Pub Date : 2024-03-19DOI: 10.1016/S1047-9651(24)00004-4
Joan Stilling (Editor), Joel Stein (Editors)
{"title":"Innovations in Stroke Recovery and Rehabilitation","authors":"Joan Stilling (Editor), Joel Stein (Editors)","doi":"10.1016/S1047-9651(24)00004-4","DOIUrl":"https://doi.org/10.1016/S1047-9651(24)00004-4","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 2","pages":"Page i"},"PeriodicalIF":1.7,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140162280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.1016/S1047-9651(24)00006-8
{"title":"Contributors","authors":"","doi":"10.1016/S1047-9651(24)00006-8","DOIUrl":"https://doi.org/10.1016/S1047-9651(24)00006-8","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 2","pages":"Pages iii-vii"},"PeriodicalIF":1.7,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140162316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.1016/j.pmr.2024.02.012
Brian D. Greenwald MD , Kristen A. Harris MD , Harsha Ayyala MD , Dustin J. Gordon PhD
{"title":"Community Reintegration After Traumatic Brain Injury","authors":"Brian D. Greenwald MD , Kristen A. Harris MD , Harsha Ayyala MD , Dustin J. Gordon PhD","doi":"10.1016/j.pmr.2024.02.012","DOIUrl":"10.1016/j.pmr.2024.02.012","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 3","pages":"Pages 637-650"},"PeriodicalIF":1.1,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140275216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-07DOI: 10.1016/j.pmr.2024.01.001
Blessen C. Eapen MD
{"title":"Stroke Recovery, Rehabilitation, and Innovation","authors":"Blessen C. Eapen MD","doi":"10.1016/j.pmr.2024.01.001","DOIUrl":"10.1016/j.pmr.2024.01.001","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 2","pages":"Pages xv-xvi"},"PeriodicalIF":1.7,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.1016/j.pmr.2023.10.001
Blessen C. Eapen MD
{"title":"Rehabilitation Management of Disorders of Consciousness","authors":"Blessen C. Eapen MD","doi":"10.1016/j.pmr.2023.10.001","DOIUrl":"10.1016/j.pmr.2023.10.001","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 1","pages":"Pages xiii-xiv"},"PeriodicalIF":1.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.1016/S1047-9651(23)00112-2
SUNIL KOTHARI (Editor), BEI ZHANG (Editor)
{"title":"Disorders of Consciousness","authors":"SUNIL KOTHARI (Editor), BEI ZHANG (Editor)","doi":"10.1016/S1047-9651(23)00112-2","DOIUrl":"https://doi.org/10.1016/S1047-9651(23)00112-2","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 1","pages":"Page i"},"PeriodicalIF":1.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138423248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.1016/S1047-9651(23)00116-X
{"title":"Forthcoming Issues","authors":"","doi":"10.1016/S1047-9651(23)00116-X","DOIUrl":"https://doi.org/10.1016/S1047-9651(23)00116-X","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 1","pages":"Page xii"},"PeriodicalIF":1.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138423252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.1016/S1047-9651(23)00114-6
{"title":"Contributors","authors":"","doi":"10.1016/S1047-9651(23)00114-6","DOIUrl":"https://doi.org/10.1016/S1047-9651(23)00114-6","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 1","pages":"Pages iii-vi"},"PeriodicalIF":1.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138423250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.1016/S1047-9651(23)00113-4
{"title":"Copyright","authors":"","doi":"10.1016/S1047-9651(23)00113-4","DOIUrl":"https://doi.org/10.1016/S1047-9651(23)00113-4","url":null,"abstract":"","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"35 1","pages":"Page ii"},"PeriodicalIF":1.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138423249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20eCollection Date: 2023-01-01DOI: 10.5458/jag.jag.JAG-2022_0015
Saki Gotoh, Kohji Kitaguchi, Tomio Yabe
Pectin, a type of soluble fiber, promotes morphological changes in the small intestinal villi. Although its physiological significance is unknown, we hypothesized that changes in villus morphology enhance the efficiency of nutrient absorption in the small intestine and investigated the effect of pectin derived from persimmon on calcium absorption using polarized Caco-2 cells. In polarized Caco-2 cells, pectin altered the mRNA expression levels of substances involved in calcium absorption and the regulation of intracellular calcium concentration and significantly reduced calcium absorption. Although this was comparable to the results of absorption and permeability associated with the addition of active vitamin D, the simultaneous action of pectin and active vitamin D did not show any additive effects. Furthermore, as active vitamin D significantly increases the activity of intestinal alkaline phosphatase (ALP), which is known to be involved in the regulation of intestinal absorption of calcium and lipids, we also investigated the effect of pectin on intestinal ALP activity. As a result, it was found that, unlike the effect of active vitamin D, pectin significantly reduced intestinal ALP activity. These results suggest that pectin stimulates polarized Caco-2 cells through a mechanism distinct from the regulation of calcium absorption by vitamin D, modulating total calcium absorption from the elongated villi through morphological changes in the small intestine by suppressing it at the cellular level.
果胶是一种可溶性纤维，能促进小肠绒毛的形态变化。虽然其生理意义尚不清楚，但我们假设绒毛形态的变化会提高小肠吸收营养物质的效率，并利用极化 Caco-2 细胞研究了从柿子中提取的果胶对钙吸收的影响。在极化的 Caco-2 细胞中，果胶改变了参与钙吸收和细胞内钙浓度调节的物质的 mRNA 表达水平，并显著降低了钙的吸收。虽然这与添加活性维生素 D 后的吸收和渗透性结果相当，但果胶和活性维生素 D 的同时作用并未显示出任何叠加效应。此外，由于活性维生素 D 能显著提高肠道碱性磷酸酶（ALP）的活性，而众所周知，ALP 参与调节肠道对钙和脂质的吸收，因此我们还研究了果胶对肠道 ALP 活性的影响。结果发现，与活性维生素 D 的作用不同，果胶能显著降低肠道 ALP 活性。这些结果表明，果胶刺激极化的 Caco-2 细胞的机制不同于维生素 D 对钙吸收的调节，它通过在细胞水平上抑制小肠的形态变化来调节伸长绒毛对钙的总吸收。
{"title":"Pectin Modulates Calcium Absorption in Polarized Caco-2 Cells via a Pathway Distinct from Vitamin D Stimulation.","authors":"Saki Gotoh, Kohji Kitaguchi, Tomio Yabe","doi":"10.5458/jag.jag.JAG-2022_0015","DOIUrl":"10.5458/jag.jag.JAG-2022_0015","url":null,"abstract":"<p><p>Pectin, a type of soluble fiber, promotes morphological changes in the small intestinal villi. Although its physiological significance is unknown, we hypothesized that changes in villus morphology enhance the efficiency of nutrient absorption in the small intestine and investigated the effect of pectin derived from persimmon on calcium absorption using polarized Caco-2 cells. In polarized Caco-2 cells, pectin altered the mRNA expression levels of substances involved in calcium absorption and the regulation of intracellular calcium concentration and significantly reduced calcium absorption. Although this was comparable to the results of absorption and permeability associated with the addition of active vitamin D, the simultaneous action of pectin and active vitamin D did not show any additive effects. Furthermore, as active vitamin D significantly increases the activity of intestinal alkaline phosphatase (ALP), which is known to be involved in the regulation of intestinal absorption of calcium and lipids, we also investigated the effect of pectin on intestinal ALP activity. As a result, it was found that, unlike the effect of active vitamin D, pectin significantly reduced intestinal ALP activity. These results suggest that pectin stimulates polarized Caco-2 cells through a mechanism distinct from the regulation of calcium absorption by vitamin D, modulating total calcium absorption from the elongated villi through morphological changes in the small intestine by suppressing it at the cellular level.</p>","PeriodicalId":54617,"journal":{"name":"Physical Medicine and Rehabilitation Clinics of North America","volume":"9 1 1","pages":"59-66"},"PeriodicalIF":1.1,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10738857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78411190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号