where cross-povidone as a superdisintegrant, mannitol as diluent, micro-crystalline cellulose as binder, magnesium stearate as lubricant and talc as a glidant used. the preformulation parameters such as bulk density, tapped density, compressibility index and hausner’s ratio were analysed. The thickness, hardness, friability, weight variation, disintegration time & drug content uniformity was evaluated. the in-vitro drug release studied were performed in the usp type (ii) paddle using 0.1N HCl as a dissolution media at 75 rpm speed and temperature of 37±0.5ºC. The % drug release at different time interval was estimated using UV method. Based on the evaluation result f9 trial was selected as the best formulation. The in-vitro drug release profile of the drugs was compared with marketed reference product. All the evaluated result was found to be satisfied with the reference products.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46030929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-a07
M. Mehmood, Muhammad Bilal, A. Shoaib
In this article, we have extended the results of Y. U. Gaba by taking multiplicative G-metric space instead of G-metric space. In this way, we proved contraction mapping theorems on multiplicative, G-metric spaces using rational type contraction conditions for a single map. Later on, we extended our results in the settings of triplet maps. We have also given examples to support our results.
{"title":"RATIONAL TYPE CONTRACTION MAPPING THEOREMS ON MULTIPLICATIVE G-METRIC SPACES","authors":"M. Mehmood, Muhammad Bilal, A. Shoaib","doi":"10.46939/j.sci.arts-22.3-a07","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-a07","url":null,"abstract":"In this article, we have extended the results of Y. U. Gaba by taking multiplicative G-metric space instead of G-metric space. In this way, we proved contraction mapping theorems on multiplicative, G-metric spaces using rational type contraction conditions for a single map. Later on, we extended our results in the settings of triplet maps. We have also given examples to support our results.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44561839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-b05
M. Sen, C. Jeyaseelan
Rapid industrialization, urbanization and technological advancement in this century have drastically changed the biogeochemical cycles and balance of some of the heavy metals, thereby leading to environmental pollution in alarming proportions. Lead (i.e., Pb2+) is toxic to most organisms for concentrations higher than 0.05 mg/L, moreover, it is carcinogenic to animals. In the present study, batch biosorption of Pb2+ from wastewaters was studied using the nonliving biomass of Aspergillus sp. and Fusarium sp. isolated from soil. The specific metal removal increased with increase in initial lead ion concentration upto 500 mg/L observed with both the biomasses. A complete removal of the metal was observed at an initial metal ion concentration 50 mg/L and at pH 5.0. A maximum removal of 42.5 mg/g with Fusarium sp. and 37.3 mg/g with Aspergillus sp. was observed at pH 5.0 at 500 mg/L initial lead ion concentration. The adsorption equilibrium was obtained within 1h for all the concentration used. The adsorption equilibrium constants were obtained using both Freundlich and Langmuir adsorption isotherms. The desorption studies disclose the effective recovery of lead from the metal concentrated biomass using 0.1N Nitric acid solution within 0.5 h of time period increasing its effectiveness of reuse.
{"title":"EFFECTIVE REMOVAL AND RECOVERY OF LEAD FROM INDUSTRIAL WASTEWATERS USING NATURAL BIOMASS","authors":"M. Sen, C. Jeyaseelan","doi":"10.46939/j.sci.arts-22.3-b05","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-b05","url":null,"abstract":"Rapid industrialization, urbanization and technological advancement in this century have drastically changed the biogeochemical cycles and balance of some of the heavy metals, thereby leading to environmental pollution in alarming proportions. Lead (i.e., Pb2+) is toxic to most organisms for concentrations higher than 0.05 mg/L, moreover, it is carcinogenic to animals. In the present study, batch biosorption of Pb2+ from wastewaters was studied using the nonliving biomass of Aspergillus sp. and Fusarium sp. isolated from soil. The specific metal removal increased with increase in initial lead ion concentration upto 500 mg/L observed with both the biomasses. A complete removal of the metal was observed at an initial metal ion concentration 50 mg/L and at pH 5.0. A maximum removal of 42.5 mg/g with Fusarium sp. and 37.3 mg/g with Aspergillus sp. was observed at pH 5.0 at 500 mg/L initial lead ion concentration. The adsorption equilibrium was obtained within 1h for all the concentration used. The adsorption equilibrium constants were obtained using both Freundlich and Langmuir adsorption isotherms. The desorption studies disclose the effective recovery of lead from the metal concentrated biomass using 0.1N Nitric acid solution within 0.5 h of time period increasing its effectiveness of reuse.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45010944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-a13
Şule Sağlam, K. Karakaya
In this study, a new distribution is introduced. The Burr-Hatke distribution is considered the baseline distribution. Since the baseline distribution has one parameter, the new unit distribution also has one parameter. Some distributional properties such as moments, coefficients of skewness and kurtosis, stochastic ordering, etc. of the new distribution are studied. Five estimators such as maximum likelihood, least squares, weighted least squares, Anderson-Darling, and Cramer-von Mises are examined to estimate the unknown parameter of the new model. The performances of the estimators are analyzed according to the bias and mean square error criteria calculated by Monte Carlo simulation. Two numerical data analyses are performed. A new quantile regression model is also introduced based on the new distribution as an alternative to beta and Kumaraswamy regression. A Monte Carlo simulation is also conducted for the new regression model.
{"title":"UNIT BURR-HATKE DISTRIBUTION WITH A NEW QUANTILE REGRESSION MODEL","authors":"Şule Sağlam, K. Karakaya","doi":"10.46939/j.sci.arts-22.3-a13","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-a13","url":null,"abstract":"In this study, a new distribution is introduced. The Burr-Hatke distribution is considered the baseline distribution. Since the baseline distribution has one parameter, the new unit distribution also has one parameter. Some distributional properties such as moments, coefficients of skewness and kurtosis, stochastic ordering, etc. of the new distribution are studied. Five estimators such as maximum likelihood, least squares, weighted least squares, Anderson-Darling, and Cramer-von Mises are examined to estimate the unknown parameter of the new model. The performances of the estimators are analyzed according to the bias and mean square error criteria calculated by Monte Carlo simulation. Two numerical data analyses are performed. A new quantile regression model is also introduced based on the new distribution as an alternative to beta and Kumaraswamy regression. A Monte Carlo simulation is also conducted for the new regression model.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44380932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-a02
Zeli̇ha Erpehli̇van, H. Kocayiğit, Tuba Ağirman Aydin
In this study, we examine timelike helices in R2^4 and some integral characterizations of these curves in terms of Frenet frame. In addition, we study timelike B2 slant helices in R2^4 and present the differential equations for vector positions.
{"title":"SOME INTEGRAL CHARACTERIZATIONS OF TIMELIKE HELICES IN R2^4","authors":"Zeli̇ha Erpehli̇van, H. Kocayiğit, Tuba Ağirman Aydin","doi":"10.46939/j.sci.arts-22.3-a02","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-a02","url":null,"abstract":"In this study, we examine timelike helices in R2^4 and some integral characterizations of these curves in terms of Frenet frame. In addition, we study timelike B2 slant helices in R2^4 and present the differential equations for vector positions.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44214060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-b02
L. Rotaru, R. Văruţ, Flavius Truicu, Alina Girniceanu, M. Forțofoiu, C. Constantin
To identify the pattern of myoglobin compared to hemoglobin blockade by the combustion products contained in the fire smoke using computational chemistry tools. The myoglobin unavailability can be a determining factor of the severity and consequences of smoke poisoning, generating the inability of patients to attempt evacuate themselves, compromising myocardial function, leading to crush syndrome-like effects and increasing of multi-organ failure to the victims of mass burn casualties event. In this study, it was used quantum chemical calculations performed with the Gaussian program suite using DFT/B3LYP/6-311G level of theory to optimize molecular geometries, calculate the molecular electrostatic potential, and obtain the vibrational spectrum. These calculations were applied to the myoglobin and hemoglobin model, thus studying their binding to the essential components of toxic fire smoke. Comparing the structural descriptors – frontier molecular orbitals, energy difference, electric dipole moment (μ), was obtained the highest values as belonging to hydrogen cyanide (2.9), which may explain its increased reactivity, meaning strong interaction with both myoglobin and hemoglobin, followed by hydrochloric acid (1.03) and carbon monoxide (0.122). Within the framework of complex intoxication generated by the inhalation of fire smoke, myoglobin is blocked in a temporal manner and according to a very similar pattern to hemoglobin. It follows that the significant rhabdomyolysis found in these patients is due not only to hypoxemia but also to the primary unavailability of myoglobin, and myocardial damage is also multifactorial. Although slightly discussed, the calculation of different structural and geometric descriptors for hydrochloric acid reveals for hydrochloric acid high values, suggesting binding affinities comparable to those of carbon monoxide. Molecular modeling programs allow for new approaches and can identify parameters or areas of their reference that influence the management of patients intoxicated with fire smoke components.
{"title":"MYOGLOBIN vs. HEMOGLOBIN BLOCKADE MODEL RELATED SMOKE GAS INHALATION - A COMPUTATIONAL ANALYSIS","authors":"L. Rotaru, R. Văruţ, Flavius Truicu, Alina Girniceanu, M. Forțofoiu, C. Constantin","doi":"10.46939/j.sci.arts-22.3-b02","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-b02","url":null,"abstract":"To identify the pattern of myoglobin compared to hemoglobin blockade by the combustion products contained in the fire smoke using computational chemistry tools. The myoglobin unavailability can be a determining factor of the severity and consequences of smoke poisoning, generating the inability of patients to attempt evacuate themselves, compromising myocardial function, leading to crush syndrome-like effects and increasing of multi-organ failure to the victims of mass burn casualties event. In this study, it was used quantum chemical calculations performed with the Gaussian program suite using DFT/B3LYP/6-311G level of theory to optimize molecular geometries, calculate the molecular electrostatic potential, and obtain the vibrational spectrum. These calculations were applied to the myoglobin and hemoglobin model, thus studying their binding to the essential components of toxic fire smoke. Comparing the structural descriptors – frontier molecular orbitals, energy difference, electric dipole moment (μ), was obtained the highest values as belonging to hydrogen cyanide (2.9), which may explain its increased reactivity, meaning strong interaction with both myoglobin and hemoglobin, followed by hydrochloric acid (1.03) and carbon monoxide (0.122). Within the framework of complex intoxication generated by the inhalation of fire smoke, myoglobin is blocked in a temporal manner and according to a very similar pattern to hemoglobin. It follows that the significant rhabdomyolysis found in these patients is due not only to hypoxemia but also to the primary unavailability of myoglobin, and myocardial damage is also multifactorial. Although slightly discussed, the calculation of different structural and geometric descriptors for hydrochloric acid reveals for hydrochloric acid high values, suggesting binding affinities comparable to those of carbon monoxide. Molecular modeling programs allow for new approaches and can identify parameters or areas of their reference that influence the management of patients intoxicated with fire smoke components.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46393696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-a03
Ö. Gümüs, A. Selvam, R. Janagaraj
In this study, the dynamics of a discrete-time plant-herbivore model obtained using the forward Euler method are discussed. The existence of fixed points is investigated. A topological classification is made to examine the behavior of the positive fixed point where the plant and the herbivore coexist. In addition, the existence conditions and direction of Neimark-Sacker bifurcation of the model are investigated using bifurcation theory. Hybrid control method is applied to control the chaos caused by Neimark-Sacker bifurcation. Examples including time series figures, bifurcation figures, phase portraits and maximum Lyapunov exponent are provided to support our theoretical results.
{"title":"NEIMARK-SACKER BIFURCATION AND CONTROL OF CHAOTIC BEHAVIOR IN A DISCRETE-TIME PLANT-HERBIVORE SYSTEM","authors":"Ö. Gümüs, A. Selvam, R. Janagaraj","doi":"10.46939/j.sci.arts-22.3-a03","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-a03","url":null,"abstract":"In this study, the dynamics of a discrete-time plant-herbivore model obtained using the forward Euler method are discussed. The existence of fixed points is investigated. A topological classification is made to examine the behavior of the positive fixed point where the plant and the herbivore coexist. In addition, the existence conditions and direction of Neimark-Sacker bifurcation of the model are investigated using bifurcation theory. Hybrid control method is applied to control the chaos caused by Neimark-Sacker bifurcation. Examples including time series figures, bifurcation figures, phase portraits and maximum Lyapunov exponent are provided to support our theoretical results.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48773589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-a11
L. Ciurdariu
In this paper some new Radon type inequalities for some seminorms on pseudo-Hilbert spaces and norms in Hilbert spaces are presented. Then several consequences and applications are given
{"title":"A VARIANT OF RADON’S INEQUALITY FOR SEMINORMS","authors":"L. Ciurdariu","doi":"10.46939/j.sci.arts-22.3-a11","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-a11","url":null,"abstract":"In this paper some new Radon type inequalities for some seminorms on pseudo-Hilbert spaces and norms in Hilbert spaces are presented. Then several consequences and applications are given","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45330398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-a05
Mehmet Fidan, A. Sarioğlugìl
The purpose of this paper, first, is to give a definition of the focal surfaces of the inverse of a given regular surface in E3. Second, some new characteristic properties of the focal surfaces are to express depending on the algebraic invariants of the inverse surface of a given regular surface. In the last part of the study, we gave examples supporting our claims and plotted their graphics with the help of Maple software.
{"title":"GEOMETRY OF THE FOCAL SURFACES OF THE INVERSE SURFACE OF A REGULAR SURFACE IN E3","authors":"Mehmet Fidan, A. Sarioğlugìl","doi":"10.46939/j.sci.arts-22.3-a05","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-a05","url":null,"abstract":"The purpose of this paper, first, is to give a definition of the focal surfaces of the inverse of a given regular surface in E3. Second, some new characteristic properties of the focal surfaces are to express depending on the algebraic invariants of the inverse surface of a given regular surface. In the last part of the study, we gave examples supporting our claims and plotted their graphics with the help of Maple software.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41330371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.46939/j.sci.arts-22.3-a04
B. Kuloğlu, E. Özkan
In this paper, inspiring Hosoya’s triangle, we define a new Narayana triangle. Then, we represent this Narayana triangle geometrically on the plane. In addition, we give some identities and properties of the new Narayana triangle.
{"title":"NEW NARAYANA TRIANGLE","authors":"B. Kuloğlu, E. Özkan","doi":"10.46939/j.sci.arts-22.3-a04","DOIUrl":"https://doi.org/10.46939/j.sci.arts-22.3-a04","url":null,"abstract":"In this paper, inspiring Hosoya’s triangle, we define a new Narayana triangle. Then, we represent this Narayana triangle geometrically on the plane. In addition, we give some identities and properties of the new Narayana triangle.","PeriodicalId":54169,"journal":{"name":"Journal of Science and Arts","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49389226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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