Pub Date : 2023-01-01DOI: 10.29374/2527-2179.bjvm003423
Gabriella Carvalho Abend, Stephanie Favato de Azevedo, Arthur Saturiano dos Santos, Gustavo Carvalho Cobucci, Heloisa Justen Moreira de Souza
We report a two-month-old male cat weighing 630 grams with congenital hypothyroidism. The main complaints were difficulty defecating for more than three days and prostration. Physical examination revealed a broad, flat face, a short neck, enlarged submandibular lymph nodes, chemosis, mild bilateral mucopurulent ocular discharge, seborrheic coat, with gingival thickening around the upper and lower deciduous incisor teeth with partial eruption. The abdomen was distended due to constipation and right unilateral cryptorchidism. Based on this, feline congenital hypothyroidism was suspected. Hormonal tests (free T4 by equilibrium dialysis of 0.06 ng/dl, total T4 of 0.1 ng/ml and TSH of 4.7 ng/ml) confirmed this. Treatment was started with levothyroxine sodium (5-32.2 µg/kg/day). After 120 days of treatment, there was clinical stabilization. Then the patient underwent orchiectomy of the left and of the right ectopic testicles, and at 380 days of treatment, the thyroid scintigraphy showed intense uptake of the radiopharmaceutical by both thyroid lobes and a significant increase in volume. Clinical evaluation showed weight gain (2.6 kilograms during treatment), improvement in the shape of the skull, and a notable increase in body size. At 17 months of age, hormone values were within the reference limits after administration of levothyroxine sodium (32.2µg/kg/day).
{"title":"Feline congenital hypothyroidism: a case report","authors":"Gabriella Carvalho Abend, Stephanie Favato de Azevedo, Arthur Saturiano dos Santos, Gustavo Carvalho Cobucci, Heloisa Justen Moreira de Souza","doi":"10.29374/2527-2179.bjvm003423","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm003423","url":null,"abstract":"We report a two-month-old male cat weighing 630 grams with congenital hypothyroidism. The main complaints were difficulty defecating for more than three days and prostration. Physical examination revealed a broad, flat face, a short neck, enlarged submandibular lymph nodes, chemosis, mild bilateral mucopurulent ocular discharge, seborrheic coat, with gingival thickening around the upper and lower deciduous incisor teeth with partial eruption. The abdomen was distended due to constipation and right unilateral cryptorchidism. Based on this, feline congenital hypothyroidism was suspected. Hormonal tests (free T4 by equilibrium dialysis of 0.06 ng/dl, total T4 of 0.1 ng/ml and TSH of 4.7 ng/ml) confirmed this. Treatment was started with levothyroxine sodium (5-32.2 µg/kg/day). After 120 days of treatment, there was clinical stabilization. Then the patient underwent orchiectomy of the left and of the right ectopic testicles, and at 380 days of treatment, the thyroid scintigraphy showed intense uptake of the radiopharmaceutical by both thyroid lobes and a significant increase in volume. Clinical evaluation showed weight gain (2.6 kilograms during treatment), improvement in the shape of the skull, and a notable increase in body size. At 17 months of age, hormone values were within the reference limits after administration of levothyroxine sodium (32.2µg/kg/day).","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29374/2527-2179.bjvm0010231
Nathana Beatriz Martins, Nataly Nogueira Ribeiro Pinto, Tainara Santana Galvão da Silva, Aline Santana da Hora
In this study, we conducted a retrospective survey of 63 giant anteaters (Myrmecophaga tridactyla) using the Federal University of Uberlândia, Minas Gerais State, Brazil as reference site for wild animals. We analyzed the clinical records of 63 animals from January 2016 to February 2020. The information obtained included the location where the anteater was found, the reason for rescue, estimated life stage, gender, weight, general condition of the animal, clinical signs, diagnosis, and destination. Of the 63 animals, 30.15%, (n = 19/63) were found in rural areas, 25.40% (n = 16/63) in urban areas, and 22.22% (n = 14/63) near highways. The main reason for rescue was run-over accidents (n = 18/63, 28.60%). Regarding life stage distribution, 27% (n = 17/63) were cubs, 25.40% (n = 16/63) were adolescent, and 41.26% (n = 26/63) were adults. There was a higher frequency of females (n = 35/63, 56%), and three (9%) of them were pregnant or had cubs. For injury evaluation, three of the 63 giant anteaters were dead on arrival at the rehabilitation site; therefore, we excluded them from this aspect of the study. Of the 60 remaining anteaters, only 13.33% (n = 8/60) of the animals were healthy upon physical examination.The most common condition was traumatic brain injury (n = 32/60 53.33%), followed by fractures (n = 23/60, 38.33%), neonate triad (n = 15/60, 25%), and abrasions (n = 15/60, 25%). The animals presented a high mortality rate (n = 39/60, 65%). The animals presented a high mortality rate (39, 65%). The low number of giant anteaters reintroduced to their natural habitat and the high mortality rate of animals sent to rehabilitation centers show that the protection of giant anteaters is important to reduce the number of these animals sent to rehabilitation centers.
{"title":"Threats to the conservation of the vulnerable giant anteater (Myrmecophaga tridactyla) in the Cerrado biome: a retrospective survey","authors":"Nathana Beatriz Martins, Nataly Nogueira Ribeiro Pinto, Tainara Santana Galvão da Silva, Aline Santana da Hora","doi":"10.29374/2527-2179.bjvm0010231","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm0010231","url":null,"abstract":"In this study, we conducted a retrospective survey of 63 giant anteaters (Myrmecophaga tridactyla) using the Federal University of Uberlândia, Minas Gerais State, Brazil as reference site for wild animals. We analyzed the clinical records of 63 animals from January 2016 to February 2020. The information obtained included the location where the anteater was found, the reason for rescue, estimated life stage, gender, weight, general condition of the animal, clinical signs, diagnosis, and destination. Of the 63 animals, 30.15%, (n = 19/63) were found in rural areas, 25.40% (n = 16/63) in urban areas, and 22.22% (n = 14/63) near highways. The main reason for rescue was run-over accidents (n = 18/63, 28.60%). Regarding life stage distribution, 27% (n = 17/63) were cubs, 25.40% (n = 16/63) were adolescent, and 41.26% (n = 26/63) were adults. There was a higher frequency of females (n = 35/63, 56%), and three (9%) of them were pregnant or had cubs. For injury evaluation, three of the 63 giant anteaters were dead on arrival at the rehabilitation site; therefore, we excluded them from this aspect of the study. Of the 60 remaining anteaters, only 13.33% (n = 8/60) of the animals were healthy upon physical examination.The most common condition was traumatic brain injury (n = 32/60 53.33%), followed by fractures (n = 23/60, 38.33%), neonate triad (n = 15/60, 25%), and abrasions (n = 15/60, 25%). The animals presented a high mortality rate (n = 39/60, 65%). The animals presented a high mortality rate (39, 65%). The low number of giant anteaters reintroduced to their natural habitat and the high mortality rate of animals sent to rehabilitation centers show that the protection of giant anteaters is important to reduce the number of these animals sent to rehabilitation centers.","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":"280 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136216766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.29374/2527-2179.bjvm003022
Mariana Henrique da Silveira Costa, Paulo Roberto Medeiros, U. P. Melo, Renato Fernandes de Souza, Gabriel Evangelista Lopes da Silva, C. Ferreira, Daniel Barbosa de Assis, Leanderson Paiva da Silva, Emilson Lima de Brito
Abstract Horse owners are crucial in recognizing colic because they are responsible for identifying the signs of colic and deciding whether to seek veterinary intervention. Common reasons for delayed response to clinical issues include lack of understanding or knowledge of the subject and difficulty in recognizing subtle clinical signs of abdominal pain. Examining horse owners' basic knowledge of colic, their motivations, obstacles in seeking veterinary care, and their responses to the various clinical symptoms manifested during colic will identify current knowledge gaps and decision-making barriers. This study aimed to examine the experiences, recognition, and attitudes of horse owners during an episode of equine colic in Rio Grande do Norte, Brazil. A cross-sectional study was conducted using questionnaires in Rio Grande do Norte, Brazil. The sample consisted of horse owners, competitors of any equestrian modality (provided that they were responsible for a horse at the time of the application of the questionnaire), or individuals who had previously owned a horse. There were differences related to the recognition and attitudes adopted towards colic in horses compared to the studies performed in other countries. The overall results of this study highlight the need for educational campaigns for horse owners to fill knowledge gaps about colic and the need for a clearer picture of colic, including what it is, the predisposing factors, and the range of symptoms. Additionally, this knowledge will equip horse owners to appropriately respond to these symptoms.
{"title":"Survey on the recognition, attitudes, and experience of horse owners during episodes of equine colic in Rio Grande do Norte, Brazil","authors":"Mariana Henrique da Silveira Costa, Paulo Roberto Medeiros, U. P. Melo, Renato Fernandes de Souza, Gabriel Evangelista Lopes da Silva, C. Ferreira, Daniel Barbosa de Assis, Leanderson Paiva da Silva, Emilson Lima de Brito","doi":"10.29374/2527-2179.bjvm003022","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm003022","url":null,"abstract":"Abstract Horse owners are crucial in recognizing colic because they are responsible for identifying the signs of colic and deciding whether to seek veterinary intervention. Common reasons for delayed response to clinical issues include lack of understanding or knowledge of the subject and difficulty in recognizing subtle clinical signs of abdominal pain. Examining horse owners' basic knowledge of colic, their motivations, obstacles in seeking veterinary care, and their responses to the various clinical symptoms manifested during colic will identify current knowledge gaps and decision-making barriers. This study aimed to examine the experiences, recognition, and attitudes of horse owners during an episode of equine colic in Rio Grande do Norte, Brazil. A cross-sectional study was conducted using questionnaires in Rio Grande do Norte, Brazil. The sample consisted of horse owners, competitors of any equestrian modality (provided that they were responsible for a horse at the time of the application of the questionnaire), or individuals who had previously owned a horse. There were differences related to the recognition and attitudes adopted towards colic in horses compared to the studies performed in other countries. The overall results of this study highlight the need for educational campaigns for horse owners to fill knowledge gaps about colic and the need for a clearer picture of colic, including what it is, the predisposing factors, and the range of symptoms. Additionally, this knowledge will equip horse owners to appropriately respond to these symptoms.","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47995600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.29374/2527-2179.bjvm003222
U. P. Melo, M. Palhares, C. Ferreira, F. Leme, V. Gheller
Abstract This study aimed to evaluate the effects of the total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy. Sixteen healthy male and female adult horses of mixed breed, aged between 4 and 14 years, and having a mean body weight of 248.40 ± 2.28 kg and a body score index of 3–4 (scale of 1–5) were divided into four groups with four animals per group. After an adaptation period of 30 days, they were randomly divided into four experimental groups: enteral fluid therapy, enteral fluid therapy associated with glutamine, total parenteral nutrition associated with glutamine, and parenteral fluid therapy. The experiment was further divided into two phases: Phase 1 and Phase 2. In Phase 1, an exploratory laparotomy was performed, treatments were administered to the groups and the horses received no food or water other than those given to their respective groups. In Phase 2, the animals were re-fed. Each phase had a total duration of 144 h. Venous blood samples were collected every 24 h throughout the experimental period for blood gas and electrolyte analyses. The following parameters were evaluated: pH, partial pressure of carbon dioxide, total carbon dioxide, bicarbonate, base shift, anion gap, sodium, potassium, chloride, total calcium and magnesium. Completely randomized designs with a 4 × 7 factorial scheme (groups × harvest time) in Phase 1 and a 4 × 6 factorial scheme (groups × harvest time) in Phase 2 were used with four replications. All values were considered significant when p≤0.05 (95% probability). Blood pH, bicarbonate concentration, and base shift in the PARGL group decreased, indicating metabolic acidosis. Changes in the acid–base and electrolyte balance were more intense in the PARGL group than in the other groups. These results demonstrated the need to monitor blood gas and electrolyte balance in horses with food restriction under nutritional support or prolonged fluid therapy so that such changes are promptly corrected.
{"title":"Effects of total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy","authors":"U. P. Melo, M. Palhares, C. Ferreira, F. Leme, V. Gheller","doi":"10.29374/2527-2179.bjvm003222","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm003222","url":null,"abstract":"Abstract This study aimed to evaluate the effects of the total parenteral nutrition associated with glutamine, enteral fluid therapy with or without glutamine, and fluid therapy on the acid–base and electrolyte balance of horses starved after exploratory laparotomy. Sixteen healthy male and female adult horses of mixed breed, aged between 4 and 14 years, and having a mean body weight of 248.40 ± 2.28 kg and a body score index of 3–4 (scale of 1–5) were divided into four groups with four animals per group. After an adaptation period of 30 days, they were randomly divided into four experimental groups: enteral fluid therapy, enteral fluid therapy associated with glutamine, total parenteral nutrition associated with glutamine, and parenteral fluid therapy. The experiment was further divided into two phases: Phase 1 and Phase 2. In Phase 1, an exploratory laparotomy was performed, treatments were administered to the groups and the horses received no food or water other than those given to their respective groups. In Phase 2, the animals were re-fed. Each phase had a total duration of 144 h. Venous blood samples were collected every 24 h throughout the experimental period for blood gas and electrolyte analyses. The following parameters were evaluated: pH, partial pressure of carbon dioxide, total carbon dioxide, bicarbonate, base shift, anion gap, sodium, potassium, chloride, total calcium and magnesium. Completely randomized designs with a 4 × 7 factorial scheme (groups × harvest time) in Phase 1 and a 4 × 6 factorial scheme (groups × harvest time) in Phase 2 were used with four replications. All values were considered significant when p≤0.05 (95% probability). Blood pH, bicarbonate concentration, and base shift in the PARGL group decreased, indicating metabolic acidosis. Changes in the acid–base and electrolyte balance were more intense in the PARGL group than in the other groups. These results demonstrated the need to monitor blood gas and electrolyte balance in horses with food restriction under nutritional support or prolonged fluid therapy so that such changes are promptly corrected.","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48459044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-28DOI: 10.29374/2527-2179.bjvm002921
I. Lima, Viviane S. Magalhães, Rodrigo Machado de Oliveira, Thais P Ferreira, G. C. M. Santos, Melina C C Alves, G. A. Pereira, Fernanda Cristina Santos da Silva, Liliane Ferreira Rodrigues, D. A. Borges, Priscila C. Oliveira, F. Scott, Y. P. Cid
Doxycycline (DOX) is the antibiotic of choice for the treatment of canine monocytic ehrlichiosis (CME), one of the main infectious diseases affecting dogs. Despite the therapeutic simplicity, the need for long-term use of DOX tablets (28 days) and gastrointestinal effects may pose problems. The aim of the study was to develop a DOX chewable tablet, evaluate its palatability and pharmacokinetic profile in comparison with a commercial formulation, Doxifin®, and evaluate the influence of co-administration with vitamin supplement on the bioavailability of doxycycline. The AUC0-t values found for DOX chewable tablets (13.85 ± 3.81 μg.h/mL) and Doxifin® (15.88 ± 4.38 μg.h/mL) did not differ significantly (p<0.05). The co-administration of the vitamin supplement Hemolitan® influenced the pharmacokinetic profile of DOX, leading to a decrease in bioavailability for chewable DOX tablets and Doxifin®, with relative bioavailability values (F) of 64% and 62%, respectively. Palatability evaluations confirmed the palatability of the chewable tablets. Therefore, a DOX chewable tablet is an important alternative that can overcome some of the challenges associated with the characteristic bitter taste of doxycycline, with considerable reduction animal stress, and with plasma doxycycline concentrations equivalent in practical terms to a conventional product.
{"title":"Development and pharmacokinetic evaluation of chewable doxycycline tablets in Beagle dogs: comparison with a commercial formulation and evaluation of co-administration with vitamin supplement on the bioavailability","authors":"I. Lima, Viviane S. Magalhães, Rodrigo Machado de Oliveira, Thais P Ferreira, G. C. M. Santos, Melina C C Alves, G. A. Pereira, Fernanda Cristina Santos da Silva, Liliane Ferreira Rodrigues, D. A. Borges, Priscila C. Oliveira, F. Scott, Y. P. Cid","doi":"10.29374/2527-2179.bjvm002921","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm002921","url":null,"abstract":"Doxycycline (DOX) is the antibiotic of choice for the treatment of canine monocytic ehrlichiosis (CME), one of the main infectious diseases affecting dogs. Despite the therapeutic simplicity, the need for long-term use of DOX tablets (28 days) and gastrointestinal effects may pose problems. The aim of the study was to develop a DOX chewable tablet, evaluate its palatability and pharmacokinetic profile in comparison with a commercial formulation, Doxifin®, and evaluate the influence of co-administration with vitamin supplement on the bioavailability of doxycycline. The AUC0-t values found for DOX chewable tablets (13.85 ± 3.81 μg.h/mL) and Doxifin® (15.88 ± 4.38 μg.h/mL) did not differ significantly (p<0.05). The co-administration of the vitamin supplement Hemolitan® influenced the pharmacokinetic profile of DOX, leading to a decrease in bioavailability for chewable DOX tablets and Doxifin®, with relative bioavailability values (F) of 64% and 62%, respectively. Palatability evaluations confirmed the palatability of the chewable tablets. Therefore, a DOX chewable tablet is an important alternative that can overcome some of the challenges associated with the characteristic bitter taste of doxycycline, with considerable reduction animal stress, and with plasma doxycycline concentrations equivalent in practical terms to a conventional product.","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46225953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-23DOI: 10.29374/2527-2179.bjvm106020
Nathalia da Silva Ramos Elias, Helton Carlos Sabino Pereira, A. L. C. Neto, E. E. Silveira, Amilton C. Santos, A. C. Neto
Any technique that assists the study of anatomy is important for the development of learning because knowledge creates a fundamental connection to the clinical and surgical routine. Three-dimensional (3D) model printing has gained visibility by achieving similarities between the real model and the printed one. This work aimed to produce 3D-printed anatomical pieces which are true to the real parts of the flat (scapula) and long (humerus, radius and ulna) bones of the thoracic limb in cats. Domestic cat bones from the FMVZ-USP Veterinary Macroscopic Anatomy Laboratory collection were used to obtain the scanned images and prints of the 3D models. The obtained 3D models were similar to the real bones and included the anatomical particularities of the species. Anatomical details of the scapula, humerus, radius, and ulna were reliably obtained. This study produced digital and printed 3D anatomical models of the flat and long bones of the thoracic limb, which can be used interactively and dynamically to teach comparative and applied anatomy.
{"title":"Bioprinting of 3D anatomical models of flat and long thoracic limb bones of domestic cats (Felis catus Linnaeus, 1758)","authors":"Nathalia da Silva Ramos Elias, Helton Carlos Sabino Pereira, A. L. C. Neto, E. E. Silveira, Amilton C. Santos, A. C. Neto","doi":"10.29374/2527-2179.bjvm106020","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm106020","url":null,"abstract":"Any technique that assists the study of anatomy is important for the development of learning because knowledge creates a fundamental connection to the clinical and surgical routine. Three-dimensional (3D) model printing has gained visibility by achieving similarities between the real model and the printed one. This work aimed to produce 3D-printed anatomical pieces which are true to the real parts of the flat (scapula) and long (humerus, radius and ulna) bones of the thoracic limb in cats. Domestic cat bones from the FMVZ-USP Veterinary Macroscopic Anatomy Laboratory collection were used to obtain the scanned images and prints of the 3D models. The obtained 3D models were similar to the real bones and included the anatomical particularities of the species. Anatomical details of the scapula, humerus, radius, and ulna were reliably obtained. This study produced digital and printed 3D anatomical models of the flat and long bones of the thoracic limb, which can be used interactively and dynamically to teach comparative and applied anatomy.","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42510082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-23DOI: 10.29374/2527-2179.BJVM003620
H. Santos, T. Hess, Jason Brummer, P. Graham, B. McIntosh, R. Splan
Insulin resistance is a prevalent disorder among horses and is associated with abnormal adiposity, laminitis, equine metabolic syndrome, and pituitary pars intermedia dysfunction. The processes leading to equine insulin resistance and associated conditions remain subject for study. MicroRNAs (miRNAs) are involved in regulation of many biological processes and diseases. The current study aimed to investigate the circulating miRNA profile of insulin resistant horses and ponies. It was hypothesized that insulin resistant horses would have a different circulating miRNA profile compared to healthy ones. 12 Thoroughbred/ Thoroughbred-cross and 12 Welsh/Dartmoor non-pregnant mares were evaluated for insulin sensitivity using frequent sampling intravenous glucose tolerance test (FSIGTT). Serum samples were collected for miRNA profiling through RT-qPCR analysis. Horses and ponies were divided into insulin sensitive (IS) or insulin resistant (IR) groups and their miRNA profiles compared. Results demonstrated that 13 miRNAs were differently expressed between IR and IS horses, 15 between IR and IS ponies, 17 between horses and ponies, and 10 between IR and IS animals (horses and ponies combined) (p<0.05). Finally, 8 miRNAs were proposed as potential regulators of equine insulin resistance. miRNA profiling is a potential tool to evaluate insulin resistance and associated conditions.
{"title":"Circulating microRNAs in insulin resistant horses and ponies","authors":"H. Santos, T. Hess, Jason Brummer, P. Graham, B. McIntosh, R. Splan","doi":"10.29374/2527-2179.BJVM003620","DOIUrl":"https://doi.org/10.29374/2527-2179.BJVM003620","url":null,"abstract":"Insulin resistance is a prevalent disorder among horses and is associated with abnormal adiposity, laminitis, equine metabolic syndrome, and pituitary pars intermedia dysfunction. The processes leading to equine insulin resistance and associated conditions remain subject for study. MicroRNAs (miRNAs) are involved in regulation of many biological processes and diseases. The current study aimed to investigate the circulating miRNA profile of insulin resistant horses and ponies. It was hypothesized that insulin resistant horses would have a different circulating miRNA profile compared to healthy ones. 12 Thoroughbred/ Thoroughbred-cross and 12 Welsh/Dartmoor non-pregnant mares were evaluated for insulin sensitivity using frequent sampling intravenous glucose tolerance test (FSIGTT). Serum samples were collected for miRNA profiling through RT-qPCR analysis. Horses and ponies were divided into insulin sensitive (IS) or insulin resistant (IR) groups and their miRNA profiles compared. Results demonstrated that 13 miRNAs were differently expressed between IR and IS horses, 15 between IR and IS ponies, 17 between horses and ponies, and 10 between IR and IS animals (horses and ponies combined) (p<0.05). Finally, 8 miRNAs were proposed as potential regulators of equine insulin resistance. miRNA profiling is a potential tool to evaluate insulin resistance and associated conditions.","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43857262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29374/2527-2179.bjvm001521
Andrew J. Lacqua, E. Rozanski, Dylan A. Fry, Scott L. Gregorich, A. Sato
E-mail: andrewlacquadvm@gmail.com Abstract A 6-year-old 12 kg male neutered mixed breed dog presented in lateral recumbency with dysphoria and vocalization following a self-inflicted fork impalement injury. Computed tomography (CT) was performed which showed a penetrating wound through the right orbit, into the calvarium, and through the brain parenchyma. The dog was hospitalized with supportive care, sedatives, analgesia, antiepileptics, anti-inflammatories, antibiotics, and desmopressin acetate (DDAVP) to control post-traumatic central diabetes insipidus (PTCDI) which developed during recovery. Magnetic resonance imaging (MRI) findings 16 days later revealed resolving ventricular hemorrhage and mild perilesional edema and inflammation. Normal mentation and ambulation slowly returned and 3 months later the dog was clinically normal. To the author’s knowledge, this is the first report of a self-inflicted penetrating brain injury in a dog. This case demonstrates successful medical management of a dog with a traumatic brain injury (TBI) and PTCDI which is an uncommon occurrence in o conhecimento do autor, este é o primeiro relato de uma lesão cerebral penetrante autoinfligida em um cão. Este caso demonstra o manejo médico bem-sucedido de um cão com lesão cerebral traumática (TCE) e PTCDI, que é uma ocorrência incomum em
摘要一只体重12公斤的6岁雄性绝育杂交犬在自伤叉刺伤后出现侧卧、烦躁不安和发声。计算机断层扫描(CT)显示穿透伤穿过右眼眶，进入颅骨，并穿过脑实质。犬接受支持性护理、镇静、镇痛、抗癫痫、抗炎、抗生素和醋酸去氨加压素(DDAVP)治疗，以控制康复期间出现的创伤后中枢性尿囊症(PTCDI)。16天后磁共振成像(MRI)显示脑室出血消退，病灶周围轻度水肿和炎症。逐渐恢复正常的精神状态和行动能力，3个月后临床恢复正常。据作者所知，这是第一次报道狗自己造成的穿透性脑损伤。本病例展示了成功的医疗管理犬外伤性脑损伤(TBI)和PTCDI，这是一种罕见的情况下，发生在身体，身体，身体，身体，大脑穿透性自身虹膜炎，。Este caso demonstra o manejo msamicdico bem-sucedido de um comcomlesleso cerebral traumática (TCE) e PTCDI, que uma ocorrência inumum em
{"title":"Diagnostic findings and successful management of central diabetes insipidus following a self-inflicted penetrating brain injury in a dog","authors":"Andrew J. Lacqua, E. Rozanski, Dylan A. Fry, Scott L. Gregorich, A. Sato","doi":"10.29374/2527-2179.bjvm001521","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm001521","url":null,"abstract":"E-mail: andrewlacquadvm@gmail.com Abstract A 6-year-old 12 kg male neutered mixed breed dog presented in lateral recumbency with dysphoria and vocalization following a self-inflicted fork impalement injury. Computed tomography (CT) was performed which showed a penetrating wound through the right orbit, into the calvarium, and through the brain parenchyma. The dog was hospitalized with supportive care, sedatives, analgesia, antiepileptics, anti-inflammatories, antibiotics, and desmopressin acetate (DDAVP) to control post-traumatic central diabetes insipidus (PTCDI) which developed during recovery. Magnetic resonance imaging (MRI) findings 16 days later revealed resolving ventricular hemorrhage and mild perilesional edema and inflammation. Normal mentation and ambulation slowly returned and 3 months later the dog was clinically normal. To the author’s knowledge, this is the first report of a self-inflicted penetrating brain injury in a dog. This case demonstrates successful medical management of a dog with a traumatic brain injury (TBI) and PTCDI which is an uncommon occurrence in o conhecimento do autor, este é o primeiro relato de uma lesão cerebral penetrante autoinfligida em um cão. Este caso demonstra o manejo médico bem-sucedido de um cão com lesão cerebral traumática (TCE) e PTCDI, que é uma ocorrência incomum em","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69978283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29374/2527-2179.bjvm001821
Mariana Silva Revoredo Alves, A. Reis, Marisa Beatriz da Silva Rocha, Melina C C Alves, D. A. Borges, Barbara Rauta de Avelar, D. R. Campos, Y. P. Cid, F. Scott
The aim of the present study was to evaluate the hemolymph of engorged females of Rhipicephalus microplus ticks exposed to the growth regulator fluazuron. Firstly, the engorged females were divided into two groups (control and treated) and these were subjected to an immersion test. Hemolymph was collected 24 and 48 hours after the immersion test, to evaluate the cellular and metabolic response. In comparison with the control group, the treated group had lower total hemocyte counts at both times, with lower granulocyte counts and higher spherulocyte counts. There were reductions in glucose and total protein values in both the control and the treated group at the 48-hour evaluation, compared with the 24-hour evaluation. There were no changes in activity levels of lactate dehydrogenase and aspartate aminotransferase enzymes in either group at both times. Fluazuron was not able to promote changes in the energy metabolism of the ticks under the conditions established for this study, but this growth regulator proved to be capable of promoting changes in hemocyte dynamics.
{"title":"Cellular and metabolic response of hemolymph from engorged Rhipicephalus microplus females exposed to fluazuron","authors":"Mariana Silva Revoredo Alves, A. Reis, Marisa Beatriz da Silva Rocha, Melina C C Alves, D. A. Borges, Barbara Rauta de Avelar, D. R. Campos, Y. P. Cid, F. Scott","doi":"10.29374/2527-2179.bjvm001821","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm001821","url":null,"abstract":"The aim of the present study was to evaluate the hemolymph of engorged females of Rhipicephalus microplus ticks exposed to the growth regulator fluazuron. Firstly, the engorged females were divided into two groups (control and treated) and these were subjected to an immersion test. Hemolymph was collected 24 and 48 hours after the immersion test, to evaluate the cellular and metabolic response. In comparison with the control group, the treated group had lower total hemocyte counts at both times, with lower granulocyte counts and higher spherulocyte counts. There were reductions in glucose and total protein values in both the control and the treated group at the 48-hour evaluation, compared with the 24-hour evaluation. There were no changes in activity levels of lactate dehydrogenase and aspartate aminotransferase enzymes in either group at both times. Fluazuron was not able to promote changes in the energy metabolism of the ticks under the conditions established for this study, but this growth regulator proved to be capable of promoting changes in hemocyte dynamics.","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69978362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29374/2527-2179.bjvm002121
M. C. Valadão, Ítalo Stoupa Vieira, L. Carvalho, Paulo Henrique Neves, Rafaela Teixeira Magalhães, A. K. Campos, J. V. Araújo
Extensive rearing systems enable higher occurrence of helminths, which is a hindrance in poultry farming, significantly affecting productivity. A survey was conducted to determine the prevalence of gastrointestinal helminths in chickens reared in extensive system in the city of Viçosa, Minas Gerais, Brazil between December 2017 to September 2018. A total of 5579 specimens were recovered from the gastrointestinal tracts of most animals (81.55% of prevalence). Of the positive poultries, only 41.67% had mixed infections, and of these, more than 90% were nematodes and cestodes co-infections. Three nematodes ( Ascaridia galli , Heterakis gallinarum , Capillaria sp.), seven cestodes ( Raillietina tetragona , R. echinobothrida , R. cesticillus , Choanotaenia infundibulum , Hymenolepis cantaniana , H. carioca and Davainea proglottina ) and two trematodes ( Postharmostomum commutatum and Echinostoma sp.) species were identified. The most dominant helminth species was H. gallinarum (60.19%), which also presented higher average intensity (35.46 ± 0.65) and abundance (21.34 ± 3.01) among all recovered species. The tapeworm species correspond to 42.23% of prevalence and the trematodes correspond to only 3.40%. Despite the scarcity of data in the Brazilian literature on poultry helminths reared in extensive systems, regional parasitological surveys are important. It is expected that these results will contribute to the adoption of prophylactic measures and alternative control strategies in order to reduce the risk of helminth infection in poultry. determinar
{"title":"Gastrointestinal helminth parasites of Gallus gallus raised in extensive system in the city of Viçosa, Minas Gerais, Brazil","authors":"M. C. Valadão, Ítalo Stoupa Vieira, L. Carvalho, Paulo Henrique Neves, Rafaela Teixeira Magalhães, A. K. Campos, J. V. Araújo","doi":"10.29374/2527-2179.bjvm002121","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm002121","url":null,"abstract":"Extensive rearing systems enable higher occurrence of helminths, which is a hindrance in poultry farming, significantly affecting productivity. A survey was conducted to determine the prevalence of gastrointestinal helminths in chickens reared in extensive system in the city of Viçosa, Minas Gerais, Brazil between December 2017 to September 2018. A total of 5579 specimens were recovered from the gastrointestinal tracts of most animals (81.55% of prevalence). Of the positive poultries, only 41.67% had mixed infections, and of these, more than 90% were nematodes and cestodes co-infections. Three nematodes ( Ascaridia galli , Heterakis gallinarum , Capillaria sp.), seven cestodes ( Raillietina tetragona , R. echinobothrida , R. cesticillus , Choanotaenia infundibulum , Hymenolepis cantaniana , H. carioca and Davainea proglottina ) and two trematodes ( Postharmostomum commutatum and Echinostoma sp.) species were identified. The most dominant helminth species was H. gallinarum (60.19%), which also presented higher average intensity (35.46 ± 0.65) and abundance (21.34 ± 3.01) among all recovered species. The tapeworm species correspond to 42.23% of prevalence and the trematodes correspond to only 3.40%. Despite the scarcity of data in the Brazilian literature on poultry helminths reared in extensive systems, regional parasitological surveys are important. It is expected that these results will contribute to the adoption of prophylactic measures and alternative control strategies in order to reduce the risk of helminth infection in poultry. determinar","PeriodicalId":54480,"journal":{"name":"Revista Brasileira De Medicina Veterinaria","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69978685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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