Pub Date : 2026-01-31DOI: 10.1186/s12969-025-01181-5
Pamela F Weiss, Levon Utidjian, Mitchell Maltenfort, Hanieh Razzaghi, Timothy G Brandon, Cassandra Muir, Cora Sears, Edward J Oberle, Jennifer Cooper, Kevin Baszis, Mary B Toth, Esi M Morgan, Christopher B Forrest
{"title":"Leveraging the PEDSnet clinical research network and electronic health record data to enhance efficiency of trial enrollment for a rare pediatric rheumatic disease.","authors":"Pamela F Weiss, Levon Utidjian, Mitchell Maltenfort, Hanieh Razzaghi, Timothy G Brandon, Cassandra Muir, Cora Sears, Edward J Oberle, Jennifer Cooper, Kevin Baszis, Mary B Toth, Esi M Morgan, Christopher B Forrest","doi":"10.1186/s12969-025-01181-5","DOIUrl":"https://doi.org/10.1186/s12969-025-01181-5","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1186/s12969-026-01189-5
Randal De Souza, Beth Rutstein, Maria Schletzbaum-Bowler, Nora Singer, Melanie Kohlheim, Vincent Del Gaizo, Kelly Wise, Melica Nikahd, Guy N Brock, Rebecca Sadun, Monica I Ardura, Merav Heshin Bekenstein, Vidya Sivaraman
{"title":"Variability in vaccination practices in children with rheumatic diseases: results of a childhood arthritis and rheumatology research alliance (CARRA)-wide survey.","authors":"Randal De Souza, Beth Rutstein, Maria Schletzbaum-Bowler, Nora Singer, Melanie Kohlheim, Vincent Del Gaizo, Kelly Wise, Melica Nikahd, Guy N Brock, Rebecca Sadun, Monica I Ardura, Merav Heshin Bekenstein, Vidya Sivaraman","doi":"10.1186/s12969-026-01189-5","DOIUrl":"https://doi.org/10.1186/s12969-026-01189-5","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Juvenile Behçet's disease (JBD) is a rare multisystem inflammatory disorder that primarily affects the oral and genital mucosa, as well as vessels of any caliber. Between 4% and 26% of Behçet's disease cases begin before the age of 16. JBD remains underreported, with only 55 cases documented in Colombia in 2022. Its aetiology is uncertain, with possible infectious and genetic triggers. The wide range of clinical variability often leads to delayed diagnosis and treatment, increasing the risk of serious complications such as thrombosis and neurological damage.
Materials and methods: A multicenter longitudinal study with retrospective data collection was conducted in patients under 18 years of age who met international diagnostic criteria for JBD between 2014 and 2024 in three Colombian cities: Cali, Bogotá, and Pereira. Clinical and paraclinical data were extracted from medical records and analysed via IBM SPSS Statistics v29 to obtain descriptive statistics and frequency distributions.
Results and discussion: Fifteen patients were included, with a female predominance (60%). The mean age at symptom onset was 6.1 years, with a mean age at diagnosis of 11.8 years, revealing a diagnostic delay of 5.7 years. The most common manifestations were recurrent oral aphthosis (100%), genital ulcers (73.3%), arthralgia (60%), and neurological (40%) and vascular (20%) involvement-mainly venous thrombosis. The pathergy test was positive in 44.4% of patients, and viral antigens were detected in 46.7%. All patients received colchicine and corticosteroids; 86.7% required additional immunosuppressive therapy, and two patients were treated with biologics.
Conclusion: Juvenile Behçet's disease in Colombia presents heterogeneous clinical presentations, with a high prevalence of mucocutaneous, musculoskeletal, and neurological involvement. A significant delay in diagnosis was observed, highlighting the need for increased clinical awareness and suspicion. Colchicine and corticosteroids are generally effective, although most patients require immunosuppressive agents, and some require biologic therapy. These findings emphasize the importance of timely diagnosis and individualized treatment strategies to reduce morbidity in affected children.
{"title":"Juvenile Behçet's disease 2014-2024: multicenter study in Colombia.","authors":"Laura-María Zabala-Sepúlveda, Nathalie Yepes-Madrid, María-Del-Pilar Gómez-Mora, Ricardo-Ernesto Yépez-Zambrano, Angela-Catalina Mosquera-Pongutá, Christine Arango-Slingsby, Mónica-Alexandra Gil-Artunduaga, José-Fernando Gómez-Urrego","doi":"10.1186/s12969-026-01190-y","DOIUrl":"10.1186/s12969-026-01190-y","url":null,"abstract":"<p><strong>Introduction: </strong>Juvenile Behçet's disease (JBD) is a rare multisystem inflammatory disorder that primarily affects the oral and genital mucosa, as well as vessels of any caliber. Between 4% and 26% of Behçet's disease cases begin before the age of 16. JBD remains underreported, with only 55 cases documented in Colombia in 2022. Its aetiology is uncertain, with possible infectious and genetic triggers. The wide range of clinical variability often leads to delayed diagnosis and treatment, increasing the risk of serious complications such as thrombosis and neurological damage.</p><p><strong>Materials and methods: </strong>A multicenter longitudinal study with retrospective data collection was conducted in patients under 18 years of age who met international diagnostic criteria for JBD between 2014 and 2024 in three Colombian cities: Cali, Bogotá, and Pereira. Clinical and paraclinical data were extracted from medical records and analysed via IBM SPSS Statistics v29 to obtain descriptive statistics and frequency distributions.</p><p><strong>Results and discussion: </strong>Fifteen patients were included, with a female predominance (60%). The mean age at symptom onset was 6.1 years, with a mean age at diagnosis of 11.8 years, revealing a diagnostic delay of 5.7 years. The most common manifestations were recurrent oral aphthosis (100%), genital ulcers (73.3%), arthralgia (60%), and neurological (40%) and vascular (20%) involvement-mainly venous thrombosis. The pathergy test was positive in 44.4% of patients, and viral antigens were detected in 46.7%. All patients received colchicine and corticosteroids; 86.7% required additional immunosuppressive therapy, and two patients were treated with biologics.</p><p><strong>Conclusion: </strong>Juvenile Behçet's disease in Colombia presents heterogeneous clinical presentations, with a high prevalence of mucocutaneous, musculoskeletal, and neurological involvement. A significant delay in diagnosis was observed, highlighting the need for increased clinical awareness and suspicion. Colchicine and corticosteroids are generally effective, although most patients require immunosuppressive agents, and some require biologic therapy. These findings emphasize the importance of timely diagnosis and individualized treatment strategies to reduce morbidity in affected children.</p>","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":"24 1","pages":"4"},"PeriodicalIF":2.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12870820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1186/s12969-026-01186-8
Rongjun Zheng, Lixia Zou, Suzanne C Li, Meiping Lu
{"title":"JAK inhibitors for the treatment of juvenile localized scleroderma: a case report and literature review.","authors":"Rongjun Zheng, Lixia Zou, Suzanne C Li, Meiping Lu","doi":"10.1186/s12969-026-01186-8","DOIUrl":"https://doi.org/10.1186/s12969-026-01186-8","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146068735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1186/s12969-026-01188-6
Myroslava Kulyk, Oleksandr Yeremiya, Rene Westhovens, Kurt De Vlam, Marta Dzhus
{"title":"Muscle mass, strength, and sarcopenia in juvenile idiopathic arthritis: a scoping review.","authors":"Myroslava Kulyk, Oleksandr Yeremiya, Rene Westhovens, Kurt De Vlam, Marta Dzhus","doi":"10.1186/s12969-026-01188-6","DOIUrl":"https://doi.org/10.1186/s12969-026-01188-6","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1186/s12969-026-01185-9
Jordi Anton, Angelo Ravelli
{"title":"The emerging role of clinimetrics in pediatric rheumatology.","authors":"Jordi Anton, Angelo Ravelli","doi":"10.1186/s12969-026-01185-9","DOIUrl":"10.1186/s12969-026-01185-9","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":"24 1","pages":"3"},"PeriodicalIF":2.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1186/s12969-026-01184-w
Dominic S Bräm, Verena Gotta, Gilbert Koch, Klervi Golhen, Andreas Woerner, Andrew Atkinson, Johannes N van den Anker, Marc Pfister, Tatjana Welzel
{"title":"Evaluation of adalimumab tapering regimens in children and adolescents with juvenile idiopathic arthritis in remission: a simulation study.","authors":"Dominic S Bräm, Verena Gotta, Gilbert Koch, Klervi Golhen, Andreas Woerner, Andrew Atkinson, Johannes N van den Anker, Marc Pfister, Tatjana Welzel","doi":"10.1186/s12969-026-01184-w","DOIUrl":"10.1186/s12969-026-01184-w","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":"6"},"PeriodicalIF":2.3,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1186/s12969-026-01183-x
Carter Worth, Emma Leisinger, Linder Wendt, Patrick Ten Eyck, Katherine Schultz
{"title":"A retrospective study of pediatric rheumatology referrals reveals large discrepancies in referring providers' musculoskeletal exams.","authors":"Carter Worth, Emma Leisinger, Linder Wendt, Patrick Ten Eyck, Katherine Schultz","doi":"10.1186/s12969-026-01183-x","DOIUrl":"10.1186/s12969-026-01183-x","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":"5"},"PeriodicalIF":2.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号