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Can atypical response in endothelial dysfunction-related genes and microRNAs arise from low hydrogen peroxide exposure? 低过氧化氢暴露会导致内皮功能障碍相关基因和 microRNA 的非典型反应吗?
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_021
Meral Urhan-Kucuk, Menderes Yusuf Terzi

Objective: Vascular endothelium is a tissue in which several vasoactive substances are produced and secreted. Reactive oxygen species can cause endothelial dysfunction (ED). miRNAs can be implicated in the oxidative stress-related ED during vascular disease pathogeneses. Our aim is to investigate effect of H2O2-induced oxidative stress on expression levels of genes and miRNAs that are key players in ED.

Methods: H2O2 effect on cell viability of human umbilical-vein endothelial cells (HUVEC) at 24-hour was measured with MTT. Low sub-cytotoxic H2O2 concentrations (25, 50 µM) were selected to analyze their oxidative stress-inducing capacities with MDA assay and their effects on EDN1, NOS3, VCAM1, SERPINE1, miR21, miR22, miR126, and miR146a levels with RT-qPCR.

Results: Each tested H2O2 concentration reduced HUVEC cell viability. Fifty µM H2O2 augmented cellular MDA levels. Intriguingly, EDN1, VCAM1, and SERPINE1 and all analyzed miRNAs' levels attenuated upon H2O2 treatment whereas there was no change in NOS3 levels compared to control. There was a positive correlation between miR-21 and VCAM1.

Conclusion: Rather than individual alterations in analyzed parameters, consistent changes in our findings i.e., parallel decreases in EDN1, VCAM1, SERPINE1 mRNA levels as well as miRNAs, suggests that H2O2 concentration-dependent modulation of expression patterns can bring about various impacts on ED (Tab. 1, Fig. 5, Ref. 63).

目的:血管内皮是产生和分泌多种血管活性物质的组织。在血管疾病的发病过程中,miRNAs 可能与氧化应激相关的内皮功能障碍(ED)有关。我们的目的是研究 H2O2 诱导的氧化应激对 ED 中起关键作用的基因和 miRNAs 表达水平的影响。方法:用 MTT 测定 24 小时内 H2O2 对人脐静脉内皮细胞(HUVEC)活力的影响,选择低亚毒性 H2O2 浓度(25、50 µM),用 MDA 分析其氧化应激诱导能力,用 RT-qPCR 分析其对 EDN1、NOS3、VCAM1、SERPINE1、miR21、miR22、miR126 和 miR146a 水平的影响:每种测试的 H2O2 浓度都会降低 HUVEC 细胞的活力。50 µM H2O2 会增加细胞的 MDA 水平。耐人寻味的是,H2O2 处理后,EDN1、VCAM1 和 SERPINE1 以及所有分析的 miRNA 水平都有所降低,而 NOS3 水平与对照组相比没有变化。miR-21 与 VCAM1 呈正相关:结论:我们的研究发现,EDN1、VCAM1、SERPINE1 mRNA 和 miRNA 水平的平行下降表明,H2O2 浓度依赖性表达模式的调节可对 ED 产生各种影响(表 1,图 5,参考文献 63)。
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引用次数: 0
Binary fire hawks optimizer with deep learning driven non-invasive diabetes detection and classification. 二元火鹰优化器与深度学习驱动的无创糖尿病检测和分类。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_020
Namakkal Ramasamy Periasamy

Non-invasive diabetes detection refers to the utilization and development of technologies and methods that can monitor and diagnose diabetes without requiring invasive procedures, namely invasive glucose monitoring or blood sampling. The objective is to provide a more convenient and less burdensome approach to screening and management of diabetes. It is noteworthy that while non-invasive method offers promising avenues for diabetes detection, they frequently require validation through clinical studies and might have limitation in terms of reliability and accuracy than classical invasive approaches. In recent times, deep learning (DL) and feature selection (FS) are used to monitor and diagnose diabetes accurately without requiring invasive procedures. This technique combines the FS method with the DL algorithm for making accurate predictions and extracting relevant features from non-invasive data. This article introduces a new Binary Fire Hawks Optimizer with Deep Learning-Driven Non-Invasive Diabetes Detection and Classification (BFHODL-NIDDC) technique. The major intention of the BFHODL-NIDDC technique focuses on the involvement of non-invasive procedures for the detection of diabetes. In the BFHODL-NIDDC technique, data preprocessing is initially performed to preprocess the input data. Next, the BFHO algorithm chooses an optimal subset of features and improves the classifier results. For the identification of diabetes, multichannel convolutional bidirectional long short-term memory (MC-BLSTM) model is used. At last, the beetle antenna search (BAS) algorithm is used for the hyperparameter selection of the MC-BLSTM method which in turn enhances the detection performance of the MC-BLSTM model. A series of simulations were conducted on the diabetes dataset to assess the diabetes detection performance of the BFHODL-NIDDC technique. The experimental outcomes illustrated better performance of the BFHODL-NIDDC method over other recent approaches in terms of different metrics (Tab. 4, Fig. 9, Ref. 23). Keywords: diabetes, non-invasive detection, binary fire hawks optimizer, deep learning, hyperparameter tuning.

无创糖尿病检测是指利用和开发无需侵入性程序(即侵入性葡萄糖监测或血液采样)即可监测和诊断糖尿病的技术和方法。其目的是提供一种更方便、负担更轻的糖尿病筛查和管理方法。值得注意的是,虽然非侵入性方法为糖尿病检测提供了前景广阔的途径,但它们往往需要通过临床研究进行验证,而且与传统侵入性方法相比,在可靠性和准确性方面可能存在局限性。近来,深度学习(DL)和特征选择(FS)被用于在无需侵入性程序的情况下准确监测和诊断糖尿病。该技术将 FS 方法与 DL 算法相结合,可从非侵入性数据中进行准确预测并提取相关特征。本文介绍了一种新的二元火鹰优化器与深度学习驱动的无创糖尿病检测和分类(BFHODL-NIDDC)技术。BFHODL-NIDDC 技术的主要意图在于利用无创程序检测糖尿病。在 BFHODL-NIDDC 技术中,首先对输入数据进行预处理。接下来,BFHO 算法选择最佳特征子集,改进分类器结果。对于糖尿病的识别,采用了多通道卷积双向长短期记忆(MC-BLSTM)模型。最后,在 MC-BLSTM 方法的超参数选择中使用了甲虫天线搜索(BAS)算法,从而提高了 MC-BLSTM 模型的检测性能。为了评估 BFHODL-NIDDC 技术的糖尿病检测性能,对糖尿病数据集进行了一系列模拟。实验结果表明,就不同指标而言,BFHODL-NIDDC 方法的性能优于其他最新方法(表 4,图 9,参考文献 23)。关键词:糖尿病;无创检测;二元火鹰优化器;深度学习;超参数调整。
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引用次数: 0
Medication adherence: measurement methods and approaches. 坚持用药:测量方法和途径。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_40
Patricia Schnorrerova, Petra Matalova, Martin Wawruch

Medication adherence is crucial for optimal treatment outcomes, yet many patients struggle to follow their prescribed regimens, impacting patients, families, and healthcare systems. Measurement of adherence is vital for effective care planning and intervention. This review explores medication adherence challenges and measurement methods, including therapeutic drug monitoring (TDM), medication event monitoring system (MEMS), analysis of adherence in insurance/pharmacy database, pill counts, and self-reports, each with its advantages and limitations.This review advocates a partnership-based approach to adherence, stressing standardized reporting and team-based care. Adherence is influenced by many factors such as complex regimens, packaging, patient perspectives, side effects. Effectively addressing these factors is crucial for improving patient outcomes. In summary, medication adherence is vital but complex. The article covers various adherence measurement methods to promote medication adherence as an important matter (Tab. 5, Fig. 2, Ref. 91). Text in PDF www.elis.sk Keywords: medication adherence, adherence barriers, primary non-adherence, medication event monitoring system, pill count, self-report.

坚持用药对于获得最佳治疗效果至关重要,然而许多患者却难以坚持按处方用药,这对患者、家庭和医疗系统都造成了影响。对用药依从性的测量对于有效的护理计划和干预至关重要。本综述探讨了用药依从性面临的挑战和测量方法,包括治疗药物监测(TDM)、用药事件监测系统(MEMS)、保险/药房数据库中的依从性分析、药片计数和自我报告,每种方法都有其优势和局限性。服药依从性受许多因素的影响,如复杂的治疗方案、包装、患者观点、副作用等。有效解决这些因素对于改善患者的治疗效果至关重要。总之,坚持用药至关重要,但也很复杂。文章介绍了各种用药依从性测量方法,以促进用药依从性这一重要事项(表 5,图 2,参考文献 91)。Text in PDF www.elis.sk Keywords: medication adherence, adherence barriers, primary non-adherence, medication event monitoring system, pill count, self-report.
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引用次数: 0
Navigating the complexities of developing a classification of esophagogastric junction tumors suitable for preoperative setting. 探索适合术前设置的食管胃交界处肿瘤分类的复杂性。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_015
Petr Lochman

Despite the worldwide decrease in the incidence of gastric cancer, the proportion of occurrence of carcinomas of the esophagogastric junction and proximal third of stomach is on the rise. The cause of this development is believed to lie in an increasing incidence of reflux esophagitis with Barrett´s metaplasia and successful eradication of Helicobacter pylori infection. The aim of this work is to present various views on the definition of the esophagogastric junction itself and to give an overview of tumor classification schemes being used (Fig. 2, Ref. 54). Keywords: gastric cancer, esophagogastric junction, definition, classification.

尽管胃癌的发病率在全球范围内有所下降,但食管胃交界处和胃近三分之一部位的癌变比例却在上升。据信,这种发展的原因在于反流性食管炎伴巴雷特化生的发病率不断上升,以及幽门螺杆菌感染的成功根除。本文旨在介绍有关食管胃交界处本身定义的各种观点,并概述目前使用的肿瘤分类方案(图 2,参考文献 54)。关键词:胃癌、食管胃交界处、定义、分类。
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引用次数: 0
A novel marker for prediabetic conditions: Uric acid-to-HDL cholesterol ratio. 糖尿病前期症状的新型标记物:尿酸与高密度脂蛋白胆固醇的比率。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.4149/BLL_2023_130
Sumeyye Buse Balci, Burcin Meryem Atak, Tuba Duman, Feyza Nihal Ozkul, Gulali Aktas

Objectives: The objective of this study was to identify a parameter that can facilitate the diagnosis of prediabetes and predict the likelihood of its development in individuals at high risk.

Methods: In this retrospective study, the study population was selected from Bolu Abant Izzet Baysal University Hospital's patients. Participants were divided into two groups, prediabetes and healthy group. We excluded individuals with certain conditions or taking certain medications. The study compared the ratios of uric acid to high-density lipoprotein (HDL) between the two groups and identified the optimal point of differentiation.

Results: The study analyzed data from 228 individuals, including 125 with prediabetes and 103 healthy controls. Those with prediabetes had a significantly higher median UHR (0.13 (0.07-0.24) %) compared to healthy individuals (0.09 (0.05-0.16) %) (p < 0.001). Higher UHR values were associated with a greater risk of prediabetes. A UHR cut-off points greater than 0.11 % had a sensitivity of 74 % and specificity of 69 % in detecting prediabetes.

Conclusion: The study provides evidence that UHR can serve as a practical and valuable diagnostic and screening tool for prediabetes (Tab. 2, Fig. 1, Ref. 23). Text in PDF www.elis.sk Keywords: serum uric acid, HDL cholesterol, UHR, prediabetes.

研究目的本研究的目的是确定一个有助于诊断糖尿病前期和预测高危人群糖尿病发展可能性的参数:在这项回顾性研究中,研究对象选自博卢阿班特-伊扎特-拜萨尔大学医院的患者。参与者被分为两组,即糖尿病前期组和健康组。我们排除了患有某些疾病或正在服用某些药物的人。研究比较了两组患者尿酸与高密度脂蛋白(HDL)的比率,并确定了最佳区分点:研究分析了 228 人的数据,其中包括 125 名糖尿病前期患者和 103 名健康对照者。与健康人(0.09 (0.05-0.16) %)相比,糖尿病前期患者的 UHR 中位数(0.13 (0.07-0.24) %)明显更高(p < 0.001)。UHR 值越高,患糖尿病前期的风险越大。在检测糖尿病前期方面,UHR 临界点大于 0.11 % 的灵敏度为 74 %,特异度为 69 %:本研究提供的证据表明,UHR 可作为诊断和筛查糖尿病前期的实用且有价值的工具(表 2,图 1,参考文献 23)。Text in PDF www.elis.sk Keywords: serum uric acid, HDL cholesterol, UHR, prediabetes.
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引用次数: 0
Extremely rare complication in high-risk newborn on long-term parenteral nutrition and large stool losses through ileostomy. 在长期接受肠外营养并通过回肠造口术丢失大量粪便的高危新生儿中极为罕见的并发症。
IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_87
Barbora Gogolova-Bujnova, Jana Brucknerova, Ingrid Brucknerova

Aim: To analyse postnatal characteristics, clinical and laboratory findings, results of investigations in the newborn (25 gestational weeks; Apgar score: 6/9 points; born per caesarean section; birth weight: 600 g; birth length: 31 cm; head circumference: 21 cm) from the first high-risk pregnancy with acquired form of acrodermatitis enteropathica.

Results: After summarizing the clinical picture with laboratory findings, we analysed the components of parenteral nutrition with regard to the deficiency of trace elements and vitamins. The zinc depletion dominated.

Conclusion: The diagnosis is clinical, based on the presence of a typical clinical picture together with a low serum zinc concentration. Standard preparations with elementary elements do not sufficiently cover the daily needs of children, other possibilities of supplementation in intravenous form are not available. It is necessary to supplement zinc in premature children, in children with high losses of zinc (with diarrhoea, in patients with a stoma, in patients with severe skin disease) (Fig. 4, Ref. 15).

目的:分析首次高危妊娠合并获得性肠病性肢皮炎新生儿(孕周:25;Apgar 评分:6/9 分;剖腹产;出生体重:600 克;出生身长:31 厘米;头围:21 厘米)的产后特征、临床和实验室检查结果:结果:在对临床症状和实验室结果进行总结后,我们分析了肠外营养中微量元素和维生素的缺乏情况。结论:诊断是以临床为依据的:结论:临床诊断的依据是典型的临床表现和低血清锌浓度。含有基本元素的标准制剂不足以满足儿童的日常需要,也没有其他静脉补充剂。对于早产儿和锌丢失较多的儿童(腹泻患者、造口患者、严重皮肤病患者),有必要补充锌元素(图 4,参考文献 15)。
{"title":"Extremely rare complication in high-risk newborn on long-term parenteral nutrition and large stool losses through ileostomy.","authors":"Barbora Gogolova-Bujnova, Jana Brucknerova, Ingrid Brucknerova","doi":"10.4149/BLL_2024_87","DOIUrl":"10.4149/BLL_2024_87","url":null,"abstract":"<p><strong>Aim: </strong>To analyse postnatal characteristics, clinical and laboratory findings, results of investigations in the newborn (25 gestational weeks; Apgar score: 6/9 points; born per caesarean section; birth weight: 600 g; birth length: 31 cm; head circumference: 21 cm) from the first high-risk pregnancy with acquired form of acrodermatitis enteropathica.</p><p><strong>Results: </strong>After summarizing the clinical picture with laboratory findings, we analysed the components of parenteral nutrition with regard to the deficiency of trace elements and vitamins. The zinc depletion dominated.</p><p><strong>Conclusion: </strong>The diagnosis is clinical, based on the presence of a typical clinical picture together with a low serum zinc concentration. Standard preparations with elementary elements do not sufficiently cover the daily needs of children, other possibilities of supplementation in intravenous form are not available. It is necessary to supplement zinc in premature children, in children with high losses of zinc (with diarrhoea, in patients with a stoma, in patients with severe skin disease) (Fig. 4, Ref. 15).</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":" ","pages":"558-563"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral annular plane systolic excursion (MAPSE) as a predictor of atrial fibrillation development after coronary artery bypass surgery. 二尖瓣环平面收缩期偏移(MAPSE)作为冠状动脉搭桥手术后心房颤动发生的预测指标。
IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_78
Cemal Koseoglu, Can Ramazan Oncel, Goksel Dagasan, Ali Coner, Ozgur Akkaya

Objective: To predict the possibility of postoperative atrial fibrillation (AF) with mitral annular plane systolic excursion (MAPSE) measurement, which is a cheap, reproducible echocardiographic method and to monitor these patients more closely and to evaluate them more effectively postoperatively.

Material and methods: 247 patients scheduled for coronary artery bypass surgery were evaluated and 200 patients were included in the study.The enrolled patients were classified into the two groups according to the occurrence of postoperative AF or maintained sinus rhythm after coronary artery bypass surgery (normal sinus rhythm [NSR] group vs. AF group).The clinical and demographic data of all the patients were recorded on admission. Two-dimensional transthoracic echocardiography (TTE) was performed prior to elective surgery.

Results: Postoperative new onset AF occurred in 37 (18.5%) patients. In the multivariate logistic regression analysis carried out after the formation of the model based on the parameters related to AF development, the relationships with white blood cell count, LAd and MAPSE were observed to be prevalent.When MAPSE, which is a parameter used to predict the development of postoperative atrial fibrillation, was compared in the ROC analysis, the area under the curve was found to be 0.831, 95% CI lower-95% CI upper (0.761-0.901) (p<0.001).The distinguishing MAPSE value in predicting postoperative atrial fibrillation development was found to be 11.6 (sensitivity: 90%, specificity: 81%).

Conclusions: We showed that MAPSE could play a role in determining postoperative atrial fibrillation development after coronary artery bypass surgery (Tab. 2, Fig. 2, Ref. 28).

目的通过二尖瓣环平面收缩期偏移(MAPSE)测量这种廉价、可重复的超声心动图方法预测术后房颤(AF)的可能性,并对这些患者进行更密切的监测和更有效的术后评估。根据冠状动脉搭桥术后出现房颤或维持窦性心律的情况,将入选患者分为两组(正常窦性心律[NSR]组与房颤组)。在择期手术前进行了二维经胸超声心动图(TTE)检查:结果:37 例(18.5%)患者术后出现新发房颤。在根据房颤发生相关参数建立模型后进行的多变量逻辑回归分析中,观察到与白细胞计数、LAd 和 MAPSE 的关系普遍存在。当在 ROC 分析中比较用于预测术后房颤发生的参数 MAPSE 时,发现其曲线下面积为 0.831,95% CI 下限-95% CI 上限(0.761-0.901)(pConclusions:我们的研究表明,MAPSE 可在冠状动脉搭桥术后心房颤动的发生中起决定作用(表 2,图 2,参考文献 28)。
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引用次数: 0
Distal pancreatectomy. 胰腺远端切除术
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_36
Martin Vojtko, Kristina Cmarkova, Miroslav Pindura, Blazej Palkoci, Roman Kycina, Lenka Nosakova, Marek Vojtko, Peter Banovcin, Juraj Miklusica

Ntroduction: Distal pancreatectomy is a standard surgical procedure for selected benign, premalignant, and malignant lesions localized in the pancreatic body or tail. Surgical resection remains the only curative option for patients diagnosed with adenocarcinoma of the pancreas.

Patients and methods: Perioperative and postoperative clinical courses were retrospectively assessed in patients, who underwent distal pancreatectomy during the 2011‒2021 period.

Results: During the 2011‒2021 period, a total of 112 distal pancreatectomies were performed. 67 patients (59.8%) underwent laparoscopic distal pancreatectomy, and 45 patients (40.2%) open laparotomy. The conversion was necessary for 13 patients (11.6%). Distal pancreatectomies performed laparoscopically were associated more often with biochemical leak and the development of grade B fistula, on the other hand grade C fistula developed only in patients operated by open laparotomy (LPT). The mean operating time was slightly longer in the laparoscopic group (227.1 min vs 214.6 min). The mean estimated blood loss was significantly higher in the LPT group (540.4 ml vs 191.9 ml). The mean hospitalization time was slightly longer in the LPT group (11.8 days vs 9.3 days). The rates of early reoperations were comparable between both groups (6 vs 5).

Conclusion: Laparoscopic techniques are preferred in centers around the world to bring patients benefits by using a minimally invasive approach. These techniques are also preferred in our center, in nearly 60% of all distal pancreatectomies performed during 10 years, but on the other hand, there is a much more careful approach chosen in cases of malignant disease to achieve adequate radicality (Tab.4, Ref. 20).

简介:胰腺远端切除术是针对胰腺体或胰尾局部良性、恶性和恶性病变的标准手术方法。手术切除仍是确诊为胰腺腺癌患者的唯一治愈选择:对2011-2021年间接受胰腺远端切除术的患者的围手术期和术后临床过程进行回顾性评估:结果:2011-2021年间,共进行了112例远端胰腺切除术。67名患者(59.8%)接受了腹腔镜远端胰腺切除术,45名患者(40.2%)接受了开腹手术。13名患者(11.6%)需要进行转换手术。腹腔镜胰腺远端切除术更常见于生化渗漏和 B 级瘘管的形成,而只有开腹手术(LPT)患者才会形成 C 级瘘管。腹腔镜手术组的平均手术时间稍长(227.1 分钟对 214.6 分钟)。腹腔镜手术组的平均估计失血量明显更高(540.4 毫升对 191.9 毫升)。LPT 组的平均住院时间略长(11.8 天 vs 9.3 天)。两组的早期再手术率相当(6 vs 5):结论:腹腔镜技术是全球各中心的首选,通过微创方法为患者带来益处。在我们中心,10 年间近 60% 的胰腺远端切除术也首选腹腔镜技术,但另一方面,在恶性疾病病例中,为了达到足够的根治效果,我们选择了更为谨慎的方法(表 4,参考文献 20)。
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引用次数: 0
Armeo®Spring therapy improves movement efficiency and contributes to a better quality of life. Armeo® Spring疗法提高了运动效率,有助于改善生活质量。
IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_96
Sarka Anezka Cechova, Dalibor Pastucha, Hana Tomaskova, Sarka Banikova, Marcela Dabrowska, Iva Fiedorova

Objectives: The main objective was to explore the effect of exoskeleton-assisted rehabilitation on quality of life in the subacute state of ischemic stroke.

Background: Central upper extremity hemiparesis affects self-care, social participation, and quality of life. Exoskeleton devices serve as a therapeutic tool and an assessment tool that offers precise tracking of patient progress and evaluation of impairment.

Methods: The trial was carried out from April 2022 to September 2023. Twenty-seven patients were randomly assigned to the intervention (14 participants; mean age 64.71 years; 5 women, 9 men) and control group (13 participants; mean age 64.69 years; 6 women, 7 men). Both groups received equal total therapy (10 to 12 sessions, 5 times a week). The intervention group received 30 minutes of Armea®Spring training combined with conventional rehabilitation. The control group was subjected to conventional rehabilitation.

Results: In the comparison between groups, the experimental group achieved significant changes in quality of life, movement efficiency, and functional performance of the upper extremities.

Conclusions: Armeo®Spring therapy combined with usual care led to significantly larger changes in health-related quality of life and upper extremity movement efficiency compared to conventional rehabilitation (Tab. 4, Fig. 3, Ref. 64.) Text in PDF www.elis.sk Keywords: stroke, hemiparesis, health-related quality of life, Armeo®Spring, movement efficiency, activities of daily living.

目的:主要目的是探讨外骨骼辅助康复对缺血性脑卒中亚急性期生活质量的影响:主要目的是探讨外骨骼辅助康复对缺血性中风亚急性期生活质量的影响:背景:中枢性上肢偏瘫影响生活自理、社会参与和生活质量。外骨骼设备既是一种治疗工具,也是一种评估工具,可精确跟踪患者的康复进展并评估受损情况:试验于 2022 年 4 月至 2023 年 9 月进行。27 名患者被随机分配到干预组(14 人;平均年龄 64.71 岁;5 名女性,9 名男性)和对照组(13 人;平均年龄 64.69 岁;6 名女性,7 名男性)。两组接受的治疗总次数相同(10 至 12 次,每周 5 次)。干预组接受 30 分钟的 Armea®Spring 训练和常规康复训练。结果:结果:通过组间比较,实验组在生活质量、运动效率和上肢功能表现方面均有显著变化:结论:Armeo®Spring疗法结合常规护理与传统康复训练相比,在与健康相关的生活质量和上肢运动效率方面的变化明显更大(表4,图3,参考文献64)。全文载于PDF www.elis.sk 关键词:中风 偏瘫 与健康相关的生活质量 Armeo®Spring 运动效率 日常生活活动
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引用次数: 0
Risk factors for external ventricular drainage infections. 心室外引流感染的风险因素。
IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-01-01 DOI: 10.4149/BLL_2024_113
Veronika Magocova, Jan Banoci, Vladimir Katuch, Miroslav Gajdos

Introduction: External ventricular drainage (EVD) is frequently used in neurosurgical interventions to drain cerebrospinal fluid (CSF). Nevertheless, it carries a high incidence of infectious complications, notably secondary meningitis and ventriculitis. In light of the previous rates of these EVD-related infections, we introduced a set of guidelines to lower the infection rate. This study aimed to assess the influence of the hospital-wide adoption of the EVD handling protocol on secondary infections related to EVD.

Material and methods: We enrolled 171 patients scheduled for EVD placement for reasons other than infectious meningitis or ventriculitis from January 2021 to March 2024. A matched cohort of patients underwent logistic regression to adjust for and analyze regression discontinuity.

Results: Infections were more prevalent in the group before the protocol's implementation (18.27% compared to 7.46%, p<0.0001). Regression analysis within the matched score cohort (n=104 in pre-protocol groups and n=67 in post-protocol groups) indicated that the period before the protocol was independently linked to a higher incidence of infections.

Conclusion: Implementing a stringent hospital-wide protocol for EVD handling can significantly diminish the rate of secondary infections associated with EVD (Tab. 3, Fig. 1, Ref. 15). Text in PDF www.elis.sk Keywords: external ventricular drainage, meningitis, ventriculitis, infection.

简介:脑室外引流术(EVD)常用于神经外科手术中引流脑脊液(CSF)。然而,其感染性并发症的发生率很高,尤其是继发性脑膜炎和脑室炎。鉴于以往这些 EVD 相关感染的发生率,我们引入了一套指南来降低感染率。本研究旨在评估全院采用 EVD 处理方案对 EVD 相关继发感染的影响:我们在 2021 年 1 月至 2024 年 3 月期间招募了 171 名因感染性脑膜炎或脑室炎以外的原因而计划接受 EVD 置管术的患者。对匹配的患者队列进行了逻辑回归,以调整和分析回归的不连续性:结果:在实施方案之前的组别中,感染发生率更高(18.27% 对 7.46%,p):在全院范围内实施严格的EVD处理方案可显著降低与EVD相关的二次感染率(表3,图1,参考文献15)。PDF 格式的文本 www.elis.sk 关键词:脑室外引流术 脑膜炎 脑室炎 感染
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引用次数: 0
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Bratislava Medical Journal-Bratislavske Lekarske Listy
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