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A Review of the Effect of Iron Supplementation on the Gut Microbiota of Children in Developing Countries and the Impact of Prebiotics 铁补充剂对发展中国家儿童肠道微生物群的影响及益生元影响综述
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-04-08 DOI: 10.1017/s0954422424000118
Ishawu Iddrisu, Andrea Monteagudo-Mera, Carlos Poveda, Muhammed Shahzad, Gemma E. Walton, Simon C. Andrews
Iron is essential for many physiological functions of the body, and it is required for normal growth and development. Iron deficiency (ID) is the most common form of micronutrient malnutrition and is particularly prevalent in infants and young children in developing countries. Iron supplementation is considered the most effective strategy to combat the risk of ID and ID anaemia (IDA) in infants, although iron supplements cause a range of deleterious gut-related problems in malnourished children. The purpose of this review is to assess the available evidence on the effect of iron supplementation on the gut microbiota during childhood ID and to further assess whether prebiotics offer any benefits for iron supplementation. Prebiotics are well known to improve gut-microbial health in children and recent reports indicate that prebiotics can mitigate the adverse gut-related effects of iron supplementation in ID and IDA children. Thus, provision of prebiotics alongside iron supplements has the potential for an enhanced strategy for combating ID and IDA among children in the developing world. However, further understanding is required before the benefit of such combined treatments of ID in nutritionally-deprived children across populations can be fully confirmed. Such enhanced understanding is of high relevance in resource-poor countries where ID, poor sanitation and hygiene, alongside inadequate access to good drinking water and poor health systems are serious public health concerns.
人体的许多生理功能都离不开铁,正常的生长发育也需要铁。缺铁(ID)是最常见的微量营养素营养不良形式,在发展中国家的婴幼儿中尤为普遍。补铁被认为是应对婴儿缺铁性贫血(IDA)风险的最有效策略,尽管补铁会给营养不良儿童带来一系列有害的肠道相关问题。本综述旨在评估铁补充剂对儿童 ID 期肠道微生物群影响的现有证据,并进一步评估益生元对铁补充剂是否有任何益处。众所周知,益生元可改善儿童的肠道微生物健康,而最近的报告表明,益生元可减轻 ID 和 IDA 儿童补充铁剂对肠道的不良影响。因此,在提供铁补充剂的同时提供益生元,有可能成为发展中国家儿童防治 ID 和 IDA 的强化策略。然而,在完全确认这种联合疗法对不同人群中营养不良儿童的 ID 的益处之前,还需要进一步的了解。在资源匮乏的国家,IDA、恶劣的环境卫生和个人卫生,以及无法获得充足的优质饮用水和糟糕的医疗系统都是严重的公共卫生问题。
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引用次数: 0
Challenges in Identifying Malnutrition in Obesity; An Overview of the State of the Art and Directions for Future Research 识别肥胖症营养不良所面临的挑战;技术现状和未来研究方向概述
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-04-05 DOI: 10.1017/s095442242400012x
Natasha Nalucha Mwala, Jos W. Borkent, Barbara S. van der Meij, Marian A.E. de van der Schueren
(Protein-energy) malnutrition in individuals living with obesity presents complex diagnostic challenges due to the distinctive physiological characteristics of obesity. This narrative review critically examines the identification of malnutrition within the population with obesity, distinguishing malnutrition from related conditions such as sarcopenic obesity. While noting some shared features, the review highlights key differences between these conditions. The review also highlights the limitations of current malnutrition screening tools, which are not designed for individuals living with obesity. These tools primarily rely on anthropometric measurements, neglecting (among others) nutrient intake assessment, which hinders accurate malnutrition detection. Additionally, this review discusses limitations in existing diagnostic criteria, including the Global Leadership Initiative on Malnutrition (GLIM) criteria, when applied to individuals living with obesity. Challenges include the identification of appropriate cut-off values for phenotypic criteria (unintentional weight loss, low body mass index and muscle mass) and etiological criteria such as reduced food intake and inflammation for the population with obesity. Overall, this review emphasises the need for modified screening tools and diagnostic criteria to recognise and assess malnutrition in obesity, leading to improved clinical outcomes and overall well-being.
(由于肥胖症的独特生理特征,肥胖症患者的(蛋白质-能量)营养不良给诊断带来了复杂的挑战。这篇叙述性综述对肥胖人群中营养不良的识别进行了批判性研究,并将营养不良与肌肉疏松性肥胖等相关疾病进行了区分。在注意到一些共同特征的同时,综述强调了这些病症之间的主要区别。综述还强调了当前营养不良筛查工具的局限性,因为这些工具不是为肥胖症患者设计的。这些工具主要依赖于人体测量,忽视了营养摄入评估(其中包括),从而阻碍了营养不良的准确检测。此外,本综述还讨论了现有诊断标准(包括《全球营养不良领导倡议》(GLIM)标准)在应用于肥胖症患者时存在的局限性。面临的挑战包括为表型标准(无意体重减轻、低体重指数和肌肉质量)和病因标准(如肥胖人群食物摄入减少和炎症)确定合适的临界值。总之,本综述强调有必要修改筛查工具和诊断标准,以识别和评估肥胖症患者的营养不良情况,从而改善临床疗效和整体健康。
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引用次数: 0
Effects of energy-restricted diets with or without nuts on weight, body composition and glycaemic control in adults: a scoping review. 含或不含坚果的能量限制饮食对成人体重、身体成分和血糖控制的影响:范围综述。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-23 DOI: 10.1017/S0954422424000106
Lauren C Mead, Alison M Hill, Sharayah Carter, Alison M Coates

Energy-restricted (ER) diets promote weight loss and improve body composition and glycaemic control. Nut consumption also improves these parameters. However, less is known about the combined benefit of these two strategies. This scoping review implemented a systematic search of Medline, Embase and Scopus to identify randomised controlled trials evaluating the effect of ER diets with or without nuts on body mass, body composition and glycaemic control in adults. After reviewing titles and abstracts, twenty-nine full-text articles were screened, resulting in seven studies reported in eight papers that met the inclusion criteria. Energy restriction was achieved by prescribing a set energy target or reducing intake by 1000-4200 kJ from daily energy requirements. Interventions ranged from 4 to 52 weeks in duration and contained 42-84 g/d of almonds, peanuts, pistachios or walnuts. While all studies reported that energy restriction resulted in significant weight loss, the addition of nuts to ER diets demonstrated significantly greater weight loss in only approximately half of the included studies (4/7 studies). There was limited evidence to support additional benefits from nuts for body composition measures or glycaemic control. Although improvements in weight loss and glycaemia were not consistent when nuts were included in ER diets, no study revealed an adverse effect of nut consumption on health outcomes. Future studies could explore the effect of consuming different types and amounts of nuts, combined with various levels of energy restriction on weight, body composition and glycaemic control.

能量限制(ER)饮食可促进减肥,改善身体成分和血糖控制。食用坚果也能改善这些参数。然而,人们对这两种策略的综合益处知之甚少。本范围界定综述对 Medline、Embase 和 Scopus 进行了系统性检索,以确定评估添加或不添加坚果的 ER 饮食对成年人体重、身体成分和血糖控制效果的随机对照试验。在审阅了标题和摘要后,筛选出 29 篇全文文章,结果有 8 篇论文中报告的 7 项研究符合纳入标准。能量限制是通过规定一个设定的能量目标或从每日能量需求量中减少 1,000-4,200 千焦的摄入量来实现的。干预持续时间为 4-52 周不等,杏仁、花生、开心果或核桃的含量为 42-84 克/天。虽然所有研究都报告说能量限制导致体重显著下降,但在 ER 膳食中添加坚果仅在约一半的纳入研究(4/7 项研究)中证明体重下降幅度显著增大。支持坚果对身体成分测量或血糖控制有额外益处的证据有限。虽然在 ER 饮食中加入坚果后,体重减轻和血糖控制的改善效果并不一致,但没有研究表明食用坚果对健康结果有不利影响。未来的研究可以探索食用不同种类和数量的坚果,并结合不同程度的能量限制对体重、身体成分和血糖控制的影响。
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引用次数: 0
Programmes to manage food selectivity in individuals with autism spectrum disorder. 管理自闭症谱系障碍患者食物选择性的计划。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-22 DOI: 10.1017/S0954422424000052
Chiara Breda, Sara Santero, Maria Vittoria Conti, Hellas Cena

Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders characterised by impaired social communication and restricted interests/repetitive behaviours. In this regard, sensory processing difficulties and delayed oral motor skills often predispose individuals with ASD to food selectivity (FS). It is usually associated with repetitive eating patterns that can lead to multiple malnutrition conditions. The objective of this narrative review is to present an overview about the existing nutritional interventions aiming at promoting a healthy eating pattern and addressing food selectivity among individuals with ASD. Regarding the interventions targeting nutrition education, the majority of the analysed studies failed to demonstrate their effectiveness. On the other hand, many educational interventions involving taste or cooking sessions, as well as behavioural interventions for FS, demonstrated effective results. Moreover, multidisciplinary in tailoring such programmes, including psychology speech therapy and nutritional skills, is acknowledged as a key approach.

自闭症谱系障碍(ASD)是一组复杂的神经发育障碍,其特点是社交沟通障碍和兴趣/重复行为受限。在这方面,感官处理困难和口腔运动技能发育迟缓往往使自闭症患者容易出现食物选择性(FS)。它通常与重复进食模式有关,可导致多种营养不良状况。本综述旨在概述旨在促进健康饮食模式和解决 ASD 患者食物选择性问题的现有营养干预措施。关于以营养教育为目标的干预措施,大部分分析研究未能证明其有效性。另一方面,许多涉及品尝或烹饪课程的教育干预措施以及针对FS的行为干预措施都取得了有效的结果。此外,多学科定制此类计划(包括心理言语治疗和营养技能)被认为是一种关键方法。
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引用次数: 0
Effect of vegetable consumption on risk of gastric cancer: a systematic review and multi-level meta-analysis of prospective studies. 蔬菜摄入对胃癌风险的影响:前瞻性研究的系统回顾和多层次元分析》。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-20 DOI: 10.1017/S0954422424000040
Xiaomin Wu, Guoqiang Qin, Rui Zhang, Yunning Liu, Liling Chen, Jingyang Su, Chao Kong, Zhongze Fang, Jing Wu

Vegetables are known to be beneficial to human health, but the association between vegetable consumption and gastric cancer remains uncertain. To synthesise knowledge about the relationship between vegetable group consumption and gastric cancer risk, update present meta-analyses and estimate associations between vegetable consumption and gastric cancer risk based solely on prospective studies, we perform a PRISMA-compliant three-level meta-analysis. Systematic search identified thirteen prospective studies with fifty-two effect sizes that met all inclusion criteria and no exclusion criteria for our meta-analysis. Pooled risk ratios (RRs) showed a positive association between high vegetable consumption and low gastric cancer risk (pooled RR 0·93, 95% confidence interval 0·90-0·97, P = 0·06). In moderator analyses for indicators of gender, region and quantity of vegetable intake, there was no significant difference between subgroups. However, the effect became significant in populations with lower than the minimum risk exposure level (TMREL) of vegetable consumption (P < 0·05). Higher vegetable intake is associated with a decreased risk of gastric cancer. This effect may be limited to specific populations, such as ones with lower vegetable consumption. Evidence from our study has important public health implications for dietary recommendations.

众所周知,蔬菜有益于人类健康,但蔬菜消费与胃癌之间的关系仍不确定。综合有关蔬菜类消费与胃癌风险之间关系的知识,更新现有的荟萃分析,并仅根据前瞻性研究估计蔬菜消费与胃癌风险之间的关系。符合PRISMA标准的三级荟萃分析。通过系统检索发现了 13 项前瞻性研究,其 52 个效应大小符合我们荟萃分析的所有纳入标准,且无排除标准。汇总风险比(RRs)显示,高蔬菜摄入量与低胃癌风险之间存在正相关(汇总RR=0.93,95% CI:0.90-0.97,P=0.06)。在对性别、地区和蔬菜摄入量等指标进行调节分析时,亚组之间没有显著差异。然而,在蔬菜摄入量低于最低风险暴露水平(TMREL)的人群中,影响变得显著(p
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引用次数: 0
Addressing nutritional issues and eating behaviours among university students: a narrative review. 解决大学生的营养问题和饮食行为:叙述性综述。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-15 DOI: 10.1017/S0954422424000088
Noha M Almoraie, Noor M Alothmani, Wajd D Alomari, Amal H Al-Amoudi

University life is a critical period for establishing healthy eating habits and attitudes. However, university students are at risk of developing poor eating habits due to various factors, including economic conditions, academic stress and lack of information about nutritional concepts. Poor diet quality leads to malnutrition or overnutrition, increasing the risk of preventable diseases. Food environments on university campuses also play a significant role in shaping the dietary habits of students, with the availability of and accessibility to healthy food options being important factors influencing food choices and overall diet quality. Disordered eating habits and body dissatisfaction are prevalent among university students and can lead to eating disorders. Income and living arrangements also influence dietary habits, with low household income and living alone being associated with unhealthy eating habits. This study is a narrative review that aimed to address nutritional issues and eating behaviours, specifically among university students. We investigated the eating behaviours of university students, including their dietary patterns, food choices and food environments. The objective of this review was to provide insights into the nutritional issues and eating behaviours of university students, with the aim of identifying target areas for intervention to improve the overall health and wellbeing among college students. University food environments need to be restructured to promote healthy eating, including the availability, accessibility, affordability and labelling of healthy foods, and policies to limit the availability of unhealthy foods and drinks on campus.

大学生活是建立健康饮食习惯和态度的关键时期。然而,由于经济条件、学业压力、缺乏营养观念等各种因素,大学生有可能养成不良的饮食习惯。不良的饮食质量会导致营养不良或营养过剩,增加罹患可预防疾病的风险。大学校园的饮食环境对学生饮食习惯的形成也起着重要作用,健康食品的可供性和可及性是影响食品选择和整体饮食质量的重要因素。大学生中普遍存在饮食习惯紊乱和对身体不满意的现象,并可能导致饮食失调。收入和生活安排也会影响饮食习惯,家庭收入低和独居与不健康的饮食习惯有关。本研究是一项叙事性综述,旨在探讨营养问题和饮食行为,特别是大学生的饮食行为。我们调查了大学生的饮食行为,包括他们的饮食模式、食物选择和饮食环境。本综述旨在深入了解大学生的营养问题和饮食行为,从而确定干预的目标领域,改善大学生的整体健康和福祉。为促进健康饮食,需要对大学食品环境进行重组,包括健康食品的可提供性、可获得性、可负担性和标签,以及限制校园内不健康食品和饮料供应的政策。
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引用次数: 0
Current perspectives and challenges in the estimation of fruit juice consumption across the lifecycle in Europe. 欧洲果汁生命周期消费估算的现状与挑战。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-15 DOI: 10.1017/S095442242400009X
Janette Walton, Laura Kehoe

Fruit juice (FJ) is typically low in energy, contains natural sugars, important amounts of micronutrients and is not permitted to have added sugars/sweeteners. However, its role in a healthy diet is under scrutiny partly due to the wider adoption of the definition for free sugars in nutrition policy. This review aimed to identify data on FJ consumption from national food consumption surveys across Europe, to examine current intakes, percent consumers and its contribution to intakes of energy, total sugars, free sugars, vitamin C, folate and potassium. Data were extracted on the population mean intake of FJ and its contribution to nutrient intakes across the lifecycle and crude estimates of population mean intakes across countries were reported for the total population and for consumers only. This review highlighted significant gaps/challenges regarding the availability of country-specific national food consumption surveys across Europe and specifically data on FJ consumption (including complexities surrounding categorisations). Nonetheless, using a comparable/homogenous definition, the mean intake of FJ among consumers was approximately 1 × 150 ml glass/day for adults/older adults, with lower intakes among infants (86 g/d), children (108 g/d) and teenagers (112 g/d). FJ made important contributions to intakes of vitamin C while making little contribution to energy intakes but also contributed 2-14 % of free sugars intake (which may be considered modest compared to other sources). The complexity of collating and interpreting data on FJ intake as elucidated in this review raises questions surrounding the categorisation of FJ in research and presents significant challenges for policymakers with respect to dietary guidance for FJ.

果汁(FJ)通常能量较低,含有天然糖分和重要的微量营养素,并且不允许添加糖/甜味剂。然而,由于营养政策中更广泛地采用了游离糖的定义,果汁在健康饮食中的作用正受到审查。本综述旨在从欧洲各国的食品消费调查中确定游离糖的消费数据,研究当前的摄入量、消费者百分比及其对能量、总糖、游离糖、维生素 C、叶酸和钾摄入量的贡献。研究人员提取了关于FJ人口平均摄入量及其在整个生命周期中对营养素摄入量的贡献的数据,并报告了各国总人口和消费者的FJ人口平均摄入量的粗略估计值。该综述强调了欧洲各国在特定国家食品消费调查方面存在的巨大差距/挑战,特别是在FJ消费数据方面(包括分类的复杂性)。尽管如此,根据可比/同质的定义,成人/老年人的果冻平均摄入量约为 1x150 毫升玻璃/天,婴儿(86 克/天)、儿童(108 克/天)和青少年(117 克/天)的摄入量较低。果冻对维生素 C 的摄入量有重要贡献,但对能量摄入量的贡献不大,而且还占游离糖摄入量的 2%-14%(与其他来源相比,这一比例可能不算高)。本综述阐明了整理和解释游离糖摄入量数据的复杂性,提出了在研究中对游离糖进行分类的问题,并对决策者制定游离糖膳食指南提出了重大挑战。
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引用次数: 0
An overview of nutritional factors in the aetiopathogenesis of myocardial fibrosis in great apes. 类人猿心肌纤维化发病机制中的营养因素概述。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-12 DOI: 10.1017/S0954422424000076
Laurens Van Mulders, Laurent Locquet, Christine Kaandorp, Geert P J Janssens

The main cause of mortality in great apes in zoological settings is cardiovascular disease (CVD), affecting all four taxa: chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla spp.) and orangutan (Pongo spp.). Myocardial fibrosis, the most typical histological characterisation of CVD in great apes, is non-specific, making it challenging to understand the aetiopathogenesis. A multifactorial origin of disease is assumed whereby many potential causative factors are directly or indirectly related to the diet, which in wild-living great apes mainly consists of high-fibre, low-carbohydrate and very low-sodium components. Diets of great apes housed in zoological settings are often different compared with the situation in the wild. Moreover, low circulating vitamin D levels have recently been recognised in great apes housed in more northern regions. Evaluation of current supplementation guidelines shows that, despite implementation of different dietary strategies, animals stay vitamin D insufficient. Therefore, recent hypotheses designate vitamin D deficiency as a potential underlying factor in the pathogenesis of myocardial fibrosis. The aim of this literature review is to: (i) examine important differences in nutritional factors between zoological and wild great ape populations; (ii) explain the potential detrimental effects of the highlighted dietary discrepancies on cardiovascular function in great apes; and (iii) elucidate specific nutrition-related pathophysiological mechanisms that may underlie the development of myocardial fibrosis. This information may contribute to understanding the aetiopathogenesis of myocardial fibrosis in great apes and pave the way for future clinical studies and a more preventive approach to great ape CVD management.

在动物园中,类人猿死亡的主要原因是心血管疾病(CVD),影响到所有四个类群:黑猩猩(Pan troglodytes)、倭黑猩猩(Pan paniscus)、大猩猩(Gorilla spp.)和猩猩(Pongo spp.)。心肌纤维化是类人猿心血管疾病最典型的组织学特征,但并不具有特异性,因此要了解其发病机制非常困难。野生类人猿的饮食主要由高纤维、低碳水化合物和极低钠组成。在动物园中饲养的类人猿的饮食通常与野生环境中的饮食不同。此外,最近在北方地区饲养的类人猿中发现循环维生素D水平较低。对现行补充剂指南的评估表明,尽管实施了不同的饮食策略,动物体内的维生素D仍然不足。因此,最近有假说认为维生素 D 缺乏是心肌纤维化发病机制中的潜在潜在因素。本文献综述旨在:(i) 研究动物学巨猿种群与野生巨猿种群之间营养因素的重要差异;(ii) 解释突出的饮食差异对巨猿心血管功能的潜在不利影响;(iii) 阐明可能导致心肌纤维化的特定营养相关病理生理机制。这些信息可能有助于了解类人猿心肌纤维化的发病机制,并为未来的临床研究和类人猿心血管疾病的预防性治疗铺平道路。
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引用次数: 0
Mollusc and crustacean consumption in the first 1000 days: a scoping review. 头 1,000 天的软体动物和甲壳类动物消费:范围审查。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-12 DOI: 10.1017/S0954422424000064
Brietta M Oaks, Emmanuel A Gyimah, Eliza Kleban, Kathleen Ragsdale, Lora L Iannotti

Mollusc and crustacean consumption in the first 1000 d may improve maternal and child health by providing essential nutrients. However, in some contexts, molluscs and crustaceans have been associated with allergies and environmental contamination, potentially leading to adverse health and development outcomes. It is unclear whether the health benefits of consuming molluscs and crustaceans, collectively classified as shellfish in nutrition, are outweighed by the potential risks to pregnant women and children. We conducted a scoping review (PROSPERO: CRD42022320454) in PubMed, Scopus and EBSCO Global Health of articles published between January 2000 and March 2022 that assessed shellfish consumption during pregnancy, lactation or childhood (0-2 years) in relation to maternal health, child health or child development. A total of forty-six articles were included in this review. Overall, shellfish consumption was associated with higher biomarkers of environmental contaminants, with mercury being the most studied and having the strongest evidence base. The limited research on nutritional biomarker status shows an association between shellfish consumption and iodine status. Preterm birth was not associated with shellfish consumption, but newborn anthropometry showed mixed results, with several studies reporting lower birth weight with higher shellfish consumption. The few studies that examined child development and maternal health outcomes reported no significant associations. This review revealed trade-off health risks and benefits with inclusion of molluscs and crustaceans in the dietary patterns of mothers and young children. More research is needed to understand how these aquatic animal-source foods may be safely consumed and leveraged for improving human nutrition.

在婴儿出生后 1 000 天内食用软体动物和甲壳类动物可提供必需的营养,从而改善母婴健康。然而,在某些情况下,软体动物和甲壳类动物与过敏和环境污染有关,可能导致不良的健康和发育结果。目前还不清楚食用软体动物和甲壳类动物(在营养学中统称为贝类)对健康的益处是否大于对孕妇和儿童的潜在风险。我们在 PubMed、Scopus 和 EBSCO Global Health 中对 2000 年 1 月至 2022 年 3 月间发表的文章进行了范围界定综述(PROSPERO:CRD42022320454),这些文章评估了妊娠期、哺乳期或儿童期(0-2 岁)贝类消费与孕产妇健康、儿童健康或儿童发育的关系。本综述共纳入 46 篇文章。总体而言,食用贝类与较高的环境污染物生物标志物有关,其中汞的研究最多,证据基础也最雄厚。有关营养生物标志物状况的有限研究表明,食用贝类与碘状况有关。早产与贝类摄入量无关,但新生儿人体测量结果不一,有几项研究报告称,贝类摄入量越高,出生体重越低。对儿童发育和孕产妇健康结果进行研究的少数几项研究报告称,两者之间没有显著关联。本综述揭示了将软体动物和甲壳类动物纳入母亲和幼儿膳食模式的健康风险和益处之间的权衡。需要开展更多研究,以了解如何安全食用和利用这些水生动物源食品改善人类营养。
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引用次数: 0
Emerging evidence on selenoneine and its public health relevance in coastal populations: a review and case study of dietary Se among Inuit populations in the Canadian Arctic. 有关硒酮及其在沿海居民中的公共卫生意义的新证据:加拿大北极地区因纽特人膳食中硒含量的回顾与案例研究。
IF 5.7 2区 医学 Q1 Nursing Pub Date : 2024-02-08 DOI: 10.1017/S0954422424000039
Matthew Little, Adel Achouba, Pierre Ayotte, Mélanie Lemire

Selenium is an essential mineral yet both deficiency and excess are associated with adverse health effects. Dietary intake of Se in humans varies greatly between populations due to food availability, dietary preferences, and local geological and ecosystem processes impacting Se accumulation into agricultural products and animal populations. We argue there is a need to evaluate and reconsider the relevance of public health recommendations on Se given recent evidence, including the metabolic pathways and health implications of Se. This argument is particularly pertinent for Inuit populations in Northern Canada, who often exceed dietary tolerable upper intake levels and exhibit very high whole blood Se concentrations due to their dependence on local country foods high in the newly discovered Se compound, selenoneine. Since selenoneine appears to have lower toxicity compared to other Se species and does not contribute to the circulating pools of Se for selenoprotein synthesis, we argue that total dietary Se or total Se in plasma or whole blood are poor indicators of Se adequacy for human health in these populations. Overall, this review provides an overview of the current evidence of Se speciation, deficiency, adequacy, and excess and implications for human health and dietary recommendations, with particular reference to Inuit populations in the Canadian Arctic and other coastal populations consuming marine foods.

硒是一种人体必需的矿物质,但缺乏和过量都会对健康造成不良影响。由于食物供应、饮食偏好以及影响硒在农产品和动物体内积累的当地地质和生态系统过程,不同人群的硒膳食摄入量差异很大。我们认为,鉴于最近的证据,包括硒的代谢途径和对健康的影响,有必要评估和重新考虑有关硒的公共卫生建议的相关性。这一论点对加拿大北部的因纽特人尤为重要,由于他们依赖于富含新发现的硒化合物--硒酮的当地乡村食物,他们的膳食摄入量往往超过膳食可耐受上限,并表现出极高的全血硒浓度。由于硒酮与其他硒化合物相比毒性较低,且不参与硒蛋白合成的硒循环池,因此我们认为,膳食中的硒总量或血浆或全血中的硒总量并不能很好地反映这些人群体内硒对人体健康的充足性。总之,本综述概述了目前有关硒的种类、缺乏、充足和过量的证据,以及对人类健康和膳食建议的影响,特别是对加拿大北极地区因纽特人和其他食用海洋食品的沿海居民的影响。
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Nutrition Research Reviews
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