Erena Kimura, Mina Komuta, Abbas Agaimy, Kazuma Ito, Akari Nagashima, Yuta Norimatsu, Sohshi Morimura, Takayuki Shiomi, Makoto Sugaya, Toshihisa Hamada
{"title":"The First Case of GAB1::ABL1 Fusion-Positive Spindle Cell Soft Tissue Neoplasm in a Japanese Patient","authors":"Erena Kimura, Mina Komuta, Abbas Agaimy, Kazuma Ito, Akari Nagashima, Yuta Norimatsu, Sohshi Morimura, Takayuki Shiomi, Makoto Sugaya, Toshihisa Hamada","doi":"10.1111/1346-8138.70038","DOIUrl":"10.1111/1346-8138.70038","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 1","pages":"e41-e42"},"PeriodicalIF":2.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cotrimoxazole-Induced Drug-Induced Hypersensitivity Syndrome/Drug Reaction With Eosinophilia and Systemic Symptoms With Persistent Human Herpesvirus-6 DNA Detection and Flare Without Elevated TARC Levels","authors":"Yukari Hamamura, Tomoki Niimura, Katsura Matsumoto, Takeshi Kambara","doi":"10.1111/1346-8138.70028","DOIUrl":"10.1111/1346-8138.70028","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 1","pages":"e27-e29"},"PeriodicalIF":2.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Anaphylaxis due to Carmine Added as a Colorant to Thai Tea","authors":"Motoaki Sou, Erina Hagihara, Ayaka Itou, Sachiko Koshikawa, Naoko Inomata","doi":"10.1111/1346-8138.70034","DOIUrl":"10.1111/1346-8138.70034","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 1","pages":"e34-e36"},"PeriodicalIF":2.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Late-Onset Nagashima-Type Palmoplantar Keratosis in a Chinese Family With a Novel Potential Causative Heterozygous M208I Variant of the SERPINB7 Gene","authors":"Jiayue Wang, Sheng Wang","doi":"10.1111/1346-8138.70036","DOIUrl":"10.1111/1346-8138.70036","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 1","pages":"e39-e40"},"PeriodicalIF":2.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients with cutaneous lupus erythematosus (CLE) are highly susceptible to nonmelanoma skin cancers, including cutaneous squamous cell carcinoma (SCC). Despite the well-established involvement of plasmacytoid dendritic cells (pDCs) in CLE development, the exact role of pDCs in the pathogenesis of CLE-related SCC remains unclear. This report presents a case of SCC arising from a subacute cutaneous lupus erythematosus (SCLE) lesion. Histopathological examination revealed a notable decrease in CD123+ pDCs in the SCC lesion compared with that in the SCLE lesion in the same patient. pDCs may exert cytotoxic effects against cancer cells; thus, the absence of pDCs in the microenvironment of cutaneous SCC may facilitate immune evasion by cancer cells, thereby promoting tumor progression. These findings indicate the complex relationship between pDCs and cutaneous SCC development in patients with CLE. Future studies should clarify the role of pDCs in tumor surveillance and progression.
{"title":"Decreased Plasmacytoid Dendritic Cells in Cutaneous Squamous Cell Carcinoma Arising From Subacute Cutaneous Lupus Erythematosus: A Case Report","authors":"Yao-Yu Lu, Yu-Cheng Liu, Yun-Wen Chiu, Shiou-Fu Lin, Yi-Hsien Shih","doi":"10.1111/1346-8138.70017","DOIUrl":"10.1111/1346-8138.70017","url":null,"abstract":"<div>\u0000 \u0000 <p>Patients with cutaneous lupus erythematosus (CLE) are highly susceptible to nonmelanoma skin cancers, including cutaneous squamous cell carcinoma (SCC). Despite the well-established involvement of plasmacytoid dendritic cells (pDCs) in CLE development, the exact role of pDCs in the pathogenesis of CLE-related SCC remains unclear. This report presents a case of SCC arising from a subacute cutaneous lupus erythematosus (SCLE) lesion. Histopathological examination revealed a notable decrease in CD123<sup>+</sup> pDCs in the SCC lesion compared with that in the SCLE lesion in the same patient. pDCs may exert cytotoxic effects against cancer cells; thus, the absence of pDCs in the microenvironment of cutaneous SCC may facilitate immune evasion by cancer cells, thereby promoting tumor progression. These findings indicate the complex relationship between pDCs and cutaneous SCC development in patients with CLE. Future studies should clarify the role of pDCs in tumor surveillance and progression.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 1","pages":"126-130"},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hu X, Liu L, Huang Y et al. “Novel Molecular Subtyping Revealed Molecular Pathways That Contribute to the Pathogenesis of Rosacea,” The Journal of Dermatology, 52, no. 8 (2025): 1285–1296, https://doi.org/10.1111/1346-8138.17798.
In the authorship section, Ji Li was incorrectly listed as the sole corresponding author. There should be three co-corresponding authors: Zhili Deng, Mengting Chen, and Ji Li.
{"title":"Correction to “Novel Molecular Subtyping Revealed Molecular Pathways That Contribute to the Pathogenesis of Rosacea”","authors":"","doi":"10.1111/1346-8138.70021","DOIUrl":"10.1111/1346-8138.70021","url":null,"abstract":"<p>Hu X, Liu L, Huang Y et al. “Novel Molecular Subtyping Revealed Molecular Pathways That Contribute to the Pathogenesis of Rosacea,” <i>The Journal of Dermatology</i>, 52, no. 8 (2025): 1285–1296, https://doi.org/10.1111/1346-8138.17798.</p><p>In the authorship section, Ji Li was incorrectly listed as the sole corresponding author. There should be three co-corresponding authors: Zhili Deng, Mengting Chen, and Ji Li.</p><p>Their email addresses are as follows:</p><p>Zhili Deng: <span>[email protected]</span></p><p>Mengting Chen: <span>[email protected]</span></p><p>Ji Li: <span>[email protected]</span></p><p>We apologize for this error.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mamiko Tosa, Shin-Ichi Ansai, Masataka Akimoto, Rei Ogawa
Heterotopic ossification within keloid tissue is an uncommon but clinically relevant phenomenon. However, its histopathological characteristics and etiological mechanisms remain poorly understood. To investigate the histological features of ossified keloids and assess potential contributing factors, with a focus on chronic inflammation and foreign body reaction. We retrospectively analyzed 39 histologically confirmed ossified keloids and compared them with two non-ossified control cohorts: a frequency-matched group (n = 78) adjusted for age, sex, and anatomical site, and a broader institutional cohort (n = 345). Histological assessment included evaluation of inflammatory cell infiltration and identification of foreign materials such as hair shafts and suture remnants. Group comparisons were performed using Fisher's exact test. Multivariable logistic regression analysis was also performed to identify independent determinants of ossification, including age, sex, anatomical site, etiology, disease duration, and the presence of foreign bodies. Inflammatory cell infiltration was frequently observed across all groups without significant differences. However, foreign materials were detected significantly more often in ossified keloids (66.7%) than in both the matched (15.4%) and total non-ossified cohorts (8.1%) (p < 0.001). Logistic regression revealed that the presence of foreign bodies was independently associated with ossification (OR = 14.4, 95% CI: 6.1–33.8, p < 0.001), while female sex and acne/folliculitis etiology were also significant predictors. Ossified keloids exhibit characteristic features of active bone formation, including lamellar bone and osteoblast-like cells in the deep dermis, and are frequently associated with embedded foreign materials. These findings suggest that chronic inflammation and foreign body reaction may play key roles in ectopic ossification. Our multivariable analysis further indicates that host-related factors, such as sex and etiology, also contribute to this process, underscoring that foreign bodies alone are not sufficient. Combined with prior evidence indicating increased recurrence rates in ossified keloids, these histological features may serve as prognostic markers and inform surgical management strategies.
{"title":"Histopathological Features of Ossified Keloids and Their Association With Recurrence: The Role of Inflammation and Foreign Bodies","authors":"Mamiko Tosa, Shin-Ichi Ansai, Masataka Akimoto, Rei Ogawa","doi":"10.1111/1346-8138.70011","DOIUrl":"10.1111/1346-8138.70011","url":null,"abstract":"<div>\u0000 \u0000 <p>Heterotopic ossification within keloid tissue is an uncommon but clinically relevant phenomenon. However, its histopathological characteristics and etiological mechanisms remain poorly understood. To investigate the histological features of ossified keloids and assess potential contributing factors, with a focus on chronic inflammation and foreign body reaction. We retrospectively analyzed 39 histologically confirmed ossified keloids and compared them with two non-ossified control cohorts: a frequency-matched group (<i>n</i> = 78) adjusted for age, sex, and anatomical site, and a broader institutional cohort (<i>n</i> = 345). Histological assessment included evaluation of inflammatory cell infiltration and identification of foreign materials such as hair shafts and suture remnants. Group comparisons were performed using Fisher's exact test. Multivariable logistic regression analysis was also performed to identify independent determinants of ossification, including age, sex, anatomical site, etiology, disease duration, and the presence of foreign bodies. Inflammatory cell infiltration was frequently observed across all groups without significant differences. However, foreign materials were detected significantly more often in ossified keloids (66.7%) than in both the matched (15.4%) and total non-ossified cohorts (8.1%) (<i>p</i> < 0.001). Logistic regression revealed that the presence of foreign bodies was independently associated with ossification (OR = 14.4, 95% CI: 6.1–33.8, <i>p</i> < 0.001), while female sex and acne/folliculitis etiology were also significant predictors. Ossified keloids exhibit characteristic features of active bone formation, including lamellar bone and osteoblast-like cells in the deep dermis, and are frequently associated with embedded foreign materials. These findings suggest that chronic inflammation and foreign body reaction may play key roles in ectopic ossification. Our multivariable analysis further indicates that host-related factors, such as sex and etiology, also contribute to this process, underscoring that foreign bodies alone are not sufficient. Combined with prior evidence indicating increased recurrence rates in ossified keloids, these histological features may serve as prognostic markers and inform surgical management strategies.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"231-236"},"PeriodicalIF":2.7,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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