V Danielides, K Ingels, G Patrikakos, P C M de Wilde
Objective: Fibroosseous lesions are rare entities of the nose and paranasal sinuses, the terminology and classification of which are still confusing. Psammomatoid or aggressive (juvenile) ossifying fibroma is a benign messenchymal tumor usually met in the young age (5-15 years), in the sinonasal tract, bearing distinctive histomorphologic features and a tendency towards locally aggressive behaviour.
Methodology: We report here a rare case of an aggressive psammomatoid ossifying fibroma of the inferior turbinate and the lateral nasal wall, with obstruction of the nasolacrimal duct, in a 68-year-old woman.
Results: Diagnosis was based on physical examination, CT scan imaging and histopathological examination. Treatment consisted of endoscopic intranasal resection of the tumor accompanied by removal of the lateral nasal wall.
Conclusions: Fibro-osseous tumors of the nose and paranasal sinuses require aggressive surgical approach in order to avoid recurrence. Complete surgical excision may not always be possible mainly due to the tumor's extent and location.
{"title":"Aggressive psammomatoid ossifying fibroma of the inferior turbinate and lateral nasal wall.","authors":"V Danielides, K Ingels, G Patrikakos, P C M de Wilde","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Fibroosseous lesions are rare entities of the nose and paranasal sinuses, the terminology and classification of which are still confusing. Psammomatoid or aggressive (juvenile) ossifying fibroma is a benign messenchymal tumor usually met in the young age (5-15 years), in the sinonasal tract, bearing distinctive histomorphologic features and a tendency towards locally aggressive behaviour.</p><p><strong>Methodology: </strong>We report here a rare case of an aggressive psammomatoid ossifying fibroma of the inferior turbinate and the lateral nasal wall, with obstruction of the nasolacrimal duct, in a 68-year-old woman.</p><p><strong>Results: </strong>Diagnosis was based on physical examination, CT scan imaging and histopathological examination. Treatment consisted of endoscopic intranasal resection of the tumor accompanied by removal of the lateral nasal wall.</p><p><strong>Conclusions: </strong>Fibro-osseous tumors of the nose and paranasal sinuses require aggressive surgical approach in order to avoid recurrence. Complete surgical excision may not always be possible mainly due to the tumor's extent and location.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 1","pages":"87-90"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22294405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this review is to provide an overview of the central auditory nervous system (CANS). Three main relay nuclei are located between the auditory nerve and the primary auditory cerebral cortex: 1- the cochlear nucleus, 2- the contralateral inferior colliculus and 3- the contralateral medial geniculate body. Some fibers of this main ascending pathway branch off to other nuclei such as the nuclei of the superior olivary complex and the nucleus of the lateral lemniscus. Fiber tracts connect the two sides of the ascending pathway at several levels, in such a manner that each ear projects heavier to the contralateral temporal cortex. As sensory information travels within the CANS, its processing occurs not only in a serial order but also in a parallel manner resulting a highly efficient and redundant system. Finally, this review put forth a model of central auditory processing that can serve as the basis for evaluating and addressing the needs of eventual revalidation.
{"title":"Anatomophysiology of the central auditory nervous system: basic concepts.","authors":"J P Demanez, L Demanez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this review is to provide an overview of the central auditory nervous system (CANS). Three main relay nuclei are located between the auditory nerve and the primary auditory cerebral cortex: 1- the cochlear nucleus, 2- the contralateral inferior colliculus and 3- the contralateral medial geniculate body. Some fibers of this main ascending pathway branch off to other nuclei such as the nuclei of the superior olivary complex and the nucleus of the lateral lemniscus. Fiber tracts connect the two sides of the ascending pathway at several levels, in such a manner that each ear projects heavier to the contralateral temporal cortex. As sensory information travels within the CANS, its processing occurs not only in a serial order but also in a parallel manner resulting a highly efficient and redundant system. Finally, this review put forth a model of central auditory processing that can serve as the basis for evaluating and addressing the needs of eventual revalidation.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 4","pages":"227-36"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24156774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Vantrappen, N Rommel, A Swillen, C W Cremers, J P Fryns, K Devriendt
The Velo-Cardio-Facial Syndrome (VCFS), caused by a submicroscopic deletion in the long arm of chromosome 22, has a broad clinical spectrum of ENT manifestations including for instance velopharyngeal dysfunction, hearing problems and laryngotracheal anomalies. In the current report we present guidelines for diagnosis, treatment and follow-up of the ENT manifestations in patients with a deletion 22q11, based on our experience and the literature.
{"title":"Velo-cardio-facial syndrome: guidelines for diagnosis, treatment and follow-up of ent manifestations.","authors":"G Vantrappen, N Rommel, A Swillen, C W Cremers, J P Fryns, K Devriendt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Velo-Cardio-Facial Syndrome (VCFS), caused by a submicroscopic deletion in the long arm of chromosome 22, has a broad clinical spectrum of ENT manifestations including for instance velopharyngeal dysfunction, hearing problems and laryngotracheal anomalies. In the current report we present guidelines for diagnosis, treatment and follow-up of the ENT manifestations in patients with a deletion 22q11, based on our experience and the literature.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 2","pages":"101-6"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22463373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Konstantinidis, S Triaridis, A Printza, A Triaridis, G Noussios, K Karagiannidis
Septorhinoplasty is the most difficult and complicated procedure in facial plastic surgery. Because of the complex interdependency of the anatomical parts, alteration of one may have an impact on another. Form and function are completely interwoven in septorhinoplasty. The selection of appropriate candidates involves an understanding of their expectations. Outcome research is a new concept in clinical medicine and its importance is increasingly recognized for the patient management and policy decisions. This study includes an analysis of patients' subjective opinion of the surgical outcome after septo-rhinoplasty, with the use of Glasgow Benefit Inventory (postoperatively) and the Nasal Symptom Questionnaire (pre- and postoperatively). In this study we analyze the patient subjective rating of benefit in 41 consecutive patients who underwent septo-rhinoplasty within the first 8 months of 2001, and had completed a follow up period of more than 6 months postoperatively. The early complication rate was recorded and analyzed along with data regarding the patient satisfaction rate using GBI and NSQ. The response rate was 80%, which is high. Patients had significant improvement in all subscales of GBI (General, Social, Physical) related with a decreased number of nasal symptoms postoperatively and a good aesthetic result.
{"title":"Assessment of patient benefit from septo-rhinoplasty with the use of Glasgow Benefit Inventory (GBI) and Nasal Symptom Questionnaire (NSQ).","authors":"I Konstantinidis, S Triaridis, A Printza, A Triaridis, G Noussios, K Karagiannidis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Septorhinoplasty is the most difficult and complicated procedure in facial plastic surgery. Because of the complex interdependency of the anatomical parts, alteration of one may have an impact on another. Form and function are completely interwoven in septorhinoplasty. The selection of appropriate candidates involves an understanding of their expectations. Outcome research is a new concept in clinical medicine and its importance is increasingly recognized for the patient management and policy decisions. This study includes an analysis of patients' subjective opinion of the surgical outcome after septo-rhinoplasty, with the use of Glasgow Benefit Inventory (postoperatively) and the Nasal Symptom Questionnaire (pre- and postoperatively). In this study we analyze the patient subjective rating of benefit in 41 consecutive patients who underwent septo-rhinoplasty within the first 8 months of 2001, and had completed a follow up period of more than 6 months postoperatively. The early complication rate was recorded and analyzed along with data regarding the patient satisfaction rate using GBI and NSQ. The response rate was 80%, which is high. Patients had significant improvement in all subscales of GBI (General, Social, Physical) related with a decreased number of nasal symptoms postoperatively and a good aesthetic result.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 2","pages":"123-9"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22463377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Histological studies were performed in 20 guinea pigs, both sexes, weighing 250-300 g and divided into two groups: I--control (anaesthetized animals without surgery), II--examined (in anaesthetized animals through an incision of the skin and muscles of the neck), the left or right vertebral artery was exposed and a vascular clip was inserted into the foramen of the transverse process of the 2-nd cervical vertebra. 50 days after this procedure, the guinea pigs were again anaesthetized by intraperitoneal injection of 35% solution of chloral hydrate, then vascular and cochlear perfusion with 3.6% solution of glutaraldehyde was performed. Simultaneously, by means of micropreparation, samples of cochlea were made for electron studies by means of electron microscope (Philips EM 300). In qualitative histopathologic examinations in guinea pigs of II group, the ischemia changes of the outer hair cells were greater in the side of irritation of the vertebral artery than at the opposite side. At the receptor side of these cells, under the membrane, there are multilamellar outgrowths in the shape of cisterns, partly expanded. The relative volume of external compartment of mitochondria in control group is as follows respectively: 0.15 +/- 0.0% at the right side and 0.15 +/- 0.08% at the left side, and in II group, respectively: 0.22 +/- 0.06% at the side of irritation and 0.19 +/- 0.07% at the opposite side. The obtained data in electron microscopy, both qualitative and quantitative pointed at ischemia changes of outer hair cells in guinea pigs after prolonged irritation of periarterial plexus of vertebral artery.
{"title":"Qualitative and quantitative studies in electron microscopy on influence of experimental ischemia of the vertebral arteries on the outer hair cells function in guinea pigs.","authors":"J Olszewski, W Chudzik, J Miłoński, K Kuśmierczyk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Histological studies were performed in 20 guinea pigs, both sexes, weighing 250-300 g and divided into two groups: I--control (anaesthetized animals without surgery), II--examined (in anaesthetized animals through an incision of the skin and muscles of the neck), the left or right vertebral artery was exposed and a vascular clip was inserted into the foramen of the transverse process of the 2-nd cervical vertebra. 50 days after this procedure, the guinea pigs were again anaesthetized by intraperitoneal injection of 35% solution of chloral hydrate, then vascular and cochlear perfusion with 3.6% solution of glutaraldehyde was performed. Simultaneously, by means of micropreparation, samples of cochlea were made for electron studies by means of electron microscope (Philips EM 300). In qualitative histopathologic examinations in guinea pigs of II group, the ischemia changes of the outer hair cells were greater in the side of irritation of the vertebral artery than at the opposite side. At the receptor side of these cells, under the membrane, there are multilamellar outgrowths in the shape of cisterns, partly expanded. The relative volume of external compartment of mitochondria in control group is as follows respectively: 0.15 +/- 0.0% at the right side and 0.15 +/- 0.08% at the left side, and in II group, respectively: 0.22 +/- 0.06% at the side of irritation and 0.19 +/- 0.07% at the opposite side. The obtained data in electron microscopy, both qualitative and quantitative pointed at ischemia changes of outer hair cells in guinea pigs after prolonged irritation of periarterial plexus of vertebral artery.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 2","pages":"151-4"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22463335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Congenital laryngeal cysts are a rare cause of stridor in the neonate. Nevertheless, delayed diagnosis and treatment can cause life-threatening airway obstruction. Even though the diagnosis is easily made by careful inspection, treatment results often in recurrence. These facts are illustrated by a case of a baby with a saccular cyst. Immediately after diagnosis and 5 days later the cyst was de-roofed using a CO2 laser via an endolaryngeal approach. Because of a second recurrence an excision of the cyst was performed via a lateral cervical approach.
{"title":"Congenital laryngeal cyst: a case report.","authors":"S Mariën, A Jespers, G Vidts, B Schmelzer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Congenital laryngeal cysts are a rare cause of stridor in the neonate. Nevertheless, delayed diagnosis and treatment can cause life-threatening airway obstruction. Even though the diagnosis is easily made by careful inspection, treatment results often in recurrence. These facts are illustrated by a case of a baby with a saccular cyst. Immediately after diagnosis and 5 days later the cyst was de-roofed using a CO2 laser via an endolaryngeal approach. Because of a second recurrence an excision of the cyst was performed via a lateral cervical approach.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 2","pages":"119-21"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22463376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper presents an overview of the use of EPs in the assessment of the CANS. Emphasis is laid on recent developments and research efforts centered on appraising how the auditory neural code is processed by the central pathways. It is shown how, in addition to their classical site-of-lesion testing role, EPs can, especially when combined with ecological (mostly speech-like) stimuli, yield highly valuable information on the neurophysiological processes leading to the perception of auditory objects as well as speech. Special space is devoted to the Mismatch Negativity that currently provides the only objective measure of the accuracy with which the CANS detects auditory and phonetic contrasts.
{"title":"The role of evoked potentials (EPs) in the assessment of the human central auditory nervous system (CANS).","authors":"P Deltenre, C Colin, B Dachy, A L Mansbach","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper presents an overview of the use of EPs in the assessment of the CANS. Emphasis is laid on recent developments and research efforts centered on appraising how the auditory neural code is processed by the central pathways. It is shown how, in addition to their classical site-of-lesion testing role, EPs can, especially when combined with ecological (mostly speech-like) stimuli, yield highly valuable information on the neurophysiological processes leading to the perception of auditory objects as well as speech. Special space is devoted to the Mismatch Negativity that currently provides the only objective measure of the accuracy with which the CANS detects auditory and phonetic contrasts.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 4","pages":"253-66"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24156777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Vermeire, J P Brokx, N Lemkens, P D'Haese, P H Van de Heyning
The ability to understand speech must be considered the most important measurable aspect of human auditory function. Due to the innovative developments in hearing aids and cochlear implants, there has been a renewed interest in speech recognition testing. During recent years, the start of several multi-centre studies have increased the urge to come to some consensus on the use of different speech materials. In this article a global overview of existing types of speech material in Dutch will be given. For each type, there is a reference to similar speech audiometric tests in French, English and German.
{"title":"Speech recognition tests in sensorineural hearing loss.","authors":"K Vermeire, J P Brokx, N Lemkens, P D'Haese, P H Van de Heyning","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ability to understand speech must be considered the most important measurable aspect of human auditory function. Due to the innovative developments in hearing aids and cochlear implants, there has been a renewed interest in speech recognition testing. During recent years, the start of several multi-centre studies have increased the urge to come to some consensus on the use of different speech materials. In this article a global overview of existing types of speech material in Dutch will be given. For each type, there is a reference to similar speech audiometric tests in French, English and German.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 3","pages":"169-75"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24037985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D T Nyembue, J M Tshiswaka, M J Sabue, C K Muyunga
Aim: The study intended to identify bacteria active in the chronic suppurative otitis media and to determine their sensitivity to current antibiotics.
Methods: After clinical evaluation, middle-ear secretions were taken for bacteriological examination from 78 children meeting the inclusion criteria. All children with cholesteatoma and those with tumors occluding the ear canal were excluded.
Results: The most frequent isolated germs, in descending order frequency, were as follows: Proteus mirabilis (23%), Pseudomonas aeruginosa (22%), Citrobacter (20%) and Salmonella (5%). There were no cases of mixed flora. Ofloxacin was susceptible on all isolates. Neomycin, gentamicin and polymyxin B were susceptible on 96%, 83% and 67% of the isolates respectively. All isolates were resistant to amoxycillin.
Conclusion: Peudomonas, Proteus and Citrobacter are the most common causes of chronic otitis media among children in our community of congolese children. Ofloxacin and neomycin are the most highly effective against most of the isolated germs, and are therefore recommended as the first line local treatment. Amoxycillin and chloramphenicol should be avoided.
{"title":"Bacteriology of chronic suppurative otitis media in congolese children.","authors":"D T Nyembue, J M Tshiswaka, M J Sabue, C K Muyunga","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>The study intended to identify bacteria active in the chronic suppurative otitis media and to determine their sensitivity to current antibiotics.</p><p><strong>Methods: </strong>After clinical evaluation, middle-ear secretions were taken for bacteriological examination from 78 children meeting the inclusion criteria. All children with cholesteatoma and those with tumors occluding the ear canal were excluded.</p><p><strong>Results: </strong>The most frequent isolated germs, in descending order frequency, were as follows: Proteus mirabilis (23%), Pseudomonas aeruginosa (22%), Citrobacter (20%) and Salmonella (5%). There were no cases of mixed flora. Ofloxacin was susceptible on all isolates. Neomycin, gentamicin and polymyxin B were susceptible on 96%, 83% and 67% of the isolates respectively. All isolates were resistant to amoxycillin.</p><p><strong>Conclusion: </strong>Peudomonas, Proteus and Citrobacter are the most common causes of chronic otitis media among children in our community of congolese children. Ofloxacin and neomycin are the most highly effective against most of the isolated germs, and are therefore recommended as the first line local treatment. Amoxycillin and chloramphenicol should be avoided.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 3","pages":"205-8"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24039109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As the acoustic information travels within the central auditory nervous system, the processing of the signal undergoes several levels of serial and parallel "bottom-up" processing influenced by high level cognitive "top-down" processes. Because the multiple location of the operational sites, the central auditory deficits are frequently quite subtle and need a test battery approach to be identified. Each of the four principal processes has at least to be tested: the closure task, the dichotic ability, the temporal ordering task and the binaural interaction function. The purpose of this review is to provide an overview of the psychoacoustic test procedures of identifying lesions or dysfunction's in the central auditory system.
{"title":"Central auditory processing assessment.","authors":"L Demanez, J P Demanez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As the acoustic information travels within the central auditory nervous system, the processing of the signal undergoes several levels of serial and parallel \"bottom-up\" processing influenced by high level cognitive \"top-down\" processes. Because the multiple location of the operational sites, the central auditory deficits are frequently quite subtle and need a test battery approach to be identified. Each of the four principal processes has at least to be tested: the closure task, the dichotic ability, the temporal ordering task and the binaural interaction function. The purpose of this review is to provide an overview of the psychoacoustic test procedures of identifying lesions or dysfunction's in the central auditory system.</p>","PeriodicalId":55407,"journal":{"name":"B-Ent","volume":"57 4","pages":"243-52"},"PeriodicalIF":0.2,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24156776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}