Pub Date : 2021-07-07DOI: 10.56042/ijca.v60i3.39627
Raji Thomasa, Densely Doseb, Nelson Joseph, Pc, R. T. Pardasanid, T. Mukherjeee
Raji Thomas*, Densely Dose, Nelson Joseph P, R T Pardasani & T Mukherjee aDepartment of Chemistry, School of Science and Humanities, Sreenidhi Institute of Science & Technology, Hyderabad 501 301, India bDepartment of Chemistry, Mar Athanasius College, Kothamangalam, Kerala, India cDepartment of Chemistry, Union Christian college, Aluva, Kerala, India dDepartment of Chemistry, Central University of Rajasthan, Bandar Sindri, Rajasthan, India eChemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India *E-mail: rajithomas28@yahoo.com
Raji Thomas*， Dose, Nelson Joseph P, R T Pardasani & T Mukherjee a印度海得拉巴501 301,Sreenidhi科学技术研究所，科学与人文学院化学系b，印度喀拉拉邦Kothamangalam, Mar Athanasius学院化学系c，印度喀拉拉邦Aluva, Union Christian学院化学系d，拉贾斯坦邦中央大学化学系，拉贾斯坦邦Sindri班达尔，印度Bhabha原子研究中心印度孟买400085 *电子邮件:rajithomas28@yahoo.com
{"title":"Electron transfer study on newly synthesized Ti(IV)/Zr(IV) complexes of amide and oxime functionality: A pulse radiolytic and theoretical revelation","authors":"Raji Thomasa, Densely Doseb, Nelson Joseph, Pc, R. T. Pardasanid, T. Mukherjeee","doi":"10.56042/ijca.v60i3.39627","DOIUrl":"https://doi.org/10.56042/ijca.v60i3.39627","url":null,"abstract":"Raji Thomas*, Densely Dose, Nelson Joseph P, R T Pardasani & T Mukherjee aDepartment of Chemistry, School of Science and Humanities, Sreenidhi Institute of Science & Technology, Hyderabad 501 301, India bDepartment of Chemistry, Mar Athanasius College, Kothamangalam, Kerala, India cDepartment of Chemistry, Union Christian college, Aluva, Kerala, India dDepartment of Chemistry, Central University of Rajasthan, Bandar Sindri, Rajasthan, India eChemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India *E-mail: rajithomas28@yahoo.com","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"11 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72951278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.56042/ijca.v60i3.39450
K. SHARMAa, Ashraf Alib, Prasad P Phadnisa, Chandan Kumarc, Anand Ballalc, Ashutosh Dashc, R. K. Vatsaa
The manganese doped zinc selenide nanoparticles (ZnSe:Mn NPs) have been synthesized by thermolysis method using oleic acid and oleylamine as capping agents, and 1-octadecene as solvent. Coating of mesoporous silica is done on ZnSe:Mn (ZnSe:Mn@mSilica) which is further functionalized with amine functional groups by treating with (3-aminopropyl)trimethoxysilane. Further pegylation is done to achieve water dispersibility by conjugating carboxyl groups of poly(ethylene glycol) diacid with the amine groups. These pegylated NPs are subsequently treated with ethylenediamine followed by acrylic acid. Conjugation of tris-(hydroxymethyl-aminomethane) is performed by Michael-type addition reaction to afford ZnSe:Mn@mSilica-PEG-Tris-OH. These tris functionalized NPs have exhibited broad emission ranging from 590-620 nm that is an indicative for their suitability in diagnosis and monitoring progress of cancer treatment. To explore the usefulness of increased surface area because of mesoporosity, doxorubicin is loaded on ZnSe:Mn@mSilica-PEG-Tris-OH NPs through silyl ether linkage and evaluated for cytotoxicity against WEHI-164 mouse fibrosarcoma and RAJI human hematopoietic origin cancer cell lines. A decrease in 12% of cell viability of WEHI-164 cells while 30% decrease in RAJI cell lines (IC 50 ≈ 45 nM) are observed. This shows that our formulation has more cytotoxic in RAJI cancer cell lines than that of WEHI-164 cancer cells. These results reveal that the formulation has potential for the application in drug delivery and diagnosis in chemotherapeutics.
{"title":"One pot synthesis of luminescent Mn doped ZnSe nanoparticles and its silica based water dispersible formulation for targeted delivery of doxorubicin","authors":"K. SHARMAa, Ashraf Alib, Prasad P Phadnisa, Chandan Kumarc, Anand Ballalc, Ashutosh Dashc, R. K. Vatsaa","doi":"10.56042/ijca.v60i3.39450","DOIUrl":"https://doi.org/10.56042/ijca.v60i3.39450","url":null,"abstract":"The manganese doped zinc selenide nanoparticles (ZnSe:Mn NPs) have been synthesized by thermolysis method using oleic acid and oleylamine as capping agents, and 1-octadecene as solvent. Coating of mesoporous silica is done on ZnSe:Mn (ZnSe:Mn@mSilica) which is further functionalized with amine functional groups by treating with (3-aminopropyl)trimethoxysilane. Further pegylation is done to achieve water dispersibility by conjugating carboxyl groups of poly(ethylene glycol) diacid with the amine groups. These pegylated NPs are subsequently treated with ethylenediamine followed by acrylic acid. Conjugation of tris-(hydroxymethyl-aminomethane) is performed by Michael-type addition reaction to afford ZnSe:Mn@mSilica-PEG-Tris-OH. These tris functionalized NPs have exhibited broad emission ranging from 590-620 nm that is an indicative for their suitability in diagnosis and monitoring progress of cancer treatment. To explore the usefulness of increased surface area because of mesoporosity, doxorubicin is loaded on ZnSe:Mn@mSilica-PEG-Tris-OH NPs through silyl ether linkage and evaluated for cytotoxicity against WEHI-164 mouse fibrosarcoma and RAJI human hematopoietic origin cancer cell lines. A decrease in 12% of cell viability of WEHI-164 cells while 30% decrease in RAJI cell lines (IC 50 ≈ 45 nM) are observed. This shows that our formulation has more cytotoxic in RAJI cancer cell lines than that of WEHI-164 cancer cells. These results reveal that the formulation has potential for the application in drug delivery and diagnosis in chemotherapeutics.","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"65 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87210610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.56042/ijca.v60i3.31459
{"title":"Synthesis, characterization, antimicrobial and DNA cleavage study of organoantimony(III) and organoarsenic(III) complexes with monofunctional bidentate Schiff base","authors":"","doi":"10.56042/ijca.v60i3.31459","DOIUrl":"https://doi.org/10.56042/ijca.v60i3.31459","url":null,"abstract":"","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"6 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87740789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.56042/ijca.v60i3.34009
{"title":"Synthesis and characterization of Schiff bases of pyrazole aldehyde and their metal complexes of Cu(II), Ni(II) and Co(II)","authors":"","doi":"10.56042/ijca.v60i3.34009","DOIUrl":"https://doi.org/10.56042/ijca.v60i3.34009","url":null,"abstract":"","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"40 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81007050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.56042/ijca.v60i3.35034
Prabhakar Chetti, A. Tripathi, Ritu Mittal, A. Chaskar
Density functional calculations have been performed to see the effect of sulfur substitution in place of oxygen at central four membered acceptor squarate ring on electronic excitations, charge transfer and second order non-linear optical properties in visible absorbing squaraines (SQ). Molecules oxy-thiosquaraines (OSQ) and thiosquaraines (SSQ) have shown red shift in absorption as compared to their corresponding SQ molecules. The lowest five electronic excitations for all the molecules have been calculated by using TDDFT method. Further, effect of electron donating and electron withdrawing groups on absorption maxima have been studied. The large red shifts in case of electron withdrawing group within the same series of molecules (SQ, OSQ and SSQ) are due to destabilization of HOMO and stabilization of LUMO levels. Charge transfers in these molecules are reported by using VMOdes. Second hyperpolarizabilities ( γ ) for these molecules are calculated by SOS method. This study may be helpful in synthesizing new C-N bonding SQ, OSQ and SSQ dyes which are further useful in
{"title":"A DFT study on Electronic Excitations, Charge Transfer and NLO Properties of Visible Absorbing Squaraine and Thiosquaraine dyes","authors":"Prabhakar Chetti, A. Tripathi, Ritu Mittal, A. Chaskar","doi":"10.56042/ijca.v60i3.35034","DOIUrl":"https://doi.org/10.56042/ijca.v60i3.35034","url":null,"abstract":"Density functional calculations have been performed to see the effect of sulfur substitution in place of oxygen at central four membered acceptor squarate ring on electronic excitations, charge transfer and second order non-linear optical properties in visible absorbing squaraines (SQ). Molecules oxy-thiosquaraines (OSQ) and thiosquaraines (SSQ) have shown red shift in absorption as compared to their corresponding SQ molecules. The lowest five electronic excitations for all the molecules have been calculated by using TDDFT method. Further, effect of electron donating and electron withdrawing groups on absorption maxima have been studied. The large red shifts in case of electron withdrawing group within the same series of molecules (SQ, OSQ and SSQ) are due to destabilization of HOMO and stabilization of LUMO levels. Charge transfers in these molecules are reported by using VMOdes. Second hyperpolarizabilities ( γ ) for these molecules are calculated by SOS method. This study may be helpful in synthesizing new C-N bonding SQ, OSQ and SSQ dyes which are further useful in","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"10 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72403452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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