Pub Date : 2017-10-01DOI: 10.1016/j.jisp.2017.01.001
Amanda F. Nahhas , Tasneem F. Mohammad , Iltefat H. Hamzavi
Vitiligo is a disorder characterized by the development of depigmented macules and patches secondary to melanocyte destruction. Several treatment options are available, including medical, light-based, and surgical therapies, that are often used in combination to achieve maximal repigmentation. Vitiligo surgery is an effective yet underperformed treatment, mainly because of lack of awareness and availability. The purpose of this article is to review one method of vitiligo surgery, the melanocyte-keratinocyte transplantation procedure, and discuss its utility in treating vitiligo.
{"title":"Vitiligo Surgery: Shuffling Melanocytes","authors":"Amanda F. Nahhas , Tasneem F. Mohammad , Iltefat H. Hamzavi","doi":"10.1016/j.jisp.2017.01.001","DOIUrl":"10.1016/j.jisp.2017.01.001","url":null,"abstract":"<div><p>Vitiligo is a disorder characterized by the development of depigmented macules and patches secondary to melanocyte destruction. Several treatment options are available, including medical, light-based, and surgical therapies, that are often used in combination to achieve maximal repigmentation. Vitiligo surgery is an effective yet underperformed treatment, mainly because of lack of awareness and availability. The purpose of this article is to review one method of vitiligo surgery, the melanocyte-keratinocyte transplantation procedure, and discuss its utility in treating vitiligo.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S34-S37"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2017.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35381938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-01DOI: 10.1016/j.jisp.2016.10.020
F. Ly , C.C. Ebelle , K. Sylla , A. Sarr , A. Diop , M.T. Ndiaye Diop , N. Sall Diop , A. Diouf , H. Hakim , E.A. Sy , A. Kane
{"title":"018 IMPACT OF COSMETIC PRODUCTS WITH HYDROQUINONE ON THE MEASURE OF CAPILLARY BLOOD SUGAR IN DIABETIC SENEGALESE WOMEN: CASE CONTROL STUDY","authors":"F. Ly , C.C. Ebelle , K. Sylla , A. Sarr , A. Diop , M.T. Ndiaye Diop , N. Sall Diop , A. Diouf , H. Hakim , E.A. Sy , A. Kane","doi":"10.1016/j.jisp.2016.10.020","DOIUrl":"https://doi.org/10.1016/j.jisp.2016.10.020","url":null,"abstract":"","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Page S87"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.10.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72081241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"002 The NEW HAvUN Score: Risk-Stratification for Cellulitis from Non-cellulitic Conditions of the Lower Extremity","authors":"Ezaldein Harib ∗, Waldman Abigail, Grunseich Karl, Jubanyik Karen","doi":"10.1016/j.jisp.2016.10.004","DOIUrl":"https://doi.org/10.1016/j.jisp.2016.10.004","url":null,"abstract":"","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Page S85"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72020175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-01DOI: 10.1016/j.jisp.2017.01.003
Alon Mantel , J. Tyson McDonald , Kennedy Goldsborough , Valerie M. Harvey , Joanne Chan
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone. At the same time, treatment with PGD2 induced reactive oxygen species as indicated by generation of the lipid peroxidation product, 4-hydroxynonenal. To determine whether these two events are linked, we used the reactive oxygen species scavenger N-acetyl-cysteine, which blocked the enhanced testosterone production from PGD2-treated keratinocytes. Our study suggests the existence of a possible crosstalk between the PGD2-reactive oxygen species axis and testosterone metabolism in keratinocytes. Thus, we propose that AGA patients might benefit from the use of N-acetyl-cysteine or other antioxidants as a supplement to currently available or emerging AGA therapies such as finasteride, minoxidil, and PGD2 receptor blockers.
{"title":"Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes","authors":"Alon Mantel , J. Tyson McDonald , Kennedy Goldsborough , Valerie M. Harvey , Joanne Chan","doi":"10.1016/j.jisp.2017.01.003","DOIUrl":"10.1016/j.jisp.2017.01.003","url":null,"abstract":"<div><p>Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone. At the same time, treatment with PGD2 induced reactive oxygen species as indicated by generation of the lipid peroxidation product, 4-hydroxynonenal. To determine whether these two events are linked, we used the reactive oxygen species scavenger N-acetyl-cysteine, which blocked the enhanced testosterone production from PGD2-treated keratinocytes. Our study suggests the existence of a possible crosstalk between the PGD2-reactive oxygen species axis and testosterone metabolism in keratinocytes. Thus, we propose that AGA patients might benefit from the use of N-acetyl-cysteine or other antioxidants as a supplement to currently available or emerging AGA therapies such as finasteride, minoxidil, and PGD2 receptor blockers.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S81-S84"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2017.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35380891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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