Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Mesenteric adipose tissue B lymphocytes promote intestinal injury in severe acute pancreatitis by mediating enteric pyroptosis","authors":"Qing Huang,&nbsp;Jia-Wen Liu,&nbsp;Hai-Bin Dong,&nbsp;Zheng-Jie Wei,&nbsp;Jin-Zhe Liu,&nbsp;Yu-Tang Ren,&nbsp;Xuan Jiang,&nbsp;Bo Jiang","doi":"10.1016/j.hbpd.2023.11.006","DOIUrl":"10.1016/j.hbpd.2023.11.006","url":null,"abstract":"<div><h3>Background</h3><p>Visceral adipose tissue<span><span> (VAT) has been linked to the severe acute pancreatitis (SAP) prognosis, although the underlying mechanism remains unclear. It has been reported that pyroptosis worsens SAP. The present study aimed to verify whether mesenteric adipose tissue (MAT, a component of VAT) can cause secondary </span>intestinal injury through the pyroptotic pathway.</span></p></div><div><h3>Methods</h3><p>Thirty-six male Sprague Dawley (SD) rats were divided into six different groups. Twelve rats were randomly divided into the SAP and control groups. We monitored the changes of MAT and B lymphocytes infiltration<span> in MAT of SAP rats. Twelve SAP rats were injected with MAT B lymphocytes or phosphate buffer solution (PBS). The remaining twelve SAP rats were first injected with MAT B lymphocytes, and then with MCC950 (NLRP3 inhibitor) or PBS. We collected blood and tissue samples from pancreas, gut and MAT for analysis.</span></p></div><div><h3>Results</h3><p><span><span>Compared to the control rats, the SAP group showed inflammation in MAT, including higher expression of tumor necrosis factor (TNF-α) and interleukin-6 (IL-6), lower expression of IL-10, and histological changes. Flow cytometry analysis revealed B lymphocytes infiltration in MAT but not </span>T lymphocytes and macrophages. The SAP rats also exhibited intestinal injury, characterized by lower expression of zonula occludens-1 (ZO-1) and </span>occludin<span><span>, higher levels of lipopolysaccharide<span> and diamine oxidase, and pathological changes. The expression of </span></span>NLRP3<span> and n-GSDMD, which are responsible for pyroptosis, was increased in the intestine of SAP rats. The injection of MAT B lymphocytes into SAP rats exacerbated the inflammation in MAT. The upregulation of pyroptosis reduced tight junction in the intestine, which contributed to the SAP progression, including higher inflammatory indicators and worse histological changes. The administration of MCC950 to SAP + MAT B rats downregulated pyroptosis, which subsequently improved the intestinal barrier and ameliorated inflammatory response of SAP.</span></span></p></div><div><h3>Conclusions</h3><p>In SAP, MAT B lymphocytes aggravated local inflammation, and promoted the injury to the intestine through the enteric pyroptotic pathway.</p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 3","pages":"Pages 300-309"},"PeriodicalIF":3.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight","authors":"Min-Zhi Chen ,&nbsp;Ping Xie ,&nbsp;Xiao-Chang Wu ,&nbsp;Zhen-Hua Tan ,&nbsp;Hai Qian ,&nbsp;Zhi-Hong Ma ,&nbsp;Xing Yao","doi":"10.1016/j.hbpd.2023.11.007","DOIUrl":"10.1016/j.hbpd.2023.11.007","url":null,"abstract":"<div><h3>Background</h3><p>Obesity is a common public health<span> issue and is currently deemed a disease. Research has shown that the risk of gallstones<span> in individuals with obesity is elevated. This study aimed to explore the bile proteomics<span> differences between cholelithiasis patients with obesity and normal body weight.</span></span></span></p></div><div><h3>Methods</h3><p>Bile samples from 20 patients (10 with obesity and 10 with normal body weight) who underwent laparoscopic cholecystectomy<span> at our center were subjected to tandem mass tag labeling (TMT) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), followed by further bioinformatic analysis.</span></p></div><div><h3>Results</h3><p>Among the differentially expressed proteins, 23 were upregulated and 67 were downregulated. Bioinformatic analysis indicated that these differentially expressed proteins were mainly involved in cell development, inflammatory responses, glycerolipid<span> metabolic processes, and protein activation cascades. In addition, the activity of the peroxisome proliferator-activated receptor (PPAR, a subfamily of nuclear receptors) signaling pathway was decreased in the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Two downregulated proteins in the PPAR signaling pathway, APO A-I and APO A-II, were confirmed using enzyme-linked immunosorbent assay.</span></p></div><div><h3>Conclusions</h3><p>The PPAR signaling pathway may play a crucial role in the development of cholelithiasis among patients with obesity. Furthermore, biliary proteomics profiling of gallstones patients with obesity is revealed, providing a reference for future research.</p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 4","pages":"Pages 385-392"},"PeriodicalIF":3.3,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138471283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma: A prospective multicenter cohort study","authors":"Ming-Da Wang ,&nbsp;Chen Yuan ,&nbsp;Ke-Chun Wang ,&nbsp;Nan-Ya Wang ,&nbsp;Ying-Jian Liang ,&nbsp;Hong Zhu ,&nbsp;Xiang-Min Tong ,&nbsp;Tian Yang","doi":"10.1016/j.hbpd.2023.11.004","DOIUrl":"10.1016/j.hbpd.2023.11.004","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Cancer-related fatigue (CRF) is a common and debilitating symptom experienced by patients with advanced-stage cancer, especially those undergoing antitumor therapy. This study aimed to evaluate the efficacy and safety of Renshenguben (RSGB) oral solution, a ginseng-based </span>traditional Chinese medicine, in alleviating CRF </span>in patients with advanced hepatocellular carcinoma (HCC) receiving antitumor treatment.</p></div><div><h3>Methods</h3><p>In this prospective, open-label, controlled, multicenter study, patients with advanced HCC at BCLC stage C and a brief fatigue inventory (BFI) score of ≥ 4 were enrolled. Participants were assigned to the RSGB group (RSGB, 10 mL twice daily) or the control group (with supportive care). Primary and secondary endpoints were the change in multidimensional fatigue inventory (MFI) score, and BFI and functional assessment of cancer therapy-hepatobiliary (FACT-Hep) scores at weeks 4 and 8 after enrollment. Adverse events (AEs) and toxicities were assessed.</p></div><div><h3>Results</h3><p>A total of 409 participants were enrolled, with 206 assigned to the RSGB group. At week 4, there was a trend towards improvement, but the differences were not statistically significant. At week 8, the RSGB group exhibited a significantly lower MFI score (<em>P</em> &lt; 0.05) compared to the control group, indicating improved fatigue levels. Additionally, the RSGB group showed significantly greater decrease in BFI and FACT-Hep scores at week 8 (<em>P</em><span> &lt; 0.05). Subgroup analyses among patients receiving various antitumor treatments showed similar results. Multivariate linear regression analyses revealed that the RSGB group experienced a significantly substantial decrease in MFI, BFI, and FACT-Hep scores at week 8. No serious drug-related AEs or toxicities were observed.</span></p></div><div><h3>Conclusions</h3><p>RSGB oral solution effectively reduced CRF in patients with advanced HCC undergoing antitumor therapy over an eight-week period, with no discernible toxicities. These findings support the potential of RSGB oral solution as an adjunctive treatment for managing CRF in this patient population.</p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 3","pages":"Pages 249-256"},"PeriodicalIF":3.3,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138471284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Robotic surgery and liver transplantation: A single-center experience of 501 robotic donor hepatectomies”","authors":"Xiang-Yan Liu ,&nbsp;Yun-Yang Xu ,&nbsp;Ze Xiang ,&nbsp;Shu-Sen Zheng","doi":"10.1016/j.hbpd.2023.11.005","DOIUrl":"10.1016/j.hbpd.2023.11.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 1","pages":"Pages 109-110"},"PeriodicalIF":3.3,"publicationDate":"2023-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THANKS","authors":"","doi":"10.1016/S1499-3872(23)00201-1","DOIUrl":"https://doi.org/10.1016/S1499-3872(23)00201-1","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"22 6","pages":"Page I"},"PeriodicalIF":3.3,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71731821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical techniques to prevent delayed gastric emptying after pancreaticoduodenectomy","authors":"Peng Duan ,&nbsp;Lu Sun ,&nbsp;Kai Kou ,&nbsp;Xin-Rui Li ,&nbsp;Ping Zhang","doi":"10.1016/j.hbpd.2023.11.001","DOIUrl":"10.1016/j.hbpd.2023.11.001","url":null,"abstract":"<div><h3>Background</h3><p><span>Delayed gastric emptying (DGE) is one of the most common complications after </span>pancreaticoduodenectomy<span> (PD). DGE represents impaired gastric motility without significant mechanical obstruction and is associated with an increased length of hospital stay, increased healthcare costs, and a high readmission rate. We reviewed published studies on various technical modifications to reduce the incidence of DGE.</span></p></div><div><h3>Data sources</h3><p>Studies were identified by searching PubMed for relevant articles published up to December 2022. The following search terms were used: “pancreaticoduodenectomy”, “pancreaticojejunostomy”, “pancreaticogastrostomy”, “gastric emptying”, “gastroparesis” and “postoperative complications”. The search was limited to English publications. Additional articles were identified by a manual search of references from key articles.</p></div><div><h3>Results</h3><p>In recent years, various surgical procedures and techniques have been explored to reduce the incidence of DGE. Pyloric resection, Billroth II<span> reconstruction, Braun's enteroenterostomy, and antecolic reconstruction may be associated with a decreased incidence of DGE, but more high-powered studies are needed in the future. Neither laparoscopic nor robotic surgery has demonstrated superiority in preventing DGE, and the use of staplers is controversial regarding whether they can reduce the incidence of DGE.</span></p></div><div><h3>Conclusions</h3><p>Despite many innovations in surgical techniques, there is no surgical procedure that is superior to others to reduce DGE. Further larger prospective randomized studies are needed.</p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 5","pages":"Pages 449-457"},"PeriodicalIF":3.6,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135509532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meetings and Courses","authors":"","doi":"10.1016/S1499-3872(23)00188-1","DOIUrl":"https://doi.org/10.1016/S1499-3872(23)00188-1","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"22 6","pages":"Page II"},"PeriodicalIF":3.3,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71731820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retroaortic left renal vein associated to variations of liver vasculature and biliary system in a patient submitted to total pancreatectomy","authors":"Alessandro Fancellu ,&nbsp;Mario Maiore ,&nbsp;Lavinia Grasso ,&nbsp;Miriam Ferrara ,&nbsp;Alberto Porcu","doi":"10.1016/j.hbpd.2023.11.003","DOIUrl":"10.1016/j.hbpd.2023.11.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 5","pages":"Pages 526-529"},"PeriodicalIF":3.6,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A successful case report of menstrual blood derived-mesenchymal stem cell-based therapy for Wilson's disease","authors":"Jia-Jun Wu, Yong Huang, Hai-Nv Gao, Guo-Ping Sheng","doi":"10.1016/j.hbpd.2023.11.002","DOIUrl":"https://doi.org/10.1016/j.hbpd.2023.11.002","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"43 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135510606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of hepatocellular carcinoma with portal vein tumor thrombus: State of art and future perspectives","authors":"Paschalis Gavriilidis ,&nbsp;Timothy M Pawlik ,&nbsp;Daniel Azoulay","doi":"10.1016/j.hbpd.2023.10.009","DOIUrl":"10.1016/j.hbpd.2023.10.009","url":null,"abstract":"<div><h3>Background</h3><p>Despite advances in the diagnosis of patients with hepatocellular carcinoma (HCC), 70%–80% of patients are diagnosed with advanced stage disease. Portal vein<span> tumor thrombus (PVTT) is among the most ominous signs of advanced stage disease and has been associated with poor survival if untreated.</span></p></div><div><h3>Data sources</h3><p>A systematic search of MEDLINE (PubMed), Embase, Cochrane Library and Database for Systematic Reviews<span><span> (CDSR), Google Scholar, and National Institute for Health and Clinical Excellence (NICE) databases until December 2022 was conducted using free text and MeSH terms: hepatocellular carcinoma, portal vein tumor thrombus, </span>portal vein thrombosis<span><span>, vascular invasion, liver and/or hepatic resection, </span>liver transplantation, and systematic review.</span></span></p></div><div><h3>Results</h3><p>Centers of surgical excellence have reported promising results related to the individualized surgical management of portal thrombus versus arterial chemoembolization<span> or systemic chemotherapy. Critical elements to the individualized surgical management of HCC and portal thrombus include precise classification of the portal vein tumor thrombus, accurate identification of the subgroups of patients who may benefit from resection, as well as meticulous surgical technique. This review addressed five specific areas: (a) formation of PVTT; (b) classifications of PVTT; (c) controversies related to clinical guidelines; (d) surgical treatments versus non-surgical approaches; and (e) characterization of surgical techniques correlated with classifications of PVTT.</span></p></div><div><h3>Conclusions</h3><p>Current evidence from Chinese and Japanese high-volume centers demonstrated that patients with HCC and associated PVTT can be managed with surgical resection with acceptable results.</p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 3","pages":"Pages 221-227"},"PeriodicalIF":3.3,"publicationDate":"2023-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}