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Atypical surge of hospitalized and severe cases of pertussis: A single center 19-years study from China. 百日咳住院重症病例的非典型激增:来自中国的一项为期 19 年的单一中心研究。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-12 DOI: 10.1016/j.pulmoe.2024.06.006
Y Hu, L Wang, K Yao, Q Wang
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引用次数: 0
Application and internal validation of lung ultrasound score in COVID-19 setting: Correspondence. 肺部超声评分在 COVID-19 环境中的应用和内部验证:通讯
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-12 DOI: 10.1016/j.pulmoe.2024.06.001
H Daungsupawong, V Wiwanitkit
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引用次数: 0
A rare case of pneumocystosis under anti-PD-L1 therapy. 抗PD-L1疗法下的一例罕见肺囊肿病例。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-12 DOI: 10.1016/j.pulmoe.2024.05.004
Maria João Santos, Maria João Cavaco, Fernanda Paula Santos, Filipe Froes
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引用次数: 0
Application and internal validation of lung ultrasound score in COVID-19 setting: The ECOVITA observational study. Authors' reply. 肺部超声评分在 COVID-19 环境中的应用和内部验证:ECOVITA 观察性研究。作者回复。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-12 DOI: 10.1016/j.pulmoe.2024.06.004
L Rinaldi, F Perrotta
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引用次数: 0
Methicilin-susceptible Staphylococcus aureus clonal complex 398: An unusual agent of necrotizing pneumonia 甲氧西林敏感金黄色葡萄球菌克隆复合体398:一种罕见的坏死性肺炎病原体。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-01 DOI: 10.1016/j.pulmoe.2023.10.003
C. Nobre , P. Moniz , N.A. Faria
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引用次数: 0
Use of automatic 6-minute walking test recording system in patients with chronic respiratory diseases 在慢性呼吸系统疾病患者中使用自动6分钟步行测试记录系统。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-01 DOI: 10.1016/j.pulmoe.2023.08.011
R. Torres-Castro , H. Pascual , A. Alonso , E. Gimeno-Santos , M. Palomo , J.A. Barberà , J. Bigorra , J. Batlle , X. Masip-Bruin , I. Blanco
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引用次数: 0
Predictors of immune-related adverse events and outcomes in patients with NSCLC treated with immune-checkpoint inhibitors 接受免疫检查点抑制剂治疗的 NSCLC 患者发生免疫相关不良事件和预后的预测因素。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-01 DOI: 10.1016/j.pulmoe.2022.03.003
M. Serino , C. Freitas , M. Martins , P. Ferreira , C. Cardoso , F. Veiga , V. Santos , D. Araújo , H. Novais-Bastos , A. Magalhães , H. Queiroga , G. Fernandes , V. Hespanhol

Objective

To identify predictors of immune-related adverse events (IRAEs) in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs). Assess associations between outcomes and the development of IRAEs.

Methods

Retrospective analysis of patients with NSCLC treated with ICIs between 2016 and 2020 in the Pulmonology Department of our hospital. Patients with and without IRAEs were compared. A logistic regression analysis was performed to determine predictors of IRAEs. Progression-free survival (PFS) and overall survival (OS) curves were calculated using the Kaplan-Meier method, and the long-rank test was used to assess survival differences between groups. Univariate and multivariate Cox proportional-hazards regression models were used to identify factors associated with PFS and OS. The value considered statistically significant was p≤0.05.

Results

A total of 184 patients (77.7% men, mean age 66.9±9.5 years) treated with ICIs were analyzed. During follow-up, 49 (26.6%) patients developed IRAEs and 149 (81.0%) died. According to the multivariate logistic regression analysis, treatment with statins (OR:3.15; p = 0.007), previous systemic corticosteroid therapy (OR:3.99; p = 0.001), disease controlled as response to ICI (OR:5.93; p < 0.001) and higher hemoglobin values (OR:1.28; p = 0.040) were independent predictors for the development of IRAEs. Patients who developed IRAEs had significantly longer medians of PFS (41.0 vs 9.0 weeks, p < 0.001) and OS (89.0 vs 28.0 weeks; p < 0.001).

Conclusions

Patients treated with statins, pre-ICI systemic corticosteroids, higher baseline hemoglobin value and controlled disease as initial response to ICI had a higher risk of developing IRAEs. The development of IRAEs was associated with better outcomes.

目的确定接受免疫检查点抑制剂(ICIs)治疗的非小细胞肺癌(NSCLC)患者发生免疫相关不良事件(IRAEs)的预测因素。评估结果与IRAEs发生之间的关联:回顾性分析我院肺科2016年至2020年间接受ICIs治疗的NSCLC患者。对出现和未出现 IRAEs 的患者进行比较。进行逻辑回归分析以确定IRAEs的预测因素。采用Kaplan-Meier法计算无进展生存期(PFS)和总生存期(OS)曲线,并用长秩检验评估组间生存期差异。采用单变量和多变量考克斯比例危险回归模型确定与无进展生存期和总生存期相关的因素。P≤0.05为具有统计学意义:共分析了184名接受ICIs治疗的患者(77.7%为男性,平均年龄(66.9±9.5)岁)。在随访期间,49例(26.6%)患者发生了IRAE,149例(81.0%)患者死亡。根据多变量逻辑回归分析,他汀类药物治疗(OR:3.15;P = 0.007)、既往接受过系统性皮质类固醇治疗(OR:3.99;P = 0.001)、疾病控制为对 ICI 的反应(OR:5.93;P 结论:他汀类药物治疗、既往接受过系统性皮质类固醇治疗、疾病控制为对 ICI 的反应:接受他汀类药物治疗、接受 ICI 前全身皮质类固醇治疗、基线血红蛋白值较高、对 ICI 最初反应时病情得到控制的患者发生 IRAE 的风险较高。IRAE的发生与更好的预后有关。
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引用次数: 0
Nontuberculous Mycobacteria in Portugal: Trends from the last decade 葡萄牙的非结核分枝杆菌:过去十年的趋势。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-01 DOI: 10.1016/j.pulmoe.2022.01.011
A. Santos , S. Carneiro , A. Silva , J.P. Gomes , R. Macedo

Introduction and objectives

Nontuberculous mycobacteria (NTM) are opportunistic human pathogens found in the environment. The transmission seems to be associated with inhalation of aerosol droplets, ingestion or trauma events. Recent studies indicate that NTM disease is increasing worldwide, however, the true clinical impact of NTM infections is difficult to determine due to challenges in discriminating between disease and colonization as they are ubiquitous in the environment. In addition, understanding the epidemiology of NTM is difficult and has not yet been established. In this work, we used a country NTM representative collection from the National Reference Laboratory for Tuberculosis (NRL-TB) of the National Institute of Health (INSA), to characterize the circulation trends of NTM species in Portugal and the most affected regions, contributing to a better understanding of the NTM epidemiology.

Material and methods

We conducted a nationwide retrospective study where all individuals with positive NTM cultures at the NRL-TB of the INSA from 2014 to December 2020 were included. Positive cultures were identified using GenoType Mycobacterium CM/AS® (Hain Lifescience) according to manufacturer's instructions, or hsp65 DNA sequencing as previously described. Social-demographic data from patients were also analyzed and patients classified into 3 groups according only to microbiological data, “definite NTM disease”, “NTM colonization” and, “possible NTM disease”.

Results

In the period 2014-2020, the NRL-TB performed 50397 cultures. Among these, 1118 cultures were NTM positive retrieved from 944. Most of our cases were in patients whose mean age was 64±15.9 years, and no significant differences between gender was observed, although more frequent in male patients. Overall, from the 944 cases, we were able to identified 93 “definite NTM disease” cases and 79 “possible NTM disease”. Mycobacterium avium complex (MAC) (40,8%), Mycobacterium abscessus-chelonae complex (MABC) (9,6%) and Mycobacterium fortuitum (6,3%) were responsible for most of the infections. The geographical distribution of NTM cases varied significantly and was possible to observe that was independent of population density. The region were most cases occurred was Lisbon Metropolitan Area (31,9%), followed by North (25,3%) and Centre (24,4%), however North region has the highest number of “definite NTM disease” cases (n=33).

Conclusions

This is the first national wide epidemiological study on this subject, contributing to a better understanding of NTM dynamics in Portugal. MAC was the NTM species responsible for the majority of infections and, LMA the region with the highest number of cases. It was also possible to conclude that the number of NTM isolates is independent of the demography of the region.

引言和目的:非结核分枝杆菌(NTM)是存在于环境中的机会性人类病原体。其传播似乎与吸入气溶胶飞沫、摄入或创伤事件有关。最近的研究表明,NTM 疾病在全球范围内呈上升趋势,然而,由于 NTM 在环境中无处不在,很难区分疾病和定植,因此很难确定 NTM 感染的真正临床影响。此外,了解 NTM 的流行病学也很困难,而且尚未建立。在这项工作中,我们利用国家卫生研究院(INSA)结核病国家参考实验室(NRL-TB)收集的全国性 NTM 代表性样本,描述了葡萄牙和受影响最严重地区 NTM 物种的流通趋势,从而有助于更好地了解 NTM 的流行病学:我们在全国范围内开展了一项回顾性研究,纳入了2014年至2020年12月期间在葡萄牙国家卫生研究院结核病实验室(NRL-TB)培养出NTM阳性的所有患者。根据制造商的说明,使用 GenoType Mycobacterium CM/AS® (Hain Lifescience) 或之前描述的 hsp65 DNA 测序对阳性培养物进行鉴定。此外,还对患者的社会人口学数据进行了分析,并根据微生物学数据将患者分为三类:"明确的非淋菌性结核病"、"非淋菌性结核病定植 "和 "可能的非淋菌性结核病":2014-2020 年间,NRL-TB 共进行了 50397 次培养。其中,944 人中有 1118 人的培养结果为 NTM 阳性。大多数病例的平均年龄为(64±15.9)岁,性别间无明显差异,但男性病例较多。总体而言,在 944 个病例中,我们发现了 93 个 "明确的非结核分枝杆菌病 "病例和 79 个 "可能的非结核分枝杆菌病 "病例。大部分感染病例的病原体分别是:禽分枝杆菌复合体(MAC)(40.8%)、脓肿-干酪分枝杆菌复合体(MABC)(9.6%)和富特分枝杆菌(6.3%)。非结核分枝杆菌病例的地理分布差异很大,与人口密度无关。病例最多的地区是里斯本大都会区(31.9%),其次是北部地区(25.3%)和中部地区(24.4%),但北部地区的 "确诊NTM疾病 "病例数最多(33例):这是首次在全国范围内就这一主题开展流行病学研究,有助于更好地了解葡萄牙的非淋菌性结核病动态。MAC 是造成大多数感染的非淋菌性真菌,而 LMA 则是病例数最多的地区。研究还得出结论,NTM 分离物的数量与该地区的人口结构无关。
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引用次数: 0
Association between sputum myeloperoxidase concentration and acute exacerbation of bronchiectasis 痰中髓过氧化物酶浓度与支气管扩张急性加重的关系。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-01 DOI: 10.1016/j.pulmoe.2023.10.006
B. Yang , H. Lee , H. Yun , C. Seong , E.-G. Kim , J.‑K. Choi
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引用次数: 0
Regarding the prognostic factors in patients with ALK-positive non-small cell lung cancer treated with crizotinib 关于接受克唑替尼治疗的ALK阳性非小细胞肺癌患者的预后因素。
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-07-01 DOI: 10.1016/j.pulmoe.2024.02.007
Limei Hu , Youjun Xie , Hongying Zhao
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引用次数: 0
期刊
Pulmonology
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